公开(公告)号：US20180328851A1

公开(公告)日：2018-11-15

申请号：US15705748

申请日：2017-09-15

Applicant: Electronics and Telecommunications Research Institute ,  Korea Advanced Institute of Science and Technology

Inventor： Won Kyoung LEE ,  Ki-Hun JEONG ,  Moonseong PARK

IPC: G01N21/65 ,  G01N21/64

CPC classification number: G01N21/658 ,  G01J3/433 ,  G01J3/44 ,  G01J2001/4242 ,  G01J2003/4424 ,  G01N21/274 ,  G01N21/6428 ,  G01N2201/06113 ,  G01N2201/067 ,  G01N2201/121

Abstract: Disclosed is an apparatus and method for processing a bio optical signal based on a spread spectrum scheme including a demodulator configured to collect a bio optical signal generated in response to an incident beam modulated based on a spreading code being scattered from a target analyte, and remove a noise from the bio optical signal by demodulating the bio optical signal based on the spreading code, wherein the bio optical signal has a correlation with the modulated incident beam.

公开(公告)号：US10059978B2

公开(公告)日：2018-08-28

申请号：US14897432

申请日：2014-06-11

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Ozan Akkus ,  Mikhail Slipchenko ,  Anna Akkus ,  Shan Yang ,  Bolan Li

IPC: C12Q1/34 ,  C12Q1/40 ,  G01N21/65 ,  C12Q1/37 ,  G01N1/40

CPC classification number: C12Q1/40 ,  C12Q1/37 ,  G01N1/4077 ,  G01N21/65 ,  G01N2001/4088 ,  G01N2201/121 ,  G01N2333/928 ,  G01N2333/958 ,  G01N2800/107 ,  G01N2800/345

Abstract: Methods for determining whether certain compounds, in particular crystals, are present in a sample of a biological fluid that indicates an individual has a particular disease or condition, such as but not limited to gout, pseudogout or urinary tract stones. In some embodiments, the methods include the steps of digestion and filtration of a sample of synovial fluid in order to isolate, if present, monosodium urate monohydrate (MSU), calcium pyrophosphate dihydrate (CPPD), or calcium phosphate crystals from the sample, wherein the filtrate is analyzed with a Raman device to ascertain the presence and type of the crystals. Devices for performing steps of the method are disclosed.

公开(公告)号：US09927371B2

公开(公告)日：2018-03-27

申请号：US14691966

申请日：2015-04-21

Applicant: KLA-Tencor Corporation

Inventor： Mark S. Wang ,  Chris Kirk ,  Andrey Kharisov

IPC: G01N21/00 ,  G01N21/88 ,  G02B21/00 ,  G02B21/36 ,  G01N21/95 ,  H01L21/66

CPC classification number: G01N21/8851 ,  G01N21/9501 ,  G01N2201/068 ,  G01N2201/10 ,  G01N2201/121 ,  G02B21/0028 ,  G02B21/0032 ,  G02B21/0072 ,  G02B21/365 ,  H01L22/12

Abstract: A line scan wafer inspection system includes a confocal slit aperture filter to remove sidelobes and enhance resolution in the scanning direction. A position detector associated with the slit aperture filter monitors and corrects illumination line image positions relative to the slit aperture to keep image position variations within tolerable limits. Each detector measures a line position and then uses the line position signal to adjust optical, mechanical, and electronic components in the collection path in a feedback loop. The feedback loop may be employed in a runtime calibration process or during inspection to enhance stability.

公开(公告)号：US09891174B2

公开(公告)日：2018-02-13

申请号：US14985679

申请日：2015-12-31

Applicant: SAMSUNG ELECTRONICS CO., LTD.

Inventor： Kui Hyun Kim ,  Sang Bum Park ,  Joo Hee Park

IPC: G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  G01N21/00 ,  G01N21/77 ,  G01N35/00 ,  B01L3/00 ,  G01N21/78

CPC classification number: G01N21/77 ,  B01L3/5027 ,  B01L2200/0684 ,  B01L2300/0803 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0409 ,  G01N21/78 ,  G01N35/00069 ,  G01N35/00623 ,  G01N2021/7773 ,  G01N2021/7783 ,  G01N2035/00346 ,  G01N2035/00851 ,  G01N2201/121

Abstract: Disclosed herein are a reactor, a test apparatus, and a test method, which measure, when a material included in a sample acts as an interfering material with respect to estimating a concentration of a target material, a concentration of the interfering material, and correct an estimated concentration of the target material based on the concentration of the interfering material, thereby improving the reliability and accuracy of the concentration of the target material. The reactor includes: a target material detecting chamber in which a first reagent that includes a first material that is activated by a target material is contained; a first material detecting chamber in which a second reagent that includes the target material is contained; an inlet hole into which a sample is injected; and a channel configured to connect the inlet hole, the target material detecting chamber, and the first material detecting chamber to each other.

