公开(公告)号：WO2013124740A3

公开(公告)日：2014-01-09

申请号：PCT/IB2013000670

申请日：2013-02-25

Applicant: STICHTING VU VUMC ,  STICHTING NL KANKER INST

Inventor： JIMENEZ CORNELIA RAMONA ,  WARMOES MARC OMER ,  PHAM THANG VIET ,  ROTTENBERG SVEN

IPC: G01N33/574

CPC classification number: G01N33/57415 ,  G01N33/57484 ,  G01N2800/52

Abstract: BRCA-deficiency signatures comprising differentially regulated proteins present in BRCA1-deficient tumors, and BRCA-deficiency signatures comprising nucleic acids isolated from BRCA1-deficient tumors, as well as methods of using the same, are disclosed.

Abstract translation: 公开了包含BRCA1缺陷型肿瘤中存在的差异调节蛋白质的BRCA缺陷特征以及包含从BRCA1缺陷型肿瘤分离的核酸的BRCA缺陷型特征，以及使用该BRCA缺陷型鉴定的方法。

公开(公告)号：WO2013187761A1

公开(公告)日：2013-12-19

申请号：PCT/NL2013/050415

申请日：2013-06-12

Applicant: STICHTING VU-VUMC

Inventor： HEUS, Ferry Adam Henricus ,  KOOL, Jeroen

IPC: G01N30/84 ,  B01D15/08 ,  B01D15/24

CPC classification number: G01N30/84 ,  B01D15/24 ,  G01N30/30 ,  G01N30/80 ,  G01N2030/025 ,  G01N2030/065 ,  G01N2030/8435

Abstract: The invention is directed to a process to separate compounds starting from a mixture of two or more compounds by performing the following steps:(a) passing a portion of a gaseous mixture of a carrier gas and the mixture of compounds through a GC column wherein two or more compounds of the mixture are discharged at a different time from the column. In a step (b) a fluid is added to the gaseous flow to obtain a flow comprising of the fluid as a gas, the carrier gas and the compounds. In a step (c) the flow of step (b) is cooled to obtain a flow comprising a gaseous phase comprising the carrier gas and a liquid phase comprising the condensed fluid and the compounds. In a step(d) the one or more liquid fractions from the flow of step (c)are isolated.

Abstract translation: 本发明涉及从两种或更多种化合物的混合物开始分离化合物的方法，其通过以下步骤：（a）将载气和混合物的气体混合物的一部分通过GC柱，其中两个 或更多的混合物的化合物在与该柱不同的时间排出。 在步骤（b）中，将流体添加到气流中以获得包含作为气体的流体，载气和化合物的流动。 在步骤（c）中，将步骤（b）的流程冷却以获得包括包含载气的气相和包含冷凝流体和化合物的液相的流。 在步骤（d）中，分离来自步骤（c）的流程的一种或多种液体馏分。

公开(公告)号：WO2013176549A1

公开(公告)日：2013-11-28

申请号：PCT/NL2013/050378

申请日：2013-05-24

Applicant: STICHTING VU-VUMC

Inventor： PETERMAN, Erwin ,  MANGEOL, Pierre

IPC: G02B21/22 ,  G02B21/36

CPC classification number: G02B21/22 ,  G02B21/365

Abstract: The present invention relates to an optical apparatus (202) comprising a sample support (219) and imaging means (2119) arranged, when said optical apparatus (202) is in use, to receive a first beam (2115) emanating from the sample support (219) under a first angle (2127) with respect to a reference axis (2131)wherein the optical apparatus (202) further comprises a reflector (217) and in that the imaging means (2119) are arranged to receive at least a second beam (2113, 211) emanating from the sample support (219) under a second angle (2129) with respect to the reference axis (2131),the second angle (2129) being different from the first angle (2127), the second beam (2113, 211) when passing from the sample support (219) to the imaging means (2119) being reflected by the reflector (217).

Abstract translation: 本发明涉及一种光学设备（202），包括样本支撑件（219）和成像装置（2119），当所述光学设备（202）在使用中时，所述成像装置（2119）被布置成接收从样品支架 （2131），其中所述光学设备（202）还包括反射器（217），并且所述成像装置（2119）被布置成接收至少第二个 从所述样品支撑件（219）以相对于所述参考轴线（2131）的第二角度（2129）发出的所述第一角度（2113,211），所述第二角度（2129）不同于所述第一角度（2127），所述第二光束 （2113,211）当从样品支撑件（219）通过被反射器（217）反射的成像装置（2119）时。

公开(公告)号：WO2013070079A2

公开(公告)日：2013-05-16

申请号：PCT/NL2012/050793

申请日：2012-11-09

Applicant: VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK, ,  STICHTING VU-VUMC

Inventor： REIJERKERK, Arie ,  DE VRIES, Helga Eveline

IPC: C12Q1/68

CPC classification number: C12Q1/6809 ,  C12Q2600/178

Abstract: The blood-brain barrier (BBB) separates the blood and the central nervous system (CNS). Here it is disclosed that blood-brain barrier function can be increased with particular nucleic acid sequences, in particular in patients suffering from or diagnosed with Multiple Sclerosis. The use of compounds comprising such nucleic acid sequences for increasing blood-brain barrier function is described.

