公开(公告)号：WO2009097174A9

公开(公告)日：2010-02-04

申请号：PCT/US2009030304

申请日：2009-01-07

Applicant: STC UNM ,  SITDIKOV RAVIL ,  IVNITSKIV DMITRI ,  LOPEZ GABRIEL ,  RAMIREZ BRIANNA ,  ATANASSOV PLAMEN

Inventor： SITDIKOV RAVIL ,  IVNITSKIV DMITRI ,  LOPEZ GABRIEL ,  RAMIREZ BRIANNA ,  ATANASSOV PLAMEN

IPC: G01N27/327 ,  G01N27/28 ,  G01N27/416 ,  G01N33/48 ,  G01N33/487

CPC classification number: G01N33/557 ,  B82Y5/00 ,  G01N2333/11

Abstract: A simple, fast, selective and highly sensitive electrochemical method assay and disposable device for detection of viruses, bacteria, proteins, DNA, and/or organic/inorganic compounds. The sensor has a multi-layered construction, with each successive layer performing a different function. The design further allows for the packing of numerous microscopic electrode transducers onto the small footprint of a biochip device, allowing for a high-density array of sensors.

Abstract translation: 一种用于检测病毒，细菌，蛋白质，DNA和/或有机/无机化合物的简单，快速，选择性和高灵敏度的电化学方法测定和一次性装置。 传感器具有多层结构，每个连续的层执行不同的功能。 该设计还允许将许多微电极换能器包装到生物芯片装置的小尺寸上，从而允许高密度的传感器阵列。

公开(公告)号：WO2009089066A3

公开(公告)日：2009-10-22

申请号：PCT/US2009000179

申请日：2009-01-12

Applicant: STC UNM ,  MIAO YUBIN ,  GUO HAIXUN

Inventor： MIAO YUBIN ,  GUO HAIXUN

IPC: G01N33/68 ,  C07K2/00 ,  G01N33/60

CPC classification number: A61K51/088 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0053 ,  A61K45/06 ,  C07K14/685 ,  G01N33/5743 ,  G01N33/60

Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds comprising a cyclic peptide wherein the compound binds to a MSH receptor to image and treat cancers, especially, melanoma, including metastatic melanoma in vivo. The present invention represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these cancers. The novel imaging probes are capable of detecting cancerous melanoma cells, as well as their metastatic spread in tissues. This represents a quantum step forward in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention will also be useful to initiate therapy for melanoma as well as monitor patients response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.

Abstract translation: 本发明涉及包含环肽的新型非侵入性诊断工具/化合物，其中所述化合物结合MSH受体以在体内成像和治疗癌症，特别是黑素瘤，包括转移性黑素瘤。 本发明代表了目前依赖于组织活检以诊断这些癌症的本领域的明显进步。 新型成像探针能够检测癌细胞黑素瘤细胞，以及它们在组织中的转移扩散。 这代表了使用非侵入性分子成像技术在黑素瘤的诊断和治疗中包括转移性黑素瘤的量子进步。 本发明的新型探针也可用于启动黑素瘤的治疗以及监测患者对化疗治疗的反应和用于治疗黑素瘤/转移性黑色素瘤的其它干预或治疗。 根据本发明的化合物可用作许多病症和疾病状态的诊断工具以及用于治疗这些病症和疾病状态的治疗剂。

公开(公告)号：WO2009070331A3

公开(公告)日：2009-07-23

申请号：PCT/US2008013209

申请日：2008-11-28

Applicant: STC UNM ,  LARSON RICHARD S ,  SKLAR LARRY A ,  EDWARDS BRUCE S ,  IVNITSKI-STEELE IRENA D ,  OPREA TUDOR I ,  LOVATO DEBBIE M ,  KHAWAJA HADYA M ,  WINTER STUART S ,  YOUNG SUSAN M

Inventor： SKLAR LARRY A ,  EDWARDS BRUCE S ,  IVNITSKI-STEELE IRENA D ,  OPREA TUDOR I ,  LOVATO DEBBIE M ,  KHAWAJA HADYA M ,  WINTER STUART S ,  YOUNG SUSAN M

