公开(公告)号：EP2609406A1

公开(公告)日：2013-07-03

申请号：EP11754548.3

申请日：2011-07-26

Applicant: Canon Kabushiki Kaisha

Inventor： OUCHI, Toshihiko

IPC: G01J1/42 ,  G01N21/35 ,  G01J3/42 ,  G01J3/433

CPC classification number: G01N21/17 ,  G01J3/0218 ,  G01J3/42 ,  G01J3/4338 ,  G01N21/3581 ,  G01N2021/1787 ,  G01N2201/067 ,  G02F1/2255 ,  G02F2001/212 ,  G02F2203/54

Abstract: An optical pulse generating apparatus that supplies pump light and probe light includes a light source and a modulation unit configured to modulate light emitted from the light source, thereby dividing the light into the pump light and the probe light. The modulation unit is configured such that a frequency for modulating the light is variable. The modulation unit changes a difference between a moment of the pump light incident on an object and a moment of the probe light incident on the object by changing the frequency.

公开(公告)号：EP1774024A2

公开(公告)日：2007-04-18

申请号：EP05763933.8

申请日：2005-07-01

Applicant: Blueshift Biotechnologies, Inc.

Inventor： COMITA, Paul, B. ,  SHUMATE, Christopher, B. ,  MILLER, Steven, C. ,  CROMWELL, Evan, F.

IPC: C12Q1/68 ,  G01N33/53

CPC classification number: G01N33/582 ,  B82Y5/00 ,  B82Y10/00 ,  C12Q1/6816 ,  G01N21/6408 ,  G01N21/6428 ,  G01N21/6445 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6432 ,  G01N2021/6441 ,  G01N2021/6478 ,  G01N2021/6484 ,  G01N2201/067 ,  G01N2201/0697 ,  G01N2201/0833 ,  C12Q2563/107 ,  C12Q2561/119

Abstract: Methods, apparatus, and system, implementing and using techniques for detecting a presence of one or more target analytes in particular regions of interest of one or more samples. One or more samples including objects and one or more target analytes are provided. Some of the target analytes are labeled with a fluorophore and are bound to some of the objects in the samples. The samples are illuminated with fluorescence inducing light and fluorescent light is collected from one or more regions of the one or more samples. At least one anisotropy measurement of the samples is performed to identify regions of interest where one or more target analytes are bound to the objects. The collected fluorescent light from the regions of interest is analyzed to determine a presence of target analytes that are bound to the objects in the one or more samples.

公开(公告)号：EP1745410A2

公开(公告)日：2007-01-24

申请号：EP05735712.1

申请日：2005-04-13

Applicant: Biorad Laboratories, Inc.

Inventor： RAGSDALE, Charles, W.

IPC: G06K9/00

CPC classification number: G01N21/6452 ,  G01N2021/4709 ,  G01N2021/6419 ,  G01N2021/6471 ,  G01N2201/067 ,  G01N2201/0691

Abstract: A method is provided for measuring a response to a stimulus of a plurality of samples spots of a sample using a measuring system having a measurement range to generate an image of the sample in digital space. The method includes, for each sample, while measuring the response, varying the stimulus to include at least one stimulus value where the measured response corresponds to a value in an intermediate portion of the measuring range, and storing a value of the measured response that corresponds to a value in the intermediate portion of the measurement range, and the stimulus value that produced that value of the measured response.

公开(公告)号：EP0760090B1

公开(公告)日：1997-11-05

申请号：EP94927859.2

申请日：1994-08-09

Applicant: TECHNISCHE UNIVERSITEIT DELFT ,  Stichting voor de Technische Wetenschappen

Inventor： HEFFELS, Camiel, Marie, Godfried

IPC: G01N15/02

CPC classification number: G01N15/0211 ,  G01N2015/0216 ,  G01N2015/0294 ,  G01N2021/4716 ,  G01N2201/067

Abstract: To determine the shape characteristics of particles, a light beam (preferably a laser beam) is directed onto a transparent cell containing particles flowing therein and the intensity of the light scattered by the particles is measured with the aid of a photodetector array or a mask containing programmable light valves, comprising one or more concentric rings or parts of rings, at least one of which is provided with one or more isolated segments. The rings and the isolated segments are coupled to an energy meter, the signal amplitudes of which are statistically processed to give amplitude classes. The shape characteristics are determined from a graphical or numerical comparison of the amplitude classes. If at least one ring is subdivided into several segments, calculation of the correlation between the signals from the various ring segments leads to an accurate determination of the average shape characteristics of the particles.

