公开(公告)号：WO1994023643A1

公开(公告)日：1994-10-27

申请号：PCT/US1993003427

申请日：1993-04-12

Applicant: NONINVASIVE MEDICAL TECHNOLOGY CORPORATION

Inventor： NONINVASIVE MEDICAL TECHNOLOGY CORPORATION ,  STEUER, Robert, R. ,  HARRIS, David, B.

IPC: A61B05/00

CPC classification number: G01N21/3151 ,  A61B5/14535 ,  A61B5/14546 ,  A61B5/14551 ,  A61B5/14552 ,  A61B5/6826 ,  A61B5/6838 ,  A61B5/6843 ,  G01N2021/3144 ,  G01N2021/3148 ,  G01N2021/3181 ,  G01N2201/0625 ,  G01N2201/0691

Abstract: A system for determining the hematocrit transcutaneously and noninvasively. Disclosed are a finger clip assembly (6) and an earlobe clip assembly (10), each including at least a pair of emitters (1, 2) and a photodiode (3) in appropriate alignment to enable operation in either a transmittion mode or a reflectance mode. At least two, and preferably three, predetermined wavelengths of light are passed onto or through body tissues such as the finger (7), earlobe (11), or scalp, etc. and the extinction of each wavelength is detected. Mathematical manipulation of the detected values compensates for the effects of body tissue and fluid and determines the hematocrit value. If a fourth wavelength of light is used which is extinguished substantially differently by oxyhemoglobin and reduced hemoglobin and which is not substantially extinguished by plasma, then the blood oxygen saturation value, is determinable independently of the hematocrit value. It is also within the scope of the present invention to detect and analyze multiple wavelengths using a logarithmic DC analysis technique. In this embodiment, a pulse wave is not required. Hence, this embodiment may be utilized in states of low blood pressure or low blood flow.

Abstract translation: 用于经皮和非侵入性测定血细胞比容的系统。 公开了一种手指夹组件（6）和耳垂夹子组件（10），每个夹片组件（10）均包括至少一对发射器（1,2）和光电二极管（3），以适当对准，以使得能够以透射模式或 反射模式。 至少两个，优选三个预定波长的光通过身体组织，例如手指（7），耳垂（11）或头皮等，并且检测每个波长的消光。 检测值的数学操作可补偿身体组织和液体的影响，并确定血细胞比容值。 如果使用第四波长的光，其通过氧合血红蛋白和血红蛋白降低而基本上不同，并且其基本上不被血浆消除，则血氧饱和度值可以独立于血细胞比容值来确定。 使用对数DC分析技术来检测和分析多个波长也在本发明的范围内。 在本实施例中，不需要脉波。 因此，该实施例可以用于低血压或低血流量的状态。

公开(公告)号：WO1994022362A1

公开(公告)日：1994-10-13

申请号：PCT/US1994003546

申请日：1994-03-31

Applicant: NELLCOR INCORPORATED ,  HOLLUB, Seth, D.

Inventor： NELLCOR INCORPORATED

IPC: A61B05/00

CPC classification number: A61B5/14551 ,  G05B19/0423 ,  G05B2219/25249 ,  G05B2219/2657

Abstract: An apparatus for measuring the concentration of blood constituents in which the architecture of the electronic processor reduces the amount of controller processing time required for tasks such as data acquisition and generation of system control signals. A demodulator is coupled to a probe for converting a first electrical signal to digital data. An interface is coupled to the demodulator for receiving the digital data and generating interrupts when a first amount of the digital data has been received. A buffer memory is coupled to the interface for storing the digital data. A controller having a controller memory (in specific embodiments, a CPU having a CPU memory) is also coupled to the buffer memory. The controller transfers the digital data from the buffer memory to the controller memory in response to the interrupts. The controller then processes the digital data to calculate the arterial oxygen concentration.

Abstract translation: 一种用于测量血液成分浓度的装置，其中电子处理器的架构减少了诸如数据采集和产生系统控制信号的任务所需的控制器处理时间量。 解调器耦合到探针，用于将第一电信号转换成数字数据。 接口耦合到解调器，用于接收数字数据，并且当已经接收到第一数量的数据量时产生中断。 缓冲存储器耦合到接口以存储数字数据。 具有控制器存储器（在具体实施例中，具有CPU存储器的CPU）的控制器也耦合到缓冲存储器。 控制器响应中断将数字数据从缓冲存储器传送到控制器存储器。 然后，控制器处理数字数据以计算动脉氧浓度。

公开(公告)号：WO1994022361A1

公开(公告)日：1994-10-13

申请号：PCT/US1994003518

申请日：1994-03-30

Applicant: NON INVASIVE TECHNOLOGY, INC. ,  PHOTONICS RESEARCH CORPORATION

Inventor： NON INVASIVE TECHNOLOGY, INC. ,  PHOTONICS RESEARCH CORPORATION ,  CHANCE, Britton ,  KAUFMANN, Kenneth, J.

