公开(公告)号：US5547656B1

公开(公告)日：1999-07-20

申请号：US44909095

申请日：1995-05-24

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61B6/03 ,  A61K9/10 ,  A61K9/14 ,  A61K49/04 ,  A61K51/06 ,  A61K101/02 ,  A61P9/00 ,  C08K5/02 ,  C08L101/00 ,  G01N33/60 ,  A61B8/13

CPC classification number: A61K49/0419 ,  Y10T428/2982 ,  Y10T428/31862

公开(公告)号：US5527521B1

公开(公告)日：1999-11-09

申请号：US45673895

申请日：1995-06-01

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61B6/03 ,  A61K9/10 ,  A61K9/14 ,  A61K49/04 ,  A61K51/06 ,  A61K101/02 ,  A61P9/00 ,  C08K5/02 ,  C08L101/00 ,  G01N33/60 ,  A61B8/13 ,  A61B5/055

CPC classification number: A61K49/0419 ,  Y10T428/2982 ,  Y10T428/31862

公开(公告)号：WO9809600A3

公开(公告)日：1998-04-16

申请号：PCT/US9715033

申请日：1997-08-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  SHEN DEKANG ,  WU GUANLI

IPC: A61K49/18 ,  A61K49/22 ,  A61K51/12 ,  C07F7/08 ,  A61K

CPC classification number: C07F7/0854 ,  A61K49/1806 ,  A61K49/223 ,  A61K51/1227

Abstract: Novel silicon amphiphilic compounds which comprise a silicon residue. The silicon amphiphilic compounds are particularly suitable for use in compositions for diagnostic imaging, such as ultrasound. Compositions of the silicon amphiphilic compounds comprise a gas or gaseous precursor, and may take the form of vesicle compositions, such as micelles or liposomes.

公开(公告)号：WO9700638A3

公开(公告)日：1997-02-20

申请号：PCT/US9607887

申请日：1996-06-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS ,  YELLOWHAIR DAVID ,  BARRETTE TERRENCE R

IPC: A61K49/00 ,  A61B5/055 ,  A61B8/00 ,  A61J3/00 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01F3/04 ,  B01F11/00 ,  B01F15/00 ,  A61B

CPC classification number: A61K49/22 ,  A61J3/00 ,  A61K9/127 ,  A61K9/1277 ,  A61K9/1278 ,  A61K41/0028 ,  A61K41/0052 ,  A61K49/1815 ,  A61K49/223 ,  A61K49/227 ,  A61K2800/87 ,  A61M5/3145 ,  B01F3/04099 ,  B01F11/0025 ,  B01F13/0033 ,  B01F15/00435 ,  Y10S366/605

Abstract: A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3°. The total length of travel around the figure-8 pattern is at least 0.7 cm.

公开(公告)号：EP0959908A4

公开(公告)日：2002-11-20

申请号：EP98946919

申请日：1998-09-09

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  GERTZ EDWARD W

IPC: A61K49/22 ,  A61K49/04 ,  A61K9/127 ,  A61K9/50 ,  A61K47/48

CPC classification number: A61K49/223 ,  A61K49/227 ,  A61K49/228 ,  B82Y5/00

公开(公告)号：EP0935415A4

公开(公告)日：2002-08-14

申请号：EP97921460

申请日：1997-04-30

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS

IPC: C12N15/09 ,  A61K9/127 ,  A61K41/00 ,  A61K45/08 ,  A61K47/02 ,  A61K47/18 ,  A61K47/30 ,  A61K47/42 ,  A61K48/00 ,  A61P3/10 ,  A61P7/00 ,  A61P9/10 ,  A61P11/00 ,  A61P21/00 ,  A61P31/18 ,  A61P35/00 ,  C12N5/10 ,  C12N15/87 ,  C12N15/88 ,  C12P21/02 ,  A01N43/04 ,  A61K31/70 ,  C07H21/04 ,  C12N15/12 ,  C12N15/85

CPC classification number: A61K48/00 ,  A61K9/1272 ,  A61K41/0028 ,  C12N15/87 ,  C12N15/88

公开(公告)号：EP0977597A4

公开(公告)日：2000-02-09

申请号：EP97940615

申请日：1997-08-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/10 ,  A61K31/401 ,  A61K45/08 ,  A61K49/00 ,  A61K49/22 ,  A61B8/14

CPC classification number: A61B5/411 ,  A61B5/201 ,  A61K49/223 ,  A61K49/227

Abstract: A method for providing an image of an internal region of a patient has been developed. The method reduces imaging artifacts by providing enhanced contrast between tissue and blood during imaging. The method comprises administering to a patient a contrast agent in combination with a renal vasodilator and performing ultrasound imaging of the region. Renal disease, including renal arterial stenosis, may be diagnosed using the method.

Abstract translation: 一种用于提供患者的内部区域的图像的方法已被开发出来。 该方法通过提供在成像期间组织和血液之间增强的对比度降低成像伪影。 该方法包括施用给患者组合的造影剂与肾血管扩张剂和执行区域的超声成像。 肾脏病，肾动脉狭窄，包括可以利用该方法进行诊断。

公开(公告)号：EP0988061A4

公开(公告)日：2002-05-02

申请号：EP98908866

申请日：1998-02-27

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/00 ,  A61K9/127 ,  A61K31/7105 ,  A61K31/711 ,  A61K39/00 ,  A61K41/00 ,  A61K45/00 ,  A61K47/24 ,  A61K47/30 ,  A61K47/42 ,  A61K48/00 ,  A61K49/00 ,  A61K49/22 ,  A61K49/04 ,  A61K47/48

CPC classification number: A61K41/0028 ,  A61K9/1271 ,  A61K47/544 ,  A61K49/223 ,  Y10S977/788 ,  Y10S977/801 ,  Y10S977/906 ,  Y10S977/907 ,  Y10S977/926

公开(公告)号：EP0930844A4

公开(公告)日：2002-03-13

申请号：EP97928998

申请日：1997-06-16

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY O ,  FRITZ THOMAS A ,  RAMASWAMI VARADA RAJAN

IPC: A61M5/00 ,  A61B8/00 ,  A61K49/00 ,  A61K49/22 ,  A61K51/02 ,  A61B5/055

CPC classification number: A61K49/223 ,  Y10S977/801 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93

Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

公开(公告)号：EP1017425A4

公开(公告)日：2002-03-06

申请号：EP97938609

申请日：1997-08-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K49/22

CPC classification number: A61B5/411 ,  A61B5/201 ,  A61K49/223 ,  A61K49/227

Abstract: Improved method for providing an image of an internal region of a patient, especially the cardiovascular region. Embodiments of the invention involve the administration to the patient of a contrast agent which comprises a vesicle composition comprising lipid or polymer vesicles and a gas or gaseous precursor, in combinationwith a coronary vasodilator. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The methods are particularly useful for diagnosing the presence of diseased tissue in the cardiovascular region of a patient, as well as for measuring blood flow in the cardiovascular region of a patient.