公开(公告)号：WO1996034850A1

公开(公告)日：1996-11-07

申请号：PCT/US1996006156

申请日：1996-05-02

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ARENDSEN, David, L. ,  ROSENBERG, Saul, H. ,  ROCKWAY, Todd, W. ,  STEIN, Herman, H. ,  FUNG, Anthony, K., L.

IPC: C07C233/60

CPC classification number: C07D207/335 ,  C07C69/74 ,  C07C233/19 ,  C07C233/58 ,  C07C233/60 ,  C07C233/62 ,  C07C233/63 ,  C07C235/06 ,  C07C235/36 ,  C07C235/40 ,  C07C235/80 ,  C07C235/82 ,  C07C237/22 ,  C07C237/24 ,  C07C245/12 ,  C07C251/42 ,  C07C259/06 ,  C07C259/08 ,  C07C275/26 ,  C07C311/07 ,  C07C323/40 ,  C07C327/46 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/12 ,  C07C2602/08 ,  C07D213/20 ,  C07D257/04 ,  C07D257/06 ,  C07D271/113 ,  C07D277/34 ,  C07D307/52 ,  C07D307/58 ,  C07D309/32 ,  C07D317/64 ,  C07D333/20

Abstract: The present invention provides a compound of formula (I) processes for the preparation of the compounds of the invention, intermediates useful in these processes, a pharmaceutical composition, and methods of using the compounds of the invention.

Abstract translation: 本发明提供式（I）化合物，其制备本发明化合物的方法，可用于这些方法的中间体，药物组合物和使用本发明化合物的方法。

公开(公告)号：WO1996034529A1

公开(公告)日：1996-11-07

申请号：PCT/US1996006154

申请日：1996-05-02

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  WARRIOR, Prem ,  HEIMAN, Daniel, F. ,  REHBERGER, Linda, A.

IPC: A01N63/04

CPC classification number: A01N63/04 ,  A01N57/30 ,  A01N47/24 ,  A01N37/06 ,  A01N61/00 ,  A01N2300/00

Abstract: A method for suppressing plant damage by nematodes which comprises the concurrent administration, to the locus, soil or seeds of plants in need of such treatment, of (a) a metabolite of the fungus Myrothecium verrucaria and (b) a chemical pesticide, as well as synergistic nematocidal compositions useful therein.

Abstract translation: 一种抑制线虫的植物损害的方法，其包括同时施用需要这种处理的植物的所在地，土壤或种子，（a）真菌Myrothecium v​​errucaria的代谢物和（b）化学农药，以及 作为其中有用的协同杀线虫组合物。

公开(公告)号：WO1996030027A1

公开(公告)日：1996-10-03

申请号：PCT/US1996003902

申请日：1996-03-22

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ANDERSON, Steven, Neal ,  SCHALLER, Joseph, Paul ,  MAZER, Terrence, Bruce ,  KIRCHNER, Stephen, John

IPC: A61K31/725

CPC classification number: A61K31/737 ,  A61K31/731

Abstract: A method is provided for inhibiting rotavirus infection of human cells by treating the rotavirus with a sulfated polysaccharide. Sulfated polysaccharides include carrageenan and dextran sulfate. The most effective agent in inhibiting cellular rotavirus infection is lambda-carrageenan, which may be formulated in a liquid and ingested enterally. A composition containing lambda-carrageenan is an aspect of the invention.

Abstract translation: 提供了通过用硫酸化多糖处理轮状病毒来抑制人类细胞的轮状病毒感染的方法。 硫酸化多糖包括角叉菜胶和硫酸葡聚糖。 抑制细胞轮状病毒感染的最有效的药剂是λ-角叉菜胶，其可以配制成液体并肠内摄入。 含有λ-角叉菜胶的组合物是本发明的一个方面。

公开(公告)号：WO1996027800A1

公开(公告)日：1996-09-12

申请号：PCT/US1996002495

申请日：1996-02-26

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  WILLIAMS, Gregg, T. ,  GROSKOPF, William, R. ,  BAKER, Harold, N. ,  AGDEPPA, Dalmacio, A.

