公开(公告)号：WO1997010206A1

公开(公告)日：1997-03-20

申请号：PCT/US1996013892

申请日：1996-08-27

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  CHEMBURKAR, Sanjay, R. ,  PATEL, Hemantkumar, H. ,  SAWICK, David, P. ,  THOMAS, Albert, V.

IPC: C07C273/18

CPC classification number: C07C43/29 ,  C07C43/295 ,  C07C273/1827 ,  C07C275/64

Abstract: The present invention provides a process for the preparation of a compound of formula (I), wherein R is a straight or branched alkyl group of from one to twelve carbon atoms; M represents hydrogen or a pharmaceutically acceptable cation; and A is selected from optionally substituted carbocyclic phenyl.

Abstract translation: 本发明提供了制备式（I）化合物的方法，其中R是具有1至12个碳原子的直链或支链烷基; M表示氢或药学上可接受的阳离子; 并且A选自任选取代的碳环苯基。

公开(公告)号：WO1997002830A2

公开(公告)日：1997-01-30

申请号：PCT/US1996011243

申请日：1996-07-02

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  DOHNALEK, Margaret, Ione, Halpin ,  OSTROM, Karin, Margaret ,  HILTY, Milo, Duane

IPC: A61K31/70

CPC classification number: A23G3/368 ,  A23C9/203 ,  A23L2/52 ,  A23L33/10 ,  A23L33/21 ,  A23V2002/00 ,  A61K31/702 ,  A23V2250/28 ,  A23V2250/70 ,  A23V2250/156

Abstract: A method is provided for reducing the incidence of otitis media in infants and young children by enterally administering indigestible oligosaccharides. More specifically, the present invention relates to a method for reducing the incidence of otitis media comprising administering to humans an indigestible oligosaccharide selected from the group consisting of fructooligosaccharides, fructosans, xylooligosaccharides and galactooligosaccharides. The indigestible oligosaccharides can be produced through enzymatic synthesis, chemical techniques or isolated from plant materials and are administered in the form of a nutritional product, candy, tablets, chewing gums, lozenges, milk products, yogurts and the like. In a preferred embodiment of this invention, the indigestible oligosaccharides have a DP of 2 to 20 and still more preferably are the fructooligosaccharides GF2, GF3 and GF4.

Abstract translation: 提供了一种通过肠内施用难消化的寡糖来减少婴幼儿中耳炎发生率的方法。 更具体地说，本发明涉及一种降低中耳炎发生率的方法，包括向人体施用选自由低聚果糖，果糖，低聚木糖，低聚半乳糖组成的组中的消化不良的寡糖。 不可消化的寡糖可以通过酶合成，化学技术或从植物材料中分离出来，以营养产品，糖果，片剂，口香糖，锭剂，乳制品，酸奶等的形式施用。 在本发明的优选实施方式中，难消化的寡糖的DP为2〜20，进一步优选为低聚果糖GF2，GF3，GF4。

公开(公告)号：WO1996041200A1

公开(公告)日：1996-12-19

申请号：PCT/US1996006820

申请日：1996-05-13

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  TAKEDA, Masaaki ,  KATO, Yuko ,  PELLETIER, Brent, Allen

IPC: G01N35/10

CPC classification number: G01N35/1016 ,  G01M3/26 ,  G01N2035/102

Abstract: Embodiments described herein provide a pipetting apparatus with leak detection and a method for detecting a leak. In one embodiment, an automatic pipetting apparatus comprises a nozzle having a lower end portion through which a fluid sample is aspirated and dispensed by changes in air pressure supplied to the nozzle. A piping system operatively connects the nozzle to a pump for supplying the air pressure to the nozzle. A pressure sensor is operatively connected with the piping system for measuring internal pressure in the piping system. Means is operatively connected with the nozzle for three-dimensionally moving the nozzle between an aspirating position of the fluid sample and a dispensing position. Leak detecting means is operatively connected with the pressure sensor for detecting a leak in the piping system based upon a measured result obtained by measuring the internal pressure in the piping system with the pressure sensor while the nozzle, which has aspirated a predetermined volume of the fluid sample, is being moved between the aspirating position and the dispensing position by the moving means.

