-
1.发明公开Procédé d'obtension d'ADN, ARN, peptides, polypeptides ou protéines, par une technique de recombination d'ADN 失效一种用于通过重组DNA方法获得的DNA，RNA，肽，多肽或蛋白质的过程
公开(公告)号：EP1186660A2
公开(公告)日：2002-03-13
申请号：EP01126393.6
申请日：1985-06-17
Applicant: KAUFFMAN, Stuart A.
Inventor： Kauffmann, Stuart Alan , Ballivet, Marc
IPC: C12N15/10
CPC classification number: C12N15/1093 , A61K39/00 , C07K14/005 , C07K14/485 , C07K2319/00 , C12N9/2471 , C12N15/10 , C12N15/1034 , C12N15/1048 , C12N15/64 , C12N15/66 , C12N15/68 , C12N15/70 , C12N2730/10122 , C12Y302/01023
Abstract: Pour l'obtention d'un ensemble de peptides, polypeptides ou protéines capable de catalyser une séquence de réactions chimiques conduisant à la formation d'au moins un composé désiré, on produit une bibliothèque de gènes au moins partiellement constitués de polynucléotides synthétiques stochastiques, on amplifie ces gènes et on effectue un criblage de façon à identifier une pluralité de gènes capables d'être exprimés sous forme d'un ensemble de peptides, polypeptides ou protéines ayant l'aptitude catalytique désirée, définie ci-dessus. On utilise ensuite l'information génétique ainsi obtenue pour produire en ensemble de peptides, polypeptides ou protéines ayant ladite aptitude catalytique. On peut finalment utiliser cet ensemble pour la production d'un composé chimique, éventuellement nouveau, ayant une propriété donnée.
Abstract translation: 微Biologicale prodn。 肽或多肽（i）包括第一生产，同时在相同的培养基中，许多基因（A）至少部分地随机的，合成的多核苷酸，以及引入合成的基因构成到宿主细胞中。 的（A）-contg。 菌株培养以便克隆（A）和诱导由（A）编码蛋白质的表达。 所述修饰的菌株中筛选/选择以鉴定出那些产生所需的（I）gemäß到一个特定属性。 这些菌株然后分离和培养以产生（I）。 在变形例中，（A）-contg。 转化体选择用于特定随机DNA或RNA序列的存在，并从适当的菌株的培养物中回收这种序列。
-
公开(公告)号：EP0695368A1
公开(公告)日：1996-02-07
申请号：EP94916542.0
申请日：1994-04-19
Applicant: KAUFFMAN, Stuart A.
CPC classification number: C12N15/1093 , C07K1/047 , C12N9/0002 , C12P1/00 , C12P19/34 , C12Q1/6811 , C40B40/10 , C40B50/06
Abstract: Methods for the generation of new compounds are disclosed. The present invention eliminates the need to know in advance the structure or chemical composition of a compound having a desired property. The disclosure of the present invention provides that diversity of unknown compounds may be produced by 'random' chemistry, and such a diversity of unknown compounds may be screened for one or more desired properties to detect the presence of suitable compounds. In one aspect, a starting group of organic compounds is caused to undergo a series of chemical reactions to create a diversity of new organic compounds that are screened for the presence of organic compounds having the desired property. In another aspect of the present invention, a diversity of compounds is generated from a group of substrates which are subjected to a group of enzymes representing a diversity of catalytic activities.
-
3.发明授权Procédé d'obtention d'ADN, ARN, peptides, polypeptides ou protéines, par une technique de recombinaison d'ADN 失效一种用于通过重组方法获得DMS DNA，RNA，肽，多肽或蛋白质的过程
公开(公告)号：EP0590689B2
公开(公告)日：2006-08-16
申请号：EP93116225.9
申请日：1985-06-17
Applicant: KAUFFMAN, Stuart A.
Inventor： Ballivet, Marc , Kauffman, Stuart A.
