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公开(公告)号：WO2003031952A1
公开(公告)日：2003-04-17
申请号：PCT/JP2001/008587
申请日：2001-09-28
Applicant: 株式会社 日立製作所 , 保田健二 , 高橋 智
IPC: G01N21/64
CPC classification number: G01N21/76 , G01N21/253 , G01N2201/0846
Abstract: A luminescent microarray plate suitable for use in luminescent reaction and a luminescence detecting device using the microarray plate. Each microarray minute reaction region is surrounded by a partition to prevent entrance of the luminescence from the surroundings, and the luminescence of the minute region is detected by an optical transmission guide to reduce the entrance of luminescence from the surrounding thereby to improve the precision and sensitivity.
Abstract translation: 适用于发光反应的发光微阵列板和使用微阵列板的发光检测装置。 每个微阵列分钟反应区域都被隔板包围，以防止周围的发光进入，并且通过光传输引导件检测微区的发光，以减少周围的发光的入射，从而提高精度和灵敏度 。
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182.发明申请
公开(公告)号：WO02090906A3
公开(公告)日：2003-04-17
申请号：PCT/US0214639
申请日：2002-05-09
Applicant: HOSPITAL FOR SPECIAL SURGERY
Inventor： CAMACHO NANCY P , BOSTROM MATHIAS P G , BERTHA STEVE L
CPC classification number: G01N21/552 , A61B5/0059 , A61B5/4504 , G01N21/35 , G01N21/359 , G01N2021/559 , G01N2201/0846
Abstract: A method of evaluating the surface of a material that has a distinguishable infrared spectrum comprising (a) positioning an infrared fiber optic probe to be in contact with a surface of the sample or material at a region of interest for detecting attenuated total reflectance or within a sufficient distance from the surface of the region for detecting reflection, (b) detecting mid- or near-infrared radiation attenuated total reflectance or reflection off of the surface of the sample or the material, (c) analyzing the infrared radiation from step (b) for at least one of peak height, peak area, frequency and chemometric parameters, and (d) actuating the removal device when a signal from the infrared fiber optic probe is between pre-selected values for at least one of peak height, peak area, frequency and chemometric parameters for the sample of the material.
Abstract translation: 一种评估具有可区别的红外光谱的材料的表面的方法，包括（a）将红外光纤探针定位成与感兴趣区域的样品或材料的表面接触以检测衰减的全反射率，或者在 距离用于检测反射的区域的表面足够的距离，（b）检测中间或近红外辐射减弱了样品或材料表面的全反射或反射，（c）分析来自步骤（b）的红外辐射 ），用于峰高，峰面积，频率和化学计量参数中的至少一个，以及（d）当来自红外光纤探针的信号处于峰值高度，峰值面积之中的至少一个的预选值之间时，启动去除装置 ，样品的频率和化学计量参数。
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公开(公告)号：WO0060332A3
公开(公告)日：2001-05-31
申请号：PCT/US0009183
申请日：2000-04-06
Applicant: TUFTS COLLEGE
Inventor： WALT DAVID R , DICKINSON TODD A
CPC classification number: C12Q1/682 , B01J2219/00317 , B01J2219/0045 , B01J2219/00466 , B01J2219/005 , B01J2219/00524 , B01J2219/00585 , B01J2219/00648 , B01J2219/00659 , C12Q1/6834 , C40B60/14 , G01N21/6428 , G01N21/6452 , G01N21/7703 , G01N33/0031 , G01N33/54313 , G01N2201/0846 , Y10T436/101666 , Y10T436/109163
Abstract: A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.
