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公开(公告)号：JP2004264312A
公开(公告)日：2004-09-24
申请号：JP2004168607
申请日：2004-06-07
Applicant: Bio-Rad Lab Inc , バイオ−ラド ラボラトリーズ,インコーポレイティド
Inventor： HEFFELFINGER DAVID M , BATTERSON REBECCA ANN , SALGADO RENATO
IPC: G01N21/64 , C12M1/00 , C12M1/34 , C12N15/09 , C12Q1/68 , G01N21/75 , G01N21/78 , G01N33/53 , G01N37/00 , G03B42/00
CPC classification number: G03B42/00 , G01N2021/6419 , G01N2021/6421 , G01N2021/6471 , G01N2021/6484 , G01N2201/024
Abstract: PROBLEM TO BE SOLVED: To provide a small optical scanner usable with various sample forms and structures, which can be used to give a plurality of excitation/irradiation wavelengths and detect radiations in various wavelengths.
SOLUTION: An apparatus capable of measuring quantities of biological or other types of samples labeled using an arbitrary variety of techniques is provided. The provided scanner includes a source module that preferably contains an internal laser emitting two different wavelengths of approximately the same intensity. An optional external light source may be coupled to the source module, thus adding further flexibility through the addition of other wavelengths. The scanner also includes a detection module. Within the detection module are two detectors, thus allowing the simultaneous detection of multiple wavelengths. A bifurcated optical cable is used to transfer the excitation and/or readout light from the source module to the sample and subsequently transfer the emitted and/or scattered light from the sample to the detection module.
COPYRIGHT: (C)2004,JPO&NCIPI-
公开(公告)号：JP2004226414A
公开(公告)日：2004-08-12
申请号：JP2004066380
申请日：2004-03-09
Applicant: Bio Rad Lab Inc , バイオ−ラッド ラボラトリーズ,インコーポレイティド
Inventor： HEFFELFINGER DAVID M , VAN HORN CRAIG
IPC: G01N21/63 , G01N27/447 , G01N37/00
CPC classification number: G01N27/44721 , G01N27/44726
Abstract: PROBLEM TO BE SOLVED: To provide an improved electrophoretic device that enables accurate quantitative fluoroscopy. SOLUTION: The electrophoretic device includes a platform for retaining an electrophoretic gel; a first light source 1403 for illuminating the electrophoretic gel; a first lens assembly 1407 for imaging radiation from a labeled region of the electrophoretic gel onto a first detector 1409; a mirror 1417 for reflecting illumination from a second light source 1411 onto the first detector 1409 via the first lens assembly 1407 to measure using the first detector 1409 the intensity pattern of the second light source 1411 passing through the first lens assembly 1407 to determine the profile of the first lens assembly; and a processor connected to the first detector 1409 for normalizing the image of the electrophoretic gel using the profile of the first lens assembly. COPYRIGHT: (C)2004,JPO&NCIPI
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公开(公告)号：JP2004085585A
公开(公告)日：2004-03-18
申请号：JP2003413618
申请日：2003-12-11
Applicant: Bio Rad Lab Inc , バイオ−ラッド ラボラトリーズ,インコーポレイティド
Inventor： PEREZ EVELIO , FERNWOOD GEORGE
IPC: G01N27/447
CPC classification number: G01N27/44704 , G01N27/44743
Abstract: PROBLEM TO BE SOLVED: To provide an insert which can be assembled quickly in a leaktight state, free of damages or breakages and a slab gel cast molding system using the insert. SOLUTION: In the system, both a flat plate acting as a mold and a vessel for slab gel are retained by clamping frames, wherein lateral borders of the plate slides into facing channels to be wedged between lever operated cams compressing the channels barrier against the plate surface. The coupled plate is retained by a vertical support rack, equipped with fingers operating the clamp with spring force-applied notch. The clamp with notch pushes the plate downward to seal an opening on the plate bottom rim for a gasket. Additionally a wale formation comb for the insert between plates is equipped with flexible fingers, having an angle outside for sealing spacers between plates. COPYRIGHT: (C)2004,JPO
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Patent Agency Ranking
公开(公告)号：JP2010166918A
公开(公告)日：2010-08-05
申请号：JP2010041133
申请日：2010-02-26
Applicant: Bio-Rad Lab Inc , バイオ−ラッド ラボラトリーズ インコーポレーティッド
Inventor： WANG YAN
CPC classification number: C12N9/1252 , C07H21/04
Abstract: PROBLEM TO BE SOLVED: To provide an Sso7-polymerase conjugate protein exhibiting improved activity in a polymerase reaction.
SOLUTION: The Sso7-polymerase conjugate protein includes an Sso7 domain having at least 60% identity to a specific amino acid sequence linked to a polymerase domain; wherein an amino acid at a position that is a surface residue position as determined with reference to the specific amino acid sequence is replaced with a different amino acid residue; wherein replacement of the surface residue results in processivity that is less than the processivity of a wild Sso7-polymerase fusion product and greater than the processivity of the polymerase domain which is not fused to the Sso7 domain.