IPC: G01N33/74

CPC classification number: G01N33/743 ,  C07J41/0016 ,  C07J41/0038 ,  G01N33/535 ,  Y10S435/806 ,  Y10S436/906

Abstract: A method and kit for measurement of a steroid by means of a competitive immunoassay, preferably a competitive enzyme immunoassay. The method and kit involve the use of a steroid analogue conjugated to a label. The steroids that are amenable to detection by the method and kit of the present invention include estradiol and progesterone. The method comprises the steps of: a) incubating a mixture of a test sample suspected of containing a given steroid, a solid phase coupled to an antibody specific for that steroid, and a conjugate of an analogue of that steroid to form steroid/antibody complexes and conjugate/antibody complexes on said solid phase; b) separating said solid phase from said mixture; c) measuring the amount of label present in said mixture or in said solid phase; and d) determining the amount of steroid in said sample from the amount of label. The kit comprises a solid phase coupled to an antibody specific for a steroid and a conjugate of an analogue of that steroid.

Abstract translation: 用于通过竞争性免疫测定（优选竞争性酶免疫测定）测量类固醇的方法和试剂盒。 该方法和试剂盒涉及使用与标记物缀合的类固醇类似物。 适用于通过本发明的方法和试剂盒检测的类固醇包括雌二醇和孕酮。 该方法包括以下步骤：a）将疑似含有给定类固醇的测试样品，与特定于该类固醇的抗体偶联的固相与该类固醇类似物的缀合物孵育以形成类固醇/抗体复合物 和所述固相上的缀合物/抗体复合物; b）从所述混合物中分离所述固相; c）测量所述混合物或所述固相中存在的标记物的量; 和d）从所述标签的量确定所述样品中类固醇的量。 该试剂盒包括与特异于类固醇的抗体和该类固醇类似物的缀合物偶联的固相。

公开(公告)号：WO1996025968A1

公开(公告)日：1996-08-29

申请号：PCT/US1996001402

申请日：1996-01-31

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  PIONTEK, Carl, J. ,  BAKER, Paul, A.

IPC: A61M25/01

CPC classification number: A61M25/0102 ,  A61J15/00 ,  A61J15/0007

Abstract: The present invention is an improved stylet for enteric or nasoenteric feeding tubes. In broadest terms, the present invention comprises: a stylet for a feeding tube, the stylet having: (a) a stylet hub having a bore therethrough and adapted to be attached to one end of the feeding tube, the bore having an inner surface; (b) a longitudinally extending reinforcement member adapted to extend through the feeding tube, the reinforcement member having a proximal end; and (c) a hollow member having an outer surface and having an aperture, the hollow member disposed in the bore so as to hold the inlet end of the reinforcement member between the outer surface and the inner surface through an interference fit.

Abstract translation: 本发明是用于肠或肠内供体管的改进的探针。 本发明包括：用于进料管的探针，所述探针具有：（a）具有穿过其中的孔的探针毂，并且适于附接到所述进料管的一端，所述孔具有内表面; （b）适于延伸通过所述进料管的纵向延伸的加强构件，所述加强构件具有近端; 和（c）具有外表面并具有孔的中空构件，所述中空构件设置在孔中，以便通过过盈配合将加强构件的入口端保持在外表面和内表面之间。

公开(公告)号：WO1996021481A1

公开(公告)日：1996-07-18

申请号：PCT/US1996000368

申请日：1996-01-03

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  GECKLE, Ronita, Kay ,  MAZER, Terrence, Bruce ,  WALTON, Joseph, Edward ,  PIONTEK, Carl, Joseph ,  DUEL, Susan, Beth ,  DAAB-KRZYKOWSKI, Andre ,  McCAMISH, Mark, Anthony ,  JOSEPH, Robert, Louis ,  PIERSON, William, Guy

IPC: A61M05/00

CPC classification number: A61M31/002 ,  A61J15/00 ,  A61J15/0026 ,  A61J15/0069 ,  A61M5/007 ,  A61M5/1407

Abstract: A method is disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient. During enteral tube feeding the nutritional product passes through a formulation chamber, e.g., a drip chamber, having located therein at least one controlled release dosage form unit containing at least one beneficial agent. The beneficial agent may be selected from nutrients, medicaments, probiotics, or diagnostic agents or mixtures thereof, and any such together with a physiologically acceptable marker dye in controlled release dosage form and/or the same or different additional beneficial agent not in controlled release dosage form. Controlled release dosage forms may be of a conventional sustained release type or an osmotically driven delivery device.

