公开(公告)号：EP1978351A2

公开(公告)日：2008-10-08

申请号：EP08011345.9

申请日：1999-05-17

Applicant: Applera Corporation

Inventor： Gambini, Michael R. ,  Atwood, John G. ,  Young, Eugene F. ,  Lakatos, Edward J. ,  Cerrone, Anthony L.

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/1811 ,  C12Q1/686 ,  C12Q2545/101 ,  G01N21/0303 ,  G01N21/274 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2201/0245 ,  G01N2201/06113 ,  G01N2201/0628 ,  G01N2201/0635 ,  G01N2201/0636 ,  G01N2201/068 ,  C12Q2563/107

Abstract: The invention relates to an optical instrument which is particularly suited for DNA PCR monitoring. The instrument comprises a plurality of spaced-apart reaction ingredient containers (1b), a light source (11) adapted to direct an excitation beam (22) toward the plurality of containers (1b), a Fresnel lens (3) disposed along an excitation beam path between the light source (11) and the plurality of containers (1b) and a detector (10) disposed along an excitation beam path and arranged to receive emission beams (26) emitted from the Fresnel lens (3) which is also disposed along an emission beam path between the plurality of containers (1b) and the detector (10).

Abstract translation: 本发明涉及特别适用于DNA PCR监测的光学仪器。 该仪器包括多个间隔开的反应配料容器（1b），适于朝向多个容器（1b）引导激发光束（22）的光源（11），沿激励设置的菲涅耳透镜（3） 光源（11）和多个容器（1b）之间的光束路径以及沿着激发光束路径设置的检测器（10），所述检测器（10）布置成接收从菲涅耳透镜（3）发射的发射光束（26） 沿着多个容器（1b）和检测器（10）之间的发射束路径。

公开(公告)号：EP1672356A1

公开(公告)日：2006-06-21

申请号：EP05257800.2

申请日：2005-12-19

Applicant: Agilent Technologies, Inc.

Inventor： Helbing, Rene

IPC: G01N21/86 ,  A61B5/00 ,  G01N33/487

CPC classification number: G01N21/77 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B2562/0295 ,  G01N2201/0628

Abstract: A sensor (30), such as a lateral flow sensor, which includes a chemical layer (32) and a detector (36) on a flexible substrate (40). An optical signal is produced in response to an analyte (34) placed on the chemical layer. The detector detects the signal, to thereby detect the presence, absence or concentration of the analyte. The detector is on the substrate. The chemical layer and the substrate are laminated together, to thereby form an integrated sensor. The sensor can include a light source (42). The light source can be on the substrate, or on an opposite side of the chemical layer than the detector.

Abstract translation: 在柔性基板（40）上包括化学层（32）和检测器（36）的传感器（30），诸如横向流量传感器。 响应于放置在化学层上的分析物（34）产生光学信号。 检测器检测信号，从而检测分析物的存在，不存在或浓度。 检测器位于基板上。 将化学层和基板层叠在一起，从而形成集成的传感器。 传感器可以包括光源（42）。 光源可以在基板上，或者在化学层的与检测器相反的一侧上。

公开(公告)号：EP1336089A1

公开(公告)日：2003-08-20

申请号：EP01974483.8

申请日：2001-10-10

Applicant: IMPERIAL COLLEGE OF SCIENCE,TECHNOLOGY & MEDICINE

Inventor： BRADLEY, Donal ,  DE MELLO, John ,  DE MELLO, Andrew

IPC: G01N21/03 ,  B81B1/00 ,  B01J19/00

CPC classification number: G01N21/6454 ,  G01N21/05 ,  G01N21/253 ,  G01N21/31 ,  G01N2021/0346 ,  G01N2021/6482 ,  G01N2201/0628

Abstract: A microfabricated detection system, comprising: a substrate chip; a chamber defined by the substrate chip to which a fluid sample is in use delivered; and at least one detector comprising at least one light-emitting diode including an organic semiconductor element for emitting light into the chamber and at least one photocell including an organic semiconductor element for receiving light from the chamber.

公开(公告)号：EP1171764A1

公开(公告)日：2002-01-16

申请号：EP00990188.5

申请日：2000-11-21

Applicant: Iowa State University Research Foundation, Inc. ,  The Regents of The University of Michigan Technology Management Wolverine Tower Office

Inventor： AYLOTT, Jonathan W. ,  CHEN-ESTERLIT, Zoe ,  FRIEDL, Jon, H. ,  KOPELMAN, Raoul ,  SAVVATEEV, Vadim, N. ,  SHINAR, Joseph

IPC: G01N21/64

CPC classification number: G01N21/66 ,  G01N21/7703 ,  G01N2201/0628

Abstract: Optical sensor, probe and array devices for detecting chemical, biological, and physical analytes. The devices include an analyte-sensitive layer (74) optically coupled to a thin film electroluminescent layer (70) which activates the analyte-sensitive layer to provide an optical response.

