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    2-AMINOQUINOLINE DERIVATIVES HAVING D4-AGONISTIC ACTIVITY
    174.
    发明申请
    2-AMINOQUINOLINE DERIVATIVES HAVING D4-AGONISTIC ACTIVITY 审中-公开
    具有D4-激活活性的2-氨基喹啉衍生物

    公开(公告)号：WO9940068A2

    公开(公告)日：1999-08-12

    申请号：PCT/EP9900855

    申请日：1999-02-05

    Applicant: DUPHAR INT RES ,  HARTOG JACOBUS A J ,  VISSER GERBEN M ,  STEEN BARTHOLOMEUS J VAN ,  TULP MARTINUS T M ,  RONKEN ERIC ,  KRUSE CORNELIS G

    Inventor： DEN HARTOG JACOBUS A J ,  VISSER GERBEN M ,  VAN STEEN BARTHOLOMEUS J ,  TULP MARTINUS T M ,  RONKEN ERIC ,  KRUSE CORNELIS G

    IPC: A61K31/4709 ,  A61K31/496 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P43/00 ,  C07D201/00 ,  C07D215/38 ,  C07D401/12 ,  C07D405/12 ,  C07D

    CPC classification number: C07D215/38 ,  C07D401/12 ,  C07D405/12

    Abstract: The present invention relates to a group of novel 2-aminoquinoline derivatives which are potent and selective agonists of the dopamine D4-receptor. The compounds have general formula (I) wherein (R1)n represents 1 or 2 substituents, which can be the same or different, from the group C1-3-alkyl or alkoxy, halogen, trifluoromethyl, nitro, amino, and mono- or dialkyl (C1-2)-amino, or two groups R1 at adjacent carbon atoms together with the benzene ring may form the benzdioxane group or benzofuran group, X represents nitrogen or carbon, and the dotted line may represent a double bond, (R2)p represents 0, 1 or 2 substituents, which can be the same or different, from the group methyl and ethyl, or (R2)p is a methylene bridge or ethylene bridge, R3 is hydrogen or methyl, and (R)m represents 0, 1, or 2 substituents, which can be the same or different and can be located at all available positions of the quinolyl group, from the group C1-3-alkyl or alkoxy, halogen, trifluoromethyl, nitro, amino, and mono- or dialkyl (C1-2)-amino, on the understanding that R1 cannot represent o-OCH3 when X is nitrogen, (R2)p and R3 are hydrogen, m is 0 and n is 1.

    Abstract translation: 本发明涉及一组新的2-氨基喹啉衍生物，其是多巴胺D4-受体的有效和选择性激动剂。 化合物具有通式（I），其中（R1）n表示1或2个可以相同或不同的取代基，可以是C1-3 - 烷基或烷氧基，卤素，三氟甲基，硝基，氨基和单 - 或 二烷基（C1-2） - 氨基或两个相邻碳原子的R1与苯环一起形成苯并二恶烷基或苯并呋喃基，X表示氮或碳，虚线表示双键，（R2） p表示0,1或2个与甲基和乙基基团相同或不同的取代基，或（R2）p是亚甲基桥或乙烯桥，R3是氢或甲基，（R）m表示0 ，1或2个取代基，其可以相同或不同，并且可以位于喹啉基的所有可用位置，C 1-3 - 烷基或烷氧基，卤素，三氟甲基，硝基，氨基和单 - 或 二烷基（C 1-2） - 氨基，但应理解，当X为氮时，R 1不能表示o-OCH 3，（R 2）p和R 3为氢，m为0，n为 是1。

    PHOTOACTIVE MATERIAL
    176.
    发明申请
    PHOTOACTIVE MATERIAL 审中-公开

    公开(公告)号：WO2022129595A1

    公开(公告)日：2022-06-23

    申请号：PCT/EP2021/086629

    申请日：2021-12-17

    Applicant: CAMBRIDGE DISPLAY TECHNOLOGY LTD. ,  SUMITOMO CHEMICAL CO., LTD.

    Inventor： MACIEJCZYK, Michal ,  KAMTEKAR, Kiran ,  BOURCET, Florence

    IPC: H01L51/46 ,  C07D201/00 ,  C07D403/00 ,  C07D409/00 ,  C08G61/00 ,  C08G73/00

    Abstract: A material comprising an electron-accepting unit of formula (I): Ar is an aromatic ring; Ar1 is a substituted or unsubstituted 5- or 6-membered heteroaromatic ring containing N and C ring atoms; when Ar1 is a substituted or unsubstituted 6-membered heteroaromatic ring, Ar2 is a substituted or unsubstituted 6-membered heteroaromatic ring wherein the ring atoms are selected from N and C; when Ar1 is a 5-membered heteroaromatic ring, Ar2 is a substituted or unsubstituted 5- or 6-membered heteroaromatic ring; Ar3 is a 5-membered ring or a substituted or unsubstituted 6-membered ring; Ar4 is a 5-membered ring or a substituted or unsubstituted 6-membered ring or is absent; Ar5 is a substituted or unsubstituted monocyclic or polycyclic group containing at least one aromatic or heteroaromatic ring; Ar6 is a substituted or unsubstituted monocyclic or polycyclic group containing at least one aromatic or heteroaromatic ring or is absent; and each X is independently a substituent bound to a C atom of Ar3, and where present Ar4, with the proviso that at least one X is an electron withdrawing group; and wherein the material further comprises an electron-donating unit.

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