中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

4595 records (took 0.076 seconds)

    DETECTION OF GENETIC VARIANTS
    142.
    发明申请
    DETECTION OF GENETIC VARIANTS 有权

    公开(公告)号：US20230043703A1

    公开(公告)日：2023-02-09

    申请号：US17813942

    申请日：2022-07-21

    Applicant: BIO-RAD LABORATORIES, INC.

    Inventor： YAN WANG ,  STEVEN TAKASHI OKINO ,  JASON MA

    IPC: C12Q1/6827 ,  C12Q1/6883 ,  C12Q1/686

    Abstract: The subject invention pertains to the detection and differentiation of genetic variations by nucleic acid amplification. The invention provides methods of detecting one or more genetic variations in a nucleic acid that are in close proximity simultaneously. The invention further provides primer and probe oligonucleotides and methods of using said primers and probes in assays to detect genetic variants of concern of SARS-CoV-2. The methods of the invention detect genetic variants of other pathogens, including influenza, or genetic variants involved in inheritable diseases or cancer.

    REAGENT SLEEVE SYSTEM
    143.
    发明申请
    REAGENT SLEEVE SYSTEM 有权

    公开(公告)号：US20230031105A1

    公开(公告)日：2023-02-02

    申请号：US17962360

    申请日：2022-10-07

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： James Barry ,  Vishal Mehra ,  Alireza Ebrahim

    IPC: B01L3/00 ,  G01N35/10

    Abstract: A reagent sleeve system such as can be used with various analyzers using chemical phenomena, analyzers and methods of using the reagent sleeve system and analyzer are described. The reagent sleeve system can include a reagent sleeve; and a plurality of removable reagent reservoirs located within the reagent sleeve, wherein each of the plurality of removable reagent reservoirs comprises a respective peripheral wall, and first and second end walls, whereby each of the plurality of removable reagent reservoirs contains a reagent located therein, and the first end wall is pierceable by a reagent extractor, and the reagent sleeve comprises a peripheral wall that encompasses the plurality of removable reagent reservoirs and holds the plurality of reagent reservoirs for sequential use.

    PROTEIN QUANTITATION DEVICE
    144.
    发明申请
    PROTEIN QUANTITATION DEVICE 有权

    公开(公告)号：US20230026156A1

    公开(公告)日：2023-01-26

    申请号：US17877680

    申请日：2022-07-29

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Evan THRUSH ,  Steven SWIHART ,  William STRONG ,  Trey MARLOWE ,  Li LU

    IPC: G01N21/31 ,  G01N21/3577 ,  G01N21/3563

    Abstract: Systems for protein quantitation using a Fabry-Perot interferometer. In one arrangement, a quantitation device includes an infrared source, a sample holder, and a Fabry-Perot interferometer positioned to receive infrared radiation from the source passing through a sample on the sample holder. A band pass optical filter sets the working range of the interferometer, and radiation exiting the interferometer falls on a detector that produces a signal indicating the intensity of the received radiation. A controller causes the interferometer to be tuned to a number of different resonance wavelengths and receives the intensity signals, for determination of an absorbance spectrum.

    System and method for rapid multiplexed sample processing with applications for nucleic acid amplification assays
    145.
    发明授权
    System and method for rapid multiplexed sample processing with applications for nucleic acid amplification assays 有权

    公开(公告)号：US11547995B2

    公开(公告)日：2023-01-10

    申请号：US17499529

    申请日：2021-10-12

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Kalyan Handique ,  Ronald Lebofsky

    IPC: B01L3/00 ,  B01L7/00 ,  C12Q1/686

    Abstract: The invention(s) cover systems and methods for target detection in a multiplexed and rapid manner. Embodiments of the system can include: a base substrate; and an array of sample processing regions defined at a broad surface of the base substrate, wherein each of the array of sample processing regions includes: a set of microwell subarrays arranged in a gradient by volumetric capacity between an upstream end and a downstream end of each respective sample processing region, and a boundary separating each respective sample processing region from adjacent sample processing regions. The system can support methods, with example implementation by an automated platform, for returning preliminary results from a subset of microwells of the samples processing regions, as well as results pertaining to specific and non-specific amplification, for multiple targets of a sample.

    Method and system for sampling material from cells
    146.
    发明授权
    Method and system for sampling material from cells 有权

    公开(公告)号：US11542541B2

    公开(公告)日：2023-01-03

    申请号：US17105333

    申请日：2020-11-25

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Arkadiusz Bibillo ,  Pranav Patel ,  Christopher Reggiardo ,  Jonathan Petersen

    IPC: C12Q1/68 ,  C12Q1/6806 ,  C12N15/10 ,  C12Q1/6853 ,  C12Q1/6874

    Abstract: Methods, systems, and devices for sampling/isolating material from cells. An exemplary system may comprise a chip including an electrode array of sampling electrodes arranged along a surface of the chip. A cell-receiving area may be located adjacent the surface of the chip. The system also may comprise a tag array of tags supported by the chip and aligned with the electrode array. Each tag of the tag array may include an identifier that is unique to the tag within the tag array. Each tag may be configured to bind nucleic acids, or a capturing agent distinct from the tag may be aligned with each sampling electrode of the electrode array to capture a protein or other analyte of interest. The system further may comprise a control circuit configured to apply an individually controllable voltage to each sampling electrode of the electrode array and measure an electrical property of the sampling electrode.

Patent Agency Ranking