公开(公告)号：EP3137618A1

公开(公告)日：2017-03-08

申请号：EP15785253.4

申请日：2015-04-27

Applicant: Epimeron Inc.

Inventor： FACCHINI, Peter James

IPC: C12P17/12 ,  C12N15/00 ,  C12N15/52 ,  C12N15/54 ,  C12N15/62 ,  C12N15/63 ,  C12N13/00 ,  C12P13/00 ,  C12P17/00 ,  C12Q1/68 ,  C40B20/00 ,  C40B30/00

CPC classification number: C12P17/12 ,  C12N15/1082 ,  C12N15/1096 ,  C12N15/63 ,  C12Y201/01 ,  C40B10/00 ,  C40B20/00

Abstract: Novel methods that may be used for the manufacture of plant alkaloid compounds and novel polynucleotide compounds are provided. The plant alkaloid compounds are useful as medicinal compounds.

Abstract translation: 新方法也可用于植物生物碱化合物和新的多核苷酸的化合物的制造中提供。 所述植物生物碱化合物用作药用化合物是有用的。

公开(公告)号：EP2970208A4

公开(公告)日：2016-11-30

申请号：EP14764117

申请日：2014-03-14

Applicant: GEN HOSPITAL CORP

Inventor： JOUNG J KEITH ,  ANGSTMAN JAMES ,  SANDER JEFFRY D ,  MAEDER MORGAN ,  TSAI SHENGDAR

IPC: C12Q1/68 ,  C07H21/04 ,  C12N15/00

CPC classification number: C12N9/22 ,  C07K14/005 ,  C07K14/195 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/80 ,  C12N9/0071 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/96 ,  C12N15/01 ,  C12N15/102 ,  C12N15/1031 ,  C12N15/11 ,  C12N15/63 ,  C12N15/85 ,  C12N2310/20 ,  C12N2710/00033 ,  C12N2770/00033 ,  C12N2800/80 ,  C12Y114/11 ,  C12Y201/01 ,  C12Y301/00 ,  C12Y301/21004

Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems, using truncated guide RNAs (tru-gRNAs).

Abstract translation: 使用截短的引导RNA（tru-gRNA）增加RNA指导基因组编辑的特异性的方法，例如使用CRISPR / Cas9系统的编辑。

公开(公告)号：EP3077516A1

公开(公告)日：2016-10-12

申请号：EP13840184.9

申请日：2013-12-02

Applicant: Compagnie Gervais Danone ,  University College Cork, National University of Ireland Cork

Inventor： VAN SINDEREN, Douwe ,  O'CONNELL MOTHERWAY, Mary ,  WATSON, Debbie ,  SMOKVINA, Tamara ,  GARAULT, Peggy

IPC: C12N15/74 ,  C12N1/20

CPC classification number: C12N15/746 ,  C12N1/20 ,  C12N9/1007 ,  C12Y201/01

Abstract: The present invention concerns a method for genetically transforming a Bifidobacterium strain comprising a step of methylation of a shuttle vector in an E. coli or a Gram-positive bacterium strain by two type II DNA methyltransferases from a Bifidobacterium: a methyltransferase enzyme that methylates the adenine base at position 4 of the nucleotide sequence RTCAGG and a methyltransferase enzyme that methylates the cytosine base at position 4 of the nucleotide sequence GGWCC. The present invention also concerns genetic tools and culture media useful for carrying out said method.

Abstract translation: 本发明涉及用于遗传转化双歧杆菌菌株的方法，其包括通过来自双歧杆菌的两种II型DNA甲基转移酶在大肠杆菌或革兰氏阳性菌株中甲基化穿梭载体的步骤：使腺嘌呤甲基化的甲基转移酶 核苷酸序列RTCAGG的第4位的碱基和甲基化核苷酸序列GGWCC的第4位的胞嘧啶碱基的甲基转移酶。 本发明还涉及可用于实施所述方法的遗传工具和培养基。

