公开(公告)号：US10702711B2

公开(公告)日：2020-07-07

申请号：US15735806

申请日：2016-06-13

Applicant: Saskatchewan Cancer Agency

Inventor： Vijayananda Kundapur ,  Gavin Cranmer-Sargison

IPC: A61N5/10 ,  G21K1/02

Abstract: An apparatus for delivery of spatially fractionated radiation treatment to a patient, the apparatus comprising: a radiation source for generating an open radiation beam oriented along a beam axis and having photon energies up to and including a maximum photon energy greater than 0.5 MV; a mini-beam collimator located in a path of the open radiation beam, the mini-beam collimator comprising a plurality of generally planar blades extending between an entrance aperture onto which the open beam impinges and an exit aperture, the mini-beam collimator interacting with the open radiation beam to produce an output beam emitted from the exit aperture, oriented along the beam axis and comprising a spatially fractionated mini-beam dose profile, the spatially fractionated mini-beam dose profile comprising: a plurality of dose peaks at which the dose is a local maximum, the dose peaks spaced apart from one another in a transverse direction that is transverse to the beam axis; and a plurality of dose valleys at which the dose is a local minimum, each dose valley located between a pair of transversely adjacent dose peaks.

公开(公告)号：US20190203253A1

公开(公告)日：2019-07-04

申请号：US16312410

申请日：2017-07-05

Applicant: University of Saskatchewan ,  SASKATCHEWAN CANCER AGENCY

Inventor： Franco Joseph Vizeacoumar ,  Andrew Freywald ,  James Mathew Paul ,  Frederick Sagayaraj Vizeacoumar

IPC: C12Q1/02 ,  A61P35/00 ,  A61K31/506 ,  C12Q1/686

CPC classification number: C12Q1/025 ,  A61K31/506 ,  A61P35/00 ,  C12Q1/686 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/154 ,  C12Q2600/158 ,  C40B30/06 ,  G01N33/57484 ,  G01N2333/715 ,  G01N2500/10 ,  G01N2800/52 ,  G01N2800/60

Abstract: Methods for identifying a subject with a cancer eligible for treatment with an inhibitor of a Table 1 molecule, optionally a SRC kinase inhibitor or a MET kinase inhibitor, are provided. The methods comprise testing a biological sample from the subject for a deficiency in EPHB6 receptor levels, wherein the subject is eligible for treatment with an inhibitor of a Table 1 molecule, optionally a SRC kinase inhibitor or a MET kinase inhibitor, if EPHB6 receptor levels in the biological sample are deficient.

公开(公告)号：US20200038685A1

公开(公告)日：2020-02-06

申请号：US15735806

申请日：2016-06-13

Applicant: Saskatchewan Cancer Agency

Inventor： Vijayananda KUNDAPUR ,  Gavin CRANMER-SARGISON

IPC: A61N5/10 ,  G21K1/02

Abstract: An apparatus for delivery of spatially fractionated radiation treatment to a patient, the apparatus comprising: a radiation source for generating an open radiation beam oriented along a beam axis and having photon energies up to and including a maximum photon energy greater than 0.5 MV; a mini-beam collimator located in a path of the open radiation beam, the mini-beam collimator comprising a plurality of generally planar blades extending between an entrance aperture onto which the open beam impinges and an exit aperture, the mini-beam collimator interacting with the open radiation beam to produce an output beam emitted from the exit aperture, oriented along the beam axis and comprising a spatially fractionated mini-beam dose profile, the spatially fractionated mini-beam dose profile comprising: a plurality of dose peaks at which the dose is a local maximum, the dose peaks spaced apart from one another in a transverse direction that is transverse to the beam axis; and a plurality of dose valleys at which the dose is a local minimum, each dose valley located between a pair of transversely adjacent dose peaks.

公开(公告)号：WO2018006171A1

公开(公告)日：2018-01-11

申请号：PCT/CA2017/050812

申请日：2017-07-05

Applicant: UNIVERSITY OF SASKATCHEWAN ,  SASKATCHEWAN CANCER AGENCY

Inventor： VIZEACOUMAR, Franco Joseph ,  FREYWALD, Andrew ,  PAUL, James Mathew ,  VIZEACOUMAR, Frederick Sagayaraj

IPC: C12Q1/68 ,  A61P35/00 ,  C12Q1/02 ,  C40B30/06 ,  G01N33/15 ,  G01N33/48 ,  A61K31/00

Abstract: Methods for identifying a subject with a cancer eligible for treatment with an inhibitor of a Table 1 molecule, optionally a SRC kinase inhibitor or a MET kinase inhibitor, are provided. The methods comprise testing a biological sample from the subject for a deficiency in EPHB6 receptor levels, wherein the subject is eligible for treatment with an inhibitor of a Table 1 molecule, optionally a SRC kinase inhibitor or a MET kinase inhibitor, if EPHB6 receptor levels in the biological sample are deficient.

