Abstract:
A microfilter comprising a polymer layer formed from epoxy-based photo-definable dry film, and a plurality of apertures each extending through the polymer layer. A method of forming a microfilter is also disclosed. The method includes providing a first layer of epoxy-based photo-definable dry film disposed on a substrate, exposing the first layer to energy through a mask to form a pattern, defined by the mask, in the first layer of dry film, forming, from the exposed first layer of dry film, a polymer layer having a plurality of apertures extending therethrough, the plurality of apertures having a distribution defined by the pattern, and removing the polymer layer from the substrate.
Abstract:
A simple and accurate method for characterizing biomarkers in a biological sample using multiple rounds of fluorescent staining is described. The method involves the steps of quenching underrivatizing, amine stripping and regaining (QUAS-R) of cells, tissue or any biological sample.
Abstract:
A new sensitive cell biomarker of solid tumors and viral infection is identified in blood. This biomarker can be used to determine presence of carcinomas, sarcomas, and viruses, rapid determination of treatment response, early detection of cancer, early detection of cancer recurrence, and may be used to determine therapy.
Abstract:
Grids (30) and collimators, for use with electromagnetic energy emitting devices (61), include at least a metal layer that is formed, for example, by electroplating/electroforming or casting. The metal layer includes top and bottom surfaces, and a plurality of solid integrated walls (32). Each of the solid integrated walls extends from the top to bottom surface and has a plurality of side surfaces. The side surfaces of the solid integrated walls are arranged to define a plurality of openings (31) extending entirely through the layer. At least some of the walls (32) also can include projections extending into the respective openings formed by the walls (32). The projections can be of various shapes and sizes, and are arranged so that a total amount of wall material intersected by a line propagating in a direction along an edge of the grid (30) is substantially the same as another total amount of wall material intersected by another line propagating in another direction substantially parallel to the edge of the grid (30) at any distance from the edge. Methods to fabricate these grids (30) using copper, lead, nickel, gold, any other electroplating/electroforming materials or low melting temperature metals are described.
Abstract:
A grid (30), for use with electromagnetic energy emitting devices, includes at least metal layer, which is formed, for example, by electroplating. The metal layer includes top and bottom surfaces, and a plurality of solid integrated walls (32). Each of the solid integrated walls extends from the top to bottom surface and having a plurality of side surfaces. The side surfaces of the solid integrated walls (32), are arranged to define a plurality of openings extending entirely through the layer. At least some of the walls also can include projections extending into the respective openings formed by the walls. The projections can be of various shapes and sizes, and are arranged so that a total amount of wall material intersected by a line propagating in a direction along an edge of the grid is substantially the same as another total amount of wall material intersected by another line propagating in another direction substantially parallel to the edge of the grid at any distance from the edge.
Abstract:
A new sensitive cell biomarker of solid tumors is identified in blood. This biomarker can be used to determine presence of carcinomas, rapid determination of treatment response, early detection of cancer, early detection of cancer recurrence, and may be used to determine therapy.