IPC: A61K31/415 ,  A61K31/12 ,  A61P35/00

CPC classification number: A61K31/12 ,  A61K31/415 ,  A61K45/06 ,  A61K2300/00

Abstract: Compounds disclosed which inhibit ABCBl transporter protein are useful for treating diseases in which ABCBl transporter protein mediates the disease state, including numerous cancers, including hematopoietic cancers, including various leukemias, especially T-lineage acute lymphoblastic leukemia, as well as cancerous tumors, especially forms which exhibit multiple drug resistance. Pharmaceutical compositions which comprise an inhibitor of ABCBl transporter protein and at least one additional anticancer agent, optionally in combination with a pharmaceutically acceptable carrier, additive or excipient are another aspect of the present invention. A flow cytometry based, high-throughput screening (HST) assay that quantifies ABCBl efflux is also disclosed. Methods of identifying inhibitors of ABCBl, ABCG2 and ABCCl transporter proteins are also disclosed.

Abstract translation: 公开的抑制ABCB1转运蛋白的化合物可用于治疗其中ABCB1转运蛋白介导疾病状态的疾病，包括多种癌症，包括造血系统癌症，包括各种白血病，尤其是T-系急性淋巴细胞白血病，以及癌性肿瘤，特别是癌 表现出多重耐药性。 包含ABCB1转运蛋白抑制剂和至少一种另外的抗癌剂，任选地与药学上可接受的载体，添加剂或赋形剂组合的药物组合物是本发明的另一方面。 还公开了量化ABCB1流出的基于流式细胞术的高通量筛选（HST）测定法。 还公开了鉴定ABCB1，ABCG2和ABCCl转运蛋白的抑制剂的方法。

公开(公告)号：WO2009025820A3

公开(公告)日：2009-05-22

申请号：PCT/US2008009909

申请日：2008-08-20

Applicant: STC UNM ,  TIMMINS GRAHAM ,  MASTER SHARON ,  DERETIC VOJO P

Inventor： TIMMINS GRAHAM ,  MASTER SHARON ,  DERETIC VOJO P

IPC: A61K31/4409 ,  A61K31/44 ,  A61P31/00 ,  A61P43/00 ,  C07D213/127 ,  C07D213/16

CPC classification number: C07D213/81 ,  A61K9/0019 ,  A61K9/0073 ,  A61K31/44 ,  A61K31/4409 ,  C07D213/83 ,  C07D213/86

Abstract: The present invention relates to the use of isotopically labeled derivatives of isoniazid, ethionamide and related compounds as effective therapy for the treatment of mycobacterial diseases, including Mycobacterium tuberculosis.

Abstract translation: 本发明涉及异烟肼，乙硫异烟胺和相关化合物的同位素标记衍生物作为治疗包括结核分枝杆菌的分枝杆菌疾病的有效疗法的用途。

公开(公告)号：WO2009005542A3

公开(公告)日：2009-04-16

申请号：PCT/US2008001721

申请日：2008-02-08

Applicant: STC UNM ,  SANDIA CORP ,  LARSON RICHARD S ,  HJELLE BRIAN ,  HALL PAM R ,  BROWN DAVID C ,  BISOFFI MARCO ,  BROZIK SUSAN M ,  BRANCH DARREN W ,  EDWARDS THAYNE L ,  WHEELER DAVID

Inventor： LARSON RICHARD S ,  HJELLE BRIAN ,  HALL PAM R ,  BROWN DAVID C ,  BISOFFI MARCO ,  BROZIK SUSAN M ,  BRANCH DARREN W ,  EDWARDS THAYNE L ,  WHEELER DAVID

IPC: C12Q1/34 ,  C12M3/00

CPC classification number: G01N33/54373 ,  C12Q1/6825 ,  G01N29/032 ,  G01N33/553 ,  G01N2291/0422

