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公开(公告)号：SK279435B6
公开(公告)日：1998-11-04
申请号：SK610390
申请日：1990-12-07
Applicant: SCHLINGMANN GERHARD , ROSENFELD STUART A.
Inventor： SCHLINGMANN GERHARD , ROSENFELD STUART A
IPC: C07D475/04 , C12N9/00 , C12P17/18 , C12P41/00
Abstract: A process for the preparation of optically pure (6R or 6S)-diastereoisomers of 5,6(R or S),7,8-tetrahydrofolic acid derivative or a salt or esters thereof is described, comprising the conversion of the 5,6S,7,8-tetrahydrofolic acid component of a racemic mixture of 5,6,7,8-tetrahydrofolic acid to 10-formyl-5,6S,7,8-tetrahydrofolic acid in the presence of a formyl tetrahydrofolic synthetase, followed by cyclizing, hydrolyzing and derivatizing. The process is also useful to make a desired substantially pure (6R or 6S) enantiomer of a derivative or tetrahydrofolic acid or a salt or ester thereof.
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公开(公告)号：AU8002098A
公开(公告)日：1998-10-22
申请号：AU8002098
申请日：1998-08-14
Applicant: KAUFFMAN STUART A
Inventor： REBEK JULIUS JR
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公开(公告)号：GB9801171D0
公开(公告)日：1998-03-18
申请号：GB9801171
申请日：1998-01-20
Applicant: BRISTOW STUART A
IPC: F16N31/00
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Patent Agency Ranking
公开(公告)号：AU684278B2
公开(公告)日：1997-12-11
申请号：AU6598694
申请日：1994-06-28
Applicant: RUBIN JEFFREY S , FINCH PAUL W , AARONSON STUART A
Inventor： RUBIN JEFFREY S , FINCH PAUL W , AARONSON STUART A
IPC: A61K39/395 , A61K38/00 , A61K38/18 , A61K38/22 , A61P17/02 , A61P43/00 , C07H21/04 , C07K1/16 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/475 , C07K14/485 , C07K14/50 , C07K16/00 , C07K16/22 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/08 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/18 , C12N15/63 , C12N15/70 , C12N15/79 , C12P21/00 , C12P21/02 , C12Q1/68 , C12Q1/6876 , C12R1/91 , G01N33/48 , G01N33/50 , G01N33/53 , C07K13/00 , C12N15/19
Abstract: Discoveries are disclosed that show particular aspect or recombinant DNA technology can be used successfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of other polypeptides. These proteins can be produced in various functional forms from spontaneously secreting cells or from DNA segments introduced into cells. These forms variously enable biochemical and functional studies of this novel protein as well as product of antibodies. Means are described fro determining the level of expression of genes for the KGF protein, for example by measuring mRNA levels in cells or by measuring antigen secreted in extracellular or body fluids.
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公开(公告)号：CA2207692A1
公开(公告)日：1997-09-18
申请号：CA2207692
申请日：1997-06-27
Applicant: BUSSE STUART A
Inventor： BUSSE STUART A
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公开(公告)号：NO972259L
公开(公告)日：1997-05-16
申请号：NO972259
申请日：1997-05-16
Applicant: RUBIN JEFFREY S , FINCH PAUL W , AARONSON STUART A
Inventor： RUBIN JEFFREY S , FINCH PAUL W , AARONSON STUART A
IPC: A61K39/395 , A61K38/00 , A61K38/18 , A61K38/22 , A61P17/02 , A61P43/00 , C07H21/04 , C07K1/16 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/475 , C07K14/485 , C07K14/50 , C07K16/00 , C07K16/22 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/08 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/18 , C12N15/63 , C12N15/70 , C12N15/79 , C12P21/00 , C12P21/02 , C12Q1/68 , C12Q1/6876 , C12R1/91 , G01N33/48 , G01N33/50 , G01N33/53 , C12N15/62
Abstract: Discoveries are disclosed that show particular aspect or recombinant DNA technology can be used successfully to produce hitherto unknown human keratinocyte growth factor (KGF) protein free of other polypeptides. These proteins can be produced in various functional forms from spontaneously secreting cells or from DNA segments introduced into cells. These forms variously enable biochemical and functional studies of this novel protein as well as product of antibodies. Means are described fro determining the level of expression of genes for the KGF protein, for example by measuring mRNA levels in cells or by measuring antigen secreted in extracellular or body fluids.
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