Abstract translation: 提供了用于鉴定具有适合用表1分子的抑制剂，任选的SRC激酶抑制剂或MET激酶抑制剂治疗的癌症的受试者的方法。 该方法包括测试来自受试者的生物样品中EPHB6受体水平的缺乏，其中该受试者适合用表1分子的抑制剂，任选的SRC激酶抑制剂或MET激酶抑制剂治疗，如果EPHB6受体水平 生物样本不足。

公开(公告)号：WO2016201557A1

公开(公告)日：2016-12-22

申请号：PCT/CA2016/050679

申请日：2016-06-13

Applicant: CRANMER-SARGISON, Gavin ,  SASKATCHEWAN CANCER AGENCY

Inventor： CRANMER-SARGISON, Gavin ,  KUNDAPUR, Vijayananda

IPC: A61N5/00 ,  G21K1/02 ,  G21K1/04 ,  G02B27/30

CPC classification number: A61N5/1045 ,  G21K1/025

Abstract: An apparatus for delivery of spatially fractionated radiation treatment to a patient, the apparatus comprising: a radiation source for generating an open radiation beam oriented along a beam axis and having photon energies up to and including a maximum photon energy greater than 0.5MV; a mini-beam collimator located in a path of the open radiation beam, the mini-beam collimator comprising a plurality of generally planar blades extending between an entrance aperture onto which the open beam impinges and an exit aperture, the mini-beam collimator interacting with the open radiation beam to produce an output beam emitted from the exit aperture, oriented along the beam axis and comprising a spatially fractionated mini-beam dose profile, the spatially fractionated mini-beam dose profile comprising: a plurality of dose peaks at which the dose is a local maximum, the dose peaks spaced apart from one another in a transverse direction that is transverse to the beam axis; and a plurality of dose valleys at which the dose is a local minimum, each dose valley located between a pair of transversely adjacent dose peaks.

Abstract translation: 一种用于将空间分级辐射治疗递送到患者的装置，所述装置包括：辐射源，用于产生沿着光束轴定向的开放辐射束，并具有高达并包括大于0.5MV的最大光子能量的光子能量; 位于开放辐射束的路径中的微型射束准直器，所述微型射束准直器包括多个大致平面的叶片，所述多个平面叶片在所述开放射线撞击的入射孔与出射孔之间延伸，所述微型射束准直器与 所述开放辐射束产生从所述出射孔发射的输出光束，所述输出光束沿着所述光束轴线定向并且包括空间分级的小光束剂量分布，所述空间分级的小光束剂量分布图包括：多个剂量峰，其中所述剂量 是局部最大值，剂量峰在横向于光束轴线的横向上彼此间隔开; 以及多个剂量谷，其中剂量是局部最小值，每个剂量谷位于一对横向相邻剂量峰之间。

公开(公告)号：CA2989042A1

公开(公告)日：2016-12-22

申请号：CA2989042

申请日：2016-06-13

Applicant: SASKATCHEWAN CANCER AGENCY

Inventor： CRANMER-SARGISON GAVIN ,  KUNDAPUR VIJAYANANDA

IPC: A61N5/00 ,  G02B27/30 ,  G21K1/02 ,  G21K1/04

Abstract: An apparatus for delivery of spatially fractionated radiation treatment to a patient, the apparatus comprising: a radiation source for generating an open radiation beam oriented along a beam axis and having photon energies up to and including a maximum photon energy greater than 0.5MV; a mini-beam collimator located in a path of the open radiation beam, the mini-beam collimator comprising a plurality of generally planar blades extending between an entrance aperture onto which the open beam impinges and an exit aperture, the mini-beam collimator interacting with the open radiation beam to produce an output beam emitted from the exit aperture, oriented along the beam axis and comprising a spatially fractionated mini-beam dose profile, the spatially fractionated mini-beam dose profile comprising: a plurality of dose peaks at which the dose is a local maximum, the dose peaks spaced apart from one another in a transverse direction that is transverse to the beam axis; and a plurality of dose valleys at which the dose is a local minimum, each dose valley located between a pair of transversely adjacent dose peaks.

公开(公告)号：CA2989042C

公开(公告)日：2020-12-08

申请号：CA2989042

申请日：2016-06-13

Applicant: SASKATCHEWAN CANCER AGENCY

Inventor： CRANMER-SARGISON GAVIN ,  KUNDAPUR VIJAYANANDA

IPC: A61N5/00 ,  G02B27/30 ,  G21K1/02 ,  G21K1/04

Abstract: An apparatus for delivery of spatially fractionated radiation treatment to a patient, the apparatus comprising: a radiation source for generating an open radiation beam oriented along a beam axis and having photon energies up to and including a maximum photon energy greater than 0.5MV; a mini-beam collimator located in a path of the open radiation beam, the mini-beam collimator comprising a plurality of generally planar blades extending between an entrance aperture onto which the open beam impinges and an exit aperture, the mini-beam collimator interacting with the open radiation beam to produce an output beam emitted from the exit aperture, oriented along the beam axis and comprising a spatially fractionated mini-beam dose profile, the spatially fractionated mini-beam dose profile comprising: a plurality of dose peaks at which the dose is a local maximum, the dose peaks spaced apart from one another in a transverse direction that is transverse to the beam axis; and a plurality of dose valleys at which the dose is a local minimum, each dose valley located between a pair of transversely adjacent dose peaks.