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公开(公告)号：US20140248313A1
公开(公告)日：2014-09-04
申请号：US13768694
申请日：2013-02-15
Applicant: University of Saskatchewan , The University of British Columbia , Dalhousie University , International Vaccine Institute
Inventor： Sylvia van den Hurk , Volker Gerdts , Andrew Potter , Lorne Babiuk , Robert Hancock , Scott Halperin , Jennifer Kovacs-Nolan , George Mutwiri , Song Lee , Mi-Na Kweon , Jason Kindrachuk , Melissa Elliott
IPC: A61K39/39 , A61K45/06 , A61K47/30 , A61K39/155
CPC classification number: A61K39/39 , A61K39/099 , A61K39/12 , A61K39/155 , A61K45/06 , A61K47/30 , A61K2039/55516 , A61K2039/55561 , A61K2039/6093 , C07K7/08 , C12N2760/18534
Abstract: Methods and compositions for enhancing an immune response to a selected antigen are described. The methods are useful for the treatment and prevention of microbial infections, such as infections caused by bacteria, viruses, fungi and parasites. The methods and compositions include host defense peptides, polyphosphazenes and immunostimulatory sequences to enhance the immune response to a coadministered antigen.
Abstract translation: 描述了增强对所选抗原的免疫应答的方法和组合物。 该方法可用于治疗和预防微生物感染，例如由细菌，病毒，真菌和寄生虫引起的感染。 方法和组合物包括宿主防御肽，聚磷腈和免疫刺激序列，以增强对共同施用的抗原的免疫应答。
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公开(公告)号：US20030013672A1
公开(公告)日：2003-01-16
申请号：US10061979
申请日：2002-01-31
Inventor： Jeremy S. Lee , Palok Aich
IPC: A61K048/00 , C07H021/04 , C12N015/87
CPC classification number: A61K39/00 , A61K2039/53 , B82Y10/00 , C07H21/00 , C12Q1/6818 , C12Q1/686 , G11C13/0014 , G11C13/0019 , H01L51/0077 , H01L51/0093 , H01L51/0595 , C12Q2563/173 , C12Q2563/137 , C12Q2531/113 , C12Q2565/101
Abstract: The invention relates to polymers comprising metal-containing nucleic acid duplexes. Methods of using the metal-containing nucleic acid duplexes to provoke physiological responses in a host animal are provided, such as immunological methods that produce antibodies in the host.
Abstract translation: 本发明涉及包含含金属的核酸双链体的聚合物。 提供了使用含金属的核酸双链体在宿主动物中引发生理反应的方法，例如在宿主中产生抗体的免疫学方法。
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153.发明申请
公开(公告)号：WO2022067429A1
公开(公告)日：2022-04-07
申请号：PCT/CA2021/051355
申请日：2021-09-29
Applicant: THE UNIVERSITY OF SASKATCHEWAN
Inventor： MOSER, Michael , BHATTI, Jasleen , ZHANG, Wenjun , TONY, Anthony , ZHANG, Bing
Abstract: The invention discloses a temperature control, optionally cooling, apparatus comprising: a first and second and/or plurality of fillable chambers each having a first layer, a second layer, an elongated edge, preferably longitudinal edge, an inlet and an outlet in the elongated, preferably longitudinal edge, and retention members between the first layer and second layer in a series of spaced veins creating a continuous channel extending from the inlet to the outlet; and a method of cooling and or maintaining an organ comprising: a method for cooling, warming and/or maintaining the temperature of an organ prior to or during a transplant procedure, the method comprising: contacting the organ with temperature control, optionally the cooling and/or temperature maintaining, apparatus; securing the apparatus to the organ; attaching the inlets of the first and second and/or plurality of fillable chambers of the apparatus to a circulation fluid source; and/or infusing circulation fluid into the inlet, through the continuous channel, and out the outlet of each of the first and second and/or plurality of fillable chambers of the apparatus.
