公开(公告)号：US20170248576A1

公开(公告)日：2017-08-31

申请号：US15441401

申请日：2017-02-24

Applicant: SYSMEX CORPORATION

Inventor： Naoto Nishimura ,  Tsuyoshi Fukuzaki

IPC: G01N33/49 ,  G01N21/13 ,  G01N21/27 ,  G01N15/06 ,  G01N21/25

CPC classification number: G01N33/4905 ,  G01N15/06 ,  G01N21/13 ,  G01N21/255 ,  G01N21/27 ,  G01N21/272 ,  G01N21/274 ,  G01N21/314 ,  G01N21/3151 ,  G01N21/59 ,  G01N21/77 ,  G01N21/78 ,  G01N33/492 ,  G01N33/86 ,  G01N2015/0693 ,  G01N2021/135 ,  G01N2021/3148 ,  G01N2021/3181 ,  G01N2021/3188 ,  G01N2021/7783 ,  G01N2201/06153 ,  G01N2201/0631 ,  G01N2201/0826 ,  G02B6/00 ,  G02B6/0008 ,  G02B6/4204 ,  G02B6/4228

Abstract: A blood coagulation analyzer comprises: a light irradiation unit configured to apply light onto a container configured to store a measurement specimen containing a sample and a reagent, and comprising: light sources including a first light source configured to generate light of a first wavelength for blood coagulation time measurement, a second light source configured to generate light of a second wavelength for synthetic substrate measurement, and a third light source configured to generate light of a third wavelength for immunonephelometry measurement; and optical fiber parts facing the respective light sources; a light reception part configured to receive light transmitted through the container; and an analysis unit configured to analyze the sample using an electric signal outputted from the light reception part.

公开(公告)号：US20170216846A1

公开(公告)日：2017-08-03

申请号：US15429765

申请日：2017-02-10

Applicant: STOKES BIO LIMITED

Inventor： Mark DAVIES ,  Tara DALTON

IPC: B01L7/00 ,  C12Q1/68 ,  B01L3/00

CPC classification number: B01L7/525 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502784 ,  B01L2200/0673 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/0838 ,  B01L2300/0867 ,  B01L2300/18 ,  B01L2300/1822 ,  B01L2300/185 ,  B01L2400/0487 ,  C12Q1/686 ,  G01N21/6428 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A thermal cycling device comprising a number of fixed thermal zones and a fixed conduit passing through the thermal zones. A controller maintains each thermal zone including its section of conduit at a constant temperature. A series of droplets flows through the conduit so that each droplet is thermally cycled, and a detection system detects fluorescence from droplets at all of the thermal cycles. The conduit is in a single plane, and so a number of thermal cycling devices may be arranged together to achieve parallelism. The flow conduit comprises a channel and a capillary tube inserted into the channel. The detection system may perform scans along a direction to detect radiation from a plurality of cycles in a pass.

公开(公告)号：US09714899B2

公开(公告)日：2017-07-25

申请号：US15027179

申请日：2014-11-18

Applicant: versalis S.p.A.

Inventor： Francesco Bonacini ,  Erik Mantovani ,  Angelo Ferrando

IPC: C08F2/00 ,  C08F4/00 ,  C08F12/02 ,  G01N21/27 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/85 ,  C08F112/08

CPC classification number: G01N21/272 ,  C08F112/08 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/8507 ,  G01N2201/061 ,  G01N2201/0826 ,  G01N2201/13

Abstract: The present invention relates to a method for monitoring a control parameter of a polymerization reaction mixture in heterogeneous phase comprising the following steps: (a) acquiring at least one NIR reflectance spectrum of said mixture; (b) calculating a value of said control parameter by means of a calibration curve which correlates the NIR reflectance spectrum with the values of said control parameter measured with a reference measurement method. The present invention also relates to an apparatus for implementing said method.

