公开(公告)号：WO1982000088A1

公开(公告)日：1982-01-21

申请号：PCT/US1980000839

申请日：1980-07-03

Applicant: PRIME MICROELECTRONIC INSTRUMENTS INC

Inventor： PRIME MICROELECTRONIC INSTRUMENTS INC ,  STEUER R

IPC: A61B05/02

CPC classification number: G04G21/025 ,  A61B5/024 ,  A61B5/02438 ,  A61B5/681 ,  A61B2560/0468

Abstract: A cardiotachometer for indicating heart rate of a user in beats per minute. The cardiotachometer comprises a sensor (12), placed on the body of the user, for producing an electrical signal indicative of the heart rate of the user. Circuitry (28) is provided for converting the electrical signal into first and second digital signals. 60/t computation circuitry (34) responds to the first and second digital signals and produces a third digital signal having a varying frequency representative of the number of heart beats per minute. An up-counter (38) converts the third digital signal into a plurality of binary number signals, each bit of which is stored in a series of shift registers (48). A compare (54) using a plurality of exclusive OR gates, compares each of the stored binary number signals with the most recent binary number signal, from the up-counter, to determine if a plurality of compared signals are within a predetermined percentage of each other. Finally, a display (76) is provided for displaying the most recent binary number signal, when the plurality of compared signals are within the predetermined percentage of each other. Further provision is made for display of both elapsed time and time of day.

Abstract translation: 用于以每分钟的节拍指示用户的心率的心脏测速计。 心脏移动计包括放置在用户身上的传感器（12），用于产生指示用户心率的电信号。 电路（28）用于将电信号转换为第一和第二数字信号。 60 / t计算电路（34）响应第一和第二数字信号并产生具有代表每分钟心跳次数的变化频率的第三数字信号。 上计数器（38）将第三数字信号转换成多个二进制数信号，每个二进制数信号被存储在一系列移位寄存器（48）中。 使用多个异或门的比较（54）将来自上计数器的每个存储的二进制数信号与最新的二进制数信号进行比较，以确定多个比较的信号是否在每个的预定百分比之内 其他。 最后，当多个比较信号在彼此的预定百分比之内时，显示器（76）用于显示最新的二进制数信号。 进一步规定显示经过的时间和时间。

公开(公告)号：WO1981002511A1

公开(公告)日：1981-09-17

申请号：PCT/US1981000298

申请日：1981-03-10

Applicant: SORENSON RESEARCH CO INC

Inventor： SORENSON RESEARCH CO INC ,  REYNOLDS G

IPC: A61B05/02

CPC classification number: A61M5/16877 ,  A61B5/0215 ,  F16K27/0254 ,  Y10S251/903

Abstract: A novel apparatus and method for suppressing unwanted resonance in an electromanometry system. The apparatus includes a compliant air cavity (12) connected through a variable impedance device (14) which is coupled in parallel to the liquid-filled catheter (28) of the electromanometry system. By varying the hydraulic impedance through which the compliant air cavity is coupled to the system, precise impedance matching capability is provided over a wide range of hydraulic impedance values, thereby permitting suppression of unwanted resonance and improved frequency response of recorded waveforms in a wide variety of catheter-transducer systems.

Abstract translation: 一种用于抑制电子测量系统中的不期望的共振的新型装置和方法。 该装置包括通过可变阻抗装置（14）连接的顺应性空气腔（12），该可变阻抗装置（14）并联耦合到电子测量系统的液体填充导管（28）。 通过改变柔性空气腔耦合到系统的液压阻抗，在宽范围的液压阻抗值上提供精确的阻抗匹配能力，从而允许抑制不期望的共振和改善各种各样的记录波形的频率响应 导管换能器系统。

公开(公告)号：WO2005006988A1

公开(公告)日：2005-01-27

申请号：PCT/US2003/019310

申请日：2003-06-19

Applicant: EVEREST BIOMEDICAL INSTRUMENTS ,  CARLSON, Lee R. ,  MCCLATCHIE, Edward A. ,  MARTINOSKY, Joe ,  WALDEN, Ralph ,  CAUSEVIC, Elvir

Inventor： CARLSON, Lee R. ,  MCCLATCHIE, Edward A. ,  MARTINOSKY, Joe ,  WALDEN, Ralph ,  CAUSEVIC, Elvir

IPC: A61B05/02

CPC classification number: A61B5/097 ,  A61B5/08 ,  A61B5/082 ,  A61B5/083 ,  A61B5/0833 ,  A61B5/0836 ,  A61B5/087

Abstract: An improved apparatus and method for capturing and analyzing the end-tidal portion of an exhalation. The CO2 level of air drawn into the system (10) is monitored to distinguish inhalation and exhalation of breath. Upon detection of a decrease in the CO2 level in the air drawn into the system (10), indicating a transition between exhalation and inhalation a pair of flow selector valves (26, 28) are operated to capture the end-tidal volume of air drawn into the system (10) immediately prior to the detection of the decrease in the CO2 level. Incoming air is diverted around the captured volume of air, and the CO2 levels are continually monitored to ensure that the captured volume of air corresponds to the end-tidal portion of an exhalation. Once the captured volume of air is positively identified as the end-tidal portion of an exhalation, the captured volume is routed through a gas analyzer (44) for analysis of one or more predetermined gas levels.

