公开(公告)号：US20090281321A1

公开(公告)日：2009-11-12

申请号：US12505079

申请日：2009-07-17

Applicant: George Wu ,  Anantha R. Sudhakar ,  Tao Wang ,  Ji Xie ,  Frank Xing Chen ,  Marc Poirier ,  Mingsheng Huang ,  Vijay Sabesan ,  Daw-long Kwok ,  Jian Cui ,  Xiaojing Yang ,  Tiruvettipuram K. Thiruvengadam ,  Jing Liao ,  Ilia A. Zavialov ,  Hoa N. Nguyen ,  Ngiap Kie Lim

Inventor： George Wu ,  Anantha R. Sudhakar ,  Tao Wang ,  Ji Xie ,  Frank Xing Chen ,  Marc Poirier ,  Mingsheng Huang ,  Vijay Sabesan ,  Daw-long Kwok ,  Jian Cui ,  Xiaojing Yang ,  Tiruvettipuram K. Thiruvengadam ,  Jing Liao ,  Ilia A. Zavialov ,  Hoa N. Nguyen ,  Ngiap Kie Lim

IPC: C07C69/608 ,  C07D405/08 ,  C07F9/40 ,  C07D307/92 ,  C07D417/08 ,  C07D277/64

CPC classification number: C07D263/56 ,  C07C69/606 ,  C07C69/732 ,  C07C201/10 ,  C07C201/12 ,  C07C205/44 ,  C07C205/55 ,  C07C231/10 ,  C07C231/12 ,  C07C235/28 ,  C07C303/32 ,  C07C309/08 ,  C07C2601/16 ,  C07D277/64 ,  C07D307/92 ,  C07D333/56 ,  C07D405/06 ,  C07D413/06 ,  C07D417/06 ,  C07F7/1804 ,  C07F9/58 ,  Y02P20/55 ,  C07C233/28

Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:

Abstract translation: 本申请公开了一种制备可用作凝血酶受体拮抗剂的烟肼类似物的新方法。 该方法部分基于使用手性硝基中心的碱促进的动态差向异构化。 本文教导的化学结构可以举例说明如下：

公开(公告)号：US07309802B2

公开(公告)日：2007-12-18

申请号：US10417083

申请日：2003-04-17

Applicant: Joachim Rheinheimer ,  Wolfgang von Deyn ,  Joachim Gebhardt ,  Michael Rack ,  Rene Lochtman ,  Norbert Götz ,  Michael Keil ,  Matthias Witschel ,  Helmut Hagen ,  Ulf Misslitz ,  Ernst Baumann

Inventor： Joachim Rheinheimer ,  Wolfgang von Deyn ,  Joachim Gebhardt ,  Michael Rack ,  Rene Lochtman ,  Norbert Götz ,  Michael Keil ,  Matthias Witschel ,  Helmut Hagen ,  Ulf Misslitz ,  Ernst Baumann

IPC: C07C239/08

CPC classification number: C07C249/06 ,  C07C201/10 ,  C07C201/12 ,  C07C205/44 ,  C07C209/62 ,  C07C251/48 ,  C07C253/00 ,  C07C255/50 ,  C07C315/04 ,  C07C319/14 ,  C07D261/04 ,  C07D413/10 ,  C07C323/09 ,  C07C317/24 ,  C07C317/32 ,  C07C205/06 ,  C07C211/52

Abstract: A process is described for preparing isoxazoles of the formula I where the substituents are as defined below: R1 is hydrogen, C1-C6-alkyl, R2 is C1-C6-alkyl, R3, R4, R5 are hydrogen, C1-C6-alkyl, or R4 and R5 together form a bond, R6 is a heterocyclic ring, n is 0, 1 or 2; which comprises preparing an intermediate of the formula VI where R1, R3, R4 and R5 are as defined above, followed by halogenation, thiomethylation, oxidation and acylation to give compounds of the formula I. Also novel intermediates for preparing the compounds of the formula I and novel processes for preparing the intermediates are described.