公开(公告)号：US20170184578A1

公开(公告)日：2017-06-29

申请号：US15457728

申请日：2017-03-13

Applicant: TRUSTEES OF TUFTS COLLEGE

Inventor： DAVID R. WALT ,  KARRI LYNN MICHAEL-BALLARD

IPC: G01N33/543 ,  G01N21/77 ,  G01N21/64 ,  G01N21/78

CPC classification number: G01N15/1456 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00459 ,  B01J2219/00466 ,  B01J2219/005 ,  B01J2219/00524 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00704 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/0074 ,  B82Y30/00 ,  C12Q1/6837 ,  C40B40/06 ,  C40B40/10 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/7703 ,  G01N21/78 ,  G01N33/543 ,  G01N33/54313 ,  G01N2015/1438 ,  G01N2021/6441 ,  G01N2021/6484 ,  G01N2035/0097 ,  G01N2201/0826 ,  Y02A50/55 ,  Y10S435/808 ,  Y10S436/805

Abstract: A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered fashion and dispersed on a substrate to form an array while maintaining the ability to identify the location of bioactive agents and particles within the array using an optically interrogatable, optical signature encoding scheme. A wide variety of modified substrates may be employed which provide either discrete or non-discrete sites for accommodating the microspheres in either random or patterned distributions. The substrates may be constructed from a variety of materials to form either two-dimensional or three-dimensional configurations. In a preferred embodiment, a modified fiber optic bundle or array is employed as a substrate to produce a high density array. The disclosed system and method have utility for detecting target analytes and screening large libraries of bioactive agents.

公开(公告)号：US09488574B2

公开(公告)日：2016-11-08

申请号：US12682939

申请日：2008-10-13

Applicant: Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

Inventor： Thomas Koehler ,  Tim Nielsen ,  Bernhard Brendel ,  Andy Ziegler ,  Ronny Ziegler ,  Levinus Pieter Bakker ,  Martinus Bernardus Van Der Mark

IPC: G01N21/47 ,  A61B5/00 ,  G01N21/17

CPC classification number: G01N21/4795 ,  A61B5/0073 ,  A61B5/0091 ,  A61B5/4312 ,  A61B2562/146 ,  G01N2021/1787 ,  G01N2201/0826 ,  G01N2201/0833

Abstract: A device (1) for imaging the interior of an optically turbid medium is provided. The device comprises a receptacle (3; 103) structured to accommodate an optically turbid medium for examination and an optically matching medium filling a space between an inner surface (6; 106) of the receptacle (3; 103) and the optically turbid medium. The device comprises at least one light source generating light to be coupled into the receptacle (3; 103) and at least one detector for detecting light emanating from the receptacle (3; 103). A coupling surface (10; 110) optically coupled to the inner surface (6; 106) of the receptacle and a coupling member (11; 111) optically coupled to the light source and the detector are provided. The coupling surface (10; 110) and the coupling member (11; 111) are movable to a plurality of different positions relative to each other and structured to establish an optical connection from the light source to the inner surface (6; 106) of the receptacle and from the inner surface (6; 106) of the receptacle to the at least one detector in the plurality of different positions.

Abstract translation: 提供了用于对光学混浊介质的内部成像的装置（1）。 该装置包括构造成容纳用于检查的光学混浊介质的容器（3; 103）和填充容器（3; 103）的内表面（6; 106）与光学混浊介质之间的空间的光学匹配介质。 所述装置包括至少一个光源，其产生要耦合到所述插座（3; 103）中的光和至少一个用于检测从所述插座（3; 103）发出的光的检测器。 光耦合到容器的内表面（6; 106）的耦合表面（10; 110）和光学耦合到光源和检测器的耦合构件（11; 111）。 联接表面（10; 110）和联接构件（11; 111）可以相对于彼此移动到多个不同的位置，并被构造成建立从光源到内表面（6; 106）的光学连接 所述容器和所述容器的内表面（6; 106）到所述多个不同位置中的所述至少一个检测器。

