ISOTOPE PREPARATION METHOD
    126.
    发明专利

    公开(公告)号:CA3010190A1

    公开(公告)日:2017-07-13

    申请号:CA3010190

    申请日:2016-12-29

    Applicant: BAYER AS

    Abstract: The present invention comprises a method for the generation of 227 Th of pharmaceutically tolerable purity comprising i) preparing a generator mixture comprising 227 Ac, 227 Th and 223 Ra; ii) loading said generator mixture onto a strong base anion exchange resin; iii) eluting a mixture of said 223 Ra and 227 Ac from said strong base anion exchange resin using a first mineral acid in an aqueous solution; iv) eluting 227 Th from said strong base anion exchange resin using a second mineral acid in an aqueous solution whereby to generate a first 227 Th solution containing contaminant 223 Ra and 227 Ac; v) loading the first 227 Th solution onto a strong acid cation exchange resin; vi) eluting at least a part of the contaminant 223 Ra and 227 Ac from said strong acid cation exchange resin using a third mineral acid in aqueous solution; and vii) eluting the 227 Th from said strong acid cation exchange resin using a first aqueous buffer solution to provide a second 227 Th solution. Purified thorium-227 of pharmaceutical purity and a pharmaceutical composition comprising the same are also provided.

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