IPC: A61B05/00

CPC classification number: A61B5/14553

Abstract: A system for examination of biological tissue of a subject (10) includes a light source (14), (16), a light detector (22), a gated integrator (26), (28), and an integrator timing control (19) adapted to integrate detected photons over at least two selected time intervals. The light source (14), (16) is adapted to introduce into the tissue, at an input port, pulses of electromagnetic radiation of a selected wavelength in the visible or infrared range. The detector (22) detects photons of modified pulses that have migrated in the tissue from the input port. The integrator (26), (28) registers all photons detected over preselected time intervals of the arrival time of the modified pulses. A processor (30) adapted to receive data from the integrator (26), (28) determines a physiological property of the examined tissue based on the number of photons integrated over each time interval.

Abstract translation: 用于检查对象（10）的生物组织的系统包括光源（14），（16），光检测器（22），门控积分器（26），（28）和积分器定时控制（19） ）适于在至少两个选定的时间间隔内整合检测到的光子。 光源（14），（16）适于在输入端口将可选或波长范围内的所选波长的电磁辐射的脉冲引入组织。 检测器（22）检测已经从输入端口在组织中迁移的修改脉冲的光子。 积分器（26），（28）通过修改脉冲的到达时间的预选时间间隔来记录检测到的所有光子。 适于从积分器（26）接收数据的处理器（30），（28）基于在每个时间间隔内积分的光子的数量来确定所检查的组织的生理特性。

公开(公告)号：WO1994020012A1

公开(公告)日：1994-09-15

申请号：PCT/US1994002298

申请日：1994-03-02

Applicant: BIOFIELD CORP.

Inventor： BIOFIELD CORP. ,  FAUPEL, Mark, L. ,  HAHN, Steven

IPC: A61B05/00

CPC classification number: A61B5/04 ,  A61B5/04002 ,  A61B5/0408 ,  A61B5/04087 ,  A61B5/05 ,  A61B2562/0238 ,  A61B2562/08 ,  Y10S607/901

Abstract: The apparatus and method of screening and diagnosing trauma or disease in body tissues involves the use of DC bio-potential sensing electrodes (26) having DC offset potentials wihtin an acceptable range and electrical characteristics which enhance the accuracy of the bio-potential measurement. The apparatus (10) checks the electrodes (26) connected thereto prior to a measurement cycle and will not initiate the measurement cycle if improper electrodes are present. The electrodes (26) may be formed to selectively pass only certain ions thereby enhancing the sensitivity of the electrodes.

Abstract translation: 筛选和诊断身体组织中的创伤或疾病的装置和方法涉及使用具有提高生物电位测量精度的可接受范围和电特性的DC偏移电位的DC生物电位感测电极（26）。 在测量周期之前，装置（10）检查与其连接的电极（26），并且如果存在不正确的电极，则不会启动测量周期。 电极（26）可以形成为仅选择性地通过某些离子，从而增强电极的灵敏度。

公开(公告)号：WO1994020011A3

公开(公告)日：1994-09-15

申请号：PCT/DE1994000267

申请日：1994-03-09

Applicant: MIRA-GMBH GERÄTE FÜR DIE MEDIZINISCHE INFRAROTANALYSE ,  WALDMANN, Jürgen ,  FIEDLER, Lothar ,  KRZYWINSKI, Ronald ,  SCHIMKO, Gundela

Inventor： MIRA-GMBH GERÄTE FÜR DIE MEDIZINISCHE INFRAROTANALYSE

IPC: A61B05/00

公开(公告)号：WO1994018884A1

公开(公告)日：1994-09-01

申请号：PCT/US1994000540

申请日：1994-01-21

Applicant: UTAH MEDICAL PRODUCTS, INC.

