Abstract:
PROBLEM TO BE SOLVED: To obtain a protein which can neutralize the action of TNFα (tumor necrusis factor α). SOLUTION: This protein has molecular weight of about 42,000 daltons measured by SDS gel electrophoresis and has at the N-terminus an amino acid sequence; Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu (Xaa is H, phenylalanine residue (Phe) or an amino acid sequence; Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe), and a mutein is obtained by subjecting the protein having the TNFα suppressing action to a proper substitution, deletion or addition of an amino acid or peptide or the change of a glycoside group without strongly lowering the TNFα suppressing action. COPYRIGHT: (C)2004,JPO
Abstract:
PROBLEM TO BE SOLVED: To obtain a protein which can neutralize the action of TNFα. SOLUTION: The protein has a molecular weight of about 42,000 daltons in the first glycosylated form and has at the N-terminus an amino acid sequence; Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu (Xaa is H, phenylalanine residue (Phe) or an amino acid sequence; Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe), and the protein and a mutein obtained by the proper substitution, deletion or addition of an amino acid or peptide for/ from/or to/the protein or the change of a glycoside group without strongly lowering the action of the protein are used for suppressing the abnormal increase in the TNF-α.
Abstract:
The invention relates to polypeptides of general structural formula (I) X n -C 1 -X 1-50 -C 2 -X 0-5 -C 3 -X P -C 4 -X 1-100 -C 5 -X 1-50 -C 6 -X 0-5 -C 7 -X 1-50 -C 8 -X m , to their production and use thereof.
Abstract translation:结构通式(I)中X 名词 SUB> -C 1 SUP> X 1-50 SUB> -C 2 SUP> -X多肽 0-5 SUB> -C 3 SUP> X P SUB> -C 4 SUP> X 1-100 SUB> -C 5 SUP> X 1-50 SUB> -C 6 SUP> X 0-5 SUB> -C 7 SUP> X 1-50 SUB> -C 8 SUP> XM(I),它们的制备和用途。
Abstract:
Method for determining the regulatory properties of a genetic element, which comprises the following steps: a) introducing a DNA molecule having a DNA-I sequence whose regulatory properties are to be determined into a cell, said DNA-I sequence being linked with an additional DNA-II sequence encoding a laccase from Aspergillus nidulans in such a manner that the regulatory elements of the DNA-I sequence control expression of the laccase, b) cultivating the cells obtained in step (a) under conditions allowing expression of the laccase, c) associating the conditions selected under (b) with the regulatory properties of the DNA-I sequence.
Abstract:
The invention relates to a cosmetic composition for treating materials containing keratin, mucous membranes and teeth, said composition containing at least one hydrophobin polypeptide sequence (i) X n -C 1 -X 1-50 -C 2 -X 0-5 -C 3 -X p -C 4 -X 1-100 -C 5 -X 1-50 -C 6 -X 0-5 -C 7 -X 1-50 -C 8 -X m (I).
Abstract translation:用于处理角蛋白材料,粘膜和牙齿的化妆品组合物,其包含至少一种疏水蛋白多肽序列(I)中X 名词 SUB> -C 1 SUP> X 1-50 SUB > -C 2 SUP> X 0-5 SUB> -C 3 SUP> X p SUB> -C 4 < / SUP> X 1-100 SUB> -C 5 SUP> X 1-50 SUB> -C 6 SUP> -X < SUB> 0-5 SUB> -C 7 SUP> X 1-50 SUB> -C 8 SUP> X 米 SUB >(I)
Abstract:
The invention relates to novel keratin-binding protein materials and to their production and use. Particularly suitable keratin-binding polypeptides are those sequences that are contained in the human protein desmoplakin or that can be derived from modifications of human desmoplakin polypeptide sequences, such as amino acid insertions, substitutions or deletions. The polypeptide sequence of human desmoplakin is represented in SEQ ID NO: 1. A suitable keratin-binding domain (domain B) is the polypeptide sequence SEQ ID No: 1, position 2193 to 2481 and its functional equivalents. An additional keratin-binding domain (domain C) is the polypeptide sequence SEQ ID NO: 1, position 2606 to 2871 and its functional equivalents.
Abstract translation:本发明涉及新的角蛋白的结合蛋白的药物,其制备和用途。 特别合适的蝼锡结合多肽是包含在人类桥粒斑或通过修改人类Desmoplakinpolypeptidsequenzen如氨基酸插入,取代或它们的衍生缺失的那些序列。 人类桥粒斑蛋白的多肽序列为SEQ ID KO:1。 合适的角蛋白的结合结构域(结构域B)是该多肽序列SEQ ID WO:1点的位置2193至2481年,以及它们的功能等同物。 进一步的角蛋白的结合结构域(结构域C)是该多肽序列SEQ ID NO:1点的位置2606年至2871年,以及它们的功能等同物。
Abstract:
The invention relates to a method for coating fibre substrates selected form textile or leather substrates with the aid of at least one type of hydrophobin.
Abstract:
The invention relates to the use of a hydrophobin or a derivative thereof as an antifoaming agent in additive compositions or in fuels, to a method for defoaming fuels, to an additive and fuel composition containing a hydrophobin or derivative thereof and at least one additional fuel additive, and to a method for producing a fuel composition.
Abstract:
Disclosed are polypeptides of general structural formula (I) X n -C 1 -X 1-50 -C 2 -X 0-5 -C 3 -X 1-100 -C 4 -X 1-100 -C 5 -X 1-50 -C 6 -X 0-5 -C 7 -X 1-50 -C 8 -X m as well as the production and use thereof.
Abstract translation:结构通式(I)中X 名词 SUB> -C 1 SUP> X 1-50 SUB> -C 2 SUP> -X多肽 0-5 SUB> -C 3 SUP> X 1-100 SUB> -C 4 SUP> X 1-100 SUB> -C 5 SUP> X 1-50 SUB> -C 6 SUP> X 0-5 SUB> -C 7 SUP> X 1-50 SUB> -C 8 SUP> X 米 SUB>,它们的制备和用途。