Abstract translation: 描述了制备式I的异恶唑的方法，其中取代基如下所定义：R 1是氢，C 1 -C 6 - - 烷基，R 2是C 1 -C 6 - 烷基，R 3，R 4， R 5是氢，C 1 -C 6 - 烷基或R 4和/或 R 5一起形成键，R 6是杂环，n是0,1或2; 其包括制备式VI的中间体，其中R 1，R 3，R 4和R 5如上定义，然后进行卤化，硫甲基化，氧化和酰化，得到式I化合物。还有用于制备式I化合物的中间体 并描述了制备中间体的新方法。

公开(公告)号：US20070161800A1

公开(公告)日：2007-07-12

申请号：US11684630

申请日：2007-03-11

Applicant: Joachim Rheinheimer ,  Wolfgang von Deyn ,  Joachim Gebhardt ,  Michael Rack ,  Rene Lochtman ,  Norbert Gotz ,  Michael Keil ,  Matthias Witschel ,  Helmut Hagen ,  Ulf Misslitz ,  Ernst Boumann

Inventor： Joachim Rheinheimer ,  Wolfgang von Deyn ,  Joachim Gebhardt ,  Michael Rack ,  Rene Lochtman ,  Norbert Gotz ,  Michael Keil ,  Matthias Witschel ,  Helmut Hagen ,  Ulf Misslitz ,  Ernst Boumann

IPC: C07D261/02 ,  C07C317/32

CPC classification number: C07C249/06 ,  C07C201/10 ,  C07C201/12 ,  C07C205/44 ,  C07C209/62 ,  C07C251/48 ,  C07C253/00 ,  C07C255/50 ,  C07C315/04 ,  C07C319/14 ,  C07D261/04 ,  C07D413/10 ,  C07C323/09 ,  C07C317/24 ,  C07C317/32 ,  C07C205/06 ,  C07C211/52

Abstract: A process is described for preparing isoxazoles of the formula I where the substituents are as defined below: R1 is hydrogen, C1-C6-alkyl, R2 is C1-C6-alkyl, R3, R4, R5 are hydrogen, C1-C6-alkyl, or R4 and R5 together form a bond, R6 is a heterocyclic ring, n is 0, 1 or 2; which comprises preparing an intermediate of the formula VI where R1, R3, R4 and R5 are as defined above, followed by halogenation, thiomethylation, oxidation and acylation to give compounds of the formula I. Also novel intermediates for preparing the compounds of the formula I and novel processes for preparing the intermediates are described.

Abstract translation: 描述了制备式I的异恶唑的方法，其中取代基如下所定义：R 1是氢，C 1 -C 6 - - 烷基，R 2是C 1 -C 6 - 烷基，R 3，R 4， R 5是氢，C 1 -C 6 - 烷基或R 4和/或 R 5一起形成键，R 6是杂环，n是0,1或2; 其包括制备式VI的中间体，其中R 1，R 3，R 4和R 5如上定义，然后进行卤化，硫甲基化，氧化和酰化，得到式I化合物。还有用于制备式I化合物的中间体 并描述了制备中间体的新方法。

公开(公告)号：US06437168B1

公开(公告)日：2002-08-20

申请号：US09941826

申请日：2001-08-29

Applicant: Kouichi Hirota

Inventor： Kouichi Hirota

IPC: C07C25500

CPC classification number: C07C201/10 ,  C07B39/00 ,  C07C17/208 ,  C07C253/30 ,  C07C255/50 ,  C07C205/12

Abstract: A method for efficiently extracting a reaction product containing a target aromatic fluorine compound formed by the halogen exchange reaction of an aromatic chlorine compound with a fluorinating agent quickly from the reaction vessel without suffering part of the reaction product to remain as a residue inside the reaction vessel is disclosed. Specifically, the reaction product is extracted from the reactor subsequently to the halogen exchange reaction at a temperature in the range of 20-250° C. By this method, the reaction product formed in consequence of the halogen exchange reaction can be efficiently extracted quickly from the reaction vessel, and that without suffering occurrence of a residue of the reaction product.

Abstract translation: 通过芳族氯化合物与氟化剂的卤素交换反应形成的目标芳香族氟化合物的反应产物从反应容器中快速提取而不会产生部分反应产物残留在反应容器内部的方法 被披露。 具体地说，在20-250℃的温度下，从反应器中抽出反应产物进行卤素交换反应。通过这种方法，由于卤素交换反应而形成的反应产物可以从 反应容器，并且不会发生反应产物的残留物。

公开(公告)号：US5998661A

公开(公告)日：1999-12-07

申请号：US100782

申请日：1998-06-15

Applicant: Abdollah Bashir-Hashemi

Inventor： Abdollah Bashir-Hashemi

IPC: C07C201/10 ,  C07C205/05 ,  C07C205/57 ,  C07C205/00 ,  C07C61/08

CPC classification number: C07C201/10 ,  C07C2103/74 ,  C07C2103/90

Abstract: A process for selective, direct oxidation of amine or amine hydrochloride mpounds is described. It uses mixed oxidizing agents of monopersulfate and ozone.

