公开(公告)号：WO2004085992A3

公开(公告)日：2005-03-24

申请号：PCT/US2004008424

申请日：2004-03-19

Applicant: STC UNM ,  ENKE CHRISTIE

Inventor： ENKE CHRISTIE

IPC: G01N20060101 ,  G01N27/64 ,  H01J49/00 ,  H01J49/40 ,  H01J49/42

CPC classification number: H01J49/40 ,  G01N27/622 ,  H01J49/0045

Abstract: A distance of flight (DOF) approach to mass spectroscopy in which the resolution among the various ion masses is accomplished in space rather than time. A separate detector is associated with each ion mass resolution element. The DOF mass spectrometer can serve as one element in a tandem arrangement, which has the capability to produce a full two-dimensional precursor/product spectrum for each bunch of ions extracted from the source. A "distance-of-flight" (DOF) mass analyzer, having an ion storage device (21) means for applying an ion extraction voltage pulse to said storage device (22, 23), a field free region, and detectors (29), is used in combination with time-of-flight (TOF) mass analysis for precursor and product dispersion. All the precursor ions can undergo a mass changing reaction simultaneously, while still retaining the essential information about the particular precursor m/z value from which each product m/z value emanated. Through the use of a two-dimensional detector, all the products ions from all the precursors can be detected for each batch of ions analyzed.

Abstract translation: 距离飞行（DOF）方法到质谱法，其中各种离子质量的分辨率在空间而不是时间内完成。 单独的检测器与每个离子质量分辨率元件相关联。 DOF质谱仪可以作为串联布置的一个元件，其能够为从源提取的每束离子产生完整的二维前体/产物光谱。 具有离子存储装置（21）的“距离飞行”（DOF）质量分析器，用于向所述存储装置（22,23）施加离子提取电压脉冲的装置，无场区域和检测器（29）， ，与前体和产品分散体的飞行时间（TOF）质量分析结合使用。 所有的前体离子可以同时进行质量变化反应，同时仍然保留关于每个产物m / z值发射的特定前体m / z值的基本信息。 通过使用二维检测器，可以对分析的每批离子检测来自所有前体的所有产物离子。

公开(公告)号：DE69230333T2

公开(公告)日：2000-08-24

申请号：DE69230333

申请日：1992-04-29

Applicant: LECO CORP ,  ENKE CHRISTIE G ,  HOLLAND JOHN F ,  MCLANE RICHARD D ,  YEFCHAK GEORGE E

Inventor： ENKE CHRISTIE ,  HOLLAND JOHN ,  MCLANE RICHARD ,  YEFCHAK GEORGE

IPC: G01N27/62 ,  G01N30/72 ,  G01N30/86 ,  G06F17/00

Abstract: A process and apparatus employing the time compression of chromatography in mass spectrometry with array detection in which the time compressed informatioin is deconvoluted by mathematical analysis for recovery of analytical information made inaccessible in the time compression and thereby resulting in a decrease in analysis time and improved component identification without loss of sensitivity.

公开(公告)号：EP1618593A4

公开(公告)日：2007-12-05

申请号：EP04757871

申请日：2004-03-19

Applicant: STC UNM

Inventor： ENKE CHRISTIE

IPC: H01J49/40 ,  G01N20060101 ,  G01N27/64 ,  H01J49/00 ,  H01J49/42

CPC classification number: H01J49/40 ,  G01N27/622 ,  H01J49/0045

Abstract: A distance of flight (DOF) approach to mass spectroscopy in which the resolution among the various ion masses is accomplished in space rather than time. A separate detector is associated with each ion mass resolution element. The DOF mass spectrometer can serve as one element in a tandem arrangement which has the capability to produce a full two-dimensional precursor/product spectrum for each bunch of ions extracted from the source. A "distance-of-flight" (DOF) mass analyzer is used in combination with time-of-flight (TOF) mass analysis for precursor and product dispersion. All the precursor ions can undergo a mass changing reaction simultaneously, while still retaining the essential information about the particular precursor m/z value from which each product m/z value emanated. Through the use of a two-dimensional detector, all the products ions from all the precursors can be detected for each batch of ions analyzed.