公开(公告)号：CA2413269A1

公开(公告)日：2001-12-27

申请号：CA2413269

申请日：2001-06-22

Applicant: AN GO GEN INC

Inventor： STEWART DUNCAN

IPC: A61B8/00 ,  A61B8/08 ,  A61B8/12 ,  A61B17/22

Abstract: An injection catheter is provided with a piezoelectric ultrasound emitting device atits distal end, capable of emitting ultrasound of different energy levels. It can be used toimage the location of penetration of an internal organ of a patient by the catheter needle,by supply of echocontrast material through the needle and analysis of the ultrasoundreflections therefrom. It c an also be used to cause tissue perturbation or disruption at theimaged locatio n, e.g. to initiate tissue angiogenesis, by choice of suitable ultrasoundenergy level of emission, and for delivery of therapeutic substances such as DNA to thedisrupted tissue, for better uptake in gene therapy.

公开(公告)号：CA2383093A1

公开(公告)日：2001-03-29

申请号：CA2383093

申请日：1999-09-23

Applicant: AN GO GEN INC

Inventor： STEWART DUNCAN J

IPC: A61K35/36 ,  A61K35/28 ,  A61K35/33 ,  A61K38/18 ,  A61K48/00 ,  A61P9/12 ,  A61P11/00 ,  C07K14/52 ,  C12N5/10 ,  C12N15/09

Abstract: Cell-based gene transfer is effected by administering transfected fibroblast cells, from dermal or other origins, containing an expressible transgene coding for an angiogenic factor or other therapeutic factor, into the pulmonary circulation of a patient, where the cells express and secrete expression products of the transgene to act locally at the site of expressio n, and in some cases to be conveyed by the patient's circulation to other body organs. The process is especially useful in treatment of pulmonary hypertension by means of expressed angiogenic factors.

公开(公告)号：IL192893D0

公开(公告)日：2009-02-11

申请号：IL19289308

申请日：2008-07-17

Applicant: AN GO GEN INC ,  DUNCAN STEWART

IPC: A61K35/36 ,  A61K35/28 ,  A61K35/33 ,  A61K38/18 ,  A61K48/00 ,  A61P9/12 ,  A61P11/00 ,  C07K14/52 ,  C12N5/10 ,  C12N15/09

公开(公告)号：DE69936320T2

公开(公告)日：2008-02-21

申请号：DE69936320

申请日：1999-09-23

Applicant: AN GO GEN INC

Inventor： STEWART DUNCAN J

IPC: A61K35/36 ,  A61K35/28 ,  A61K35/33 ,  A61K38/18 ,  A61K48/00 ,  A61P9/12 ,  A61P11/00 ,  C07K14/52 ,  C12N5/10 ,  C12N15/09

公开(公告)号：AT364387T

公开(公告)日：2007-07-15

申请号：AT99944205

申请日：1999-09-23

Applicant: AN GO GEN INC

Inventor： STEWART DUNCAN

IPC: A61K35/36 ,  A61K35/28 ,  A61K35/33 ,  A61K38/18 ,  A61K48/00 ,  A61P9/12 ,  A61P11/00 ,  C07K14/52 ,  C12N5/10 ,  C12N15/09

公开(公告)号：IL148826D0

公开(公告)日：2002-09-12

申请号：IL14882699

申请日：1999-09-23

Applicant: AN GO GEN INC

IPC: A61K35/36 ,  A61K35/28 ,  A61K35/33 ,  A61K38/18 ,  A61K48/00 ,  A61P9/12 ,  A61P11/00 ,  C07K14/52 ,  C12N5/10 ,  C12N15/09 ,  A61K

公开(公告)号：BR9917500A

公开(公告)日：2002-05-21

申请号：BR9917500

申请日：1999-09-23

Applicant: AN GO GEN INC

Inventor： STEWART DUNCAN J

IPC: A61K35/36 ,  A61K35/28 ,  A61K35/33 ,  A61K38/18 ,  A61K48/00 ,  A61P9/12 ,  A61P11/00 ,  C07K14/52 ,  C12N5/10 ,  C12N15/09

公开(公告)号：AU2337801A

公开(公告)日：2001-07-09

申请号：AU2337801

申请日：2000-12-22

Applicant: AN GO GEN INC

Inventor： STEWART DUNCAN JOHN

IPC: A61K38/00 ,  C07K14/515 ,  C07K14/52 ,  C07K14/00

公开(公告)号：AU5724499A

公开(公告)日：2001-04-24

申请号：AU5724499

申请日：1999-09-23

Applicant: AN GO GEN INC

Inventor： STEWART DUNCAN J

IPC: A61K35/36 ,  A61K35/28 ,  A61K35/33 ,  A61K38/18 ,  A61K48/00 ,  A61P9/12 ,  A61P11/00 ,  C07K14/52 ,  C12N5/10 ,  C12N15/09

公开(公告)号：CA2266805A1

公开(公告)日：1999-09-27

申请号：CA2266805

申请日：1999-03-25

Applicant: AN-GO-GEN INC

Inventor： STEWART DUNCAN JOHN

IPC: A61K35/12 ,  A61K48/00 ,  C12N5/071 ,  C12N5/077 ,  A61K38/18 ,  A61K38/44

Abstract: Cell-based gene transfer is effected by administering transfected cells containing an expressible transgene into the pulmonary system of a patient, where the cells express and secrete expression products of the transgene directly into the pulmonary system. Also provided is the use of angiogenic factors in treatment of pulmonary hypertension.