Abstract translation: 公开了一种用于在将液体肠内营养产品从供应容器输送到将营养产品输送到患者的胃肠道的喂食管中时，用于修改液体肠内营养产品的方法。 在肠管喂养期间，营养产品通过配制室，例如滴液室，其中至少有一个含有至少一种有益剂的控释剂型单元。 有益药物可以选自营养物质，药物，益生菌或诊断剂或其混合物，以及任何这些与受控释放剂型中的生理上可接受的标记染料和/或不是控制释放剂量的相同或不同的附加有益剂 形成。 控制释放剂型可以是常规的缓释型或渗透驱动的输送装置。

公开(公告)号：WO1996021478A1

公开(公告)日：1996-07-18

申请号：PCT/US1996000364

申请日：1996-01-03

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MAZER, Terrence, Bruce ,  WALTON, Joseph, Edward ,  GECKLE, Ronita, Kay ,  PIONTEK, Carl, Joseph ,  DUEL, Susan, Beth ,  DAAB-KRZYKOWSKI, Andre ,  JOSEPH, Robert, Louis ,  PIERSON, William, Guy ,  LOUGHRIN, Thomas, Daniel ,  OSIP, Thomas, Walter

IPC: A61M05/00

CPC classification number: A61M31/002 ,  A61J15/00 ,  A61J15/0026 ,  A61J15/0069 ,  A61M5/007 ,  A61M5/1407

Abstract: A method for dye-marking a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient includes the steps of: (1) providing apparatus such as a formulation chamber, e.g., a drip chamber, connectable to the supply container, with at least one sustained release reservoir containing a physiologically acceptable and dispersible marker dye positioned within the formulation chamber, and, liquid communication means connecting the formulation chamber to the feeding tube of a patient; (2) providing a supply container containing the nutritional product; (3) connecting the formulation chamber to the supply container and the liquid communication means to the feeding tube; and (4) flowing the dye-marked nutritional product through the apparatus and into the feeding tube. The sustained release reservoir may be a conventional slow release coated tablet, microspheres, or capsule type or an osmotically driven device. The marker dye may be a colorant dye or a fluorescing dye or a mixture thereof. If quick coloration is desired, the sustained release reservoir may be coated with a soluble layer of the marker dye or marker dye not in a sustained release reservoir may be placed in the formulation chamber along with a sustained release reservoir containing dye.

Abstract translation: 液体肠营养产品在从供应容器输送到患者的胃肠道的喂养管中的染色标记方法包括以下步骤：（1）提供诸如制剂室的装置，例如 可连接到所述供应容器的滴水室与至少一个包含位于所述制剂室内的生理上可接受和可分散的标记染料的缓释储存器，以及将所述配制室连接到患者的进料管的液体连通装置; （2）提供容纳营养产品的供应容器; （3）将制剂室与供应容器和液体连通装置连接到进料管; 和（4）使染料标记的营养产品通过设备流入饲管。 持续释放储存器可以是常规的缓释包衣片剂，微球体或胶囊型或渗透驱动装置。 标记染料可以是着色剂染料或荧光染料或其混合物。 如果需要快速着色，则持续释放储存器可以涂覆有标记染料的可溶层或不在持续释放储存器中的标记染料，可以与含有染料的持续释放储存器一起放置在配制室中。

公开(公告)号：WO1996020024A1

公开(公告)日：1996-07-04

申请号：PCT/US1995015967

申请日：1995-12-11

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  RYAN, Enda, B. ,  DUGGAN, Brendan, J.

IPC: A61M25/00

CPC classification number: A61M25/0084 ,  A61M25/0113 ,  A61M2025/0089

Abstract: The catheter insertion device of the present invention includes a catheter dispenser having a catheter outlet extending from a base and a drum receptacle engaged to the base in a rotating relationship. An inlet opening in the base is coaxially aligned with the catheter outlet. A passageway extends from the inlet opening tangentially through the catheter drum to the catheter outlet. A rigid needle is disposed through the passageway so that the sharp tip extends beyond the catheter outlet. A flexible introducer catheter generally contiguously and telescopically surrounds the distal portion of the needle. The introducer catheter extends beyond the catheter outlet to a position on the needle that is proximate to the sharp tip and is operatively associated with the needle for insertion into the vein of a patient. A one way flow valve is in fluid-tight connection with the proximal end of the flexible introducer catheter. The valve forms a portion of the passageway so that when the needle is slidably removed from the passageway the valve minimizes the fluid backflow from the vein. When the catheter drum is rotated relative to the base, the drum catheter is threadably inserted into and through the one way valve, through the indwelling flexible introducer catheter and into the vein of the patient.

