公开(公告)号：US10858662B2

公开(公告)日：2020-12-08

申请号：US15527837

申请日：2015-11-19

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Jin Soo Kim ,  Tae Young Koo

IPC: C12N15/74 ,  C12N15/63 ,  C12N15/11 ,  C12N15/864 ,  C12N15/867 ,  C12N9/16 ,  C12N9/22

Abstract: The present invention relates to a method for regulating gene expression, comprising introducing into a cell each of a recombinant vector which expresses a first domain comprising N-terminus of a Cas9 protein, and a recombinant vector which expresses a second domain comprising C-terminus of a Cas9 protein, a composition comprising the recombinant vectors, a kit for regulating gene expression, and a method for intracellular production of Cas9 protein. Moreover, the present invention relates to a transformed cell introduced with a viral vector which packages the first domain, and a viral vector which packages the second domain, and to a composition comprising a virus produced therefrom.

公开(公告)号：US20200318193A1

公开(公告)日：2020-10-08

申请号：US16889372

申请日：2020-06-01

Applicant: DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Kee Tae KIM ,  Hong Gil Nam ,  Chand Parvez Danka Mohammed

IPC: C12Q1/6883 ,  C12N15/113 ,  G01N33/50 ,  G01N33/68

Abstract: The present invention relates to a method for determining a decrease in the functions of the hippocampus by using the correlation between a micro RNA (miRNA) and an N-methyl-D-aspartate receptor (NMDAR), a method for inhibiting the decrease in the functions, and a method for screening for inhibitors of the decrease in the functions. The present invention confirms that miR-204, among miRNAs up-regulated in an aged hippocampus, decreases the expression of EphB2, by accurately targeting EphB2, which is an important regulatory receptor, resulting in a decrease in the neuronal surface expression of an NR1 subunit of an NMDAR in hippocampal nerves and a decrease in the density of dendrites, thereby having an effect of determining whether the functions of the hippocampus are decreased, by using the correlation between a miRNA and an NMDAR, and furthermore, has an effect of providing a method for inhibiting the decrease in the functions of the hippocampus, and a method for screening for inhibitors of the decrease in the functions.

公开(公告)号：US10543477B2

公开(公告)日：2020-01-28

申请号：US15586068

申请日：2017-05-03

Applicant: INSTITUTE FOR BASIC SCIENCE ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Kimoon Kim ,  Gyeongwon Yun ,  Zahid Hassan ,  Jiyeong Lee ,  Jeehong Kim ,  Nam Hoon Kim ,  Kangkyun Baek ,  Ilha Hwang

IPC: B01J23/52 ,  B01J31/06 ,  C08J7/06 ,  C08J7/12 ,  B01J23/44 ,  B01J23/42 ,  B01J35/00 ,  B01J13/18 ,  B01J33/00 ,  B82Y30/00 ,  B01J35/02 ,  B01J37/02 ,  B01J37/16

Abstract: Provided are a polymer capsule loaded with transition metal particles having excellent water dispersibility and stability, and a method for preparing the same. Specifically, the polymer capsule loaded with transition metal particles according to the present invention includes a surface-modified polymer capsule surface-modified to thereby have a positive zeta potential in a dispersed state in water; and transition metal particles loaded on a surface of the surface-modified polymer capsule. In addition, a method for preparing a polymer capsule loaded with transition metal particles according to the present invention includes a) preparing a polymer capsule; b) surface-modifying the polymer capsule to prepare a polymer capsule having a positive zeta potential in a dispersed state in water; and c) sequentially adding a water-soluble transition metal precursor and a reducing agent to a water dispersion of the surface-modified polymer capsule obtained in step b).

公开(公告)号：US20190338298A1

公开(公告)日：2019-11-07

申请号：US15766445

申请日：2016-10-06

Applicant: INSTITUTE FOR BASIC SCIENCE ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  AICT

Inventor： Jin Soo KIM ,  Jungeun KIM ,  Sunghwa CHOE ,  Je Wook WOO ,  Soon II KWON ,  Hyeran KIM

IPC: C12N15/82 ,  C12N15/11 ,  C12N9/22

Abstract: The present invention relates to a method of increasing the production efficiency of gene-edited plants, regenerated from plant protoplasts, by use of a Cas protein-guide RNA ribonucleoprotein (RNP). According to the present invention, the method of increasing the production efficiency of gene-edited plants makes it possible to efficiently produce target gene-mutated plants and to minimize the introduction of foreign DNA into plants. Thus, the present invention can be very advantageously used in a wide variety of fields, including agriculture, food and biotechnology.

