公开(公告)号：SK286064B6

公开(公告)日：2008-02-05

申请号：SK18052002

申请日：2002-02-19

Applicant: SOLVAY PHARM BV

Inventor： FEENSTRA ROELOF W ,  RONKEN ERIC ,  KRUSE CORNELIS G ,  MCCREARY ANDREW C ,  VAN SCHARRENBURG GUSTAAF J M

IPC: C07D413/00 ,  A61K31/496 ,  A61P25/00 ,  A61P25/16 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D413/12 ,  C07D471/06

Abstract: Described are phenylpiperazine derivatives of general formula (I), wherein R is a group of general formula (a) or (b), and salts thereof and method for their preparation by reaction of compound of general formula (II) with compound of general formula L-(a) or L-(b), wherein L is a leaving group. Described is also a pharmaceutical preparation containing at least one phenylpiperazine derivative of general formula (I) and use of derivatives in the treatment of Parkinson Disease and CNS-disorders.

公开(公告)号：NO20072977L

公开(公告)日：2007-09-05

申请号：NO20072977

申请日：2007-06-11

Applicant: SOLVAY PHARM BV

Inventor： SCHARRENBURG GUSTAAF JOHAN MAR ,  FEENSTRA ROELOF W ,  KRUSE CORNELIS GERRIT ,  MCCREARY ANDREW C ,  PRAS-RAVES MARIA L ,  HESSELINK MAYKE B ,  TERPSTRA JAN-WILLEM ,  STOIT AXEL ,  VLIET BERNARD J VAN

IPC: C07D263/58 ,  A61K31/423 ,  A61P25/00 ,  C07D413/12

Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine -D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.

公开(公告)号：NO20072969A

公开(公告)日：2007-08-31

申请号：NO20072969

申请日：2007-06-11

Applicant: SOLVAY PHARM BV

Inventor： SCHARRENBURG GUSTAAF JOHAN MAR ,  FEENSTRA ROELOF W ,  KRUSE CORNELIS GERRIT ,  MCCREARY ANDREW C ,  PRAS-RAVES MARIA L ,  HESSELINK MAYKE B ,  TERPSTRA JAN-WILLEM ,  STOIT AXEL ,  VLIET BERNARD J VAN

IPC: C07D263/58

CPC classification number: C07D263/58 ,  C07D413/12

公开(公告)号：MX2007006817A

公开(公告)日：2007-07-24

申请号：MX2007006817

申请日：2005-12-06

Applicant: SOLVAY PHARM BV

Inventor： KRUSE CORNELIS G ,  TERPSTRA JAN-WILLEM ,  SCHARRENBURG GUSTAAF J M VAN ,  FEENSTRA ROELOF W ,  STOIT AXEL ,  PRAS-RAVES MARIA L ,  MCCREARY ANDREW C ,  VLIET BERNARD J VAN ,  HESSELINK MAYKE B

IPC: A61K31/00 ,  C07D263/58 ,  A61P25/00

Abstract: La invencion se refiere a un grupo de derivados novedosos de fenilpiperazina con un doble modo de accion: inhibicion de la reabsorcion de serotonina y agonismo parcial de receptores de dopamina-D2; la invencion tambien se refiere al uso de un compuesto que se describe en la presente para la fabricacion de un medicamento que tiene un efecto beneficioso; los compuestos tienen la formula general (1): (ver formula (1)) en donde los simbolos tienen los significados dados en la especificacion, y los tautomeros, estereoisomeros y N-oxidos de los mismos, asi como tambien las sales, hidratos y solvatos farmacologicamente aceptables de dichos compuestos de formula (1) y sus tautomeros, estereoisomeros y N-oxidos.

