公开(公告)号：WO2007123843A3

公开(公告)日：2007-11-01

申请号：PCT/US2007/009027

申请日：2007-04-12

Applicant: PENN FISHING TACKLE MANUFACTURING COMPANY ,  MARTIN, David, H. ,  TODD, John, J.

Inventor： MARTIN, David, H. ,  TODD, John, J.

IPC: A01K89/01

Abstract: A fishing reel end plate (200) may comprise a unitary disk (200) having a generally central opening (252) between a frame facing side (220) and an exterior side (210) thereof, a bridge (230) proximate the frame facing side (220) and a wall (242) joining a fundus and the exterior side (210) defining a first cavity (250) open at the exterior side (210). The bridge (230) may have a hole (232) spaced apart from a generally central opening (252) for receiving a stud (120). The unitary disk (200) may have a second cavity (260) open at the frame facing side (220) and separated from the first cavity (250) by a common portion of the wall (242). The common wall (242) portion may have an opening (212) between the first and second cavities (250, 260). The end plate (200) may be mounted to the frame (20) of a fishing reel (10).

公开(公告)号：WO2005025642A2

公开(公告)日：2005-03-24

申请号：PCT/US2004/028003

申请日：2004-08-27

Applicant: BAUMEISTER, Todd, John

Inventor： BAUMEISTER, Todd, John

IPC: A61M

CPC classification number: A61L2/0011 ,  A01N1/02 ,  A01N1/0242 ,  A01N1/0294 ,  A61M1/3681 ,  A61M2205/053 ,  A61M2205/12

Abstract: A device for irradiating blood is provided, the device including a chamber having an elongate configuration defining a hollow interior, the chamber formed of reflective material, a tubular cassette sized and shaped to be received in the interior of the chamber, the tubular cassette having an inside diameter sized and shaped to receive a reflective core having an elongate configuration with an exterior diameter smaller than the interior diameter of the cassette to provide a space for receiving and holding blood stationary, and an array of light-emitting members arranged on the chamber for emitting light of at least one wavelength into the interior of the chamber for irradiating and treating the blood inside the cassette.

Abstract translation: 提供了一种用于照射血液的装置，该装置包括具有限定中空内部的细长构型的室，由反射材料形成的室，尺寸和形状适于容纳在腔室内部的管状盒，该管状盒具有 内径尺寸和形状以接收具有细长构型的反射芯，其具有小于盒的内径的外径，以提供用于接收和保持血液静止的空间，以及布置在腔室上的发光构件阵列，用于 将至少一个波长的光发射到室的内部，用于照射和处理盒内的血液。

公开(公告)号：WO2002074989A3

公开(公告)日：2002-09-26

申请号：PCT/GB2002/001261

申请日：2002-03-18

Applicant: CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED ,  TODD, John ,  GOUGH, Stephen ,  UEDA, Hironori

Inventor： TODD, John ,  GOUGH, Stephen ,  UEDA, Hironori

IPC: C12Q1/68

Abstract: The present invention relates to the identification of Single Nucleotide Polymorphisms (SNPs) and haplotypes in the CTLA-4 locus and their association with a predisposition, susceptibility or resistance to autoimmune disease such as Graves Disease (GD) or Type 1 Diabetes Mellitus.(T1DM)

公开(公告)号：WO2002074989A2

公开(公告)日：2002-09-26

申请号：PCT/GB2002/001261

申请日：2002-03-18

Applicant: CATALYST BIOMEDICA LIMITED> ,  TODD, John ,  GOUGH, Stephen ,  UEDA, Hironori

Inventor： TODD, John ,  GOUGH, Stephen ,  UEDA, Hironori

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172

Abstract: The present invention relates to the identification of Single Nucleotide Polymorphisms (SNPs) and haplotypes in the CTLA-4 locus and their association with a predisposition, susceptibility or resistance to autoimmune disease such as Graves Disease (GD) or Type 1 Diabetes Mellitus.(T1DM)

Abstract translation: 本发明涉及CTLA-4基因座中单核苷酸多态性（SNP）和单元型的鉴定及其与自身免疫疾病如格雷夫斯病（GD）或1型糖尿病（T1DM）的易感性，易感性或耐药性的关系。 ）

公开(公告)号：WO1996019822A1

公开(公告)日：1996-06-27

申请号：PCT/GB1995002918

申请日：1995-12-14

Applicant: THE SECRETARY OF STATE FOR DEFENCE ,  LANGFORD, Marian, Lesley ,  TODD, John, Francis, James

