公开(公告)号：EP3435234A1

公开(公告)日：2019-01-30

申请号：EP18151944.8

申请日：2011-01-12

Applicant: STC.UNM

Inventor： HELINSKI, Ryan L. ,  PLUSQUELLIC, James ,  ACHARYYA, Dhruva

IPC: G06F11/10 ,  G09C1/00 ,  H04L9/08

Abstract: A system and method that generates a physical unclonable function ("PUF") security key for an integrated circuit ("IC") through use of equivalent resistance variations in the power distribution system ("PDS") to mitigate the vulnerability of security keys to threats including cloning, misappropriation and unauthorized use.

公开(公告)号：EP2720793B1

公开(公告)日：2018-03-07

申请号：EP12801152.5

申请日：2012-06-15

Applicant: STC.UNM

Inventor： SEROV, Alexey ,  HALEVI, Barr ,  ARTYUSHKOVA, Kateryna ,  ATANASSOV, Plamen, B. ,  MARTINEZ, Ulises Andres

IPC: H01M4/90 ,  B01J37/08 ,  B01J23/889 ,  B01J23/70 ,  B01J35/00 ,  H01M4/88 ,  H01M4/86

CPC classification number: H01M4/8652 ,  B01J23/70 ,  B01J23/8892 ,  B01J35/0033 ,  B01J37/084 ,  H01M4/8621 ,  H01M4/8885 ,  H01M4/9041 ,  H01M4/9083 ,  H01M4/9091 ,  H01M2004/8689

Abstract: A method of preparing M-N—C catalysts utilizing a sacrificial support approach and inexpensive and readily available polymer precursors as the source of nitrogen and carbon is disclosed. Exemplary polymer precursors include non-porphyrin precursors with no initial catalytic activity. Examples of suitable non-catalytic non-porphyrin precursors include, but are not necessarily limited to low molecular weight precursors that form complexes with iron such as 4-aminoantipirine, phenylenediamine, hydroxysuccinimide, ethanolamine, and the like.

公开(公告)号：EP3269003A1

公开(公告)日：2018-01-17

申请号：EP16765535.6

申请日：2016-03-14

Applicant: STC.UNM

Inventor： SEROV, Alexey ,  ATANASSOV, Plamen, B

IPC: H01M8/1004 ,  H01M4/86 ,  H01M4/92

CPC classification number: H01M8/1213 ,  H01M4/8605 ,  H01M4/861 ,  H01M4/8636 ,  H01M4/8642 ,  H01M8/1004

Abstract: Methods for optimizing, designing, making, and assembling various component parts and layers to produce optimized MEAs. Optimization is generally achieved by producing multi-layered MEAs wherein characteristics such as catalyst composition and morphology, ionomer concentration, and hydrophobicity/hydophilicity are specifically tuned in each layer. The MEAs are optimized for use with a variety of catalysts including catalysts with specifically designed and controlled morphology, chemical speciation on the bulk, chemical speciation on the surface, and/or specific hydrophobic or hydrophilic or other characteristics. The catalyst can incorporate non-platinum group metal (non-PGM) and/or platinum group metal (PGM) materials.

公开(公告)号：EP3055431A1

公开(公告)日：2016-08-17

申请号：EP14852570.2

申请日：2014-09-24

Applicant: STC.UNM

Inventor： EDWARDS, Jeremy Scott

IPC: C12Q1/68

Abstract: The disclosure describes a method for sequencing long portions of DNA sequence by assembling a plurality of shorter polynucleotide reads. Generally, The method includes annealing a plurality of primers to a denatured DNA molecule, appending a barcode polynucleotide to the 5′ end of the primer, subjecting the DNA molecules to a plurality of cycles of (1) pooling, (2) dividing, and (3) appending a barcode polynucleotide to the 5′ end of the primer, sequencing the barcode polynucleotides and the genomic DNA, and assembling the short read polynucleotide sequences having identical barcode polynucleotides.

Abstract translation: 本公开描述了通过组装多个较短的多核苷酸读取来测序DNA序列的长部分的方法。 通常，该方法包括将多个引物退火至变性DNA分子，将条形码多核苷酸附加到引物的5'末端，对DNA分子进行多个周期（1）合并，（2）分裂和 （3）将条形码多核苷酸添加到引物的5'末端，测序条形码多核苷酸和基因组DNA，并组装具有相同条形码多核苷酸的短读多核苷酸序列。

公开(公告)号：EP3046543A1

公开(公告)日：2016-07-27

申请号：EP14845415.0

申请日：2014-09-18

Applicant: STC.UNM ,  SANDIA CORPORATION

Inventor： BRINKER, C., Jeffrey ,  LIN, Yu-shen

IPC: A61K9/127 ,  A61K31/7088 ,  A61K38/00 ,  B82Y5/00

CPC classification number: A61K9/1271 ,  A61K9/14 ,  A61K9/5115 ,  A61K9/5123 ,  A61K31/7088 ,  A61K38/16 ,  A61K38/43 ,  A61K39/395 ,  B82Y5/00 ,  B82Y15/00 ,  C12N15/88

Abstract: In one aspect, the invention provides novel monodisperse, colloidally-stable, toroidal mesoporous silica nanoparticles (TMSNPs) which are synthesized from ellipsoid-shaped mesoporous silica nanoparticles (MSNPs) which are prepared using an ammonia basecatalyzed method under a low surfactant conditions. Significantly, the TMSNPs can be loaded simultaneously with a small molecule active agent, a siRNA, a mRNA, a plasmid and other cargo and can be used in the diagnosis and/or treatment of a variety of disorders, including a cancer, a bacterial infection and/or a viral infection, among others. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.