Abstract translation: 本文所述的实施例提供了具有泄漏检测的移液装置和用于检测泄漏的方法。 在一个实施例中，自动移液装置包括具有下端部分的喷嘴，通过该下端部抽吸流体样品并通过供给喷嘴的空气压力的变化来分配。 管道系统将喷嘴可操作地连接到泵，以将空气压力提供给喷嘴。 压力传感器与管道系统可操作地连接，用于测量管道系统中的内部压力。 装置与喷嘴可操作地连接，用于在流体样品的抽吸位置和分配位置之间三维地移动喷嘴。 泄漏检测装置与压力传感器可操作地连接，用于基于通过用压力传感器测量管道系统中的内部压力而获得的测量结果来检测管道系统中的泄漏，同时吸入预定体积的流体 样品通过移动装置在抽吸位置和分配位置之间移动。

公开(公告)号：WO1996041187A1

公开(公告)日：1996-12-19

申请号：PCT/US1996009507

申请日：1996-06-07

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  DAGHFAL, David, J. ,  COLPITTS, Tracey, L. ,  CHANG, Chi-Deu ,  MERCHANT, Barbara, T. ,  SZE, Isaac, S.-Y. ,  JAFFE, Keeve ,  BRIDON, Dominique, P.

IPC: G01N33/569

CPC classification number: C07K14/005 ,  C12N2740/16122 ,  G01N33/56988

Abstract: An improved immunoassay for detecting the presence of anti-HIV-1 or anti-HIV-2 antibody that may be present in a test sample is provided. A composition comprising site specifically haptenated peptide conjugates and test kits also are provided.

Abstract translation: 提供了用于检测可能存在于测试样品中的抗HIV-1或抗HIV-2抗体存在的改进的免疫测定。 还提供了包含位点特异性半抗原肽缀合物和测试试剂盒的组合物。

公开(公告)号：WO1996041179A1

公开(公告)日：1996-12-19

申请号：PCT/US1996009345

申请日：1996-06-05

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  OKASINSKI, Gregory, F. ,  SCHAEFER, Verlyn, G. ,  SUHAR, Thomas, S. ,  LESNIEWSKI, Richard, R.

IPC: G01N33/543

CPC classification number: C07K14/005 ,  A61K39/00 ,  C12N2770/24222 ,  G01N33/56988 ,  G01N33/5767

Abstract: A mammalian expression system capable of generating recombinant proteins from non-secretor genes. Also provided are an assay which utilizes the fusion protein, a test kit which contains the fusion protein, a diagnostic reagent which comprises the fusion protein, and a vaccine which utilizes the fusion protein produced by the disclosed plasmid.

Abstract translation: 能够从非分泌基因产生重组蛋白的哺乳动物表达系统。 还提供了利用融合蛋白的测定法，含有融合蛋白的测试试剂盒，包含融合蛋白的诊断试剂，以及利用由所公开的质粒产生的融合蛋白的疫苗。

公开(公告)号：WO1996040992A2

公开(公告)日：1996-12-19

申请号：PCT/US1996008070

申请日：1996-05-30

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  CARRINO, John, J. ,  BRAINARD, Thomas, D.

IPC: C12Q01/68

CPC classification number: C12Q1/686 ,  C12Q1/6848 ,  C12Q2537/107 ,  C12Q2525/186

Abstract: A method for reducing background caused by target-independent generation of amplification products, typically the products of a ligase chain reaction or a polymerase chain reaction, involves chemically "masking" or blocking the amplification probes or primers so that they cannot be extended or ligated until the occurence of a triggering event which can be delayed until the amplification reaction is begun. The probe masks take the form of complementary blocking oligonucleotides that are incapable of serving as template themselves and inhibit random tailing of the probe/primers. The blocking oligo masks are denatured from the probes during amplification and preferably are effectively eliminated from competing for probes in the amplification reaction