Inventor： THE SECRETARY OF STATE FOR DEFENCE

IPC: H01J49/10

CPC classification number: H01J27/16

Abstract: An rf ion source suitable for low power operation over a range of pressures in air comprises discharge electrodes having one or more cathodes (1) and an anode (2). Each cathode (1) is connected to an rf signal supply (8) through an associated coupling means (4) and the anode (2) is adapted to provide a surface area over which a plasma discharge may occur that is not substantially greater than the total cathodal area over which the discharge may occur. In this way the anode (2) presents no more useful surface than is required to accommodate the optimum area of the plasma discharge thereby preventing plasma wander and enhancing the stability of the discharge over known ion sources. By configuring the electrodes such that the respective areas of the anode and the cathode(s) over which discharge occurs are separated by no more than 5 mm and by forming the electrodes to have highly curved ends and so creating a higly distorted electric field in the inter-electrode gap when the source is in operation, it is possible to create an effective discharge with very low power input even at atmospheric p ressure.

Abstract translation: 适用于空气压力范围内的低功率运行的射频源包括具有一个或多个阴极（1）和阳极（2）的放电电极。 每个阴极（1）通过相关联的耦合装置（4）连接到rf信号电源（8），并且阳极（2）适于提供可能发生等离子体放电的表面积，其基本上不大于 可能发生放电的总阴极面积。 以这种方式，阳极（2）不会提供比为了适应等离子体放电的最佳面积所需的表面更多的有用表面，从而防止等离子体漂流并增强放电在已知离子源上的稳定性。 通过配置电极使得发生放电的阳极和阴极的相应面积被分开不超过5mm，并且通过形成电极以具有高度弯曲的端部，并且因此在所述电极中产生高度失真的电场 电源间隙在电源运行时，即使在大气压下也可以产生非常低功率输入的有效放电。

公开(公告)号：WO1994003688A1

公开(公告)日：1994-02-17

申请号：PCT/CA1993000315

申请日：1993-08-04

Applicant: TODD, John, M. ,  GRIEVE, James, A.

IPC: E04D13/08

CPC classification number: E04D13/08 ,  E02B11/005 ,  E04D2013/0813 ,  F16L11/12 ,  Y10T137/6943

Abstract: The retractable conduit of the invention comprises a sheet of memory-set polyester (4) formed as a conduit. To manufacture the memory-set strip, the polyester sheet (4) is wound into the desired retracted, e.g. coiled, position, heated and cooled. After this process the sheet of polyester will automatically assume the retracted position. In one embodiment, suitable as a splashblock, the distal end (47) of the polyester sheet (46) is wider than the end (48) attachable to a downspout (49). In another embodiment the polyester sheet (4) is sheathed in an elongated polyethylene tube (2), to form a retractable hose. In a preferred embodiment, the distal end of the hose is supported on a spool (14) which will roll along the ground as the hose is wound and unwound to further ensure that the hose retracts properly. The tube can also be provided with holes (18) to act as a sprinkler if desired.

Abstract translation: 本发明的伸缩导管包括形成为导管的记忆集聚酯片（4）。 为了制造记忆带，聚酯片（4）被卷绕成所需的缩回，例如。 盘绕，定位，加热和冷却。 在此过程之后，聚酯片将自动地呈现缩回位置。 在一个实施例中，适合作为防溅块，聚酯片（46）的远端（47）比可附接到下水口（49）的端部（48）更宽。 在另一个实施方案中，聚酯片（4）被包覆在细长的聚乙烯管（2）中，以形成伸缩软管。 在优选实施例中，软管的远端被支撑在卷轴（14）上，该卷轴（14）将在软管被卷绕和展开时沿着地面滚动以进一步确保软管适当缩回。 如果需要，管也可以设置有用作喷洒器的孔（18）。

公开(公告)号：WO2013067358A3

公开(公告)日：2015-06-25

申请号：PCT/US2012063334

申请日：2012-11-02

Applicant: SINGULEX INC ,  NEW YORK UNIVERSITY SCHOOL OF MEDICINE ,  TODD JOHN A ,  ATTUR MUKUNDAN ,  GREENBERG JEFFREY DAVID ,  ABRAMSON STEVEN

Inventor： TODD JOHN A ,  ATTUR MUKUNDAN ,  GREENBERG JEFFREY DAVID ,  ABRAMSON STEVEN

IPC: C12Q1/68

CPC classification number: G01N33/573 ,  G01N2333/96494 ,  G01N2800/102 ,  G01N2800/105

Abstract: Methods for determining osteoarthritis severity, risk, progression and methods of treatment using biomarkers in biological samples from a patient.