Abstract: Viruses and other bioagents are of high medical and biodefense concern and their detection at concentrations well below the threshold necessary to cause health hazards continues to be a challenge with respect to sensitivity, specificity, and selectivity. Ideally, assays for accurate and real time detection of viral agents and other bioagents would not necessitate any pre-processing of the analyte, which would make them applicable for example to bodily fluids (blood, sputum) and man-made as well as naturally occurring bodies of water (pools, rivers). We describe herein a robust biosensor that combines the sensitivity of surface acoustic waves (SAW) generated at a frequency of 325 MHz with the specificity provided by antibodies and other ligands for the detection of viral agents. In preferred embodiments, a lithium tantalate based SAW transducer with silicon dioxide waveguide sensor platform featuring three test and one reference delay lines was used to adsorb antibodies directed against Coxsackie virus B4 or the negative-stranded category A bioagent Sin Nombre virus (SNV), a member of the genus Hantavirus, family Bunyaviridae, negative-stranded RNA viruses. Rapid detection (within seconds) of increasing concentrations of viral particles was linear over a range of order of magnitude for both viruses, although the sensor was approximately 50x104 -fold more sensitive for the detection of SNV. For both pathogens, the sensor's selectivity for its target was not compromised by the presence of confounding Herpes Simplex virus type 1. The biosensor was able to detect SNV at doses lower than the load of virus typically found in a human patient suffering from hantavirus cardiopulmonary syndrome (HCPS). Further, in a proof-of-principle real world application, the SAW biosensor was capable of selectively detecting SNV agents in complex solutions, such as naturally occurring bodies of water (river, sewage effluent) without analyte pre-processing.

Abstract translation: 病毒和其他生物制剂对医学和生物防御有很高的关注度，并且它们的检测浓度远低于引起健康危害所必需的阈值，这仍然是灵敏度，特异性和选择性方面的挑战。 理想情况下，准确和实时检测病毒剂和其他生物剂的分析不需要对分析物进行任何预处理，这将使其适用于例如体液（血液，痰液）和人造以及自然发生的 水体（水池，河流）。 我们在此描述了一种鲁棒的生物传感器，其将频率为325MHz的表面声波（SAW）的灵敏度与由抗体和其他配体提供的用于检测病毒剂的特异性相结合。 在优选的实施方案中，具有三个测试和一个参考延迟线的具有二氧化硅波导传感器平台的基于钽酸锂的SAW换能器被用于吸附针对柯萨奇病毒B4或负链A类生物因子Sin Nombre病毒（SNV）的抗体，a 汉坦病毒属，布尼亚病毒科，负链RNA病毒成员。 对于两种病毒，增加浓度的病毒颗粒的快速检测（数秒内）在一定数量级范围内是线性的，尽管对于检测SNV而言传感器的灵敏度约为50×10 4倍。 对于这两种病原体而言，传感器对其靶标的选择性不会由于混杂的1型单纯性疱疹病毒的存在而受到损害。生物传感器能够以比通常在患有汉坦病毒心肺综合征的人类患者中发现的病毒载量低的剂量检测SNV （HCPS）。 此外，在原理验证的实际应用中，SAW生物传感器能够选择性检测复杂溶液中的SNV试剂，例如没有分析物预处理的天然存在的水体（河流，污水流出物）。

公开(公告)号：WO2005007821A3

公开(公告)日：2009-04-09

申请号：PCT/US2004021861

申请日：2004-07-07

Applicant: STC UNM ,  LARSON RICHARD S ,  SILLERUD LAUREL

Inventor： LARSON RICHARD S ,  SILLERUD LAUREL

IPC: G01N33/48 ,  C07K7/06 ,  C12N20060101 ,  G01N33/50 ,  G01N33/53 ,  G06F19/00

CPC classification number: C07K7/06 ,  G01N2333/70525

Abstract: The invention provides tertiary structures) of cyclic nonapeptide ICAM-1 inhibitors and methods of using the tertiary structures tp identify additional ICAM-1 inhibitors, particularly non-peptide modulators. The invention also provides methods of treating ICAM­1/LFA-1 mediated diseases comprising administ4ring a non-peptide ICAM-1 modulator of the invention to a patient in need thereof.