Abstract translation: 血脑屏障（BBB）分离血液和中枢神经系统（CNS）。 这里公开了可以用特定的核酸序列增加血脑屏障功能，特别是患有或诊断患有多发性硬化症的患者。 描述了包含这种核酸序列的化合物用于增加血脑屏障功能的用途。

公开(公告)号：WO2012008839A3

公开(公告)日：2012-03-01

申请号：PCT/NL2011050518

申请日：2011-07-15

Applicant: STICHTING VU VUMC ,  WUERDINGER THOMAS ,  NILSSON ROLF JONAS

Inventor： WUERDINGER THOMAS ,  NILSSON ROLF JONAS

IPC: G01N33/48

CPC classification number: C12Q1/6827 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

Abstract translation: 本发明涉及一种分析患者血液样本中疾病标志物存在的方法，所述方法包括以下步骤：a）从所述血液样品中的未核化血细胞提取核酸，以提供无核细胞提取的 核酸级分，以及b）分析所述无核细胞提取的核酸级分是否存在疾病标志物，其中所述疾病标志物是所述受试者的细胞基因中的疾病特异性突变，或其中所述疾病标记 是所述受试者的细胞的基因的疾病特异性表达谱。

公开(公告)号：WO2022114957A1

公开(公告)日：2022-06-02

申请号：PCT/NL2021/050720

申请日：2021-11-26

Applicant: STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS ,  STICHTING VU

Inventor： MEIJER, Gerrit Albert ,  VAN DEN BROEK, Evert ,  FIJNEMAN, Remondus Johannes Adriaan ,  ABELN, Sanne ,  LAKBIR, Soufyan ,  HERINGA, Jakob

IPC: C12Q1/6886

Abstract: The invention relates to methods for tumor marker analysis comprising providing a genomic DNA sample from tumor cells of a patient, preselecting a chromosomal region on the genomic DNA comprising at least part of a potential structural variant (SV); and sequencing the genomic region to characterize the potential SV. The invention further relates to methods for detecting minimal residual disease, monitoring treatment response and tumor progression in a patient by employing the SV, and to personalized therapy based on the identity of the SV.

公开(公告)号：WO2022111905A1

公开(公告)日：2022-06-02

申请号：PCT/EP2021/078193

申请日：2021-10-12

Applicant: STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN ,  ASML NETHERLANDS B.V. ,  STICHTING VU ,  UNIVERSITEIT VAN AMSTERDAM

Inventor： KRAUS, Peter, Michael ,  ROSCAM ABBING, Sylvianne, Dorothea, Christina ,  CAMPI, Filippo ,  ZHANG, ZhuangYan ,  SMORENBURG, Petrus, Wilhelmus ,  LIN, Nan ,  WITTE, Stefan, Michiel ,  DEN BOEF, Arie, Jeffrey

IPC: G03F7/20 ,  G01N21/47 ,  G01N21/956 ,  G01N23/22

Abstract: Disclosed is a metrology apparatus and method for measurement of a diffractive structure on a substrate. The metrology apparatus comprises a radiation source operable to provide first radiation for excitation of the diffractive structure such that high harmonic second radiation is generated from said diffractive structure and/or substrate; and a detection arrangement operable to detect said second radiation, at least a portion of which having been diffracted by said diffractive structure.

公开(公告)号：WO2022096110A1

公开(公告)日：2022-05-12

申请号：PCT/EP2020/081183

申请日：2020-11-05

Applicant: STICHTING VU

Inventor： BARTOLINI, Luca ,  IANNUZZI, Davide ,  VAN HAASTERECHT, Ludo

IPC: A61B1/00 ,  A61B1/015 ,  A61B1/05

Abstract: There is provided an endoscopy instrument (20) for in-vivo characterisation of tissue. The endoscopy instrument (20) comprises: a probe (26) for insertion into a body orifice and probing the tissue through the body orifice; an actuator (30,32) operably coupled to the probe (26) so that the actuator (30,32) is operable to, through the probe (26), cause mechanical deformation of the tissue; and an imaging device (24) operably coupled to the probe (26) so that the imaging device (24) is operable to, through the probe (26), obtain an image of the mechanically deformed tissue.

公开(公告)号：WO2021121733A1

公开(公告)日：2021-06-24

申请号：PCT/EP2020/079540

申请日：2020-10-21

Applicant: ASML NETHERLANDS B.V. ,  STICHTING VU ,  STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN ,  UNIVERSITEIT VAN AMSTERDAM

Inventor： COENE, Willem, Marie, Julia, Marcel ,  DEN BOEF, Arie, Jeffrey ,  TENNER, Vasco, Tomas ,  PANDEY, Nitesh ,  MESSINIS, Christos ,  DE BOER, Johannes Fitzgerald

IPC: G03H1/04 ,  G03H1/26 ,  G03F7/20

Abstract: A dark field digital holographic microscope is disclosed which is configured to determine a characteristic of interest of a structure. The dark field digital holographic microscope comprises an illumination device configured to provide at least: a first beam pair comprising a first illumination beam of radiation (1010) and a first reference beam of radiation (1030) and a second beam pair comprising a second illumination beam of radiation (1020) and a second reference beam of radiation (1040); and one or more optical elements (1070) operable to capture a first scattered radiation and to capture a second scattered radiation scattered by the structure resultant from the first and second illumination beams respectively. The beams of the first beam pair are mutually coherent and the beams of the second beam pair are mutually coherent. The illumination device is configured to impose incoherence (ADI) between the first beam pair and second beam pair.

公开(公告)号：WO2019203645A1

公开(公告)日：2019-10-24

申请号：PCT/NL2019/050229

申请日：2019-04-18

Applicant: STICHTING VU

Inventor： GROSSMANN, Tom Norbert ,  PELAY GIMENO, Marta ,  HENNIG, Sven ,  NEUBACHER, Saskia Antonie

IPC: C12N9/96 ,  C12N9/52 ,  C12N9/64

Abstract: The present invention relates to methods and cross-linkers for the macrocyclization of proteins. The invention is useful for increasing the stability of a protein.