Abstract translation: 本发明的导管插入装置包括导管分配器，该导管分配器具有从底座延伸的导管出口和以旋转关系接合到基座的鼓座。 基座中的入口开口与导管出口同轴对准。 通道从入口开口切向通过导管鼓延伸到导管出口。 通过通道设置刚性针，使得尖端延伸超过导管出口。 一个柔性导引导管通常连续地并且可伸缩地围绕针的远端部分。 引导器导管延伸超出导管出口到针的靠近尖端的位置，并且可操作地与针头相关联以插入病人的静脉。 单向流量阀与柔性引导器导管的近端流体密封连接。 阀形成通道的一部分，使得当针从通道滑动地移除时，阀使得流体从静脉回流最小化。 当导管鼓相对于基部旋转时，鼓导管可螺纹地插入并通过单向阀，通过留置的柔性引导器导管并进入患者的静脉。

公开(公告)号：WO1996018302A1

公开(公告)日：1996-06-20

申请号：PCT/US1995015019

申请日：1995-11-28

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HOBBS, David, G.

IPC: A01N63/00

CPC classification number: A01N63/00 ,  A01N25/30 ,  A01N2300/00

Abstract: The present invention relates to a pesticidal composition comprising a Bacillus thuringiensis biopesticide in an ineffective amount for controlling a pest and a surfactant in an effective amount for potentiating the pesticidal activity of the Bacillus thuringiensis biopesticide for controlling the pest or for reducing the amount of the Bacillus thuringiensis biopesticide typically needed to be a commercially effective biopesticide. The present invention further relates to a method for controlling a pest comprising exposing the pest to said pesticidal composition of the present invention.

Abstract translation: 本发明涉及杀虫组合物，其包含无效量的苏云金芽孢杆菌生物农药，用于控制害虫和有效量的表面活性剂，用于增强苏云金芽孢杆菌生物农药的杀虫活性以控制害虫或减少芽孢杆菌的量 苏云金芽孢杆菌生物农药通常需要是商业上有效的生物农药。 本发明还涉及一种用于控制害虫的方法，包括将害虫暴露于本发明的所述杀虫组合物。

公开(公告)号：WO1996013726A1

公开(公告)日：1996-05-09

申请号：PCT/US1995013091

申请日：1995-10-06

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  DOMANIK, Richard, A. ,  SOHL, Gordon ,  KOTLARIK, John ,  ABUNIMEH, Noman

IPC: G01N35/10

CPC classification number: G01N35/1016 ,  G01N2035/102

Abstract: Embodiments disclosed herein provide apparatuses and methods for verifying dispense of a fluid from a dispense nozzle. According to one method, a path of electromagnetic radiation from a source to a receiver is obstructed with the fluid dispensed from the dispense nozzle. The intensity of the electromagnetic radiation received by the receiver is measured. The measured intensity is compared with a predetermined intensity to verify the dispense of fluid from the dispense nozzle. One apparatus for verifying dispense of a fluid comprises a source of electromagnetic radiation, and a receiver of the electromagnetic radiation from the source of the electromagnetic radiation operatively associated with the source of the electromagnetic radiation such that the electromagnetic radiation from the source is received by the receiver. A path followed by the electromagnetic radiation from the source to the receiver is offset from the fluid exiting end of the dispense nozzle by a predetermined distance such that dispense of fluid and a major drop of fluid depending from the fluid exiting end of the dispense nozzle obstruct the path and such that a minor drop of fluid does not obstruct the path.

Abstract translation: 本文公开的实施例提供了用于验证从分配喷嘴分配流体的装置和方法。 根据一种方法，从分配喷嘴分配的流体阻挡从源到接收器的电磁辐射的路径。 测量由接收器接收的电磁辐射的强度。 将测量的强度与预定强度进行比较，以验证从分配喷嘴分配流体。 用于验证流体的分配的一种装置包括电磁辐射源，以及来自电磁辐射源的电磁辐射的接收器，其与电磁辐射源可操作地相关联，使得来自源的电磁辐射由 接收器。 随后从源到接收器的电磁辐射的路径偏离了从分配喷嘴的出口端流出预定距离，使得分配流体和从分配喷嘴的离开的流体离开的主要液滴被阻塞 该路径并且使得一小滴流体不阻碍路径。