CPC classification number: C12N15/1093 , A61K39/00 , C07K14/005 , C07K14/485 , C07K2319/00 , C12N9/2471 , C12N15/10 , C12N15/1034 , C12N15/1048 , C12N15/64 , C12N15/66 , C12N15/68 , C12N15/70 , C12N2730/10122 , C12Y302/01023
-
公开(公告)号：EP0695368A4
公开(公告)日：1996-05-08
申请号：EP94916542
申请日：1994-04-19
Applicant: KAUFFMAN STUART A
Inventor： KAUFFMAN STUART A , REBEK JULIUS JR
IPC: C07B61/00 , C07K1/04 , C12N9/00 , C12N15/10 , C12P1/00 , C12P19/34 , C12P21/00 , C12Q1/68 , C12N15/63
CPC classification number: C12N15/1093 , C07K1/047 , C12N9/0002 , C12P1/00 , C12P19/34 , C12Q1/6811 , C40B40/10 , C40B50/06
-
5.发明授权Procédé d'obtention d'ADN, ARN, peptides, polypeptides ou protéines, par une technique de recombinaison d'ADN 失效一种用于通过重组方法获得DMS DNA，RNA，肽，多肽或蛋白质的过程
公开(公告)号：EP0590689B1
公开(公告)日：2002-05-22
申请号：EP93116225.9
申请日：1985-06-17
Applicant: KAUFFMAN, Stuart A.
Inventor： Ballivet, Marc , Kauffman, Stuart A.
CPC classification number: C12N15/1093 , A61K39/00 , C07K14/005 , C07K14/485 , C07K2319/00 , C12N9/2471 , C12N15/10 , C12N15/1034 , C12N15/1048 , C12N15/64 , C12N15/66 , C12N15/68 , C12N15/70 , C12N2730/10122 , C12Y302/01023
-
Patent Agency Ranking6.发明公开Procédé d'obtension d'ADN, ARN, peptides, polypeptides ou protéines, par une technique de recombination d'ADN 失效一种用于通过重组DNA方法获得的DNA，RNA，肽，多肽或蛋白质的过程
公开(公告)号：EP1186660A3
公开(公告)日：2002-03-20
申请号：EP01126393.6
申请日：1985-06-17
Applicant: KAUFFMAN, Stuart A.
Inventor： Kauffmann, Stuart Alan , Ballivet, Marc
IPC: C12N15/10
CPC classification number: C12N15/1093 , A61K39/00 , C07K14/005 , C07K14/485 , C07K2319/00 , C12N9/2471 , C12N15/10 , C12N15/1034 , C12N15/1048 , C12N15/64 , C12N15/66 , C12N15/68 , C12N15/70 , C12N2730/10122 , C12Y302/01023
Abstract: Pour l'obtention d'un ensemble de peptides, polypeptides ou protéines capable de catalyser une séquence de réactions chimiques conduisant à la formation d'au moins un composé désiré, on produit une bibliothèque de gènes au moins partiellement constitués de polynucléotides synthétiques stochastiques, on amplifie ces gènes et on effectue un criblage de façon à identifier une pluralité de gènes capables d'être exprimés sous forme d'un ensemble de peptides, polypeptides ou protéines ayant l'aptitude catalytique désirée, définie ci-dessus. On utilise ensuite l'information génétique ainsi obtenue pour produire en ensemble de peptides, polypeptides ou protéines ayant ladite aptitude catalytique. On peut finalment utiliser cet ensemble pour la production d'un composé chimique, éventuellement nouveau, ayant une propriété donnée.
