発光検出装置、発光検出用マイクロアレイプレート
    181.
    发明申请
    発光検出装置、発光検出用マイクロアレイプレート 审中-公开
    荧光检测器件和发光微透镜检测器

    公开(公告)号:WO2003031952A1

    公开(公告)日:2003-04-17

    申请号:PCT/JP2001/008587

    申请日:2001-09-28

    CPC classification number: G01N21/76 G01N21/253 G01N2201/0846

    Abstract: A luminescent microarray plate suitable for use in luminescent reaction and a luminescence detecting device using the microarray plate. Each microarray minute reaction region is surrounded by a partition to prevent entrance of the luminescence from the surroundings, and the luminescence of the minute region is detected by an optical transmission guide to reduce the entrance of luminescence from the surrounding thereby to improve the precision and sensitivity.

    Abstract translation: 适用于发光反应的发光微阵列板和使用微阵列板的发光检测装置。 每个微阵列分钟反应区域都被隔板包围,以防止周围的发光进入,并且通过光传输引导件检测微区的发光,以减少周围的发光的入射,从而提高精度和灵敏度 。

    UTILIZATION OF AN INFRARED PROBE TO DISCRIMINATE BETWEEN MATERIALS
    182.
    发明申请
    UTILIZATION OF AN INFRARED PROBE TO DISCRIMINATE BETWEEN MATERIALS 审中-公开
    使用红外探测器来区分材料之间的差异

    公开(公告)号:WO02090906A3

    公开(公告)日:2003-04-17

    申请号:PCT/US0214639

    申请日:2002-05-09

    Abstract: A method of evaluating the surface of a material that has a distinguishable infrared spectrum comprising (a) positioning an infrared fiber optic probe to be in contact with a surface of the sample or material at a region of interest for detecting attenuated total reflectance or within a sufficient distance from the surface of the region for detecting reflection, (b) detecting mid- or near-infrared radiation attenuated total reflectance or reflection off of the surface of the sample or the material, (c) analyzing the infrared radiation from step (b) for at least one of peak height, peak area, frequency and chemometric parameters, and (d) actuating the removal device when a signal from the infrared fiber optic probe is between pre-selected values for at least one of peak height, peak area, frequency and chemometric parameters for the sample of the material.

    Abstract translation: 一种评估具有可区别的红外光谱的材料的表面的方法,包括(a)将红外光纤探针定位成与感兴趣区域的样品或材料的表面接触以检测衰减的全反射率,或者在 距离用于检测反射的区域的表面足够的距离,(b)检测中间或近红外辐射减弱了样品或材料表面的全反射或反射,(c)分析来自步骤(b)的红外辐射 ),用于峰高,峰面积,频率和化学计量参数中的至少一个,以及(d)当来自红外光纤探针的信号处于峰值高度,峰值面积之中的至少一个的预选值之间时,启动去除装置 ,样品的频率和化学计量参数。

    SELF-ENCODING SENSOR WITH MICROSPHERES
    183.
    发明申请
    SELF-ENCODING SENSOR WITH MICROSPHERES 审中-公开
    具有微结构的自编码传感器

    公开(公告)号:WO0060332A3

    公开(公告)日:2001-05-31

    申请号:PCT/US0009183

    申请日:2000-04-06

    Applicant: TUFTS COLLEGE

    Abstract: A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.

    Abstract translation: 公开了一种基于微球的分析化学系统,其中具有针对特定目标分析物的不同特征光学响应特征的自编码微球可以混合在一起,同时保留能力以识别大尺度随机色散中的每个传感器的传感器类型和位置 使用光学可询问编码方案的传感器阵列中的这种传感器的数量。 还公开了一种光纤束传感器,其中单个微球传感器设置在纤维束的远端处的微孔中,并且光束耦合到束内的离散纤维或纤维组。 阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编​​码,同时用激发光能照射阵列。 单个传感器阵列可携带数千个离散感测元件,其组合信号提供传感器检测限,响应时间和信噪比方面的实质性改进。

    SELF-ENCODING SENSOR WITH MICROSPHERES
    184.
    发明申请
    SELF-ENCODING SENSOR WITH MICROSPHERES 审中-公开
    具有微结构的自编码传感器

    公开(公告)号:WO00060332A2

    公开(公告)日:2000-10-12

    申请号:PCT/US2000/009183

    申请日:2000-04-06

    Abstract: A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.

    Abstract translation: 公开了一种基于微球的分析化学系统,其中具有针对特定目标分析物的不同特征光学响应特征的自编码微球可以混合在一起,同时保留能力以识别大尺度随机色散中的每个传感器的传感器类型和位置 使用光学可询问编码方案的传感器阵列中的这种传感器的数量。 还公开了一种光纤束传感器,其中单个微球传感器设置在纤维束的远端处的微孔中,并且光束耦合到束内的离散纤维或纤维组。 阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编​​码,同时用激发光能照射阵列。 单个传感器阵列可携带数千个离散感测元件,其组合信号提供传感器检测限,响应时间和信噪比方面的实质性改进。

    SYSTEM AND METHOD FOR MOLECULE SENSING USING EVANESCENT LIGHT COUPLING APPROACH

    公开(公告)号:US20170328836A1

    公开(公告)日:2017-11-16

    申请号:US15418350

    申请日:2017-01-27

    Inventor: Tao Lu

    Abstract: A system and a method for optical sensing of single molecule or molecules in various concentrations are provided. The optical sensor system comprises a first fiber, a second fiber, a light source and a detection device. The first fiber and the second fiber are fused together to form an optical coupler. The first fiber serves as the passageway for the analyte, while the second fiber serves as the waveguide for the light that will interact with the said analyte. One end of the second fiber is connected to the light source (e.g. laser), and the opposite end is connected to the detection device (e.g. spectrometer). The analyte is introduced into the first fiber through one of its ends, and is allowed to flow through inside the hollow core of the said first fiber. When light is delivered through the input end of the second fiber, the evanescent light is formed in the optical coupler and is allowed to interact with the analyte in the first fiber. One scenario in this analyte-light interaction results in, for example, the generation of Raman emission that is used as the probing signal. The spectrum of the Raman emission is analyzed by the detection device to determine the presence of target molecule.

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