公开(公告)号：EP0707459A1

公开(公告)日：1996-04-24

申请号：EP94922039.0

申请日：1994-07-01

Applicant: THE CATHOLIC UNIVERSITY OF AMERICA

Inventor： LITOVITZ, Theodore, A.

IPC: A61N1 ,  A61N2 ,  H05K9 ,  A61B19

CPC classification number: A61N2/02 ,  A61B90/04 ,  A61N1/16 ,  A61N1/323 ,  A61N2/00 ,  A61N2/06

Abstract: The disclosed embodiments of the inventions disclosed in this application develop a 'protection' electric, magnetic or electromagnetic field or fields which are either superimposed upon an ambient field which is detrimental to the health of living systems, or is incorporated into the electrical circuit of the device which is generating the detrimental field. Either arrangement is successful in 'confusing' living cells, and thereby reducing the harmful effects of the otherwise detrimental field.

公开(公告)号：EP0672655A1

公开(公告)日：1995-09-20

申请号：EP95300273.0

申请日：1995-01-17

Applicant: THE CATHOLIC UNIVERSITY OF AMERICA

Inventor： Khachik, Frederick

IPC: C07C403/24 ,  C07B61/00

CPC classification number: C07C403/24 ,  A23L5/44 ,  C07C35/21 ,  C09B61/00 ,  C09B67/0096

Abstract: A method of isolating, purifying and recrystallizing substantially pure lutein, preferably from saponified marigold oleoresin through use of a series of filtrations and water/alcohol washes to obtain crude lutein crystals. The crystals are dissolved in a halogenated organic solvent in which lutein is strongly soluble and then a second organic solvent in which lutein is only partially soluble. Upon cooling of the mixture lutein is recrystallized in a high purity and then filtered and dried under vacuum. The lutein crystals are of the formula:

Lutein in pure form may be used as an analytical standard, as a nutritional supplement for use as an antioxidant and an agent that may prevent cancer, heart disease, and eye disease such as cataracts and age-related macular degeneration, and as a color additive in human foods.

Abstract translation: 式（I）从类胡萝卜素和其它杂质基本上自由的，和从植物提取物衍生的基本上纯的结晶叶黄素确实含有叶黄素，是新的。 植物提取物为优先。 从万寿菊花中提取的。

公开(公告)号：EP4371564A3

公开(公告)日：2024-08-21

申请号：EP24155130.8

申请日：2021-07-21

Applicant: THE CATHOLIC UNIVERSITY OF AMERICA

Inventor： RAO, Venigalla B. ,  ZHU, Jingen

IPC: A61K31/7088 ,  C12N7/00 ,  C12N15/10 ,  C12N15/86

CPC classification number: C12N15/86 ,  C12N2795/1014320130101 ,  C12N2795/1014220130101 ,  C12N15/102 ,  C12N2795/1012120130101 ,  C12N7/00 ,  C12N2310/2020170501

Abstract: Described is an "artificial virus" (AV) programmed with biomolecules that can enter human cells and carry out precise human genome modification. The AVs comprise: at least one viral vector, such as bacteriophage T4; at least one therapeutic molecule, such as DNA, RNA, protein and their complex; and a lipid coating. Also described is a method of human genome modification, using such an AV, and a method of program such an AV.

公开(公告)号：EP4370696A1

公开(公告)日：2024-05-22

申请号：EP22841572.5

申请日：2022-07-06

Applicant: THE CATHOLIC UNIVERSITY OF AMERICA

Inventor： RAO, Venigalla B. ,  BATRA, Himanshu

IPC: C12N15/86 ,  C07K14/005 ,  C12N7/00 ,  C12N5/0783

CPC classification number: C12N15/86 ,  C12N2795/1014320130101 ,  C07K14/005 ,  C12N2740/1612220130101 ,  C12N2795/1014520130101 ,  C12N5/0636 ,  C12N2510/0020130101