公开(公告)号：EP2971041A4

公开(公告)日：2016-09-07

申请号：EP14764159

申请日：2014-03-14

Applicant: GEN HOSPITAL CORP

Inventor： JOUNG J KEITH ,  TSAI SHENGDAR

IPC: C12Q1/68 ,  C07H21/04 ,  C12N15/00

CPC classification number: C12N9/22 ,  C07K14/005 ,  C07K14/195 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/80 ,  C12N9/0071 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/96 ,  C12N15/01 ,  C12N15/102 ,  C12N15/1031 ,  C12N15/11 ,  C12N15/63 ,  C12N15/85 ,  C12N2310/20 ,  C12N2710/00033 ,  C12N2770/00033 ,  C12N2800/80 ,  C12Y114/11 ,  C12Y201/01 ,  C12Y301/00 ,  C12Y301/21004

Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.

公开(公告)号：EP2970986A4

公开(公告)日：2016-09-07

申请号：EP14768877

申请日：2014-03-14

Applicant: GEN HOSPITAL CORP

Inventor： JOUNG J KEITH ,  MAEDER MORGAN

IPC: C12Q1/68 ,  C07H21/04 ,  C12N15/00

CPC classification number: C12N9/22 ,  C07K14/005 ,  C07K14/195 ,  C07K2319/00 ,  C07K2319/01 ,  C07K2319/80 ,  C12N9/0071 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/96 ,  C12N15/01 ,  C12N15/102 ,  C12N15/1031 ,  C12N15/11 ,  C12N15/63 ,  C12N15/85 ,  C12N2310/20 ,  C12N2710/00033 ,  C12N2770/00033 ,  C12N2800/80 ,  C12Y114/11 ,  C12Y201/01 ,  C12Y301/00 ,  C12Y301/21004

Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.

公开(公告)号：EP2773777A4

公开(公告)日：2015-11-11

申请号：EP12846126

申请日：2012-10-31

Applicant: UNIV UTAH RES FOUND

Inventor： ALTER ORLY

IPC: G06F19/00 ,  C12N15/11 ,  C12N15/113 ,  C12Q1/68 ,  G01N33/53

CPC classification number: C12Q1/6874 ,  C12N15/1137 ,  C12N2310/14 ,  C12Q1/6809 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  C12Y201/01 ,  C12Y207/11001 ,  G16H50/30 ,  Y02A90/26 ,  C12Q2537/165

Abstract: Methods and genetic sequences are described for use in determining the diagnosis, subtype, prognosis, and disease course of high-grade gliomas, such as glioblastoma multiforme. One such method includes determining increased expression of at least one gene on a chromosome segment in cells of the glioma, the segment being 17:57,851,812-17:57,973,757; 7:127,892,509-7:127,947,649; 12:33,854-12:264,310; or 19:33,329,393-19:35,322,055; and estimating, based on the expression, a predicted length of survival, a probability of survival, or a predicted response to a therapy for the glioma.

公开(公告)号：EP2665809A4

公开(公告)日：2015-05-06

申请号：EP12736463

申请日：2012-01-18

Applicant: CJ CHEILJEDANG CORP

Inventor： LEE KWANG HO ,  LEE KEUN CHUL ,  LEE SEOK MYUNG ,  HWANG YOUNG BIN

IPC: C12N1/21 ,  C12N9/10 ,  C12N9/12 ,  C12P13/04 ,  C12P13/08 ,  C12P13/22

CPC classification number: C12N15/70 ,  C07K14/245 ,  C12N9/1007 ,  C12N9/1205 ,  C12P13/04 ,  C12P13/08 ,  C12P13/227 ,  C12Y201/01 ,  C12Y207/01023

Abstract: A microorganism of the genus Escherichia having enhanced L-amino acid productivity, wherein the microorganism is transformed to have an enhanced NAD kinase activity and an inactivated activity of an enzyme having an amino acid sequence of SEQ ID NO: 2 encoded by tehB gene and a method for producing L-amino acids using the microorganism of the genus Escherichia.