公开(公告)号：NO323778B1

公开(公告)日：2007-07-02

申请号：NO20025365

申请日：2002-11-08

Applicant: SOLVAY PHARM BV

Inventor： SCHARRENBURG GUSTAAF JOHAN MAR ,  FEENSTRA ROELOF W ,  LONG STEPHEN K ,  KRUSE CORNELIS GERRIT ,  HEIJDEN JOHANNES A M VAN DER

IPC: A61K31/4523 ,  C07D413/10 ,  A61K31/423 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/496 ,  A61P25/00 ,  A61P25/16 ,  A61P25/22 ,  A61P25/24 ,  A61P25/30 ,  A61P43/00 ,  C07D263/54 ,  C07D263/58 ,  C07D277/62 ,  C07D413/04 ,  C07D413/12 ,  C07D413/14

公开(公告)号：CA2594165A1

公开(公告)日：2006-08-31

申请号：CA2594165

申请日：2006-02-17

Applicant: SOLVAY PHARM BV

Inventor： DRUKARCH BENJAMIN ,  BURGOT JEAN-LOUIS ,  CHRISTEN MARIE-ODILE ,  FEENSTRA ROELOF W ,  SCHOFFELMEER ANTON N M ,  IWEMA BAKKER WOUTER I ,  VAN VLIET BERNARD J ,  TULP MARTINUS TH M ,  CHOLLET MARYLENE

IPC: C07D339/04 ,  A61K31/385

Abstract: The invention relates to dithiolethiones derivatives as monoamino oxidase inhibitors, in particular MAO-B inhibitors, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said dithiolethiones derivatives. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. In embodiments of the invention specific compounds disclosed herein are used for the manufacture of a medicament useful in the treatment, amelioration or prevention of conditions associated with dysfunction of monoamine neurotransmission. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.

公开(公告)号：CA2587202A1

公开(公告)日：2006-06-15

申请号：CA2587202

申请日：2005-12-06

Applicant: SOLVAY PHARM BV

Inventor： VAN SCHARRENBURG GUSTAAF J M ,  STOIT AXEL ,  TERPSTRA JAN-WILLEM ,  VAN VLIET BERNARD J ,  PRAS-RAVES MARIA L ,  MCCREARY ANDREW C ,  HESSELINK MAYKE B ,  KRUSE CORNELIS G ,  FEENSTRA ROELOF W

IPC: A61K31/423 ,  A61P25/00 ,  C07D263/58 ,  C07D413/12

Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine -D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.

公开(公告)号：AU2005313312A1

公开(公告)日：2006-06-15

申请号：AU2005313312

申请日：2005-12-06

Applicant: SOLVAY PHARM BV

Inventor： HESSELINK MAYKE B ,  KRUSE CORNELIS G ,  VLIET BERNARD J VAN ,  TERPSTRA JAN-WILLEM ,  MCCREARY ANDREW C ,  FEENSTRA ROELOF W ,  STOIT AXEL ,  SCHARRENBURG GUSTAAF J M VAN ,  PRAS-RAVES MARIA L

IPC: A61K31/423 ,  A61P25/00 ,  C07D413/12

Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine -D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.

公开(公告)号：AU2002253043B2

公开(公告)日：2006-06-08

申请号：AU2002253043

申请日：2002-02-19

Applicant: SOLVAY PHARM BV

Inventor： RONKEN ERIC ,  MCCREARY ANDREW C ,  FEENSTRA ROELOF W ,  KRUSE CORNELIS G ,  SCHARRENBURG GUSTAAF J M VAN

IPC: C07D413/12 ,  A61K31/496 ,  A61P25/00 ,  A61P25/16 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D471/06

Abstract: The invention relates to novel phenylpiperazine derivatives of the formula wherein: -R represents the group (a) or (b) as indicated in the description. These compounds are (partial) D2 receptor agonists and are usefull for treating CNS disorders, in particular Parkinson's disease.

公开(公告)号：DK1395583T3

公开(公告)日：2005-03-29

申请号：DK02722107

申请日：2002-02-19

Applicant: SOLVAY PHARM BV

Inventor： FEENSTRA ROELOF W ,  RONKEN ERIC ,  KRUSE CORNELIS G ,  MCCREARY ANDREW C ,  VAN SCHARRENBURG GUSTAAF J M

IPC: A61K31/496 ,  A61P25/00 ,  A61P25/16 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D413/12 ,  C07D471/06

Abstract: The invention relates to novel phenylpiperazine derivatives of the formula wherein: -R represents the group (a) or (b) as indicated in the description. These compounds are (partial) D2 receptor agonists and are usefull for treating CNS disorders, in particular Parkinson's disease.