Inventor： UTAH MEDICAL PRODUCTS, INC. ,  SMITH, Roger, E. ,  NEESE, Jon

IPC: A61B05/00

CPC classification number: A61B5/1464 ,  A61B5/02411 ,  A61B5/14542 ,  A61B5/4362 ,  A61B5/6839 ,  A61B5/6848 ,  A61B5/6882

Abstract: A subcutaneous radiation reflection probe for measuring oxygen saturation in living tissue includes an elongate drive shaft (4) on one end of which is detachably coupled to a mounting cup (20). The mounting cup (20) includes a hollow (48) for receiving and holding a base element (40) on which is mounted a spiral needle (24) which coils outwardly from the mounting cup (20) to terminate in a pointed end (24a). A window (60) is formed in the spiral needle (24) near the pointed end (24a) thereof for receiving and holding a radiation emitter, such as a light emitting diode (64). A radiation detector (44) is disposed on the base element (40) within the coil of the spiral needle (24). The probe may be used to measure oxygen saturation in living tissue, such as a fetal scalp, by inserting the mounting cup (20) and drive shaft (4) through an introducer (36) into a woman's vagina until the spiral needle (24) contacts the fetal scalp.

Abstract translation: 用于测量生物组织中的氧饱和度的皮下辐射反射探针包括细长的驱动轴（4），其一端可拆卸地联接到安装杯（20）。 安装杯（20）包括用于接收和保持基座元件（40）的中空部（48），其上安装有螺旋针（24），螺旋针从安装杯（20）向外盘绕，以终止在尖端（24a ）。 窗口（60）形成在其尖端（24a）附近的螺旋形针（24）中，用于接收和保持诸如发光二极管（64）的辐射发射器。 放射线检测器（44）设置在螺旋针（24）的线圈内的基座元件（40）上。 探针可用于通过将安装杯（20）和驱动轴（4）通过导引器（36）插入女性阴道中直到螺旋针（24）来测量活体组织如胎儿头皮中的氧饱和度， 接触胎儿头皮。

公开(公告)号：WO1994016614A1

公开(公告)日：1994-08-04

申请号：PCT/US1994000489

申请日：1994-01-21

Applicant: BRAIG, James, R. ,  GOLDBERGER, Daniel, S.

IPC: A61B05/00

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B5/14546 ,  G01N21/35 ,  G01N21/3581

Abstract: A method and apparatus for monitoring glucose, ethyl alcohol and other blood constituents in a noninvasive manner. The measurements are made by monitoring infrared absorption of the desired blood constituent in the long infrared wavelength range. The long wavelength infrared energy generated by source (400) is passed through a finger (406). To prevent the high energy source from burning or causing patient discomfort, shutter (404) and bandpass filters (410) cause only short bursts of energy to be sent through the finger with a very low duty cycle and low optical bandwidth. The bursts are further synchronized by shutter (404) with systole and diastole of the cardiac cycle so that only two pulses are sent per heart beat, one during diastole and one during systole. The detection signals measured at detectors (412) during application of these bursts of energy are used to calculate the concentration of blood constituents in accordance with a polynomial equation.

Abstract translation: 一种以非侵入性方式监测葡萄糖，乙醇和其他血液成分的方法和装置。 通过在长红外波长范围内监测所需血液成分的红外吸收来进行测量。 由源（400）产生的长波长红外能量通过手指（406）。 为了防止高能源燃烧或引起患者不适，快门（404）和带通滤波器（410）只能以非常低的占空比和低的光学带宽通过手指发送短的能量脉冲。 通过快门（404）与心动周期的心律和舒张进一步同步脉冲串，使得每个心跳只发送两个脉冲，一个在舒张期期间发送，一个在心脏收缩期间发送。 在应用这些脉冲能量的情况下在检测器（412）处测量的检测信号用于根据多项式方程计算血液成分的浓度。

公开(公告)号：WO1994013195A1

公开(公告)日：1994-06-23

申请号：PCT/GB1993002526

申请日：1993-12-10

Applicant: INSTITUTE OF NEUROLOGY; ,  PATSALOS, Philip, Nicholaou ,  O'CONNEL, Mark

Inventor： INSTITUTE OF NEUROLOGY;

IPC: A61B05/00

CPC classification number: A61B5/145 ,  A61B5/14528 ,  A61B10/0045 ,  A61M25/02

Abstract: A dialysis probe for insertion into the human or animal body comprises a tubular dialysis membrane (2) closed at its distal end (3); an inlet tube (4) for supplying perfusion fluid into the body of the dialysis membrane (2); and an outlet tube (5) for the exit of perfusion fluid from the body of the dialysis membrane, the inlet and outlet tubes being provided at the proximal end of the tubular dialysis membrane (2) and making sealed connection with the interior of the dialysis membrane. An anchoring member (7, 20) is provided at the proximal end of the probe and in a first embodiment comprises a plate-like member for securing directly to the body of the subject, and in a second embodiment comprises a stopper cap (21, 22, 23, 24) for plugging a cannula itself attached to the body of the subject. The anchoring member has all the remaining component parts of the probe bonded, directly or indirectly, to it.