公开(公告)号：EP3039547A1

公开(公告)日：2016-07-06

申请号：EP14840028.6

申请日：2014-08-28

Applicant: STC.UNM

Inventor： PLUSQUELLIC, James

IPC: G06F11/10

CPC classification number: G06F7/588 ,  G06F2207/58 ,  G09C1/00 ,  H04L9/002 ,  H04L9/0866 ,  H04L2209/12 ,  H04L2209/26 ,  Y04S40/24

Abstract: This disclosure describes techniques for analyzing statistical quality of bitstrings produced by a physical unclonable function (PUF). The PUF leverages resistance variations in the power grid wires of an integrated circuit. Temperature and voltage stability of the bitstrings are analyzed. The disclosure also describes converting a voltage drop into a digital code, wherein the conversion is resilient to simple and differential side-channel attacks.

公开(公告)号：EP2519627B1

公开(公告)日：2016-03-30

申请号：EP10841780.9

申请日：2010-12-31

Applicant: STC.UNM

Inventor： PEABODY, David, S. ,  CHACKERIAN, Bryce

IPC: C12N7/01 ,  C12N15/33 ,  C07K14/005 ,  A61K39/12

CPC classification number: A61K39/12 ,  A61K39/07 ,  A61K2039/5256 ,  A61K2039/5258 ,  C12N7/00 ,  C12N15/1037 ,  C12N2710/20022 ,  C12N2710/20034 ,  C12N2740/16034 ,  C12N2740/16134 ,  C12N2795/16021 ,  C12N2795/16022 ,  C12N2795/16023 ,  C12N2795/16042 ,  C12N2795/18023 ,  C40B40/08

公开(公告)号：EP2945735A1

公开(公告)日：2015-11-25

申请号：EP14740852.0

申请日：2014-01-16

Applicant: STC.UNM

Inventor： SEROV, Alexey ,  ATANASSOV, Plamen, B.

IPC: B01J23/745 ,  B01J37/08 ,  H01M4/90

CPC classification number: H01M4/9041 ,  B01J27/24 ,  B01J35/0033 ,  B01J35/10 ,  B01J37/0036 ,  B01J37/06 ,  B01J37/086 ,  H01M4/9091

Abstract: A sacrificial support-based method, a mechanosynthesis-based method, and a combined sacrificial support/mechanosynthesis support based method that enables the production of supported or unsupported catalytic materials and/or the synthesis of catalytic materials from both soluble and insoluble transition metal and charge transfer salt materials.

公开(公告)号：EP2765997A2

公开(公告)日：2014-08-20

申请号：EP12840155.1

申请日：2012-10-12

Applicant: STC.UNM ,  Sandia Corporation

Inventor： ASHLEY, Carlee Erin ,  BRINKER, C., Jeffrey ,  CARNES, Eric C. ,  FEKRAZAD, Mohammad Houman ,  FELTON, Linda A. ,  NEGRETE, Oscar ,  PADILLA, David Patrick ,  WILKINSON, Brian S. ,  WILKINSON, Dan C. ,  WILLMAN, Cheryl L.

IPC: A61K9/16 ,  A61K47/48 ,  A61K49/08 ,  A61K48/00 ,  A61K38/17 ,  A61K31/7105 ,  A61K31/7088

CPC classification number: A61K48/0008 ,  A61K9/0014 ,  A61K9/107 ,  A61K9/1271 ,  A61K9/5078 ,  A61K31/192 ,  A61K31/465 ,  A61K31/506 ,  A61K31/513 ,  A61K31/704 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K33/24 ,  A61K38/00 ,  A61K38/17 ,  A61K38/45 ,  A61K38/47 ,  A61K45/06 ,  A61K47/6923 ,  A61K49/0082 ,  A61K49/0423 ,  B82Y5/00 ,  C07K7/06 ,  C07K2319/00 ,  C12N15/113 ,  C12N15/1131 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2810/40 ,  C12Y204/02036 ,  C12Y302/02022 ,  A61K2300/00

Abstract: The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.

公开(公告)号：EP2720793A2

公开(公告)日：2014-04-23

申请号：EP12801152.5

申请日：2012-06-15

Applicant: STC.UNM

Inventor： SEROV, Alexey ,  HALEVI, Barr ,  ARTYUSHKOVA, Kateryna ,  ATANASSOV, Plamen, B. ,  MARTINEZ, Ulises Andres

IPC: B01J31/12 ,  B01J38/02 ,  H01M4/90

CPC classification number: H01M4/8652 ,  B01J23/70 ,  B01J23/8892 ,  B01J35/0033 ,  B01J37/084 ,  H01M4/8621 ,  H01M4/8885 ,  H01M4/9041 ,  H01M4/9083 ,  H01M4/9091 ,  H01M2004/8689

Abstract: A method of preparing M-N-C catalysts utilizing a sacrificial support approach and inexpensive and readily available polymer precursors as the source of nitrogen and carbon is disclosed. Exemplary polymer precursors include non-porphyrin precursors with no initial catalytic activity. Examples of suitable non-catalytic non-porphyrin precursors include, but are not necessarily limited to low molecular weight precursors that form complexes with iron such as 4-aminoantipirine, phenylenediamine, hydroxysuccinimide, ethanolamine, and the like.