Abstract translation: 使用来自患者的生物样品中的生物标志物测定骨关节炎严重程度，风险，进展和治疗方法的方法。

公开(公告)号：WO2013067358A2

公开(公告)日：2013-05-10

申请号：PCT/US2012/063334

申请日：2012-11-02

Applicant: SINGULEX, INC. ,  NEW YORK UNIVERSITY SCHOOL OF MEDICINE ,  TODD, John, A. ,  ATTUR, Mukundan ,  GREENBERG, Jeffrey, David ,  ABRAMSON, Steven

Inventor： TODD, John, A. ,  ATTUR, Mukundan ,  GREENBERG, Jeffrey, David ,  ABRAMSON, Steven

IPC: G01N33/53

CPC classification number: G01N33/573 ,  G01N2333/96494 ,  G01N2800/102 ,  G01N2800/105

Abstract: Methods for determining osteoarthritis severity, risk, progression and methods of treatment using biomarkers in biological samples from a patient.

Abstract translation: 使用来自患者的生物样品中的生物标志物测定骨关节炎严重程度，风险，进展和治疗方法的方法。

公开(公告)号：WO2009126380A2

公开(公告)日：2009-10-15

申请号：PCT/US2009/036086

申请日：2009-03-04

Applicant: SINGULEX, INC. ,  GOIX, Philippe, J. ,  PUSKAS, Robert ,  TODD, John ,  LIVINGSTON, Richard, A. ,  HELD, Douglas ,  AGEE, Sara

Inventor： GOIX, Philippe, J. ,  PUSKAS, Robert ,  TODD, John ,  LIVINGSTON, Richard, A. ,  HELD, Douglas ,  AGEE, Sara

IPC: A61B5/02 ,  G01N33/68 ,  C12Q1/68 ,  C12Q1/28 ,  G01N33/92 ,  G01N33/00

CPC classification number: G01N33/577 ,  A61B5/00 ,  A61B5/0402 ,  A61B5/412 ,  A61B5/415 ,  A61B5/418 ,  A61B5/7264 ,  A61B5/7275 ,  G01N21/6428 ,  G01N33/582 ,  G01N33/6863 ,  G01N33/6869 ,  G01N33/6872 ,  G01N33/6887 ,  G01N33/6896 ,  G01N33/74 ,  G01N33/92 ,  G01N2333/4712 ,  G01N2333/475 ,  G06F19/00 ,  Y02A90/26 ,  Y10T436/143333

Abstract: The present invention discloses methods for the detection and monitoring of a condition in a subject using highly sensitive detection of molecules. The invention provides a method for detecting or monitoring a condition in a subject, comprising detecting a first marker in a first sample from the subject and detecting a second marker, wherein the first marker comprises a biomarker, e.g., Cardiac Troponin-I (cTnl) or Vascular Endothelial Growth Factor (VEGF), and wherein the limit of detection of the first marker is less than about 10 pg/ml. The second marker can be a biomarker, physiological marker, a molecular marker or a genetic marker.

Abstract translation: 本发明公开了使用分子的高灵敏度检测来检测和监测受试者的状况的方法。 本发明提供了一种用于检测或监测受试者中的病症的方法，包括检测来自受试者的第一样品中的第一标志物并检测第二标志物，其中第一标记物包含生物标志物，例如心肌肌钙蛋白I（cTn1） 或血管内皮生长因子（VEGF），并且其中第一标记物的检测限小于约10pg / ml。 第二标记可以是生物标志物，生理学标记，分子标记或遗传标记。

公开(公告)号：WO2008048371A9

公开(公告)日：2008-11-27

申请号：PCT/US2007008394

申请日：2007-04-04

Applicant: SINGULEX INC ,  GOIX PHILIPPE ,  PUSKAS ROBERT ,  TODD JOHN ,  LIVINGSTON RICHARD ,  HELD DOUGLAS

Inventor： GOIX PHILIPPE ,  PUSKAS ROBERT ,  TODD JOHN ,  LIVINGSTON RICHARD ,  HELD DOUGLAS

IPC: G01N21/76 ,  G01N21/64

CPC classification number: G01N33/6887 ,  G01N15/06 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/577 ,  G01N33/582 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2201/1247 ,  G01N2201/12761 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/52 ,  Y10T436/105831

Abstract: Disclosed are methods, kits, and compositions for fluorescent detection of single biomolecules, e.g. proteins, using highly sensitive fluorescent dyes and a flow cell with one interrogation space for irradiation by focused laser beam. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution.

Abstract translation: 公开了用于单个生物分子的荧光检测的方法，试剂盒和组合物，例如， 使用高度敏感的荧光染料和具有一个询问空间的流动池用于通过聚焦激光束进行照射。 这些方法，试剂盒和组合物可用于确定样品中分子浓度达到1飞摩尔，1摩尔或更低的水平。 该方法，试剂盒和组合物还允许在很宽的范围，例如7个对数范围内测定浓度，而不需要样品稀释。