Abstract translation: 本发明提供三级结构）的环状肽IIICAM-1抑制剂和使用三级结构tp的方法鉴定另外的ICAM-1抑制剂，特别是非肽调节剂。 本发明还提供了治疗ICAM1 / LFA-1介导的疾病的方法，其包括向有需要的患者施用本发明的非肽ICAM-1调节剂。

公开(公告)号：WO2008067103A9

公开(公告)日：2008-09-12

申请号：PCT/US2007083017

申请日：2007-10-30

Applicant: STC UNM ,  BENTLEY PAUL A ,  DAVENPORT MICHAEL

Inventor： BENTLEY PAUL A ,  DAVENPORT MICHAEL

IPC: G01N33/553

CPC classification number: G01N33/54326 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/22

Abstract: The present invention includes a magnetically susceptible polymer component, a method of making the same, and apparatuses and systems for mixing, separating or localizing a magnetically susceptible polymer compound in a reaction. The magnetically susceptible polymer component includes a polymer and a magnetically susceptible particle of a predetermined size, which yields a component having a much-improved magnetic reactivity due to the increase in magnetic material by mass percentage. The apparatuses and systems of the present invention employ controllable magnetic fields distributable in perpendicular directions in order to precisely control the orientation, position and relative motion of any magnetically susceptible components within a reaction vessel.

Abstract translation: 本发明包括磁敏感聚合物组分，其制备方法以及用于在反应中混合，分离或定位磁敏感性聚合物化合物的装置和系统。 磁敏感聚合物组分包括预定尺寸的聚合物和磁敏感颗粒，其由于磁性材料以质量百分比的增加而产生具有大大提高的磁反应性的组分。 本发明的装置和系统采用可分散在垂直方向上的可控磁场，以便精确地控制反应容器内的任何磁敏组件的取向，位置和相对运动。

公开(公告)号：WO2008060883A3

公开(公告)日：2008-08-28

申请号：PCT/US2007083630

申请日：2007-11-05

Applicant: STC UNM ,  SHAH PRATIK B ,  BRINKER JEFFERY C ,  KOENE BRYAN E

Inventor： SHAH PRATIK B ,  BRINKER JEFFERY C ,  KOENE BRYAN E

IPC: B32B3/00 ,  B32B3/26

CPC classification number: C08J7/04 ,  C08G77/14 ,  C08J2483/04 ,  C09D5/08 ,  C09D183/06 ,  C23C18/122 ,  C23C18/1254 ,  Y10T428/265 ,  Y10T428/31663

Abstract: Exemplary embodiments provide compositions and devices for hydrophobic coatings, and methods for making them. The hydrophobic coating can be formed from a coating solution including, for example, organically modified silicates (ormosils) mixed with coupling agents. Specifically, a sol-gel solution can be formed including a plurality of alkoxy silane precursors that contains at least one glycidoxy alkoxy silane precursor. In an exemplary embodiment, the sol-gel solution can be a mixed sol-gel solution formed including a first solution mixed with a second solution. The first solution can include one or more alkoxy silane precursors, and the second solution can include at least one glycidoxy alkoxy silane precursor. A coupling agent can then be added and reacted with the (mixed) sol-gel solution forming the coating solution, which can be applied onto a substrate that needs to be protected from corrosion or from chemical and/or biological agents.