公开(公告)号：US20170311855A1

公开(公告)日：2017-11-02

申请号：US15517477

申请日：2014-10-10

Applicant: Medtor LLC

Inventor： Thomas Dietiker

IPC: A61B5/1455 ,  A61B5/00

CPC classification number: A61B5/14551 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/6826 ,  A61B5/6832 ,  A61B5/6838 ,  A61B5/6844 ,  A61B5/7207 ,  A61B5/7221 ,  G01N2201/121

Abstract: A method and system for measuring oxygen levels and various blood constituents utilizing a sensor having one or more light sources, and one or more light detectors is disclosed. The system is capable of using data collected by the one or more detectors from a non-monochromatic light source to provide accurate information during motion events occurring with an extremity the sensor. The system is also capable of detecting and providing an alert if the sensor is not properly placed on a patient or becomes disengaged therefrom.

公开(公告)号：US09562850B2

公开(公告)日：2017-02-07

申请号：US14648855

申请日：2013-12-04

Applicant: SP3H

Inventor： Sylvain Oberti ,  Johan Fournel

IPC: G01N21/3577 ,  G01N21/3504 ,  G01N21/27 ,  G01N21/31

CPC classification number: G01N21/3577 ,  G01N21/274 ,  G01N21/3504 ,  G01N2021/3181 ,  G01N2201/062 ,  G01N2201/0624 ,  G01N2201/121 ,  G01N2201/1211 ,  G01N2201/124 ,  G01N2201/1242 ,  G01N2201/1247 ,  G01N2201/127 ,  G01N2201/12723

Abstract: A method for controlling a spectrometer for analyzing a product includes steps of: acquiring a measurement representative of the operation of a light source, determining, depending on the measurement, a value of supply current of the light source, and/or a value of integration time of light-sensitive cells of a sensor, disposed on a route of a light beam emitted by the light source and having interacted with a product to be analyzed, and if the integration time and/or supply current value is between threshold values, supplying the light source with a supply current corresponding to the determined supply current value, adjusting the integration time of a light-sensitive cell to the determined integration time value, and acquiring light intensity measurements supplied by the sensor, enabling a spectrum to be formed.

Abstract translation: 一种用于控制用于分析产品的光谱仪的方法包括以下步骤：获取代表光源的操作的测量，根据测量确定光源的电源电流的值和/或积分值 传感器的感光单元的时间设置在由光源发射的光束的路径上并且与待分析的产品相互作用，并且如果积分时间和/或电源电流值在阈值之间，则提供 所述光源具有与所确定的电源电流值相对应的电源电流，将感光单元的积分时间调整到所确定的积分时间值，以及获取由所述传感器提供的光强度测量值，从而能够形成光谱。

公开(公告)号：US20160274355A1

公开(公告)日：2016-09-22

申请号：US15166668

申请日：2016-05-27

Applicant: The Regents of the University of California

Inventor： Xiaodong Tao ,  Joel A. Kubby

IPC: G02B27/00 ,  G02B27/09 ,  G02B21/16 ,  G02B21/36 ,  G01N21/64 ,  G01J9/00

CPC classification number: G02B27/0068 ,  G01J9/00 ,  G01N21/45 ,  G01N21/49 ,  G01N21/6428 ,  G01N21/6458 ,  G01N2021/4709 ,  G01N2021/6439 ,  G01N2201/06113 ,  G01N2201/0675 ,  G01N2201/121 ,  G02B21/16 ,  G02B21/244 ,  G02B21/245 ,  G02B21/361 ,  G02B21/365 ,  G02B27/0927

Abstract: Interferometric focusing (IF), rather than conventional geometric focusing, of excitation light onto a guide-star that is embedded deeply in tissue, increases its fluorescence intensity. The method can extend the depth of wavefront measurement and improve correction inside of tissues because of its ability to suppress both scattering of diffuse light and aberration of ballistic light. The results showed more than two times improvement in SNR and RMS error of the wavefront measurement. Although only ballistic light in the excitation path is corrected, the intensity after wavefront correction increased by 1.5 times. When applying IF to a two-photon microscope with a near infra-red laser, this method would further extend the measurement depth and achieve high SNR for the wavefront sensor.

Abstract translation: 干涉测深（IF），而不是传统的几何聚焦，激发光到深埋在组织中的引导星，增加其荧光强度。 该方法可以延长波前测量的深度，并改善组织内部的校正，因为其能够抑制漫射光的散射和弹道光的差异。 结果显示波前测量的SNR和RMS误差提高了两倍以上。 虽然激励路径中只有弹道光被校正，波前校正后的强度增加了1.5倍。 当将IF应用于具有近红外激光器的双光子显微镜时，该方法将进一步扩展测量深度并实现波前传感器的高SNR。

公开(公告)号：US09389185B2

公开(公告)日：2016-07-12

申请号：US14840116

申请日：2015-08-31

Applicant: MannKind Corporation

Inventor： Jason J. Antunovich ,  Arthur T. Hamfeldt ,  Rodney J. Woods ,  Sam C. Shum

IPC: G01J3/44 ,  G01N21/65 ,  G01G9/00 ,  G01N15/06

CPC classification number: G01N21/65 ,  G01G9/00 ,  G01N15/06 ,  G01N2201/06113 ,  G01N2201/121 ,  G01N2201/127

Abstract: Methods and apparatus are provided for determining weight percent of solids in a suspension using Raman spectroscopy. The methods can be utilized to acquire Raman spectral data from the suspension and to determine weight percent of solids in a process being carried out, for example, in a vessel, without the need to remove samples for analysis. The weight percent of the solids can be determined with a desired accuracy in a relatively short time, typically 10 minutes or less. The acquired Raman spectral data may be processed by chemometric software using, for example, a partial least squares algorithm and data pretreatment to provide a predicted value of weight percent solids. In some embodiments, the invention is used to determine the weight percent of microparticles of a diketopiperazine in an aqueous solution.