Abstract translation: 用于插入人或动物体内的透析探针包括在其远端（3）处封闭的管状透析膜（2）; 用于将灌注流体供应到所述透析膜（2）的主体中的入口管（4）; 和用于从所述透析膜主体排出灌注流体的出口管（5），所述入口管和出口管设置在所述管状透析膜（2）的近端并与所述透析的内部密封连接 膜。 锚固构件（7,20）设置在探针的近端处，并且在第一实施例中包括用于直接固定到对象的身体的板状构件，并且在第二实施例中包括止动帽（21， 22,23,24），用于堵塞附接到被检体的身体的套管本身。 锚固构件具有直接或间接地结合到其上的探针的所有剩余组分部分。

公开(公告)号：WO1994013193A1

公开(公告)日：1994-06-23

申请号：PCT/DE1993001193

申请日：1993-12-14

Applicant: KUHLS, Burkhard

IPC: A61B05/00

CPC classification number: A61B5/14558 ,  G01N21/21

Abstract: A measurement device for non-invasively determining the concentration of polarising substances in the human body, in particular for measuring the sugar concentration in human blood, has a light source (3), a periodically rotating polariser/analyser (6, 4) linked to an angle sensor (3) for determining the rotation frequency of the polariser (6), and a light detector (1), as well as an electronic assembly (8) for determining the blood sugar concentration from the measured values. The periodically rotating polariser (6) converts the angle of rotation of polarisation into a phase angle of the intensity curve of the transmitted light. The blood sugar concentration may be non-invasively determined by measuring the phase shift through the object (5) to be measured with respect to the reference phase, by static extinction measurement (tissues and blood) and by a dynamic measurement (only pulsating part of the blood). The measurement may be a transmission or a diffraction measurement. With only one sensor system this device is ccapable of carrying out two independent measurements (phase modulation and extinction measurement). As the modulation frequency may be freely selected, noise and interferences affecting the evaluation electronic assembly may be suppressed to a maximum extent.

公开(公告)号：WO1994008506A1

公开(公告)日：1994-04-28

申请号：PCT/US1992008644

申请日：1992-10-12

Applicant: YELDERMAN, Mark, L. ,  GOLDBERGER, Daniel, S. ,  BRAIG, James, R.

IPC: A61B05/00

CPC classification number: G01J5/04 ,  A61B1/227 ,  G01J5/02 ,  G01J5/028 ,  G01J5/045 ,  G01J5/049 ,  G01J5/08 ,  G01J5/0812 ,  G01J5/0862 ,  G01J5/14 ,  G01J2005/066 ,  G01J2005/068

Abstract: A noncontact infrared tympanic thermometer which does not require environmental stabilization or waveguide temperature control because it utilizes an optically stabilized infrared detector for detecting the infrared energy emitted by the tympanic membrane. This stability is accomplished by locating a neutral density filter (164) over half of the optical aperture (162) of the detector package (16) such that the neutral density filter (164) ''shadows'' only one of two thermopile channels (163) for detecting the infrared energy emitted by the tympanic membrane. The two thermopile channels (163) are connected in series opposition such that any optical signal equally present in both channels will yield a zero net output. Since the infrared energy emitted by the walls (161) of the detector package (16) reach each detector (163) equally, the effects of these emissions on the temperature measurement are eliminated.

Abstract translation: 一种非接触红外鼓膜温度计，其不需要环境稳定或波导温度控制，因为它使用光学稳定的红外检测器来检测由鼓膜发射的红外能量。 这种稳定性是通过将中性密度滤光器（164）定位在检测器封装（16）的光学孔（162）的一半上而实现的，使得中性密度滤光片（164）仅“阴影”两个热电堆通道中的一个 163），用于检测由鼓膜发射的红外能量。 两个热电堆通道（163）串联连接，使得两个通道中同样存在的任何光信号将产生零净输出。 由于检测器封装（16）的壁（161）发射的红外能量同样到达每个检测器（163），消除了这些排放对温度测量的影响。