公开(公告)号：US20230273132A1

公开(公告)日：2023-08-31

申请号：US18312873

申请日：2023-05-05

Applicant: The Boeing Company

Inventor： Morteza SAFAI

IPC: G01N21/88 ,  G01N21/95 ,  B29C64/393 ,  B29C64/371 ,  B33Y30/00 ,  B33Y50/02 ,  B33Y10/00

CPC classification number: G01N21/8806 ,  G01N21/95 ,  B29C64/393 ,  B29C64/371 ,  B33Y30/00 ,  B33Y50/02 ,  B33Y10/00 ,  G01N21/8851 ,  G01N2201/06113 ,  G01N2201/0628 ,  G01N2201/0627

Abstract: A method for real-time surface imperfection detection for additive manufacturing and 3-D printing parts is provided. The method includes directing a first light radiation using one or more illumination sources, wherein the first light radiation illuminates a target area of a part being manufactured in a uniform chromatic light such that the target area appears to have a substantially uniform monochromatic color; capturing a current image of a second light radiation that is scattered or reflected by the target area using one or more feedback cameras; and analyzing the current image of the second light radiation using at least one of the one or more feedback camera with a previously acquired image to determine whether a surface imperfection exists or does not exist.

公开(公告)号：US20230204517A1

公开(公告)日：2023-06-29

申请号：US17740992

申请日：2022-05-10

Applicant: HONGFUJIN PRECISION ELECTRONICS (ZHENGZHOU) CO., LTD. ,  HON HAI PRECISION INDUSTRY CO., LTD.

Inventor： TIAN-TIAN FAN ,  LI-MING ZHAO ,  YUAN-FANG DU

IPC: G01N21/88 ,  G01N21/95

CPC classification number: G01N21/8851 ,  G01N21/95 ,  G01N21/8806 ,  G01N2021/8835 ,  G01N2021/8883 ,  G01N2021/9511 ,  G01N2201/0628

Abstract: An apparatus to detect optical flatness of an OLED display layer includes a light-emitting assembly, a light-receiving assembly, and an image processor. The light-emitting assembly includes a light source and a first enhancement element. The light source emits reference light through the first enhancement element. The first enhancement element enhances brightness of the reference light and guides the enhanced reference light to a display layer of a display device being detected. The light-receiving assembly receives light reflected by the display layer according to the reference light and generates an image thereof. The image processor receives the image and obtains a result of detection as to surface flatness of the display layer according to the image.

公开(公告)号：US09823195B2

公开(公告)日：2017-11-21

申请号：US13748508

申请日：2013-01-23

Applicant: APPLIED BIOSYSTEMS, LLC

Inventor： Mark F. Oldham ,  Eugene F. Young

IPC: B01L3/00 ,  G01N21/00 ,  C12Q1/00 ,  G01N21/64 ,  B01L7/00 ,  G01N21/27

CPC classification number: G01N21/6486 ,  B01L3/5085 ,  B01L7/52 ,  C12Q2545/101 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2201/0245 ,  G01N2201/0628 ,  G01N2201/0635 ,  Y10S435/808 ,  Y10S435/809

Abstract: An instrument is provided that can monitor nucleic acid sequence amplification reactions, for example, PCR amplification of DNA and DNA fragments. The instrument includes a multi-notch filter disposed along one or both of an excitation beam path and an emission beam path. Methods are also provided for monitoring nucleic acid sequence amplifications using an instrument that includes a multi-notch filter disposed along a beam path.

公开(公告)号：US20170058310A1

公开(公告)日：2017-03-02

申请号：US15120446

申请日：2014-02-19

Applicant: EMPIRE TECHNOLOGY DEVELOPMENT LLC

Inventor： Vincenzo CASASANTA, III

IPC: C12Q1/02 ,  G01N21/552

CPC classification number: C12Q1/02 ,  G01N21/553 ,  G01N21/554 ,  G01N2201/0628 ,  G01N2201/0636 ,  G01N2201/0683

Abstract: A biosensing device, as well as methods of forming a biosensing device and detecting presence of a biofilm are disclosed. The biosensing device may include a substrate, at least one radiation source on the substrate, at least one radiation detector on the substrate, and at least one reflector arranged on the substrate such that radiation emitted from the at least one radiation source is reflected toward the at least one radiation detector. The at least one radiation detector may be configured to detect an intensity of the radiation reflected from the at least one reflector. A biofilm growth on a portion of the at least one reflector may cause a change in the intensity of the radiation reflected from the at least one reflector relative to radiation reflected from the reflector in the absence of the biofilm growth.