Abstract translation: 公开了一种基于微球的分析化学系统，其中具有针对特定目标分析物的不同特征光学响应特征的自编码微球可以混合在一起，同时保留能力以识别大尺度随机色散中的每个传感器的传感器类型和位置 使用光学可询问编码方案的传感器阵列中的这种传感器的数量。 还公开了一种光纤束传感器，其中单个微球传感器设置在纤维束的远端处的微孔中，并且光束耦合到束内的离散纤维或纤维组。 阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编码，同时用激发光能照射阵列。 单个传感器阵列可携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比方面的实质性改进。
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公开(公告)号：WO00060332A2
公开(公告)日：2000-10-12
申请号：PCT/US2000/009183
申请日：2000-04-06
CPC classification number: C12Q1/682 , B01J2219/00317 , B01J2219/0045 , B01J2219/00466 , B01J2219/005 , B01J2219/00524 , B01J2219/00585 , B01J2219/00648 , B01J2219/00659 , C12Q1/6834 , C40B60/14 , G01N21/6428 , G01N21/6452 , G01N21/7703 , G01N33/0031 , G01N33/54313 , G01N2201/0846 , Y10T436/101666 , Y10T436/109163
Abstract: A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed together while the ability is retained to identify the sensor type and location of each sensor in a random dispersion of large numbers of such sensors in a sensor array using an optically interrogatable encoding scheme. An optical fiber bundle sensor is also disclosed in which individual microsphere sensors are disposed in microwells at a distal end of the fiber bundle and are optically coupled to discrete fibers or groups of fibers within the bundle. The identities of the individual sensors in the array are self-encoded by exposing the array to a reference analyte while illuminating the array with excitation light energy. A single sensor array may carry thousands of discrete sensing elements whose combined signal provides for substantial improvements in sensor detection limits, response times and signal-to-noise ratios.
Abstract translation: 公开了一种基于微球的分析化学系统，其中具有针对特定目标分析物的不同特征光学响应特征的自编码微球可以混合在一起，同时保留能力以识别大尺度随机色散中的每个传感器的传感器类型和位置 使用光学可询问编码方案的传感器阵列中的这种传感器的数量。 还公开了一种光纤束传感器，其中单个微球传感器设置在纤维束的远端处的微孔中，并且光束耦合到束内的离散纤维或纤维组。 阵列中各个传感器的身份通过将阵列暴露于参考分析物而进行自编码，同时用激发光能照射阵列。 单个传感器阵列可携带数千个离散感测元件，其组合信号提供传感器检测限，响应时间和信噪比方面的实质性改进。
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公开(公告)号：US11800981B2
公开(公告)日：2023-10-31
申请号：US16949466
申请日：2020-10-30
Applicant: Colgate-Palmolive Company
Inventor： Deborah Ann Peru , Hrebesh Molly Subhash
IPC: A61B5/00 , G01J3/02 , G02B6/04 , G01J3/06 , A61B5/145 , A61B5/1455 , G01J3/08 , G01J3/10 , G01N21/25 , G01J3/18 , G01J3/36 , G01N21/31 , G01J3/32
CPC classification number: A61B5/0075 , A61B5/0062 , A61B5/0088 , A61B5/14546 , A61B5/14551 , A61B5/4875 , G01J3/021 , G01J3/024 , G01J3/0205 , G01J3/027 , G01J3/0208 , G01J3/0218 , G01J3/0221 , G01J3/0229 , G01J3/0264 , G01J3/0291 , G01J3/06 , G01J3/08 , G01J3/10 , G01J3/18 , G01J3/32 , G01J3/36 , G01N21/255 , G01N21/31 , G02B6/04 , A61B5/441 , A61B5/4872 , A61B2562/0233 , G01J2003/061 , G01J2003/065 , G01J2003/066 , G01N2201/0826 , G01N2201/0833 , G01N2201/0846
Abstract: A spectroscopic system may include: a probe having a probe tip and an optical coupler, the optical coupler including an emitting fiber group and first and second receiving fiber groups, each fiber group having a first end and a second end, wherein the first ends of the fiber groups are formed into a bundle and optically exposed through the probe tip; a light source optically coupled to the second end of the emitting fiber group, the light source emitting light in at least a first waveband and a second waveband, the second waveband being different from the first waveband; a first spectrometer optically coupled to the second end of the first receiving fiber group and configured to process light in the first waveband; and a second spectrometer optically coupled to the second end of the second receiving fiber group and configured to process light in the second waveband.
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Patent Agency Ranking
公开(公告)号：US20190104944A1
公开(公告)日：2019-04-11
申请号：US16116038
申请日：2018-08-29
Applicant: illumiSonics, Inc.
Inventor： Parsin Haji REZA , Roger ZEMP
CPC classification number: A61B5/0095 , G01N21/1702 , G01N21/1717 , G01N2021/1706 , G01N2021/1725 , G01N2201/06113 , G01N2201/08 , G01N2201/0846
Abstract: A photoacoustic remote sensing system (PARS) for imaging a subsurface structure in a sample has an excitation beam configured to generate ultrasonic signals in the sample at an excitation location; an interrogation beam incident on the sample at the excitation location, a portion of the interrogation beam returning from the sample that is indicative of the generated ultrasonic signals; an optical system that focuses at least one of the excitation beam and the interrogation beam with a focal point that is below the surface of the sample; and a detector that detects the returning portion of the interrogation beam.