公开(公告)号：US20160299071A1

公开(公告)日：2016-10-13

申请号：US15038583

申请日：2014-12-08

Applicant: PURAC BIOCHEM BV

Inventor： Gerrit GOBIUS DU SART ,  Jan Arie NIESSEN ,  Vincent DE JONG

IPC: G01N21/59 ,  C07D319/12

CPC classification number: G01N21/59 ,  C07D319/12 ,  G01N21/359 ,  G01N2201/0826 ,  G01N2201/12

Abstract: A method for quantification of the amount of impurities in lactide. The method is characterized in that the quantification of the impurities is based on measurements performed on absorptions in the near Infra-Red region of the electromagnetic spectrum. With this method, small amounts of impurities like water, free-acid species or both can be determined online in a reaction mixture of lactide in a relatively simple manner. This allows a simple online monitoring of the production process of lactide.

Abstract translation: 用于定量丙交酯中的杂质量的方法。 该方法的特征在于杂质的定量是基于对电磁光谱的近红外区域的吸收进行的测量。 通过这种方法，可以在相对简单的方式在丙交酯的反应混合物中在线测定少量的杂质如水，游离酸物质或两者。 这允许简单的在线监测丙交酯的生产过程。

公开(公告)号：US20160296121A1

公开(公告)日：2016-10-13

申请号：US15144478

申请日：2016-05-02

Applicant: SENO MEDICAL INSTRUMENTS, INC.

Inventor： Donald G. Herzog ,  Thomas G. Miller

IPC: A61B5/00 ,  G02B6/36 ,  G01N21/17 ,  A61B8/00 ,  A61B5/1455

CPC classification number: A61B5/0095 ,  A61B5/0035 ,  A61B5/0091 ,  A61B5/14551 ,  A61B5/6844 ,  A61B5/7425 ,  A61B5/7445 ,  A61B5/7475 ,  A61B8/0825 ,  A61B8/4281 ,  A61B8/4444 ,  A61B8/4483 ,  F04C2270/041 ,  G01N21/1702 ,  G01N2201/067 ,  G01N2201/068 ,  G01N2201/0826 ,  G02B6/3624

Abstract: A handheld optoacoustic probe includes an ultrasound transducer array and optical fibers with a first end formed into a fiber bundle providing an input and a second, distal end providing an output. A light bar guide retains the distal end of the optical fibers on the same plane. One or more optical windows may be associated with, and spaced from the light bar guide so as to prevent contact between a coupling agent and the distal ends of the optical fibers, thus mitigating a potential acoustic effect of the coupling agent in response to light emitting from the fibers. A silicon rubber acoustic lens doped with TiO2 may be provided, with a reflective metal surrounding the outer surface of the acoustic lens. A handheld probe shell houses the light bar guide, the ultrasound transducer array, and the acoustic lens.

公开(公告)号：US20160209432A1

公开(公告)日：2016-07-21

申请号：US14977350

申请日：2015-12-21

Applicant: Blood Cell Storage, Inc.

Inventor： Michael W. Reed ,  Steven J. Geelhood ,  Paul C. Harris ,  Lynn M. Barker ,  Perry Hargrave ,  Oliver Z. Nanassy

IPC: G01N33/84 ,  G01N21/80 ,  G01N21/64 ,  G01N33/66

CPC classification number: G01N33/84 ,  C12Q1/04 ,  C12Q1/22 ,  C12Q1/54 ,  G01N21/6428 ,  G01N21/77 ,  G01N21/80 ,  G01N33/492 ,  G01N33/542 ,  G01N33/582 ,  G01N33/66 ,  G01N2021/6421 ,  G01N2021/6434 ,  G01N2021/6484 ,  G01N2021/7786 ,  G01N2201/062 ,  G01N2201/068 ,  G01N2201/0826 ,  G01N2201/084 ,  G01N2400/00

Abstract: System and method for detecting and measuring chemical perturbations in a sample. The system and method are useful for non-invasive pH monitoring of blood or blood products sealed in storage bags.