Abstract translation: 公开了一种生物传感装置，以及形成生物传感装置和检测生物膜存在的方法。 生物传感装置可以包括衬底，衬底上的至少一个辐射源，衬底上的至少一个辐射检测器和布置在衬底上的至少一个反射器，使得从至少一个辐射源发射的辐射朝向 至少一个辐射检测器。 所述至少一个辐射检测器可以被配置为检测从所述至少一个反射器反射的辐射的强度。 在不存在生物膜生长的情况下，至少一个反射器的一部分上的生物膜生长可导致从至少一个反射器反射的辐射的强度相对于从反射器反射的辐射的变化。

公开(公告)号：US20160343775A1

公开(公告)日：2016-11-24

申请号：US15156953

申请日：2016-05-17

Applicant: Kabushiki Kaisha Toshiba

Inventor： Toshiya YONEHARA ,  Keiji SUGI

IPC: H01L27/28 ,  A61B5/1455 ,  A61B5/024 ,  H01L51/50 ,  H01L51/52

CPC classification number: H01L27/288 ,  A61B5/02427 ,  A61B5/14552 ,  A61B2562/0233 ,  A61B2562/12 ,  G01N21/27 ,  G01N2201/0628 ,  H01L51/504 ,  H01L51/5218 ,  H01L51/5221

Abstract: According to one embodiment, a sensor includes a light emitter and a light sensor. The light emitter includes a first electrode, a second electrode, and a first light emitting layer. The second electrode is light-transmissive. The first light emitting layer is provided between the first electrode and the second electrode. The light sensor includes a third electrode, a fourth electrode, a fifth electrode, a first photoelectric conversion layer, and a second photoelectric conversion layer. the fourth electrode is light-transmissive. The fifth electrode is provided between the third electrode and the fourth electrode. The fifth electrode is light-transmissive. The first photoelectric conversion layer is provided between the third electrode and the fifth electrode. The second photoelectric conversion layer is provided between the fourth electrode and the fifth electrode.

Abstract translation: 根据一个实施例，传感器包括光发射器和光传感器。 光发射器包括第一电极，第二电极和第一发光层。 第二电极是透光的。 第一发光层设置在第一电极和第二电极之间。 光传感器包括第三电极，第四电极，第五电极，第一光电转换层和第二光电转换层。 第四电极是透光的。 第五电极设置在第三电极和第四电极之间。 第五电极是透光的。 第一光电转换层设置在第三电极和第五电极之间。 第二光电转换层设置在第四电极和第五电极之间。

公开(公告)号：US20160178522A1

公开(公告)日：2016-06-23

申请号：US14997883

申请日：2016-01-18

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Michael R. GAMBINI ,  Edward J. LAKATOS ,  Anthony L. CERRONE ,  Eugene F. YOUNG ,  John G. ATWOOD

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  B01L3/5085 ,  B01L7/52 ,  B01L2200/10 ,  B01L2300/0654 ,  B01L2300/0663 ,  B01L2300/1811 ,  C12Q1/686 ,  C12Q2545/101 ,  G01N21/274 ,  G01N21/645 ,  G01N21/6452 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2021/6482 ,  G01N2201/0245 ,  G01N2201/06113 ,  G01N2201/0628 ,  G01N2201/0635 ,  G01N2201/0636 ,  G01N2201/068 ,  C12Q2563/107

Abstract: An optical instrument monitors PCR replication of DNA in a reaction apparatus having a temperature cycled block with vials of reaction ingredients including dye that fluoresces in presence of double-stranded DNA. A beam splitter passes an excitation beam to the vials to fluoresce the dye. An emission beam from the dye is passed by the beam splitter to a CCD detector from which a processor computes DNA concentration. A reference strip with a plurality of reference emitters emit reference beams of different intensity, from which the processor selects an optimum emitter for compensating for drift. Exposure time is automatically adjusted for keeping within optimum dynamic ranges of the CCD and processor. A module of the beam splitter and associated optical filters is associated with selected dye, and is replaceable for different dyes.

Abstract translation: 光学仪器监测具有温度循环阻滞的反应装置中DNA的PCR复制，所述反应装置具有小瓶的反应成分，包括在双链DNA存在下发荧光的染料。 分束器将激发光束传递到小瓶以使染料发荧光。 来自染料的发射光束通过分束器传递到CCD检测器，处理器从该CCD检测器计算DNA浓度。 具有多个参考发射器的参考条发射不同强度的参考光束，处理器从该参考光束选择用于补偿漂移的最佳发射器。 自动调整曝光时间以保持CCD和处理器的最佳动态范围。 分束器和相关的滤光器的模块与选定的染料相关联，并且可替代不同的染料。