Abstract translation: 通过连接酶链反应或聚合酶链反应的产物，减少由靶标无关生成产生的背景引起的背景的方法涉及化学“掩蔽”或阻断扩增探针或引物，使得它们不能被延伸或连接直到 可以延迟直到扩增反应开始的触发事件的发生。 探针掩模采用不能用作模板本身并抑制探针/引物的随机拖尾的互补阻断寡核苷酸的形式。 在扩增过程中阻断寡核苷酸被探针变性，优选在扩增反应中与探针竞争中有效地消除

公开(公告)号：WO1996039398A1

公开(公告)日：1996-12-12

申请号：PCT/US1996006812

申请日：1996-05-13

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  TIEN, Jien-Heh ,  MENZIA, Jerome, A. ,  COOPER, Arthur, J.

IPC: C07D277/28

CPC classification number: C07D277/28

Abstract: Processes are disclosed for the preparation of (2S, 3S, 5S)-5-(N-(N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-L-valinyl)amino)-2-(N-((5-thiazolyl)methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane or an acid addition salt thereof and (2S, 3S, 5S)-5-(N-(N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)amino)carbonyl)-D-valinyl)amino)-2-(N-((5-thiazolyl)methoxycarbonyl)amino-1,6-diphenyl-3-hydroxyhexane or an acid addition salt thereof.

Abstract translation: 公开了制备（2S，3S，5S）-5-（N-（N - （（N-甲基-N - （（2-异丙基-4-噻唑基）甲基）氨基）羰基） 缬氨酰基）氨基）-2-（N - （（5-噻唑基）甲氧基羰基）氨基）-1,6-二苯基-3-羟基己烷或其酸加成盐和（2S，3S，5S）-5- （N - （（N-甲基-N - （（2-异丙基-4-噻唑基）甲基）氨基）羰基）-D-缬氨酰）氨基）-2-（N - （（5-噻唑基）甲氧基羰基）氨基 - 1,6-二苯基-3-羟基己烷或其酸加成盐。

公开(公告)号：WO1996039180A1

公开(公告)日：1996-12-12

申请号：PCT/US1996007771

申请日：1996-05-24

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  RUSSELL, John, C.

IPC: A61K39/385

CPC classification number: C07K16/44 ,  A61K39/00 ,  A61K47/646

Abstract: Disclosed are novel immunogens and their use in producing an antigenic response in a target animal.

Abstract translation: 公开了新型免疫原及其在靶向动物中产生抗原应答的用途。

公开(公告)号：WO1996036340A1

公开(公告)日：1996-11-21

申请号：PCT/US1996007074

申请日：1996-05-16

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  LI, Luk, C. ,  PEC, Edward, A. ,  PARASRAMPURIA, Jagdish

IPC: A61K31/59

CPC classification number: A61K31/593 ,  A61K9/0019 ,  A61K47/22 ,  A61K47/26

Abstract: 1 alpha ,25-dihydroxycholecalciferol is a naturally occurring form of Vitamin D3. Vitamin D3 is converted to 1 alpha , 25-dihydroxycholecalciferol in the liver and kidney before it acts to stimulate intestinal calcium and phosphorous absorption. Parenteral solutions of 1 alpha , 25-dihydroxycholecalciferol are suitable for replacement therapy.

Abstract translation: 1α，25-二羟基胆钙化甾醇是天然存在的维生素D3形式。 维生素D3在肝和肾中转化为1α，25-二羟基胆钙化甾醇，然后才能刺激肠钙和磷吸收。 1α，25-二羟基胆钙化醇的肠胃外溶液适用于替代疗法。

公开(公告)号：WO1996035702A1

公开(公告)日：1996-11-14

申请号：PCT/US1996006204

申请日：1996-05-02

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  McALPINE, James, B. ,  HOCHLOWSKI, Jill, E.

IPC: C07H17/08

CPC classification number: A61K31/7048 ,  C07H17/08

Abstract: Antimicrobial compounds having formula (I) as well as pharmaceutical compositions comprising such compounds and methods of treating bacterial infection and colitis by the administration thereof.

Abstract translation: 具有式（I）的抗微生物化合物以及包含这些化合物的药物组合物以及通过给药治疗细菌感染和结肠炎的方法。