Abstract translation: 用于检测和测量样品中化学扰动的系统和方法。 该系统和方法可用于密封在储存袋中的血液或血液制品的非侵入性pH监测。

公开(公告)号：US20150018642A1

公开(公告)日：2015-01-15

申请号：US13941369

申请日：2013-07-12

Applicant: Sandeep Gulati ,  Thomas George ,  Timothy Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

Inventor： Sandeep Gulati ,  Thomas George ,  Timothy Ruchti ,  Alan Abul-Haj ,  Kevin H. Hazen

IPC: A61B5/1455 ,  A61B5/00 ,  A61B5/145

CPC classification number: G01J3/42 ,  A61B5/0022 ,  A61B5/1079 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/6801 ,  G01N21/474 ,  G01N2021/4742 ,  G01N2021/4747 ,  G01N2201/0826

Abstract: An analyzer apparatus and method of use thereof is configured to dynamically interrogate a sample. For example, an analyzer using light interrogates a tissue sample using a temporal resolution system on a time scale of less than about one hundred nanoseconds. Optionally, near-infrared photons are introduced to a sample with a known illumination zone to detection zone distance allowing calculation of parameters related to photon pathlength in tissue and/or molar absorptivity of an individual or group through the use of the speed of light and/or one or more indices of refraction. Optionally, more accurate estimation of tissue properties are achieved through use of: knowledge of incident photon angle relative to skin, angularly resolved detector positions, anisotropy, skin temperature, environmental information, information related to contact pressure, blood glucose concentration history, and/or a skin layer thickness, such as that of the epidermis and dermis.

Abstract translation: 分析装置及其使用方法被配置为动态询问样品。 例如，使用光的分析器使用时间分辨率系统在小于约百纳秒的时间尺度上询问组织样品。 可选地，将近红外光子引入具有已知照明区域到检测区距离的样品，允许通过使用光速和/或光速计算与组织中的光子路径长度和/或个体或组的摩尔吸光度相关的参数， 或一个或多个折射率。 任选地，通过使用以下方式实现对组织性质的更准确的估计：相对于皮肤的入射光子角度的知识，角度分辨的检测器位置，各向异性，皮肤温度，环境信息，与接触压力相关的信息，血糖浓度历史和/或 皮肤层厚度，如表皮和真皮层。

公开(公告)号：US20140048540A1

公开(公告)日：2014-02-20

申请号：US14000832

申请日：2011-08-19

Applicant: Hideji Tajima

Inventor： Hideji Tajima

IPC: B65D6/00

CPC classification number: B65D7/12 ,  B01L3/50855 ,  B01L3/523 ,  B01L3/5635 ,  B01L7/52 ,  B01L2200/028 ,  B01L2300/044 ,  B01L2300/0832 ,  B01L2300/1805 ,  B01L2300/1822 ,  G01N2201/0826

Abstract: The invention relates to a reaction container and a method for producing the reaction container, and provides a low-cost reaction container which is capable of consistently, quickly, and efficiently performing a process that includes a reaction such as extraction or amplification of a nucleic acid, while saving user's trouble without increasing the scale of the device.The reaction container is configured to comprise: one or two or more housing parts for reactions comprising: a narrow-mouthed piping part in which a reaction reagent or a portion thereof is housed or is housable; a wide-mouthed piping part that is communicated with the narrow-mouthed piping part and provided on an upper side of the narrow-mouthed piping part, and has an aperture that is wider than an aperture of the narrow-mouthed piping part; and a punchable film provided such that it partitions an interval between the wide-mouthed piping part and the narrow-mouthed piping part.

Abstract translation: 本发明涉及反应容器和反应容器的制造方法，提供一种低成本的反应容器，其能够一贯地，快速地且有效地进行包括诸如提取或扩增核酸的反应的方法 同时在不增加设备规模的同时节省用户的麻烦。 反应容器被构造成包括：用于反应的一个或两个或更多个壳体部分，包括：窄口管道部分，反应试剂或其一部分容纳在其中或可容纳的; 与狭窄的管道部分连通并设置在狭窄的管道部分的上侧的宽口管部分，并且具有比窄口管道部分的孔宽的孔; 以及设置成使得其在宽口管道部分和窄口管道部分之间隔开间隔的可冲压膜。