公开(公告)号：US20160303105A1

公开(公告)日：2016-10-20

申请号：US15193589

申请日：2016-06-27

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  UNIVERSITY OF SASKATCHEWAN

Inventor： Rosa A. MALDONADO ,  Miguel A. VASQUEZ ,  Jonathan R. DIMMOCK ,  Umashankar DAS

IPC: A61K31/4545 ,  A61K31/132 ,  A61K45/06

CPC classification number: A61K31/4545 ,  A61K31/13 ,  A61K31/132 ,  A61K45/06 ,  Y02A50/409 ,  Y02A50/414

Abstract: Embodiments are directed to compositions and methods for treating parasitic infections. Compounds have been identified from a library of anti-cancer drugs that serve as suitable agents for targeting trypanosomatids.

Abstract translation: 实施方案涉及用于治疗寄生虫感染的组合物和方法。 从抗癌药物文库中鉴定出化合物，其作为靶向锥虫病的合适试剂。

公开(公告)号：US09376476B2

公开(公告)日：2016-06-28

申请号：US14709877

申请日：2015-05-12

Applicant: University of Saskatchewan

Inventor： Scott Napper ,  Peter Hedlin ,  Philip Griebel ,  Lorne Babiuk ,  Neil Cashman ,  Avijit Chakrabartty ,  Andrew Potter

IPC: A61K39/00 ,  C07K14/47 ,  C07K7/06 ,  C07K7/08 ,  C07K16/28 ,  G01N33/68

CPC classification number: C07K14/47 ,  A61K39/0007 ,  A61K2039/6037 ,  C07K7/06 ,  C07K7/08 ,  C07K16/2872 ,  C07K2317/34 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2333/705 ,  G01N2800/2828

Abstract: Prion peptides comprising prion epitopes and fusions thereof, that display enhanced immunogenicity are described. Also described are methods of treating and diagnosing prion disease.

公开(公告)号：US20160174570A1

公开(公告)日：2016-06-23

申请号：US15063350

申请日：2016-03-07

Applicant: University Of Saskatchewan

Inventor： Vladimir Vujanovic ,  James J. Germida

IPC: A01N63/04

CPC classification number: A01N63/04 ,  A01H17/00 ,  A01N63/00 ,  A01N63/02 ,  B09C1/105 ,  C12R1/465 ,  C12R1/645 ,  C12R1/80 ,  A01N25/00

Abstract: The present disclosure provides compositions comprising novel endophytes capable of promoting germination endophytes that have a symbiotic relationship with plants. The present disclosure further provides methods of improving seed vitality, biotic and abiotic stress resistance, plant health and yield under both stressed and unstressed environmental conditions, comprising inoculating a seed with the novel endophyte strains and cultivating a plant therefrom.

公开(公告)号：US20160097057A1

公开(公告)日：2016-04-07

申请号：US14973174

申请日：2015-12-17

Applicant: University of Saskatchewan

Inventor： Curtis J. POZNIAK ,  Pierre Hucl

IPC: C12N15/82 ,  A01N43/50 ,  C12N9/88

CPC classification number: C12N15/8274 ,  A01H5/10 ,  A01N43/50 ,  C12N9/88 ,  C12N15/8278 ,  C12Q1/6895 ,  C12Q2600/13 ,  C12Q2600/156 ,  C12Y401/03

Abstract: The present invention is directed to wheat plants having increased resistance to an imidazolinone herbicide. More particularly, the present invention includes wheat plants containing one or more IMI nucleic acids such as a Teal IMI cultivar. The nucleic acids are preferably located on or derived from different genomes. The present invention also includes seeds produced by these wheat plants and methods of controlling weeds in the vicinity of these wheat plants.

公开(公告)号：US20160067225A1

公开(公告)日：2016-03-10

申请号：US14785220

申请日：2014-04-17

Applicant: University of Saskatchewan

Inventor： Gregg Patrick ADAMS ,  Maria Jimena YAPURA ,  Roger A. PIERSON ,  Ildiko BADEA

IPC: A61K31/4196 ,  A61K45/06 ,  A61K47/24 ,  A61K38/24 ,  A61K47/42 ,  A61K47/10 ,  A61K47/44 ,  A61K9/00 ,  A61K47/28

CPC classification number: A61K31/4196 ,  A61K9/0034 ,  A61K9/0036 ,  A61K9/127 ,  A61K31/437 ,  A61K31/5575 ,  A61K38/24 ,  A61K45/06 ,  A61K47/10 ,  A61K47/24 ,  A61K47/28 ,  A61K47/42 ,  A61K47/44 ,  A61K2300/00