公开(公告)号：EP0680276A4

公开(公告)日：1996-08-21

申请号：EP94906525

申请日：1994-01-06

Applicant: US HEALTH

Inventor： BASHKANSKY MARK ,  REINTJES JOHN F

IPC: G01N21/65 ,  A61B10/00 ,  G01N21/21 ,  G01N21/47 ,  A61B6/00 ,  G01J3/44

CPC classification number: G01N21/4795 ,  G01N2021/1789 ,  G01N2201/067

Abstract: An apparatus for imaging into or through scattering materials (17) includes a source (20) for producing a broadband laser reference beam (R) and a Stokes illumination beam (Si) correlated to the reference beam. The Stokes illumination beam is transmitted into the scattering material to obtain a Stokes signal beam (Ss) having a first image carrying component and a first nonimage component. The reference beam and the Stokes signal beam are then separately delayed (Rd, Sd) and polarized (Rp, Sp), after which they are combined to produce a combined beam (C) having a Stokes component and a reference component. A Stimulated Raman amplifier (30) responsive to the combined beam produces an amplified signal beam (A) in which the image carrying component has been amplified by a higher gain factor than the nonimage component.

公开(公告)号：EP0452095B1

公开(公告)日：1995-06-14

申请号：EP91303127.4

申请日：1991-04-09

Applicant: Hughes Aircraft Company

Inventor： Drummond, James E. ,  Shih, I-Fu

IPC: G01J3/02

CPC classification number: G01J3/1838 ,  G01J3/0237 ,  G01J3/0256 ,  G01J3/0259 ,  G01J3/0286 ,  G01J3/0289 ,  G01J3/2803 ,  G01N21/3504 ,  G01N2201/067

Abstract: This invention relates to a dispersive holographic spectrometer (12) for analyzing radiation from an infrared source (16). The holographic spectrometer (12) comprises a piezoelectric block (40) having a holographic lens (38) on one face, an array of detectors (36) on another face and a pair of vernier electrodes (32, 34) on opposite faces. Radiation from the source (16) incident upon the holographic lens (38) is dispersed into component wavelengths (44, 46) and directed towards the detector array (36). The holographic lens (38) has a holographic interference pattern recorded on it such that radiation of predetermined wavelength components are dispersed sufficiently enough such that radiation of specific wavelengths falls on different detector elements (48) of the detector array (36). By applying a voltage to the electrodes (32, 38), an electric field is created within the piezoelectric block (40) such that it is either compressed or expanded. This change in the piezoelectric block (40) alters the direction of the radiation from the holographic lens (38) to the detector array (36). Therefore, misalignment of the source (16) with the holographic lens (38) can be compensated for such that piezoelectric adjustment of the block (40) will make the radiation of individual wavelengths fall on the desired detector element (48). Further, radiation from different wavelengths can be directed from one detector element to another. The detector array (36) is self-scanning such that an absorption spectrum can be measured and recorded over a range of frequencies.

公开(公告)号：EP3091352B1

公开(公告)日：2018-09-05

申请号：EP16163767.3

申请日：2016-04-04

Applicant: Honeywell International Inc.

Inventor： JUNGWIRTH, Matthew Edward Lewis ,  GOEDERS, James

IPC: G01N21/64

CPC classification number: G21K1/003 ,  G01N21/64 ,  G01N21/6452 ,  G01N21/6458 ,  G01N2021/7786 ,  G01N2201/067

Abstract: A single cell apparatus (102) and method for single ion addressing are described herein. One apparatus includes a single cell (102) configured to set a frequency, intensity, and a polarization of a laser, shutter the laser, align the shuttered laser to an ion in an ion trap such that the ion fluoresces light and/or performs a quantum operation, and detect the light fluoresced from the ion.