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公开(公告)号：US10054540B2
公开(公告)日：2018-08-21
申请号：US15114631
申请日：2015-01-23
Applicant: DIAFIR
Inventor： Hugues Tariel , Frédéric Charpentier
IPC: G01N21/35 , G01N21/3577 , G01N21/43 , G01N21/49 , G01N21/552 , A61B5/00 , G01N33/487 , B01L3/00 , G02B6/02 , G01N21/47
CPC classification number: G01N21/3577 , A61B5/0075 , A61B2562/0233 , B01L3/5088 , B01L2200/026 , B01L2200/027 , B01L2300/0609 , B01L2300/0654 , B01L2400/065 , G01N21/431 , G01N21/49 , G01N21/552 , G01N33/487 , G01N2021/4769 , G01N2201/0846 , G01N2201/0886 , G02B6/02395
Abstract: The invention relates to a device (10) comprising a support (14) having a wave guide (42) allowing the propagation of light of at least one wavelength, generating evanescent waves outwards. According to the invention, the device comprises means for receiving a liquid sample, designed to receive the liquid sample upon contact of the wave guide (42) in such a way as to impregnate the wave guide with a portion of the liquid sample, and actuatable means for breaking the contact between the liquid sample and the wave guide (42).
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公开(公告)号：US09891105B2
公开(公告)日：2018-02-13
申请号：US15209843
申请日：2016-07-14
Applicant: Otsuka Electronics Co., Ltd.
Inventor： Hisashi Shiraiwa
CPC classification number: G01J3/28 , G01J3/0208 , G01J3/0218 , G01J3/18 , G01J3/2803 , G01J3/44 , G01J3/4406 , G01N21/6452 , G01N21/6458 , G01N21/65 , G01N2021/6484 , G01N2201/0833 , G01N2201/0846 , G02B21/0032 , G02B21/004 , G02B21/0064
Abstract: A microspectroscope includes: a light source; a plurality of light projecting optical fibers that receive light from the light source; a spectroscope; a plurality of light receiving optical fibers for guiding received light to the spectroscope; and a confocal optical system for causing each of a plurality of beams from the plurality of light projecting optical fibers to be condensed and irradiated onto a sample, and forming images of a plurality of beams from a plurality of condensing points on the sample, respectively on the plurality of light receiving optical fibers.
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189.发明申请公开(公告)号：US20180031475A1
公开(公告)日：2018-02-01
申请号：US15550325
申请日：2016-02-06
Applicant: EyeSense GmbH
Inventor： Ralf MUELLER , Hans-Georg ORTLEPP
CPC classification number: G01N21/645 , G01N2021/6471 , G01N2201/0846 , G02B21/0008 , G02B21/16 , G02B27/141 , G02B27/142 , G02B27/145
Abstract: An arrangement for examining a sample which can be excited by means of electromagnetic radiation comprises a first dichroitic beam splitter having a first and a second prism, which are connected to one another on the base surfaces thereof, and a dichroitic layer arranged between the base surfaces of the two prisms, wherein an entry surface of the first prism encloses an angle (β) in the range from 10° to
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公开(公告)号：US20170328836A1
公开(公告)日：2017-11-16
申请号：US15418350
申请日：2017-01-27
Applicant: UVic Industry Partnerships Inc.
Inventor： Tao Lu
CPC classification number: G01N21/658 , G01N21/65 , G01N2201/0612 , G01N2201/08 , G01N2201/0846 , G02B6/032 , G02B6/2551 , G02B6/2821 , G02B6/2856
Abstract: A system and a method for optical sensing of single molecule or molecules in various concentrations are provided. The optical sensor system comprises a first fiber, a second fiber, a light source and a detection device. The first fiber and the second fiber are fused together to form an optical coupler. The first fiber serves as the passageway for the analyte, while the second fiber serves as the waveguide for the light that will interact with the said analyte. One end of the second fiber is connected to the light source (e.g. laser), and the opposite end is connected to the detection device (e.g. spectrometer). The analyte is introduced into the first fiber through one of its ends, and is allowed to flow through inside the hollow core of the said first fiber. When light is delivered through the input end of the second fiber, the evanescent light is formed in the optical coupler and is allowed to interact with the analyte in the first fiber. One scenario in this analyte-light interaction results in, for example, the generation of Raman emission that is used as the probing signal. The spectrum of the Raman emission is analyzed by the detection device to determine the presence of target molecule.
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