中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

176 records (took 0.022 seconds)

    163.
    发明专利
    未知

    公开(公告)号：NO991132L

    公开(公告)日：1999-03-09

    申请号：NO991132

    申请日：1999-03-09

    Applicant: BASF AG

    Inventor： STEINER GERD ,  LUBISCH WILFRIED ,  BACH ALFRED ,  EMLING FRANZ ,  WICKE KARSTEN ,  TESCHENDORF HANS-JUERGEN ,  BEHL BERTHOLD ,  KERRIGAN FRANK ,  CHEETHAM SHARON

    IPC: A61K31/435 ,  A61K31/519 ,  A61P25/24 ,  A61P43/00 ,  C07D211/00 ,  C07D239/00 ,  C07D333/00 ,  C07D495/14 ,  C07D221/00

    Abstract: A 3-substituted 3,4,5,6,7,8-hexahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine compound of formula IwhereinR1 is hydrogen, C1-C4-alkyl, acetyl or benzoyl, optionally substituted phenyl-C1-C4-alkyl, naphthyl-C1-C3-alkyl, phenyl-C2-C3-alkanone or a phenylcarbamoyl-C2-alkyl,R2 is optionally substituted phenyl, pyridyl, pyrimidyl or pyrazinyl, or an optionally substituted bicyclus wherein one of the two fused rings is a phenyl, a pyridyl, a pyrimidyl or a pyrazinyl ring,A is NH or oxygen,B is hydrogen or methyl,C is hydrogen, methyl or hydroxyl,X is nitrogen,Y is CH2, CH2-C2, CH2-C2-CH2 or CH2-CH,Z is nitrogen, C or CH, and the linkage between Y and Z is a single or a double bond, andn is 2, 3 or 4,or a physiologically tolerated salt thereof, and compositions comprising them and their use as antagonists of 5HT1B and 5HT1A and for the treatment of depression and related disorders.

    3-substituted 3,4 dihydro-thieno{2, 3-d}pyrimidine derivatives and production and use of the same
    167.
    发明专利
    3-substituted 3,4 dihydro-thieno{2, 3-d}pyrimidine derivatives and production and use of the same 未知

    公开(公告)号：AU7917698A

    公开(公告)日：1998-12-30

    申请号：AU7917698

    申请日：1998-05-29

    Applicant: BASF AG

    Inventor： STEINER GERD ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  BACH ALFRED ,  WICKE KARSTEN ,  TESCHENDORF HANS-JURGEN ,  GARCIA-LADONA FRANCISCO-JAVIER ,  EMLING FRANZ

    IPC: A61K31/495 ,  A61K31/519 ,  A61P25/00 ,  A61P25/24 ,  A61P43/00 ,  C07D495/04

    Abstract: PCT No. PCT/EP98/03230 Sec. 371 Date Dec. 6, 1999 Sec. 102(e) Date Dec. 6, 1999 PCT Filed May 29, 1998 PCT Pub. No. WO98/56792 PCT Pub. Date Dec. 17, 19983-Substituted 3,4-dihydrothieno[2,3-d]pyrimidine derivatives of the formula I where R1 and R2 are a hydrogen atom or a C1-C4-alkyl group, R3 is a phenyl, pyridyl, pyrimidinyl or pyrazinyl group which is unsubstituted or mono- or disubstituted by halogen atoms, C1-C4-alkyl, trifluoromethyl, trifluoromethoxy, hydroxyl, C1-C4-alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups and which may be fused to a benzene nucleus which may be unsubstituted or mono- or disubstituted by halogen atoms, C1-C4-alkyl, hydroxyl, trifluoromethyl, C1-C4-alkoxy, amino, cyano or nitro groups, and may contain 1 nitrogen atom, or to a 5- or 6-membered ring, which may contain 1-2 oxygen atoms, A is NH or an oxygen atom, Y is CH2, CH2-CH2, CH2-CH2-CH2 or CH2-CH, Z is a nitrogen atom, carbon atom or CH, it being possible for the linkage between Y and Z also to be a double bond, and n is 2, 3 or 4, and the physiologically tolerated salts thereof.