公开(公告)号：EP2773777A1

公开(公告)日：2014-09-10

申请号：EP12846126.6

申请日：2012-10-31

Applicant: University Of Utah Research Foundation

Inventor： ALTER, Orly

IPC: C12Q1/68 ,  C12N15/11 ,  G01N33/53

CPC classification number: C12Q1/6874 ,  C12N15/1137 ,  C12N2310/14 ,  C12Q1/6809 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  C12Y201/01 ,  C12Y207/11001 ,  G16B30/00 ,  G16H50/30 ,  Y02A90/26 ,  C12Q2537/165

Abstract: Methods and genetic sequences are described for use in determining the diagnosis, subtype, prognosis, and disease course of high-grade gliomas, such as glioblastoma multiforme. One such method includes determining increased expression of at least one gene on a chromosome segment in cells of the glioma, the segment being 17:57,851,812-17:57,973,757; 7:127,892,509-7:127,947,649; 12:33,854-12:264,310; or 19:33,329,393-19:35,322,055; and estimating, based on the expression, a predicted length of survival, a probability of survival, or a predicted response to a therapy for the glioma.

公开(公告)号：EP2585479A2

公开(公告)日：2013-05-01

申请号：EP11736132.9

申请日：2011-06-16

Applicant: Glaxosmithkline Australia PTY Ltd.

Inventor： WINZER, Thilo Hans ,  WALKER, Tracy Carol ,  GRAHAM, Ian Alexander

IPC: C07K14/415

CPC classification number: C12P17/188 ,  C07K14/415 ,  C12N9/1007 ,  C12N15/8243 ,  C12Y201/01

Abstract: This disclosure relates to the isolation and sequencing of nucleic acid molecules that encode methyltransferase polypeptides from a Papaver somniferum cultivar; and uses in the production of noscapine and identification of poppy cultivars that include the genes that include these nucleic acid molecules.

Abstract translation: 本公开涉及从罂粟种植体品种编码甲基转移酶多肽的核酸分子的分离和测序; 并用于生产诺斯卡品和鉴定包括这些核酸分子的基因的罂粟品种。

公开(公告)号：TW201422813A

公开(公告)日：2014-06-16

申请号：TW102130678

申请日：2013-08-27

Applicant: 奇諾麥提卡公司 ,  GENOMATICA, INC.

Inventor： 柏賈德 安東尼P ,  BURGARD, ANTHONY P. ,  歐斯特赫 羅賓E ,  OSTERHOUT, ROBIN E. ,  凡 狄恩 史帝芬J ,  VAN DIEN, STEPHEN J. ,  崔西威爾 卡拉 安 ,  TRACEWELL, CARA ANN ,  法基亞 普利提 ,  PHARKYA, PRITI ,  安德瑞 史蒂芬 ,  ANDRAE, STEFAN

IPC: C12N1/21 ,  C12N15/52 ,  C12N15/31

CPC classification number: C12P7/18 ,  C07D207/12 ,  C08G18/3206 ,  C08G63/06 ,  C08G63/12 ,  C08G63/66 ,  C08G69/26 ,  C12N9/0006 ,  C12N9/0028 ,  C12N9/1007 ,  C12N9/88 ,  C12P7/24 ,  C12P19/02 ,  C12Y101/01224 ,  C12Y101/01244 ,  C12Y101/02007 ,  C12Y105/0102 ,  C12Y201/01 ,  C12Y201/0109 ,  C12Y402/01 ,  Y02P20/52

Abstract: 本發明提供一種具有甲醇代謝路徑(methanol metabolic pathway；MMP)的非天然存在之微生物生物體，其可在甲醇存在下增進還原相等物之可得性。該等還原相等物可用以增加由微生物生物體所產生之有機化合物(諸如1,4-丁二醇(BDO))之產物產率。本發明亦提供使用該種生物體產生BDO之方法。

Abstract in simplified Chinese: 本发明提供一种具有甲醇代谢路径(methanol metabolic pathway；MMP)的非天然存在之微生物生物体，其可在甲醇存在下增进还原相等物之可得性。该等还原相等物可用以增加由微生物生物体所产生之有机化合物(诸如1,4-丁二醇(BDO))之产物产率。本发明亦提供使用该种生物体产生BDO之方法。