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公开(公告)号：WO2020037397A9
公开(公告)日：2020-02-27
申请号：PCT/CA2019/051113
申请日：2019-08-15
Applicant: UNIVERSITY OF SASKATCHEWAN
Inventor： JOHNSTON, Geoffrey H.F. , ASHJAEE, Nima , JOHNSTON, James Duncan
Abstract: Implants and methods for stabilizing bone fractures are provided. In one embodiment, the implants are spheres. In another embodiment, the implants are rods. The rods can be used to stabilize peripheral portions of a bone fracture. The rods can be shaped and configured to correspond to the shape of a region of bone against which the rod will be deployed. The rods can be provided with surface features for engaging adjacent rods and/or adjacent regions of bone to further stabilize the rods. The spheres can be inserted to fill a remaining volume of the fracture cavity. The implants can be made from orthobiologic materials.
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公开(公告)号：WO2019014761A1
公开(公告)日：2019-01-24
申请号：PCT/CA2018/050866
申请日：2018-07-17
Applicant: UNIVERSITY OF SASKATCHEWAN
Inventor： GOMIS, Susantha , POPOWICH, Shelly , GOONEWARDENE, Kalhari Venukala Bandara , TIKOO, Suresh , FOLDVARI, Marianna
IPC: A61K39/39 , A61K39/00 , A61K47/10 , A61K9/127 , A61K9/14 , A61K9/72 , A61P37/04 , C07H21/04 , C12N15/117 , A23K20/153
Abstract: This application relates to compositions comprising one or more CpG oligodeoxynucleotides complexed to nanoparticles comprising a gemini surfactant and optionally a muco-adhesive polymer, which can be used for intrapulmonary delivery to induce immunity in feed animals, and the methods of making and uses thereof.
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Patent Agency Ranking
公开(公告)号：WO2018045464A1
公开(公告)日：2018-03-15
申请号：PCT/CA2017/051053
申请日：2017-09-08
Applicant: UNIVERSITY OF SASKATCHEWAN
Inventor： KAKISH, Joseph , KROL, Edward , LEE, Jeremy , ALLEN, Kevin
IPC: C07D473/06 , A61K47/55 , A61K49/00 , A61K51/04 , A61P25/16
Abstract: Bifunctional molecules having first and second alpha-synuclein binding agents coupled by a linker are disclosed. The bifunctional molecules have potential utility in the diagnosis, treatment and/or prophylaxis of disorders in which alpha-synuclein is implicated, including Parkinson's disease. Methods of making and using the bifunctional molecules are disclosed.
Abstract translation: 公开了具有通过接头偶联的第一和第二α-突触核蛋白结合剂的双功能分子。 双功能分子在诊断，治疗和/或预防涉及α-突触核蛋白的疾病（包括帕金森病）方面具有潜在的用途。 公开了制造和使用双功能分子的方法。
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157.发明申请METHODS OF IDENTIFYING AND TREATING CANCER PATIENTS WITH AN EPHB6 DEFICIENCY 审中-公开鉴定和治疗具有EPHB6缺陷的癌症患者的方法
公开(公告)号：WO2018006171A1
公开(公告)日：2018-01-11
申请号：PCT/CA2017/050812
申请日：2017-07-05
Applicant: UNIVERSITY OF SASKATCHEWAN , SASKATCHEWAN CANCER AGENCY
Inventor： VIZEACOUMAR, Franco Joseph , FREYWALD, Andrew , PAUL, James Mathew , VIZEACOUMAR, Frederick Sagayaraj
Abstract: Methods for identifying a subject with a cancer eligible for treatment with an inhibitor of a Table 1 molecule, optionally a SRC kinase inhibitor or a MET kinase inhibitor, are provided. The methods comprise testing a biological sample from the subject for a deficiency in EPHB6 receptor levels, wherein the subject is eligible for treatment with an inhibitor of a Table 1 molecule, optionally a SRC kinase inhibitor or a MET kinase inhibitor, if EPHB6 receptor levels in the biological sample are deficient.
