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    ENHANCED SURFACE PLASMON RESONANCE METHOD
    136.
    发明公开
    ENHANCED SURFACE PLASMON RESONANCE METHOD 有权
    VERFAHRENFÜRVERBESSERTEOBERFLÄCHENPLASMONRESONANZ

    公开(公告)号：EP2823287A1

    公开(公告)日：2015-01-14

    申请号：EP13707633.7

    申请日：2013-03-05

    Applicant: Biosurfit, S.A.

    Inventor： DE OLIVEIRA GARCIA DA FONSECA, Joao Manuel

    IPC: G01N21/55

    CPC classification number: G01N33/54373 ,  G01N21/41 ,  G01N21/553 ,  G01N33/54346 ,  G01N33/553 ,  G01N2201/0612 ,  G01N2201/06146 ,  G01N2201/0621 ,  G01N2201/0635 ,  G01N2201/12723

    Abstract: The disclosure relates to processing SPR signals, in particular signals obtained by illuminating a conductive surface with light at two wavelengths. Embodiments involve processing a first and second signal indicative of an intensity of light, received from a conductive layer at which SPR has occurred, as a function of angle of incidence, reflection or diffraction at the layer (depending on whether the incident light beam is received by a detector recording it in reflection or transmission from the conductive layer). The first and second signals each have two dips corresponding to a respective wavelength of the light at a respective angle at which surface plasmon resonance occurs for the respective wavelength and a peak between the two dips. The processing includes deriving a first and second value of a quantity indicative of signal magnitudes in the region of the peak. The method then provides for comparing the first and second values to detect a change in refractive index at the layer after the first signal and before the second signal was captured.

    Abstract translation: 本公开涉及处理SPR信号，特别是通过用两个波长的光照射导电表面而获得的信号。 处理SPR信号可以涉及处理表示从已经发生SPR的导电层接收的光的强度的第一和第二信号作为该层上的入射角，反射或衍射的函数。 第一和第二信号各自具有对应于在相应波长的光的相应波长处的两个倾斜，在该角度处，对于相应波长发生表面等离子体共振并且在两个下降之间产生峰值。 该处理包括导出指示峰值区域中的信号幅度的量的第一值和第二值。 可以比较第一和第二值以检测第一信号之后的层和第二信号被捕获之前的折射率的变化。

    UNIFORM EPI-ILLUMINATION OF PLANAR SAMPLES
    137.
    发明公开
    UNIFORM EPI-ILLUMINATION OF PLANAR SAMPLES 有权
    平面样本的均匀EPI照射

    公开(公告)号：EP2820676A1

    公开(公告)日：2015-01-07

    申请号：EP13755695.7

    申请日：2013-01-14

    Applicant: Bio-rad Laboratories, Inc.

    Inventor： HILLENDAHL, James W. ,  PEREZ, Evelio

    IPC: H01L27/00

    CPC classification number: F21V21/005 ,  F21V9/083 ,  F21V13/02 ,  G01N21/255 ,  G01N21/6452 ,  G01N21/6456 ,  G01N27/447 ,  G01N2021/6463 ,  G01N2021/6471 ,  G01N2201/06 ,  G01N2201/0626 ,  G01N2201/0635

    Abstract: A planar sample, particularly of the type used in biological laboratories for detection and sometimes analysis of two-dimensional arrays of proteins, nucleic acids, or other biological species, is illuminated by epi-illumination using optically filtered line lights that are arranged along opposing parallel sides of a rectangle in which the sample array resides, with two coaxial line lights on each side of the rectangle, and the two on any given side being separated by a gap whose optimal width depends on the wavelength band transmitted by the optical filter. Surprisingly, the gap eliminates the peak in intensity at the center of the sample area and the decrease that occurs from the center outward that would otherwise occur with a single continuous filtered line light, producing instead a substantially uniform intensity along the direction parallel to the line lights.