Abstract translation: 提供了使用拉曼光谱测定悬浮液中固体重量百分比的方法和装置。 这些方法可用于从悬浮液中获得拉曼光谱数据，并确定例如在容器中进行的方法中固体的重量百分比，而不需要除去样品进行分析。 固体的重量百分比可以在相对较短的时间（通常为10分钟或更短）内以期望的精度确定。 获得的拉曼光谱数据可以通过化学计量学软件使用例如偏最小二乘法算法和数据预处理来提供重量百分比固体的预测值。 在一些实施方案中，本发明用于测定水溶液中二酮哌嗪微粒的重量百分比。

公开(公告)号：US20160103073A1

公开(公告)日：2016-04-14

申请号：US14883269

申请日：2015-10-14

Applicant: Alakai Defense Systems, Inc.

Inventor： Alan R. Ford ,  Adam J. Hopkins

IPC: G01N21/65 ,  G01N33/22

CPC classification number: G01N21/65 ,  G01J3/0224 ,  G01J3/0237 ,  G01J3/0262 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/28 ,  G01J3/44 ,  G01J2003/4424 ,  G01N33/227 ,  G01N2021/1793 ,  G01N2201/0683 ,  G01N2201/121

Abstract: A method for utilizing polarization as a scheme for fluorescence removal from UV Raman spectra collected in a standoff detection scheme has been invented. In this scheme, a linearly polarized ultraviolet (UV) laser interacts with a material on a surface or in a container. The material generates Raman scattering with polarization contributions relative to that of the laser. The material possibly fluoresces as well, but the fluorescence is generally unpolarized. By subtracting a scaled version of the perpendicular component from the parallel component of the returned signal both relative to the laser source polarization—it is possible to generate a spectrum that is fluorescence free and contains the strongest features of the Raman scattered light.

Abstract translation: 已经发明了利用偏振作为在间隔检测方案中收集的UV拉曼光谱进行荧光去除的方案的方法。 在该方案中，线偏振紫外（UV）激光与表面或容器中的材料相互作用。 该材料产生相对于激光的偏振贡献的拉曼散射。 该材料也可能发荧光，但荧光通常是非极化的。 通过从相对于激光源极化的返回信号的并行分量中减去垂直分量的缩放版本，可以产生无荧光的光谱，并且包含拉曼散射光的最强特征。

公开(公告)号：US09297752B2

公开(公告)日：2016-03-29

申请号：US14388358

申请日：2013-04-04

Applicant: ADVANCED TELECOMMUNICATIONS RESEARCH INSTITUTE INTERNATIONAL

Inventor： Takeaki Shimokawa ,  Takashi Kosaka ,  Okito Yamashita ,  Masaaki Sato

IPC: G01D18/00 ,  G01N21/47 ,  A61B10/00 ,  A61B5/00

CPC classification number: G01N21/4785 ,  A61B5/0042 ,  A61B5/0073 ,  A61B5/0091 ,  A61B10/0041 ,  G01N2201/121 ,  G01N2201/12753

Abstract: In order to solve a problem that a local optical characteristic-changed region inside an object cannot be accurately estimated, an object observing apparatus includes: a light intensity information acquiring unit that acquires light intensity information received by each light-receiving probe; a light intensity change information acquiring unit that acquires, for each probe set, light intensity change information, from reference light intensity information and light intensity information; an estimating unit that acquires three-dimensional optical characteristic-changed region information, using the light intensity change information; and an output unit that outputs the optical characteristic-changed region information; the estimating unit including a correcting part that performs correction according to sensitivity attenuation in accordance with a depth; and a sparseness applying part that introduces sparseness for improving a space resolution, thereby acquiring the optical characteristic-changed region information. Accordingly, it is possible to accurately estimate a local optical characteristic-changed region inside an object.

Abstract translation: 为了解决不能准确地估计对象内的局部光学特性变化区域的问题，物体观测装置包括：光强度信息获取单元，其获取由各受光探针接收的光强度信息; 光强度变化信息获取单元，对于每个探针组，从参考光强度信息和光强度信息获取光强度变化信息; 估计单元，使用光强度变化信息获取三维光学特性变化区域信息; 以及输出单元，其输出所述光学特性变化区域信息; 所述估计单元包括根据深度执行根据灵敏度衰减的校正的校正部分; 以及引入稀疏性以提高空间分辨率的稀疏性施加部，从而获取光学特性变化区域信息。 因此，可以精确地估计物体内部的局部光学特性变化区域。