公开(公告)号：CA2191079A1

公开(公告)日：1995-11-30

申请号：CA2191079

申请日：1995-05-22

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/107 ,  A61K9/50 ,  A61K49/00 ,  A61K49/04 ,  A61K49/18 ,  B01J13/00

Abstract: Novel stabilized suspensions of a gas as diagnostic contrast agents, including computed tomography (CT) and magnetic resonance (MR) contrast agents. In preferred embodiments, the suspensions comprise stabilized gas-filled microspheres. Also in some preferred embodiments, at least a portion of the gas is derived from a gaseous precursor.

公开(公告)号：CA2118016A1

公开(公告)日：1993-11-11

申请号：CA2118016

申请日：1992-05-04

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K31/02 ,  A61K31/13 ,  A61K31/22 ,  A61K31/655 ,  A61K41/00 ,  A61N7/02 ,  A61F7/00 ,  A61K33/00

Abstract: 2118016 9321889 PCTABS00027 Gas, gaseous precursors and perfluorocarbons are presented as novel potentiators for ultrasonic hyper-thermia. The gas, gaseous precursors and perfluorocarbons which may be administered into the vasculature, interstitially or into any body cavity are designed to accumulate in cancerous and diseased tissues. When therapeutic ultrasonic energy is applied to the diseased region heating is increased because of the greater effectiveness of sound energy absorption caused by these agents.

公开(公告)号：AU2149692A

公开(公告)日：1993-01-12

申请号：AU2149692

申请日：1992-03-31

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： EVAN C. UNGER

IPC: A61F7/00 ,  A61B17/00 ,  A61B17/22 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/22 ,  A61N7/00 ,  A61N7/02 ,  A61Q19/00 ,  B01J13/02

Abstract: Gas filled liposomes prepared by a vacuum drying gas instillation method and/or gas filled liposomes substantially devoid of liquid in the interior thereof, are presented as novel potentiators for ultrasonic hyperthermia. The liposomes of the present invention, which may be administered into the vasculature, interstitially or into any body cavity are designed to accumulate in cancerous and diseased tissues. When therapeutic ultrasonic energy is applied to the diseased region heating is increased because of the greater effectiveness of sound energy absorption caused by these agents.

公开(公告)号：AU2002092A

公开(公告)日：1993-01-12

申请号：AU2002092

申请日：1992-03-31

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： EVAN C. UNGER ,  GUANLI WU

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61Q19/00 ,  B01J13/02

Abstract: Contrast agents for ultrasonic imaging comprising gas filled liposomes prepared using vacuum drying gas instillation methods, and gas filled liposomes substantially devoid of liquid in the interior thereof, are described. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in ultrasonic imaging applications are also disclosed. Also described are diagnostic kits for ultrasonic imaging which include the subject contrast agents.

公开(公告)号：AU1744292A

公开(公告)日：1992-11-02

申请号：AU1744292

申请日：1992-03-18

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： EVAN C. UNGER

IPC: A61B6/03 ,  A61K9/10 ,  A61K9/14 ,  A61K49/04 ,  A61K51/06 ,  A61K101/02 ,  A61P9/00 ,  C08K5/02 ,  C08L101/00 ,  G01N33/60

公开(公告)号：CA2107466A1

公开(公告)日：1992-10-06

申请号：CA2107466

申请日：1992-03-18

Applicant: UNGER EVAN C ,  IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61B6/03 ,  A61K9/10 ,  A61K9/14 ,  A61K49/04 ,  A61K51/06 ,  A61K101/02 ,  A61P9/00 ,  C08K5/02 ,  C08L101/00 ,  G01N33/60

Abstract: Substantially homogeneous aqueous suspensions of low density microspheres ar e presented as contrast media for imaging the gastrointestinal tract and other body cavities using computed tomography . In one embodiment, the low density microspheres are gas-filled. With computed tomography, the contrast media serve to change the relative density of certain areas within the gas- trointestinal tract and other body cavities, and improve the overall diagnostic efficacy of this imaging method.

公开(公告)号：CA2069759A1

公开(公告)日：1991-06-23

申请号：CA2069759

申请日：1990-12-19

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61B8/00 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  B01J13/02 ,  B01J13/12 ,  A61B8/14

Abstract: 2069759 9109629 PCTABS00005 Liposomes suitable as ultrasound contrast agents which contain media of various types including gases, gaseous precursors activated by pH, temperature or pressure, as well as other solid or liquid contrast enhancing agents, are described. Methods of using the same as ultrasound contrast agents are also disclosed. The present invention also comprises novel methods for synthesizing liposomes having encapsulated therein gases.

公开(公告)号：CA2211517C

公开(公告)日：2010-01-12

申请号：CA2211517

申请日：1992-05-04

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61N7/02 ,  A61K33/16 ,  A61K41/00

Abstract: Gas, gaseous precursors and perfluorocarbons are presented as novel potentiators for ultrasonic hyper-thermia. The gas, gaseous precursors and perfluorocarbons which may be administered into the vasculature, interstitially or into any body cavity are designed to accumulate in cancerous and diseased tissues. When therapeutic ultrasonic energy is applied to the diseased region heating is increased because of the greater effectiveness of sound energy absorption caused by these agents.

公开(公告)号：DE69940704D1

公开(公告)日：2009-05-20

申请号：DE69940704

申请日：1999-05-07

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  WU YUNGUI

IPC: A61B8/00 ,  G01N29/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B8/08 ,  G01N21/00 ,  G01N29/04 ,  G01S7/52 ,  G01S15/02 ,  G01S15/89 ,  G01S17/89 ,  H04N5/30

Abstract: An optoacoustic system comprises an optoacoustic transducer including a first array of acoustic transducers and a second array of optical fibers; an acoustic subsystem for controllably exciting at least a first subset of the acoustic transducers to generate acoustic pulses with a prescribed pulse width, and for forming a first image based on return acoustic pulses reflected from a patient; an optical subsystem for controllably generating optical pulses to be transmitted through at least a first subset of the optical fibers toward the patient, and for forming a second image based on light reflected from the patient; and image correlation means for correlating the first and second images. The first and second arrays may take various forms, including the form of an annular array in which the acoustic transducers are arranged coaxially and the optical fibers are disposed around an outer periphery of the first array. The first and second arrays may also take the form of linear arrays.

公开(公告)号：AT406179T

公开(公告)日：2008-09-15

申请号：AT98928973

申请日：1998-06-10

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN ,  MCGREERY THOMAS ,  WU YUNQIU

IPC: A61K49/04 ,  A61B17/20 ,  A61K9/127 ,  A61K41/00 ,  A61K47/00 ,  A61K47/48 ,  A61K49/22 ,  B06B1/00