    Abstract translation: 平面样品，特别是用于生物实验室中用于检测蛋白质，核酸或其他生物物种的二维阵列以及有时分析蛋白质，核酸或其他生物物种的二维阵列的类型的平面样品，使用光学滤波的线光照射，所述光学滤波的线光沿着相对平行 样本阵列所在的矩形的两侧，在矩形的每一侧上具有两个同轴线光源，并且在任何给定侧上的两个由间隙隔开，该间隙的最佳宽度取决于由光学滤波器传输的波长带。 令人惊讶的是，该间隙消除了样品区域中心处的强度峰值以及从中心向外发生的减少，否则将发生在单个连续的过滤后的线光下，而是沿平行于线的方向产生基本上均匀的强度 灯。

    A DUAL ILLUMINATION SYSTEM FOR AN IMAGING APPARATUS AND METHOD
    139.
    发明公开
    A DUAL ILLUMINATION SYSTEM FOR AN IMAGING APPARATUS AND METHOD 有权
    与双照明系统和图形设备和系统使用过程中系统

    公开(公告)号：EP2021774A2

    公开(公告)日：2009-02-11

    申请号：EP07777063.4

    申请日：2007-05-14

    Applicant: Xenogen Corporation

    Inventor： NILSON, David ,  RICE, Brad ,  TROY, Tamara

    IPC: G01N21/64

    CPC classification number: G01N21/6456 ,  A61B5/0059 ,  A61B5/0064 ,  A61B5/0073 ,  A61B2503/40 ,  G01N21/4795 ,  G01N2021/1787 ,  G01N2201/0635

    Abstract: A dual illumination system is disclosed for use with an imaging apparatus. The imaging apparatus defines a light-tight imaging compartment with an interior wall having a view port extending into the imaging compartment. This view port enables data acquisition of a biological specimen contained in the imaging compartment. The dual illumination system includes a first illumination assembly configured to direct structured light onto a first side of the specimen to enable structured light and surface topography measurements thereof. A second illumination assembly then directs light at the specimen wherein diffused fluorescent light emanates from a surface thereof for receipt through the view port to acquire fluorescence data of the specimen. The combination of structured light imaging and fluorescence imaging enables 3D diffuse tomographic reconstructions of fluorescent probe location and concentration.

    VORRICHTUNG UND VERFAHREN ZUR TIEFENAUFGELÖSTEN OPTISCHEN ERFASSUNG EINER PROBE
    140.
    发明公开
    VORRICHTUNG UND VERFAHREN ZUR TIEFENAUFGELÖSTEN OPTISCHEN ERFASSUNG EINER PROBE 有权
    DEVICE AND METHOD FOR DEEP光学感测一个示例

    公开(公告)号：EP1931970A2

    公开(公告)日：2008-06-18

    申请号：EP06805711.6

    申请日：2006-09-14

    Applicant: Carl Zeiss MicroImaging GmbH

    Inventor： WOLLESCHENSKY, Ralf

    IPC: G01N21/64 ,  G02B21/00

    CPC classification number: G01N21/6458 ,  G01N2021/1782 ,  G01N2021/1787 ,  G01N2201/0635 ,  G02B21/008

    Abstract: A device for optically sensing a specimen with a large depth of field comprises a lighting module (1) which illuminates a zone of the specimen during a predetermined measurement period with a pattern whose phase is modified in time during the measurement period, generating a specimen light to which a corresponding time-variable phase is imparted, a detection module (4) having a space-resolving detection zone (8) which records the specimen zone and has multiple recording pixels (12), two analysis channels (13, 14) which can be connected to the recording pixels (12), and an analysis unit (25) connected to both analysis channels (13, 14), as well as a control unit which, during the measurement period, connects each recording pixel in synchrony with the phase of the detected specimen light to the two analysis channels (13, 14), alternatively, in such a way that the detected specimen light is divided into two portions phased in relation to one another, and the analysis unit calculates an optical split-image of the specimen zone on the basis of the two phased portions supplied to the analysis channels.

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