公开(公告)号：EP4017986A1

公开(公告)日：2022-06-29

申请号：EP20855101.0

申请日：2020-08-12

Applicant: THE CATHOLIC UNIVERSITY OF AMERICA

Inventor： RAO, Venigalla B. ,  ZHU, Jingen

IPC: C12N15/86 ,  A61K39/12 ,  A61K48/00

公开(公告)号：EP3724145A1

公开(公告)日：2020-10-21

申请号：EP18889139.4

申请日：2018-11-16

Applicant: THE CATHOLIC UNIVERSITY OF AMERICA

Inventor： GONG, Weiliang ,  XU, Hui ,  LUTZE, Werner ,  PEGG, Ian L.

IPC: C04B28/00 ,  C04B14/04 ,  C04B18/08 ,  C04B18/14 ,  C04B20/00 ,  C04B14/10 ,  C04B22/12 ,  C04B103/22

公开(公告)号：EP3458542A1

公开(公告)日：2019-03-27

申请号：EP17798862.3

申请日：2017-05-18

Applicant: THE CATHOLIC UNIVERSITY OF AMERICA

Inventor： GONG, Weilang ,  XU, Hui ,  LUTZE, Werner ,  PEGG, Ian

IPC: C09K8/42 ,  C09K8/46

公开(公告)号：EP2703491B1

公开(公告)日：2017-03-08

申请号：EP13194914.1

申请日：2011-04-08

Applicant: The Catholic University of America

Inventor： Rao, Venigalla

IPC: C12N15/86 ,  C07K14/005 ,  A61K48/00

CPC classification number: C12N15/86 ,  A61K31/7088 ,  A61K31/711 ,  A61K47/48776 ,  A61K47/6901 ,  A61K48/00 ,  C07K14/005 ,  C12N7/00 ,  C12N15/87 ,  C12N15/88 ,  C12N2795/10042 ,  C12N2795/10122 ,  C12N2795/10142 ,  C12N2795/10152

公开(公告)号：EP2925787A2

公开(公告)日：2015-10-07

申请号：EP13858143.4

申请日：2013-11-27

Applicant: THE CATHOLIC UNIVERSITY OF AMERICA

Inventor： RAO, Venigalla B. ,  GAO, Guofen

IPC: C07K19/00 ,  C07K14/155 ,  C12N15/62

CPC classification number: C07K14/005 ,  C07K2319/35 ,  C07K2319/70 ,  C07K2319/735 ,  C12N7/00 ,  C12N7/02 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2795/10122 ,  C12N2795/10123

公开(公告)号：EP2542681A2

公开(公告)日：2013-01-09

申请号：EP11765160.4

申请日：2011-04-08

Applicant: The Catholic University Of America

Inventor： RAO, Venigalla

IPC: C12N15/63 ,  C12N7/01

CPC classification number: C12N15/86 ,  A61K31/7088 ,  A61K31/711 ,  A61K47/6901 ,  A61K48/00 ,  C07K14/005 ,  C12N7/00 ,  C12N15/87 ,  C12N15/88 ,  C12N2795/10042 ,  C12N2795/10122 ,  C12N2795/10142 ,  C12N2795/10152

Abstract: Complex viruses are assembled from simple protein subunits by sequential and irreversible assembly. During genome packaging in bacteriophages, a powerful molecular motor assembles at the special portal vertex of an empty prohead to initiate packaging. An aspect of the invention relates to the phage T4 packaging machine being highly promiscuous, translocating DNA into finished phage heads as well as into proheads. Single motors can force exogenous DNA into phage heads at the same rate as into proheads and phage heads undergo repeated initiations, packaging multiple DNA molecules into the same head. This shows that the phage DNA packaging machine has unusual conformational plasticity, powering DNA into an apparently passive capsid receptacle, including the highly stable virus shell, until it is full. These features allow for the design of a novel class of nanocapsid delivery vehicles.