Abstract translation: 示例性实施例提供用于疏水涂层的组合物和装置及其制备方法。 疏水涂层可以由包括例如与偶联剂混合的有机改性硅酸盐（ormosil）的涂布溶液形成。 具体地，可以形成溶胶 - 凝胶溶液，其包括含有至少一个缩水甘油氧基烷氧基硅烷前体的多个烷氧基硅烷前体。 在一个示例性实施方案中，溶胶 - 凝胶溶液可以是形成的混合溶胶 - 凝胶溶液，包括与第二溶液混合的第一溶液。 第一溶液可包括一种或多种烷氧基硅烷前体，第二溶液可包括至少一种缩水甘油氧基烷氧基硅烷前体。 然后可以加入偶联剂并与形成涂层溶液的（混合的）溶胶 - 凝胶溶液反应，所述溶液 - 凝胶溶液可以施加到需要被保护而不受腐蚀的基底上或从化学和/或生物制剂上施加。

公开(公告)号：WO2005010024A3

公开(公告)日：2005-04-07

申请号：PCT/US2004023536

申请日：2004-07-21

Applicant: STC UNM ,  LARSON RICHARD S

Inventor： LARSON RICHARD S

IPC: A61K38/00 ,  A61K38/08 ,  C07K20060101 ,  C07K7/06

CPC classification number: C07K7/06

Abstract: The present invention relates to peptide compounds which modulate the interaction of ICAM-1 and LFA-1, and in particular, function as inhibitors of the interaction of integrins, more particularly, LFA-I, and one or several distinct intercellular adhesion molecules (ICAMS), in particular ICAM-1, pharmaceutical compositions comprising effective amounts of these peptide compounds and methods for the treatment and/or prevention of related disease states and conditions which are mediated through ICAM-1/LFA-1 interactions, for example, the interaction of cellular adhesion molecules with integrins and/or the emigration of leukocytes from blood into tissue.

Abstract translation: 本发明涉及调节ICAM-1和LFA-1相互作用的肽化合物，特别是作为整联蛋白，更特别是LFA-1和一种或几种不同细胞间粘附分子（ICAMS）相互作用的抑制剂起作用 ），特别是ICAM-1，包含有效量的这些肽化合物的药物组合物以及用于治疗和/或预防通过ICAM-1 / LFA-1相互作用介导的相关疾病状态和状况的方法，例如相互作用 细胞粘附分子与整联蛋白和/或白血球从血液中迁移到组织中。

公开(公告)号：WO2004085992A3

公开(公告)日：2005-03-24

申请号：PCT/US2004008424

申请日：2004-03-19

Applicant: STC UNM ,  ENKE CHRISTIE

Inventor： ENKE CHRISTIE

IPC: G01N20060101 ,  G01N27/64 ,  H01J49/00 ,  H01J49/40 ,  H01J49/42

CPC classification number: H01J49/40 ,  G01N27/622 ,  H01J49/0045

Abstract: A distance of flight (DOF) approach to mass spectroscopy in which the resolution among the various ion masses is accomplished in space rather than time. A separate detector is associated with each ion mass resolution element. The DOF mass spectrometer can serve as one element in a tandem arrangement, which has the capability to produce a full two-dimensional precursor/product spectrum for each bunch of ions extracted from the source. A "distance-of-flight" (DOF) mass analyzer, having an ion storage device (21) means for applying an ion extraction voltage pulse to said storage device (22, 23), a field free region, and detectors (29), is used in combination with time-of-flight (TOF) mass analysis for precursor and product dispersion. All the precursor ions can undergo a mass changing reaction simultaneously, while still retaining the essential information about the particular precursor m/z value from which each product m/z value emanated. Through the use of a two-dimensional detector, all the products ions from all the precursors can be detected for each batch of ions analyzed.

Abstract translation: 距离飞行（DOF）方法到质谱法，其中各种离子质量的分辨率在空间而不是时间内完成。 单独的检测器与每个离子质量分辨率元件相关联。 DOF质谱仪可以作为串联布置的一个元件，其能够为从源提取的每束离子产生完整的二维前体/产物光谱。 具有离子存储装置（21）的“距离飞行”（DOF）质量分析器，用于向所述存储装置（22,23）施加离子提取电压脉冲的装置，无场区域和检测器（29）， ，与前体和产品分散体的飞行时间（TOF）质量分析结合使用。 所有的前体离子可以同时进行质量变化反应，同时仍然保留关于每个产物m / z值发射的特定前体m / z值的基本信息。 通过使用二维检测器，可以对分析的每批离子检测来自所有前体的所有产物离子。