Abstract: Described herein is an intravaginal device that provides biologically active circulating concentrations of an aromatase inhibitor for at least about of 4 days. Three compounds with estradiol inhibitory capability (letrozole, anastrozole and fenbendazole) were tested in vitro using bovine granulosa cell culture. Letrozole was found to be the most efficient and potent inhibitor. Liposome-based and a wax-based formulations were used to assess letrozole diffusion through bovine vaginal mucosa in a diffusion chamber study. Samples were collected over a 24 h period. The wax-based vehicle was selected for further development of a letrozole intravaginal device based on its steady release rate. In an in vivo study in cattle, 3 different intravaginal devices containing 3 g of letrozole were tested: Wax (with 1,2-Dioleoyl-sn-Glycero-3-Phosphoethanolamine, DOPE) +gel coat (n=2), Wax+gel coat (n=4) and Wax (n=4). Blood samples were collected serially from time 0 to 120 h, and daily thereafter to measure circulating concentrations of letrozole by LC/MS/MS. The addition of a letrozole-containing gel coating improved initial absorption and hastened the increase on plasma concentrations of the active ingredient, while the letrozole-containing wax-based vehicle maintained prolonged delivery from the intravaginal device.

Abstract translation: 本文描述的是提供至少约4天的芳香酶抑制剂的生物活性循环浓度的阴道内装置。 使用牛颗粒细胞培养体外测试了具有雌二醇抑制能力的三种化合物（来曲唑，阿那曲唑和芬苯达唑）。 来曲唑被发现是最有效和最有效的抑制剂。 在扩散室研究中，使用基于脂质体的蜡和基于蜡的制剂来评估通过牛阴道粘膜的来曲唑扩散。 在24小时内收集样品。 基于其稳定释放速率，选择蜡基载体进一步开发来曲唑阴道内装置。 在牛的体内研究中，测试了含有3g来曲唑的3种不同的阴道内装置：蜡（含1,2-二油酰-sn-甘油-3-磷酸乙醇胺，DOPE）+凝胶涂层（n = 2），蜡+ 凝胶涂层（n = 4）和蜡（n = 4）。 从0到120小时连续收集血液样品，然后每天通过LC / MS / MS测量来曲唑的循环浓度。 含有来曲唑的凝胶涂层改善了初始吸收并加速了活性成分的血浆浓度的增加，而含有来曲唑的蜡基载体保持了从阴道内装置延长的递送。

公开(公告)号：US20160002129A1

公开(公告)日：2016-01-07

申请号：US14769112

申请日：2014-03-06

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： Ajay Kumar Dalai ,  Rajesh Vishnudev Sharma ,  Pardeep Kumar

IPC: C07C29/60 ,  B01J23/86

CPC classification number: C07C29/60 ,  B01J23/002 ,  B01J23/868 ,  B01J23/94 ,  B01J35/002 ,  B01J35/006 ,  B01J35/0066 ,  B01J35/1014 ,  B01J35/1038 ,  B01J35/1061 ,  B01J37/03 ,  B01J37/18 ,  B01J38/12 ,  B01J2523/00 ,  Y02P20/584 ,  C07C31/205 ,  B01J2523/17 ,  B01J2523/27 ,  B01J2523/48 ,  B01J2523/67

Abstract: A process for the hydrogenolysis of glycerol to produce propylene glycol as the major product comprising contacting the glycerol with hydrogen in the presence of a heterogeneous catalyst under conditions for the formation of propylene glycol is disclosed. In particular, propylene glycol is formed with a selectivity of greater than about 90%.

Abstract translation: 公开了一种用于甘油氢解生产丙二醇作为主要产物的方法，包括在形成丙二醇的条件下，在非均相催化剂存在下使甘油与氢气接触。 特别地，形成大于约90％的选择性的丙二醇。

公开(公告)号：US20150353857A1

公开(公告)日：2015-12-10

申请号：US14729128

申请日：2015-06-03

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： Ajay Kumar Dalai ,  Rajesh Vishnudev Sharma

IPC: C10M105/36

CPC classification number: C10M105/36 ,  C10M105/42 ,  C10M177/00 ,  C11C3/08

Abstract: A process for producing a lubricant from an epoxy-triglyceride comprising treating the epoxy-triglyceride with an esterifying agent in the presence of a heterogeneous catalyst under conditions to produce the lubricant is disclosed.

Abstract translation: 公开了一种从环氧甘油三酯制备润滑剂的方法，包括在非均相催化剂存在下用酯化剂处理环氧甘油三酯以制备润滑剂。

公开(公告)号：US20140329741A1

公开(公告)日：2014-11-06

申请号：US14366358

申请日：2012-12-19

Applicant: University of Saskatchewan

Inventor： Bernard Laarveld ,  Andrew A. Olkowski

IPC: A61K38/12 ,  A61K36/55 ,  A23L1/30

CPC classification number: A61K38/12 ,  A23K20/10 ,  A23K20/147 ,  A23L33/105 ,  A23L33/18 ,  A23V2002/00 ,  A61K9/0056 ,  A61K36/55 ,  A61K2236/39 ,  C07K1/145

Abstract: The present application includes a method for improving human and animal health comprising administering an effective amount of a linus cyclopeptide (LCP) extract from flaxseed to a subject in need thereof. Also included are feeds, foodstuffs, functional food compositions, natural product compositions nutraceuticals and food additive compositions comprising an LCP extract from flaxseed.