公开(公告)号：EP3088869A1

公开(公告)日：2016-11-02

申请号：EP16154696.5

申请日：2016-02-08

Applicant: Honeywell International Inc.

Inventor： JUNGWIRTH, Matthew Edward Lewis ,  GOEDERS, James E.

IPC: G01N21/64

CPC classification number: G01N21/6404 ,  F25B23/00 ,  G01N21/64 ,  G01N21/6452 ,  G01N2021/6469 ,  G01N2021/6484 ,  G01N2201/067 ,  G06N99/002 ,  H01J49/4205

Abstract: A multi-cell apparatus (100) and method for single ion addressing are described herein. One apparatus includes a first cell (102) configured to set a frequency, intensity, and a polarization of a laser and shutter the laser, a second cell (104) configured to align the shuttered laser to an ion in an ion trap such that the ion fluoresces light and/or performs a quantum operation, and a third cell (106) configured to detect the light fluoresced from the ion.

Abstract translation: 本文描述了用于单离子寻址的多单元装置（100）和方法。 一种设备包括被配置为设置激光器的频率，强度和偏振并且使激光器快门的第一单元（102），被配置成将快门激光器与离子阱中的离子对准的第二单元（104），使得 离子发荧光和/或执行量子操作;以及第三单元（106），配置为检测从离子发出荧光的光。

公开(公告)号：EP3081924A1

公开(公告)日：2016-10-19

申请号：EP16154710.4

申请日：2016-02-08

Applicant: Honeywell International Inc.

Inventor： GOEDERS, James E. ,  JUNGWIRTH, Matthew Edward Lewis

IPC: G01N21/64

CPC classification number: G02F1/0115 ,  G01N21/645 ,  G01N2021/6484 ,  G01N2201/067 ,  G02F1/035 ,  G02F1/11 ,  G02F1/113 ,  G02F1/125 ,  G06N99/002 ,  H01J49/0018 ,  H01J49/424 ,  H01S3/0085

Abstract: Preparation cell systems and methods are described herein. One example of a system for a preparation cell includes a laser coupled to a fiber bundle comprising a plurality of fibers, a preparation cell to prepare a state of laser light received by the fiber bundle, and an exiting fiber bundle coupled to the preparation cell.

Abstract translation: 本文描述了制备细胞系统和方法。 用于制备细胞的系统的一个实例包括耦合到包含多个纤维的纤维束的激光器，用于制备由纤维束接收的激光的状态的制备单元和耦合到制备单元的出射纤维束。

公开(公告)号：EP3042239A1

公开(公告)日：2016-07-13

申请号：EP14758923.8

申请日：2014-09-03

Applicant: Leica Microsystems CMS GmbH

Inventor： KRISHNAMACHARI, Vishnu Vardhan

IPC: G02B27/28 ,  G02B21/00

CPC classification number: G01N21/21 ,  G01N21/65 ,  G01N2201/067 ,  G01N2201/0683 ,  G02B21/002 ,  G02B21/0032 ,  G02B21/0068 ,  G02B27/283 ,  G02B27/286

Abstract: The invention relates to a method for examining a sample, the sample being subjected to illumination light and detection light coming from the sample being directed to a detector, and the illumination light being directed through an acousto-optical component with which the sample can be temporarily interrupted from being subjected to illumination light. The method is characterized in that the sample is illuminated by a first illumination light bundle that has a first linear polarization direction and by a second illumination light bundle, the linear polarization direction of which is continuously switched between the first linear polarization direction and a second linear polarization direction that is different from the first linear polarization direction. The illumination light of the first linear polarization direction runs along a first light path and the illumination light of the second linear polarization direction runs along a second light path, and the acousto-optical component unites the light paths.