Abstract translation: 描述了胺或胺盐酸盐化合物的选择性，直接氧化的方法。 它使用单过硫酸盐和臭氧的混合氧化剂。

公开(公告)号：US4038328A

公开(公告)日：1977-07-26

申请号：US645983

申请日：1976-01-02

Applicant: Heinrich Pelster ,  Uwe Beck

Inventor： Heinrich Pelster ,  Uwe Beck

IPC: C07C309/42 ,  C07C67/00 ,  C07C201/00 ,  C07C205/26 ,  C07C301/00 ,  C07C303/06 ,  C07C303/22 ,  C07C79/32 ,  C07C39/26

CPC classification number: C07C201/10 ,  C07C303/06 ,  C07C303/22

Abstract: 2-NITRO-4,6-DICHLORO-5-METHYLPHENOL IS PREPARED BY THE SULFONATION OF 4-CHLORO-5-METHYLPHENOL TO FORM 2-SULFO-4-CHLORO-5-METHYLPHENOL WHICH IS CHLORINATED TO 2-SULFO-4,6-DICHLORO-5-METHYLPHENOL WHICH IS IN TURN REACTED WITH NITRIC ACID TO FORM THE DESIRED PRODUCT. The sulfonation is carried out with concentrated sulfuric acid at elevated temperatures to form 2-sulfo-4-chloro-5-methylphenol. Thereafter the reaction mixture is diluted with water to a sulfuric acid content of 20-30%. The resulting 2-sulfo-4-chloro-5-methylphenol is chlorinated with chlorine at elevated temperature and normal or elevated pressures to form 2-sulfo-4,6-dichloro-5-methylphenol which is then reacted with nitric acid.

公开(公告)号：US3903178A

公开(公告)日：1975-09-02

申请号：US24137672

申请日：1972-04-05

Applicant: FUJI PHOTO FILM CO LTD

Inventor： NAKAMURA SUSUMU ,  NISHIO DAIJIRO ,  YOKOTA YUKIO

IPC: C07C205/26 ,  C07C37/00 ,  C07C37/04

CPC classification number: C07C201/10 ,  C07C205/26

Abstract: A method for preparing 2-nitro-4, 6-dichloro-5-methylphenol and the corresponding 2-amino compound comprising sulfonating 4chloro-5-methylphenol with a sulfuric anhydride complex in a halogenated hydrocarbon solvent, chlorinating the thus obtained 2-sulfo-4-chloro-5-methylphenol, replacing the sulfonic group of the resulting 2-sulfo-4, 6-dichloro-5-methylphenol with a nitro group and, when the 2-amino compound is required, reducing the nitro group to the amino group is disclosed. The product is useful as an intermediate in preparing a cyan coupler.

Abstract translation: 一种制备2-硝基-4,​​6-二氯-5-甲基苯酚和相应的2-氨基化合物的方法，包括在卤代烃溶剂中用硫酸酐络合物磺化4-氯-5-甲基苯酚，氯化所得2- 磺基-4-氯-5-甲基苯酚，用硝基取代所得2-磺基-4,6-二氯-5-甲基苯酚的磺酸基，当需要2-氨基化合物时，将硝基还原成 公开了氨基。

公开(公告)号：US3544640A

公开(公告)日：1970-12-01

申请号：US3544640D

申请日：1967-03-10

Applicant: NORTH AMERICAN ROCKWELL

Inventor： FRANKEL MILTON B ,  ROWLEY GERALD L

IPC: C06B25/04 ,  C07C201/12 ,  C07C205/04 ,  C07C205/09 ,  C07C79/10 ,  C07C79/12

CPC classification number: C06B25/04 ,  C07C201/10 ,  C07C201/12 ,  C07C205/04 ,  C07C205/09

公开(公告)号：US2791604A

公开(公告)日：1957-05-07

申请号：US56818356

申请日：1956-02-28

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： BLACKWOOD ROBERT K ,  NATHAN KORNBLUM

IPC: C07C205/51 ,  C07C205/53

CPC classification number: C07C201/10 ,  C07C205/51

公开(公告)号：US2780657A

公开(公告)日：1957-02-05

申请号：US40214254

申请日：1954-01-04

Applicant: CALIFORNIA RESEARCH CORP

Inventor： TOLAND JR WILLIAM G

IPC: C07C201/10 ,  C07C205/06

CPC classification number: C07C201/10 ,  C07C205/06