COPYRIGHT: (C)2010,JPO&INPITAbstract translation: 待解决的问题：提供在聚合酶反应中表现出改善的活性的Sso7-聚合酶缀合蛋白。 解决方案：Sso7聚合酶缀合蛋白包括与连接于聚合酶结构域的特定氨基酸序列具有至少60％同一性的Sso7结构域; 其中在相对于特定氨基酸序列测定的表面残基位置的位置处的氨基酸被不同的氨基酸残基替换; 其中表面残基的替换导致小于野生Sso7聚合酶融合产物的进行性的流程，并且大于不融合到Sso7结构域的聚合酶结构域的进行性。 版权所有（C）2010，JPO＆INPIT
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15.发明专利
公开(公告)号：JP2007190033A
公开(公告)日：2007-08-02
申请号：JP2007114748
申请日：2007-04-24
Applicant: Bio Rad Lab Inc , バイオ−ラッド ラボラトリーズ,インコーポレイティド
Inventor： RAGSDALE CHARLES W
CPC classification number: C12M35/02 , H03K3/57 , H03K17/105
Abstract: PROBLEM TO BE SOLVED: To provide a transfection controller that enables the efficient operation of transfection and provide a method therefor. SOLUTION: The transfection controller comprises a high heat-resistant switch 114 that is equipped with a gate, a high voltage current inlet and a high voltage current output, and a restriction impedance element 122 connected to a high heat resistant switch 114 and a chemical solution 104, a charge storage device 120 that is connected to the input of the high heat resistant switch 114, and a controlling processor 110 connected to the high heat resistant switch 114 and gives the gate signal, and a restriction impedance compensator that compensates the resistance of the restriction impedance element 122, and determine the charging voltage of the charge storage device 120 required for generating a desired output voltage. COPYRIGHT: (C)2007,JPO&INPIT
Abstract translation: 要解决的问题：提供能够有效地进行转染的转染控制器并提供其方法。 解决方案：转染控制器包括高耐热开关114，其具有栅极，高压电流入口和高压电流输出，以及限制阻抗元件122，其连接到高耐热开关114和 化学溶液104，连接到高耐热开关114的输入的电荷存储装置120，以及连接到高耐热开关114并提供栅极信号的控制处理器110，以及限制阻抗补偿器，其补偿 限制阻抗元件122的电阻，并且确定产生期望输出电压所需的电荷存储装置120的充电电压。 版权所有（C）2007，JPO＆INPIT
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公开(公告)号：JP2006288403A
公开(公告)日：2006-10-26
申请号：JP2006189815
申请日：2006-07-10
Applicant: Bio Rad Lab Inc , バイオ−ラッド ラボラトリーズ,インコーポレイティド
Inventor： RAGSDALE CHARLES W
IPC: C12M1/00 , C12N15/00 , C12M1/34 , C12M1/42 , C12M3/00 , C12N1/00 , C12N15/09 , H03K3/57 , H03K17/10
CPC classification number: C12M35/02 , H03K3/57 , H03K17/105
Abstract: PROBLEM TO BE SOLVED: To provide a transfection controller making it possible to efficiently transfect, and to provide a method therefor. SOLUTION: This transfection controller comprises a gate, a highly heat-resistant switch 114 having a high-voltage current input and a high-voltage current output, a limit impedance element 122 connected to the highly heat-resistant switch 114 and a chemical solution 104, a storage capacitor 120 connected to the input of the highly heat-resistant switch 114, a control processor 110 connected to the highly heat-resistant switch 114 to impart gate signals, and a limit impedance-compensating device for compensating the resistance of the limit impedance element 122 to determine the charge voltage of the storage capacitor 120 necessary for generating a desired output voltage. COPYRIGHT: (C)2007,JPO&INPIT
Abstract translation: 要解决的问题：提供一种转染控制器，使得可以有效地转染并提供其方法。 解决方案：该转染控制器包括栅极，具有高电压电流输入和高压电流输出的高耐热开关114，连接到高耐热开关114的极限阻抗元件122和 化学溶液104，连接到高耐热开关114的输入的存储电容器120，连接到高耐热开关114以施加栅极信号的控制处理器110以及用于补偿电阻的极限阻抗补偿装置 限制阻抗元件122以确定产生期望输出电压所需的存储电容器120的充电电压。 版权所有（C）2007，JPO＆INPIT
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公开(公告)号：JP2004163440A
公开(公告)日：2004-06-10
申请号：JP2004066360
申请日：2004-03-09
Applicant: Bio Rad Lab Inc , バイオ−ラッド ラボラトリーズ,インコーポレイティド
Inventor： HEFFELFINGER DAVID M , VAN HORN CRAIG
IPC: G01N21/63 , G01N27/447 , G01N37/00
CPC classification number: G01N27/44721 , G01N27/44726
Abstract: PROBLEM TO BE SOLVED: To perform accurate quantitative fluorescence measurement. SOLUTION: This electrophoretic system is constituted of a platform for holding electrophoretic gel, a light source 1803 for illuminating the electrophoretic gel, a first lens assembly 1807 for imaging radiation from a labeled region of the electrophoretic gel on a first detector 1809, a mirror 1811 for reflecting at least a part of illumination from the light source 1803 through a second lens assembly 1815, separately from the first lens assembly 1807, and a processor connected to the first and second detectors. The mirror 1811 determines a light source profile by measuring an intensity pattern of the illumination from the light source 1803 passing through the second lens assembly 1815 by the second detector 1817. The processor normalizes the electrophoretic gel image by using the light source profile. COPYRIGHT: (C)2004,JPO
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公开(公告)号：DE3751585T3
公开(公告)日：2004-08-05
申请号：DE3751585
申请日：1987-11-17
Applicant: BIO RAD LAB INC N D GES D STAA
Inventor： LINSLEY PETER S , HORN DIANE , BROWN JOSEPH P
IPC: G01N33/53 , A61K38/00 , A61K39/395 , C07K14/00 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/30 , C07K19/00 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/574 , G01N33/577 , C12N5/12 , C07K16/28 , G01N33/68
Abstract: Novel hybridoma cell lines producing monoclonal antibodies reactive with purified mucin antigens from normal and tumor sources are generated using mucins, including purified mucins from tumor sources. Epitopes on mucin antigens from normal and tumor sources are demonstrated to be distinct, using these new antibodies. The antibodies may be useful alone or in combination, in the diagnosis and treatment of cancer including malignancies of the breast and lung.
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