Abstract translation: 一种用于捕获和分析呼气末端部分的改进的装置和方法。 监测吸入系统（10）的空气的二氧化碳含量，以区分吸入和呼气。 当检测到吸入系统（10）的空气中的CO 2水平的降低时，指示呼气和吸入之间的过渡，一对流量选择阀（26,28）被操作以捕获抽出的空气的潮气量 在检测到CO 2水平的降低之前立即进入系统（10）。 进入的空气被转移到捕获的空气体积周围，并且持续监测CO 2水平，以确保所捕获的空气体积对应于呼气的末端潮汐部分。 一旦被捕获的空气量被确定为呼气的末端潮气部分，则捕获的体积被通过气体分析器（44），以分析一个或多个预定气体水平。

公开(公告)号：WO1999023940A1

公开(公告)日：1999-05-20

申请号：PCT/US1997020186

申请日：1997-11-10

Applicant: MEDACOUSTICS, INC. ,  CHASSAING, Charles, E. ,  STEARNS, Scott, Donaldson ,  VANHORN, Mark, Harold ,  RYDEN, Carl, Ashley

Inventor： MEDACOUSTICS, INC.

IPC: A61B05/02

CPC classification number: G01S15/8979 ,  A61B7/04 ,  A61B8/4405 ,  G01S7/52036 ,  G01S7/5205 ,  G01S7/52073 ,  G01S7/52077 ,  G01S7/52079 ,  G01S15/52 ,  G01S15/8906 ,  G01S15/899 ,  G01S15/8993

Abstract: A non-invasive methodology and instrumentation for the detection and localization of abnormal blood flow in a vessel of a patient, are described. An array of sensors (131) is positioned on an area of a patient's body above a volume in which blood flow may be abnormal. Signals detected by the sensor array (13) are processed to display an image which may indicate the presence or absence of abnormal blood flow.

Abstract translation: 描述了用于检测和定位患者血管中的异常血流的非侵入性方法和仪器。 一组传感器（131）位于患者身体的血液流过异常的体积上方。 由传感器阵列（13）检测到的信号被处理以显示可以指示异常血流的存在或不存在的图像。

公开(公告)号：WO1998020792A1

公开(公告)日：1998-05-22

申请号：PCT/US1997021185

申请日：1997-11-13

Applicant: UNIVERSITY TECHNOLOGY CORPORATION

Inventor： UNIVERSITY TECHNOLOGY CORPORATION ,  SHAPIRO, Joseph, Isaac ,  WEINBERGER, Howard, David

IPC: A61B05/02

CPC classification number: A61B7/04 ,  A61B5/0456 ,  A61B5/7203 ,  A61B5/7257 ,  A61B5/726 ,  A61B7/003

Abstract: This invention is an apparatus and method for assisting an operator to diagnose physical conditions in a patient by collecting and analyzing cyclical body sounds such as heart beat, peripheral vessel sounds, or breath sounds. Several cycles of data are collected by sound detector (12) and digitized by an analog to digital converter (28). Each cycle is converted to the frequency domain (102), and phase fixed (104). Then all of the frequency converted and phase fixed cycles are signal averaged (106) together, and the results displayed (108) to the operator. The cycles may be sorted according to respiratory cycle (204, 304, 404), and averaged (210, 310, 410) in two groups. The cycles may be gated according to the patients ECG (206). The apparatus may also suggest diagnoses (218, 318, 418) or further maneuvers (214) to be performed.

Abstract translation: 本发明是一种用于通过收集和分析周期性身体声音（例如心跳，外周血管声音或呼吸音）来帮助操作者诊断患者身体状况的装置和方法。 由声音检测器（12）收集几个数据周期，并由模数转换器（28）数字化。 每个周期被转换为频域（102），相位固定（104）。 然后将所有频率转换和相位固定周期信号平均化（106），结果显示（108）给操作员。 循环可以根据呼吸周期（204,304,404）和平均值（210,310,410）进行分类。 循环可以根据患者心电图门控（206）。 该装置还可以建议要执行的诊断（218,318,418）或进一步的操纵（214）。

公开(公告)号：WO1998006325A1

公开(公告)日：1998-02-19

申请号：PCT/IL1997000240

申请日：1997-07-15

Applicant: I.S. MEDTECH LTD. ,  SKOLETSKY, Ilya

Inventor： I.S. MEDTECH LTD.