Abstract translation: 本申请包括一种改善人类和动物健康的方法，其包括向有需要的受试者施用有效量的亚麻籽亚麻素（LCP）提取物。 还包括饲料，食品，功能食品组合物，天然产品组合物营养食品和包含来自亚麻籽的LCP提取物的食品添加剂组合物。

公开(公告)号：US20140314850A1

公开(公告)日：2014-10-23

申请号：US14255001

申请日：2014-04-17

Applicant: University of Saskatchewan

Inventor： Ildiko Badea ,  Ronald Verrall ,  Jackson M. Chitanda ,  Randeep Kaur ,  Saniya Alwani

IPC: A61K47/48 ,  A61K31/4172 ,  A61K48/00 ,  A61K31/196 ,  C12N15/113

CPC classification number: C07C59/68 ,  A61K47/6929 ,  B82Y5/00 ,  C01B32/28 ,  C07B2200/11 ,  C07C255/41 ,  C07C2604/00 ,  H01J49/164 ,  Y10T428/2982 ,  Y10T436/143333

Abstract: The present application relates to functionalized nanodiamonds, to complexes comprising a functionalized nanodiamond reversibly bound to a nucleic acid and to compositions comprising such functionalized nanodiamonds and complexes. In particular, the functionalized nanodiamonds comprise at least one naturally occurring basic amino acid, or analogs or derivatives thereof, covalently linked to a nanodiamond. The present application also includes methods and uses of the complexes and compositions, for example for delivering a nucleic acid to a cell.

Abstract translation: 本申请涉及功能化纳米金刚石，包括可逆结合于核酸的功能化纳米二金刚石的复合物和包含这种官能化纳米金刚石和络合物的组合物。 特别地，官能化纳米金刚石包含共价连接到纳米金刚石的至少一种天然存在的碱性氨基酸或其类似物或衍生物。 本申请还包括复合物和组合物的方法和用途，例如将核酸递送至细胞。

公开(公告)号：US20140303010A1

公开(公告)日：2014-10-09

申请号：US14346490

申请日：2012-09-21

Applicant: University of Saskatchewan

Inventor： Brett Trost ,  Anthony Kusalik ,  Scott Napper ,  Ryan Arsenault ,  Philip Griebel

IPC: G01N33/68 ,  G06F19/22

CPC classification number: G01N33/6845 ,  C07K14/43572 ,  C12Q1/485 ,  G01N33/6818 ,  G01N33/6842 ,  G01N2333/43565 ,  G01N2333/91205 ,  G01N2440/14 ,  G16B30/00

Abstract: A method of preparing a species-specific phosphorylation site peptide array for a target organism comprising: a) selecting a plurality of known non-target organism (NTO) phosphorylation site sequences and cognate known NTO phosphorylation polypeptide sequences from one or more NTO, each of the known NTO phosphorylation site sequences comprising at least 5 residues and less than 30 residues; b) identifying a matching target organism (TO) phosphorylation site sequence and cognate TO phosphorylation polypeptide sequence for one or more of the known NTO phosphorylation site sequences; c) determining the matching TO phosphorylation site sequences that correspond to orthologue polypeptides of the cognate known NTO phosphorylation polypeptide sequences; d) selecting the matching TO phosphorylation site sequences determined to correspond to orthologue polypeptides for inclusion on the array; wherein the matching TO phosphorylation site sequences that correspond to orthologue polypeptides are determined by calculating, for each matching phosphorylation site sequence identified in b), a similarity value between the TO phosphorylation polypeptide sequence corresponding to the TO phosphorylation site sequence and a TO polypeptide sequence matching the cognate known NTO polypeptide sequence.

Abstract translation: 制备靶生物的物种特异性磷酸化位点肽阵列的方法，包括：a）从一个或多个NTO中选择多个已知的非靶生物（NTO）磷酸化位点序列和同源的已知NTO磷酸化多肽序列，每个 已知的NTO磷酸化位点序列包含至少5个残基和少于30个残基; b）鉴定一种或多种已知NTO磷酸化位点序列的匹配靶生物（TO）磷酸化位点序列和同源TO磷酸化多肽序列; c）确定与同源已知的NTO磷酸化多肽序列的直向同源多肽相对应的匹配的TO磷酸化位点序列; d）选择确定为对应于直向同源多肽的匹配的TO磷酸化位点序列以包含在阵列上; 其中对应于直向同源多肽的匹配的TO磷酸化位点序列通过对于b）中鉴定的每个匹配的磷酸化位点序列计算，对应于TO磷酸化位点序列的TO磷酸化多肽序列与匹配的TO多肽序列之间的相似性值 同源已知的NTO多肽序列。