Abstract translation: 提供了用于鉴定具有适合用表1分子的抑制剂，任选的SRC激酶抑制剂或MET激酶抑制剂治疗的癌症的受试者的方法。 该方法包括测试来自受试者的生物样品中EPHB6受体水平的缺乏，其中该受试者适合用表1分子的抑制剂，任选的SRC激酶抑制剂或MET激酶抑制剂治疗，如果EPHB6受体水平 生物样本不足。
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公开(公告)号：WO2017000073A1
公开(公告)日：2017-01-05
申请号：PCT/CA2016/050771
申请日：2016-06-30
Applicant: UNIVERSITY OF SASKATCHEWAN
Inventor： TAGHIBIGLOU, Changiz , PHAM, Nathan , PASTUSHOK, Landon , GEYER, Clarence Ronald
IPC: C07K16/28 , C07K16/40 , G01N33/53 , G01N33/543
CPC classification number: G01N33/6896 , C07K16/2896
Abstract: The present disclosure relates to a method for detecting a brain injury in a subject by comparing the amount of ADAM10 protein in a blood sample from the subject to a reference standard or to the amount of ADAM10 in a blood sample from a control. An increase in the amount of ADAM10 in the subject blood sample relative to the reference standard or control is indicative of the subject having sustained a brain injury, in particular a traumatic brain injury (TBI). The present disclosure also provides novel antibody and antibody fragments that bind to ADAM10 at different positions.
Abstract translation: 本公开内容涉及通过将来自受试者的血液样品中的ADAM10蛋白的量与对照的血液样品中的ADAM10的量相比较来检测受试者的脑损伤的方法。 相对于参考标准或对照，受试血液样品中ADAM10的量的增加表明受试者持续脑损伤，特别是创伤性脑损伤（TBI）。 本公开还提供了在不同位置结合ADAM10的新型抗体和抗体片段。
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公开(公告)号：WO2016074077A1
公开(公告)日：2016-05-19
申请号：PCT/CA2015/051161
申请日：2015-11-10
Applicant: UNIVERSITY OF SASKATCHEWAN
Inventor： BESANT, Robert W. , SIMONSON, Carey James , EVITTS, Richard William
CPC classification number: F24F3/147 , F24F12/002 , F24F2003/1458 , F24F2203/1032 , F28D21/0015 , Y02B30/563
Abstract: An energy exchange system for conditioning air in an interior space of a structure. The system may include at least one supply liquid-to-air membrane energy exchanger (LAMEE) unit for conditioning air from outside to form supply air for the interior space, and at least one exhaust LAMEE unit for collecting air from the interior space to form exhaust air. An auxiliary loop may fluidly connect between a desiccant liquid outlet of the exhaust LAMEE unit and a desiccant liquid inlet of the supply LAMEE unit. In a first mode, desiccant liquid is circulated between the supply LAMEE unit and the exhaust LAMEE unit. In a second mode, desiccant liquid is circulated between the supply LAMEE unit, the exhaust LAMEE unit, and the auxiliary loop, and water content of the desiccant liquid is decreased in the auxiliary loop.
Abstract translation: 一种用于调节结构内部空间中的空气的能量交换系统。 该系统可以包括至少一个供应液体 - 空气膜能量交换器（LAMEE）单元，用于从外部调节空气以形成用于内部空间的供应空气，以及用于从内部空间收集空气以形成至少一个排气LAMEE单元 排气 辅助回路可以在排气LAMEE单元的干燥剂液体出口和供应LAMEE单元的干燥剂液体入口之间流体连接。 在第一模式中，干燥剂液体在供应LAMEE单元和排气LAMEE单元之间循环。 在第二模式中，干燥剂液体在供应LAMEE单元，排气LAMEE单元和辅助回路之间循环，并且辅助回路中干燥剂液体的含水量减少。
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公开(公告)号：WO2015192222A1
公开(公告)日：2015-12-23
申请号：PCT/CA2015/000416
申请日：2015-06-12
Applicant: UNIVERSITY OF SASKATCHEWAN
Inventor： TAGHIBIGLOU, Changiz
CPC classification number: G01N33/6896 , A61B5/150022 , A61B5/15003 , C07K14/47 , G01N33/6893 , G01N2333/47 , G01N2333/70596 , G01N2800/28 , G01N2800/2828 , G01N2800/40 , G01N2800/56
Abstract: The disclosure provides methods of detecting and monitoring brain injury in a test subject comprising analyzing a blood sample from the test subject for increased levels of PrP C . The disclosure also provides kits for measuring the amount of PrP C in a blood sample.
Abstract translation: 本公开提供了在测试对象中检测和监测脑损伤的方法，包括分析来自测试对象的血液样品以增加PrPC水平。 本公开还提供用于测量血液样品中PrPC量的试剂盒。
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