    3-SUBSTITUTED 3,4 DIHYDRO-THIENO[2, 3-D]PYRIMIDINE DERIVATIVES AND PRODUCTION AND USE OF THE SAME
    168.
    发明专利
    3-SUBSTITUTED 3,4 DIHYDRO-THIENO[2, 3-D]PYRIMIDINE DERIVATIVES AND PRODUCTION AND USE OF THE SAME 未知

    公开(公告)号：CA2293816A1

    公开(公告)日：1998-12-17

    申请号：CA2293816

    申请日：1998-05-29

    Applicant: BASF AG

    Inventor： EMLING FRANZ ,  STEINER GERD ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  GARCIA-LADONA FRANCISCO-JAVIER ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN ,  BACH ALFRED

    IPC: A61K31/495 ,  A61K31/519 ,  A61P25/00 ,  A61P25/24 ,  A61P43/00 ,  C07D495/04

    Abstract: The invention relates to 3-substituted 3,4 dihydro-thieno¢2, 3-d! pyrimidine derivatives of formula (I) wherein R1 and R2 mean a hydrogen atom or a C1-C4 alkyl group, R3 represents a phenyl, pyridyl, pyrimidinyl or pyrazinyl group optionally mono- or disubstituted by halogen atoms, C1-C4 alkyl, trifluoromethyl, trifluoromethoxy, hydroxy, C1-C4 alkoxy, amino, monomethylamino, dimethylamino, cyano or nitro groups, said group being optionally anellated with a benzene nucleus which is optionally mono- or disubstituted by halogen atoms, C1-C4 alkyl, hydroxy, trifluoromethyl, C1-C4 alkoxy, amino, cyano or nitro groups and may contain optionally 1 nitrogen atom, or with a 5 or 6-membered ring which may contain 1-2 oxygen atoms, A represents NH or an oxygen atom, Y is CH2, CH2-CH2, CH2-CH2-CH2 or CH2-CH, Z represents a nitrogen atom, carbon atom or CH and the bond between Y and Z can also be a double bond, and n is the number 2, 3 or 4. The invention also relates to the physiologically compatible salts of the inventive 3-substituted 3,4 dihydro-thieno¢2,3-d! pyrimidine derivatives.

    METODO PARA LA EXPRESION PERMANENTE DE RECEPTORES DE GLUTAMATO.
    170.
    发明专利
    METODO PARA LA EXPRESION PERMANENTE DE RECEPTORES DE GLUTAMATO. 未知

    公开(公告)号：MX9604382A

    公开(公告)日：1997-10-31

    申请号：MX9604382

    申请日：1995-03-20

    Applicant: BASF AG

    Inventor： STERRER SYLVIA ,  ULTECH ANDREAS ,  HOGER THOMAS ,  LEMAIRE HANS-GEORG ,  BACH ALFRED

    IPC: G01N33/566 ,  C07K14/705 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/02 ,  C12R1/91

    Abstract: La presente invencion se refiere a un proceso para la preparacion de líneas de células eucarioticas con expresion ectopica permanente de receptores de glutamato mediante la transformacion de las células con un ácido nucleico que codifica los receptores de glutamato, donde cuando menos una de las siguientes condiciones de cultivo se mantiene durante el establecimiento de la linea celular: a) cultivo de las células transformadas en un medio de cultivo que contiene un precursor de glutamato,b) cultivo de las células transformadas en presencia de un antagonista de receptor de glutamato, c) cultivo de las células transformadas en una primera fase en condiciones en las cuales se reprime la expresion de receptor de glutamato, y en una segunda fase en condiciones en las cuales se cancela dicha represion, y, la presente invencion se refiere también a las líneas celulares que pueden obtenerse de esta forma y al uso de las mismas.

Patent Agency Ranking