-
131.发明专利
公开(公告)号：CA2707766A1
公开(公告)日：2001-12-13
申请号：CA2707766
申请日：2001-06-05
Applicant: UCB PHARMA SA
Inventor： ATHWAL DILJEET SINGH , BROWN DEREK THOMAS , WEIR ANDREW NEIL , POPPLEWELL ANDREW GEORGE , CHAPMAN ANDREW PAUL , KING DAVID JOHN
IPC: C12N15/09 , C12N15/63 , A61K39/395 , A61K47/48 , A61P19/02 , A61P29/00 , A61P37/06 , C07K16/24 , C07K16/46 , C12N1/21 , C12N15/13 , C12P21/02 , C12P21/08
Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNF± There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNF±
-
公开(公告)号：CA2666458C
公开(公告)日：2018-06-19
申请号：CA2666458
申请日：2007-10-18
Applicant: UCB PHARMA SA
Inventor： ADAMS RALPH , POPPLEWELL ANDREW GEORGE , RAPECKI STEPHEN EDWARD
IPC: C07K16/24 , A61K39/395 , A61P35/00 , A61P37/06 , C12N15/13
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
-
133.发明专利
-
134.发明专利
公开(公告)号：CY1118220T1
公开(公告)日：2017-06-28
申请号：CY161101159
申请日：2016-11-10
Applicant: UCB PHARMA SA
Inventor： ATHWAL DILJEET SINGH , BROWN DEREK THOMAS , WEIR ANDREW NEIL CHARLES , POPPLEWELL ANDREW GEORGE , CHAPMAN ANDREW PAUL , KING DAVID JOHN
IPC: C12N15/09 , C12N15/13 , A61K39/395 , A61K47/48 , A61P19/02 , A61P29/00 , A61P37/06 , C07K16/24 , C07K16/46 , C07K19/00 , C12N1/21 , C12N15/62 , C12N15/70 , C12P21/02 , C12P21/08
Abstract: Περιγράφονταιμόριααντισωμάτωνπουπεριέχουντουλάχιστονένα CDR προερχόμενοαπόμονοκλωνικάαντισώματαποντικού, μεειδικότηταπροςτονανθρώπινο TNFa. Περιγράφεταιεπίσηςένααντίσωμαμεμοσχευμένα CDR στοοποίοτουλάχιστονέναεκτων CDR είναιέναυβριδικό CDR. Περιγράφονταιεπιπλέοναλληλουχίες DNA πουκωδικοποιούντιςαλυσίδεςτωναντισωμάτων, φορείς, μετασχηματισμένακύτταραξενιστέςκαιχρήσειςτωναντισωμάτωνστηναντιμετώπισηνοσημάτωνπουεξαρτώνταιαπότον TNFa.
-
公开(公告)号：CA2655874C
公开(公告)日：2017-05-02
申请号：CA2655874
申请日：2007-06-25
Applicant: UCB PHARMA SA
Inventor： RAPECKI STEPHEN EDWARD , POPPLEWELL ANDREW GEORGE , ADAMS RALPH
IPC: C07K16/24 , A61K39/395 , C12N5/20 , C12N15/13
Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of IL-17, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
-
Patent Agency Ranking136.发明专利
公开(公告)号：CA2681530C
公开(公告)日：2017-03-28
申请号：CA2681530
申请日：2008-03-21
Applicant: BIOGEN IDEC INC , UCB PHARMA SA
Inventor： BURKLY LINDA C , FERRANT-ORGETTAS JANINE L , GARBER ELLEN A , HSU YEN-MING , SU LIHE , TAYLOR FREDERICK R , ADAMS RALPH , BROWN DEREK THOMAS , POPPLEWELL ANDREW GEORGE , ROBINSON MARTYN KIM , SHOCK ANTHONY , TYSON KERRY LOUISE
IPC: C12N15/13 , A61K39/395 , C07K16/28 , C12N15/63
Abstract: This invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a CD154 (CD40L) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy chain sequence according to SEQ ID NO: 1 and comprising a variable light chain sequence according to SEQ ID NO: 2 specifically binds. CD154 binding proteins of this invention may elicit reduced effector function relative to a second anti-CD154 antibody.
-
公开(公告)号：CY1115147T1
公开(公告)日：2016-12-14
申请号：CY141100263
申请日：2014-04-08
Applicant: UCB PHARMA SA
Inventor： ADAMS RALPH , POPPLEWELL ANDREW GEORGE , RAPECKI STEPHEN EDWARD , TICKLE SIMON PETER
Abstract: Ηεφεύρεσησχετίζεταιμεέναμόριοαντισώματοςπουέχειειδικότηταγιααντιγονικούςκαθοριστέςτης IL-17, τιςθεραπευτικέςχρήσειςτουμορίουαντισώματοςκαιτιςμεθόδουςπαραγωγήςτουενλόγωμορίουαντισώματος.
-
138.发明专利
公开(公告)号：SK288343B6
公开(公告)日：2016-04-01
申请号：SK3152002
申请日：2001-06-05
Applicant: UCB PHARMA SA
Inventor： ATHWAL DILJEET SINGH , BROWN DEREK THOMAS , WEIR ANDREW NEIL CHARLES , POPPLEWELL ANDREW GEORGE , CHAPMAN ANDREW PAUL , KING DAVID JOHN
IPC: A61K39/395 , C07K16/24 , A61K47/48 , C12N15/09 , A61P19/02 , A61P29/00 , A61P37/06 , C07K16/46 , C07K19/00 , C12N1/21 , C12N15/13 , C12N15/62 , C12N15/70 , C12P21/02 , C12P21/08
Abstract: Predložený vynález sa týka protilátkových molekúl, ktoré sú špecifické pre antigénne determinanty nádorového nekrotického faktoru alfa (TNF?) a ktoré obsahujú aspoň jeden úsek CDR z myšej monoklonálnej protilátky. Predložený vynález sa tiež týka tzv. CDR-očkovaných protilátok, kde aspoň jeden z úsekov CDR je hybridný CDR. Ďalej je predmetom DNA sekvencia kódujúca reťazce molekuly protilátky a tiež vektory a transformované hostiteľské bunky. Vynález sa ďalej týka terapeutického využitia protilátkových molekúl na liečenie chorôb sprostredkovaných TNF?.
-
公开(公告)号：BRPI1008692A2
公开(公告)日：2016-03-08
申请号：BRPI1008692
申请日：2010-02-17
Applicant: UCB PHARMA SA
Inventor： LAWSON ALASTAIR GRIFFITHS , POPPLEWELL ANDREW GEORGE , NESBITT ANDREW MALCOLM , SHPEKTOR DIANA , SHAW STEPHEN GRAHAM , ZHANG YI
IPC: A61K39/395 , C07K16/00 , C07K16/28
-
公开(公告)号：PL218516B1
公开(公告)日：2014-12-31
申请号：PL39935101
申请日：2001-06-05
Applicant: UCB PHARMA SA
-
-
-
-
-
-
-
-
-
Search Results
161
records
(took 0.035 seconds)