IPC: A61B05/02

CPC classification number: A61B5/441 ,  A61B5/01 ,  A61B5/026

Abstract: Apparatus (10) for measuring skin blood flow includes apparatus (12) for applying a predetermined temperature gradient to a portion of skin, thereby to change the temperature thereat from a first temperature to a second temperature; a single temperature sensing element (14) for measuring a temperature at a selected location near the portion of skin; a control apparatus (20) for operating the apparatus (12) for applying a predetermined temperature gradient, and further for operating the temperature sensing element (14) in first and second operative modes; in the first mode the temperature sensing element (14) measuring a first reference temperature at the selected location, and in the second mode the temperature sensing element (14) being operable to measure a second temperature at the selected location; wherein the second mode, the control apparatus (20) operates the apparatus (12) for applying a predetermined temperature gradient so as to maintain the predetermined gradient between the first and second temperatures; and processing apparatus (47) associated with the temperature sensing element (14) for evaluating a skin blood flow corresponding to the measured first and second temperatures, and the electrical steady state power required to maintain the predetermined temperature gradient.

Abstract translation: 用于测量皮肤血​​流的装置（10）包括用于对皮肤的一部分施加预定温度梯度的设备（12），从而将其温度从第一温度改变到第二温度; 单个温度感测元件（14），用于测量皮肤部分附近的选定位置处的温度; 用于操作所述装置（12）以施加预定温度梯度的控制装置（20），并且还用于在第一和第二操作模式下操作温度感测元件（14）; 在所述第一模式中，所述温度感测元件（14）测量所选位置处的第一参考温度，并且在所述第二模式中，所述温度感测元件（14）可操作以测量所选位置处的第二温度; 其中所述第二模式，所述控制装置（20）操作所述装置（12）以施加预定的温度梯度，以便保持所述第一和第二温度之间的预定梯度; 以及与用于评估与所测量的第一和第二温度相对应的皮肤血流的温度感测元件（14）相关联的处理装置（47）以及维持预定温度梯度所需的电稳态功率。

公开(公告)号：WO1997004702A1

公开(公告)日：1997-02-13

申请号：PCT/US1996012321

申请日：1996-07-26

Applicant: EP TECHNOLOGIES, INC.

Inventor： EP TECHNOLOGIES, INC. ,  SWANSON, David, K.

IPC: A61B05/02

CPC classification number: A61B5/6856 ,  A61B5/0422 ,  A61B5/6858 ,  A61B18/12 ,  A61B18/1492 ,  A61B2017/00101 ,  A61B2017/003 ,  A61B2018/00041 ,  A61B2018/00065 ,  A61B2018/00107 ,  A61B2018/00136 ,  A61B2018/00148 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00577 ,  A61B2018/1286 ,  A61B2018/1465 ,  A61B2018/1472 ,  A61B2090/065 ,  A61B2562/0209 ,  A61B2562/043 ,  A61B2562/046 ,  A61N1/3622 ,  A61N1/3702

Abstract: Systems (10) and methods for diagnosing and treating cardiac disorders, transmit an electrical energy pulse that temporarily stuns a zone of myocardial tissue, temporarily rendering it electrically unresponsive. The systems (10) and methods sense an electrophysiological effect due to the transmitted pulse. The systems (10) and methods alter an electrophysiological property of myocardial tissue in or near the zone based, at least in part, upon the sensed electrophysiological effect. The alteration of the electrophysiological property can be accomplished, for example, by tissue ablation or by the administration of medication. In a preferred implementation, radio frequency energy is used to both temporarily stun myocardial tissue, and to ablate myocardial tissue through a common electrode (36).

Abstract translation: 用于诊断和治疗心脏疾病的系统（10）和方法，传输暂时抑制心肌组织区域的电能脉冲，暂时使其无反应。 系统（10）和方法由于传输的脉冲感测电生理作用。 系统（10）和方法至少部分地根据感测到的电生理作用改变区域内或附近的心肌组织的电生理学性质。 电生理特性的改变可以通过例如组织消融或药物给药来实现。 在优选的实施方案中，射频能量用于暂时猝灭心肌组织，并且通过公共电极（36）消融心肌组织。

公开(公告)号：WO1994014371A1

公开(公告)日：1994-07-07

申请号：PCT/US1993012645

申请日：1993-12-23

Applicant: MCINTYRE, Kevin, M.