公开(公告)号：US20190284218A1

公开(公告)日：2019-09-19

申请号：US16352562

申请日：2019-03-13

Applicant: INSTITUTE FOR BASIC SCIENCE ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Hayoung SONG ,  Kimoon KIM ,  Eunsung LEE ,  Hyunho KIM

IPC: C07F15/00 ,  B01J31/22 ,  H01L51/00 ,  C07D265/18

Abstract: Provided are a transition metal compound including a novel carbene compound as a ligand, a preparation method thereof, and an application thereof. The transition metal compound according to the present invention may form a structurally stable complex and also have a HOMO-LUMO energy gap and singlet-triplet transition energy which are significantly low as compared with a conventional transition metal compound. In addition, according to the present invention, the transition metal compound may be synthesized in large quantities by a very simple method, thereby having high commercial utility, and thus, an application using the compound is expected.

公开(公告)号：US10280402B2

公开(公告)日：2019-05-07

申请号：US15328628

申请日：2015-08-06

Applicant: College of Medicine Pochon CHA University Industry-Academic Cooperation Foundation ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Jin Soo Kim ,  Dong Youn Hwang

IPC: C12N5/074 ,  C12Q1/6881 ,  C12N5/0735 ,  C07K14/74 ,  C12N5/073

Abstract: The present invention relates to a method for producing immune-compatible cells or a cell population which comprises a step of editing one or two alleles of one or more immune-compatible antigen genes by gene deletion or modification in an isolated cell comprising at least one of the immune-compatible antigen genes selected from HLA (human leukocyte antigen)-A, HLA-B and HLA-DR, to immune-compatible cells produced by the method, and to a cell population comprising the immune-compatible cells produced by the method.

公开(公告)号：US20180353684A1

公开(公告)日：2018-12-13

申请号：US15735563

申请日：2016-06-03

Applicant: Seoul National University R&DB Foundation ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Daehyeong KIM ,  Taeghwan HYEON ,  Seunghong CHOI ,  Hyunjae LEE ,  Taekyu CHOI

IPC: A61M5/172 ,  G01N33/66 ,  C12Q1/00 ,  G01N33/84 ,  G01N27/327

CPC classification number: A61M5/1723 ,  A61B5/00 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/1477 ,  A61B5/1486 ,  A61B5/4266 ,  A61B2562/0261 ,  A61B2562/12 ,  A61M5/00 ,  A61M37/0015 ,  A61M2205/3368 ,  A61M2205/3569 ,  A61M2205/36 ,  A61M2230/201 ,  A61M2230/208 ,  C12Q1/006 ,  G01N27/3271 ,  G01N27/3278 ,  G01N33/66 ,  G01N33/84

Abstract: Provided are a biosensor and a method for forming the same, a glucose control system, a method for forming the glucose control system, and a method for controlling glucose using the glucose control system. The biosensor comprises at least one sensor comprising a sensing unit, a bridge unit connected to the sensing unit, and an electrode unit connected to the bridge unit, wherein the sensing unit comprises a graphene layer. The method for forming the biosensor that comprises at least one sensor comprising a sensing unit, a bridge unit connected to the sensing unit and an electrode unit connected to the bridge unit, comprises forming a lower insulation layer, forming a conductive electrode layer on the lower insulation layer, forming a graphene layer on the conductive electrode layer and forming a reaction layer on the graphene layer.The glucose control system comprises a sensor unit comprising a glucose sensor, a glucose regulation unit regulating glucose concentration in a body of a user and a control unit controlling the sensor unit and the glucose regulation unit. The method for forming a glucose control system comprises forming a sensor unit comprising a glucose sensor, forming a glucose regulation unit and packaging the sensor unit and the glucose regulation unit.