-
公开(公告)号：DE3588239T3
公开(公告)日：2007-03-08
申请号：DE3588239
申请日：1985-06-17
Applicant: KAUFFMAN STUART A
Inventor： BALLIVET MARC , KAUFFMAN STUART A
IPC: C12N15/11 , G01N33/50 , A61K38/02 , A61K39/00 , A61K39/29 , C07H21/02 , C07H21/04 , C07K2/00 , C07K14/02 , C07K14/485 , C12N1/21 , C12N9/38 , C12N15/00 , C12N15/09 , C12N15/10 , C12N15/64 , C12N15/66 , C12N15/68 , C12N15/70 , C12P21/00 , C12Q1/68 , C12R1/19 , G01N33/15 , G01N33/48 , G01N33/53 , G01N33/566 , G01N33/577
Abstract: Microbiologicale prodn. of peptides or polypeptides (I) comprises first producing, simultaneously in the same medium, many genes (A) composed at least partly of stochastic, synthetic polynucleotides, and introducing these genes into host cells. The (A)-contg. strains are cultured so as to clone (A) and induce expression of proteins coded by (A). The modified strains are screened/selected to identify those which produce the required (I), according to a particular property. These strains are then isolated and cultured to produce (I). In modification, the (A)-contg. transformants are selected for presence of a particular stochastic DNA or RNA sequence, and such sequences recovered from cultures of the appropriate strains.
-
公开(公告)号：DE3588239T2
公开(公告)日：2003-01-02
申请号：DE3588239
申请日：1985-06-17
Applicant: KAUFFMAN STUART A
Inventor： BALLIVET MARC , KAUFFMAN STUART A
IPC: G01N33/50 , A61K39/00 , A61K39/29 , C07H21/02 , C07H21/04 , C07K14/02 , C07K14/485 , C12N1/21 , C12N9/38 , C12N15/00 , C12N15/09 , C12N15/10 , C12N15/64 , C12N15/66 , C12N15/68 , C12N15/70 , C12P21/00 , C12Q1/68 , C12R1/19 , G01N33/15 , G01N33/48 , G01N33/53 , G01N33/566 , G01N33/577 , C12N15/11 , C07K2/00 , A61K38/02
Abstract: Microbiologicale prodn. of peptides or polypeptides (I) comprises first producing, simultaneously in the same medium, many genes (A) composed at least partly of stochastic, synthetic polynucleotides, and introducing these genes into host cells. The (A)-contg. strains are cultured so as to clone (A) and induce expression of proteins coded by (A). The modified strains are screened/selected to identify those which produce the required (I), according to a particular property. These strains are then isolated and cultured to produce (I). In modification, the (A)-contg. transformants are selected for presence of a particular stochastic DNA or RNA sequence, and such sequences recovered from cultures of the appropriate strains.
-
公开(公告)号：AU6815894A
公开(公告)日：1994-11-08
申请号：AU6815894
申请日：1994-04-19
Applicant: KAUFFMAN STUART A
Inventor： KAUFFMAN STUART A , REBEK JULIUS JR
-
公开(公告)号：CA2160457A1
公开(公告)日：1994-10-27
申请号：CA2160457
申请日：1994-04-19
Applicant: KAUFFMAN STUART A
Inventor： KAUFFMAN STUART A , REBEK JULIUS JR
IPC: C07B61/00 , C07K1/04 , C12N9/00 , C12N15/10 , C12P1/00 , C12P19/34 , C12P21/00 , C12Q1/68 , C12Q1/6811 , C07H21/00 , C07K1/00
Abstract: Methods for the generation of new compounds are disclosed. The present invention eliminates the need to know in advance the structure or chemical compounds of a compounds having a desired property. The disclosure of the present invention provides that diversity of unknown compounds may be produced by "random" chemistry, and such a diversity of unknown compounds may be screened for one or more desired properties to detect the presence of suitable compounds. In one aspect, a starting group of organic compounds is caused to undergo a series of chemical reactions to create a diversity of new organic compounds that are screened for the presence of organic compounds having the desired property. In another aspect of the present invention, a diversity of compounds is generated from a group of substrates which are subjected to a group of enzymes representing a diversity of catalytic activities.
-
-
-
-
-
-
-
-
-
Search Results
20
records
(took 0.026 seconds)