IPC: A61B05/02

CPC classification number: A61B5/6826 ,  A61B5/02241 ,  A61B5/024 ,  A61B5/222 ,  A61B5/6838 ,  A61B5/7239

Abstract: The invention evaluates the mechanical condition of a heart in a patient (10) by noninvasively providing a pulse signal representative of arterial pulsation by placing a transducer (11) sufficiently close to the skin of the patient (10) to provide an electric signal representative of the arterial pulsation. The patient (10) is subjected to a heart-straining maneuver to provide an arterial pulse contour squarewave signal during the heart-straining maneuver having an early strain phase amplitude at the beginning of the heart-straining maneuver and a later strain amplitude at the end of the heart-straining maneuver. An indication is provided of the ratio of the late strain phase amplitude which ratio is representative of the mechanical condition of the heart of the patient (10). The invention may also provide an indication of the relationship between that ratio and the pulmonary capillary wedge pressure of the patient (10). The invention may also provide an indication of the state of the hydration of the patient (10).

Abstract translation: 本发明通过将换能器（11）放置在足够靠近患者（10）的皮肤的位置，通过非侵入式地提供表示动脉脉动的脉搏信号来评估患者（10）中的心脏的机械状态，以提供代表 动脉搏动。 患者（10）经受心脏应变机动，以在心脏应变动作期间提供动脉脉冲轮廓方波信号，其在心脏应变机动开始时具有早期应变相位振幅，并且在末端的后期应变幅度 的心脏紧张的机动。 提供了该比率代表患者（10）的心脏的机械状态的后期应变相位幅度的比率的指示。 本发明还可以提供该比率与患者（10）的肺毛细血管楔压之间的关系的指示。 本发明还可以提供患者（10）的水合状态的指示。

公开(公告)号：WO1994000050A1

公开(公告)日：1994-01-06

申请号：PCT/US1993005782

申请日：1993-06-16

Applicant: AMERICAN CARDIAC ABLATION CO., INC.

Inventor： AMERICAN CARDIAC ABLATION CO., INC. ,  NARDELLA, Paul, C.

IPC: A61B05/02

CPC classification number: A61B5/0422 ,  A61B18/1206 ,  A61B18/1402 ,  A61B18/1492 ,  A61B2018/00083 ,  A61B2018/0016 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/126 ,  A61B2018/1286 ,  A61B2018/1467

Abstract: A multi-electrode cardiac catheter (10) has pairs of electrodes (13) connected to sensing circuitry (31, 32, 40) to produce a differential signal. The sensing output is sharply defined and self normalizing. Preferably, a catheter ablation tip electrode (12) is an electrode of one pair, and the differential signal becomes non-zero when the tip contacts surrounding tissue. The shape of the differential signal provides information on the degree of electrode contact, as well as on the amount of locally-sensed tissue impedance change. The signal may be used as a trigger enable signal for a cardiac ablation catheter (10), and the applied level of RF power may be controlled based on the indicated degree of electrode contact and value of tissue impedance.

Abstract translation: 多电极心脏导管（10）具有连接到感测电路（31,32,40）的成对电极（13），以产生差分信号。 传感输出被清晰定义并自我归一化。 优选地，导管消融尖端电极（12）是一对电极，并且当尖端接触周围组织时，差分信号变为非零。 差分信号的形状提供关于电极接触程度以及局部感测的组织阻抗变化量的信息。 信号可以用作心脏消融导管（10）的触发使能信号，并且可以基于指示的电极接触程度和组织阻抗的值来控制施加的RF功率水平。

公开(公告)号：WO1993015653A1

公开(公告)日：1993-08-19

申请号：PCT/US1993000858

申请日：1993-02-02

Applicant: IVAC CORPORATION

Inventor： IVAC CORPORATION ,  MARTIN, Stephen, A. ,  BUTTERFIELD, Robert, D.

IPC: A61B05/02

CPC classification number: A61B5/021

Abstract: A method, for use in a non-invasive blood pressure monitoring system, of determining which portion of a stress sensitive element (34) of a tissue stress sensor (20) is best located for detecting the stress of tissue overlying an artery of interest. The tissue stress sensor (20) is placed in communication with tissue overlying the artery of interest and a plurality of electrical signals are obtained therefrom representing stress data across the length of the stress sensitive element (34). Each electrical signal represents stress datum communicated to a predetermined portion of the stress sensitive element. From the stress datum, a centroid of energy is computed and the centroid of energy is used to determine which portion of the stress sensitive element is best located for determining the blood pressure withing the artery of interest. A second method is disclosed which uses the centroid of a tissue foundation flexibility function to determine the best location along the stress sensitive element for determining blood pressure.