公开(公告)号：US20180277782A1

公开(公告)日：2018-09-27

申请号：US15988977

申请日：2018-05-24

Applicant: Seoul National University R&DB Foundation ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Daehyeong KIM ,  Taeghwan HYEON ,  Moonkee CHOI ,  Jiwoong YANG ,  Kwanghun KANG

IPC: H01L51/50 ,  H01L51/52 ,  H01L51/56 ,  C09D11/037 ,  C09D11/50 ,  B41F9/00 ,  H01L51/00 ,  C09K11/88 ,  B82Y40/00 ,  B82Y20/00

CPC classification number: H01L51/502 ,  B41F9/00 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00 ,  C09D11/037 ,  C09D11/50 ,  C09D11/52 ,  C09K11/883 ,  H01L51/0004 ,  H01L51/003 ,  H01L51/0035 ,  H01L51/0037 ,  H01L51/0039 ,  H01L51/0043 ,  H01L51/0097 ,  H01L51/5056 ,  H01L51/5072 ,  H01L51/5088 ,  H01L51/5092 ,  H01L51/5253 ,  H01L51/56 ,  H01L2251/301 ,  H01L2251/5338 ,  H01L2251/558 ,  H05B33/145 ,  Y02E10/549 ,  Y02P70/521 ,  Y10S977/774 ,  Y10S977/824 ,  Y10S977/892 ,  Y10S977/95

Abstract: A quantum dot electronic device comprises a first encapsulation layer, a first electrode disposed on the first encapsulation layer, a quantum dot pattern disposed on the first electrode, a second electrode disposed on the quantum dot pattern and a second encapsulation layer disposed on the second electrode. The quantum dot pattern may be famed by an intaglio transfer printing method, where the method comprises forming a quantum dot layer on a donor substrate, picking up the quantum dot layer using a stamp, putting the quantum dot layer into contact with an intaglio substrate using the stamp and separating the stamp from the intaglio substrate. Using the quantum dot transfer printing method, a subminiature quantum dot pattern can be transferred at a high transfer rate. Accordingly, a highly integrated quantum dot electronic device exhibiting excellent performance and a high integrated quantum dot light emitting device with an ultrathin film can be realized.

公开(公告)号：US20180258418A1

公开(公告)日：2018-09-13

申请号：US15872907

申请日：2018-01-16

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Jin-Soo KIM

IPC: C12N15/10 ,  C12N9/22 ,  C12N15/90 ,  C12N15/113

Abstract: Provided are a composition for inducing DNA single strand breaks in DNA, the composition comprising a cytidine deaminase, an inactivated target-specific endonuclease, and a guide RNA, a method for inducing a single-strand break in DNA, using the same, a method for analyzing a nucleic acid sequence of a base-editing-introduced DNA, and a method for identifying (or measuring or detecting) a base-editing site, base-editing efficiency at an on-target site, an off-target site, and/or target specificity.

公开(公告)号：US20180145341A1

公开(公告)日：2018-05-24

申请号：US15814839

申请日：2017-11-16

Applicant: Seoul National University, R&DB Foundation ,  Institute for Basic Science ,  Kangwon National University, University-Industry Cooperation Foundation

Inventor： Yung-Eun SUNG ,  Yong-Hun CHO ,  Ji Eun PARK ,  Chi-Yeong AHN ,  Sungjun KIM

IPC: H01M8/0234 ,  H01M8/0258 ,  H01M8/1018 ,  H01M8/241 ,  H01M8/04007

CPC classification number: H01M8/0234 ,  H01M8/0258 ,  H01M8/04007 ,  H01M8/1004 ,  H01M8/1018 ,  H01M8/241 ,  H01M2008/1095

Abstract: The present invention relates to a component including graphene foam and functioning as a flow field and a gas diffusion layer (GDL) for a fuel cell. More particularly, a component functioning as a flow field and a GDL for a fuel cell according to the present invention is made of graphene foam that enhances mass transport and suffers no corrosion under operating conditions of the fuel cell when compared with a conventional flow field, thereby realizing excellent performance and durability. Furthermore, the component functions as the GDL so a thickness of a membrane electrode assembly is reduced thereby improving cell performance significantly.