公开(公告)号：WO2008137753A2

公开(公告)日：2008-11-13

申请号：PCT/US2008062518

申请日：2008-05-02

Applicant: PORTOLA PHARM INC ,  SCARBOROUGH CARROLL ANNA CREW ,  GRETLER DANIEL D ,  CONLEY PAMELA B ,  ANDRE PATRICK ,  HUTCHALEELAHA ATHIWAT ,  PHILLIPS DAVID R ,  PANDEY ANJALI ,  WOLIN HUANG

Inventor： GRETLER DANIEL D ,  CONLEY PAMELA B ,  ANDRE PATRICK ,  HUTCHALEELAHA ATHIWAT ,  PHILLIPS DAVID R ,  PANDEY ANJALI ,  WOLIN HUANG ,  SCARBOROUGH ROBERT M

IPC: A61K31/216 ,  A61K31/517 ,  A61P7/02

CPC classification number: A61K31/517 ,  A61K31/216 ,  A61K2300/00

Abstract: The invention provides methods and compositions for rapid and reversible inhibition of platelet aggregation in human subjects in need thereof by administering compounds of the formula: (I) alone or in combination with a second agent which can be aspirin or a thrombolytic agent.

Abstract translation: 本发明提供了在需要的人类受试者中快速和可逆地抑制血小板聚集的方法和组合物，其通过单独给予式（I）化合物或与可以是阿司匹林或溶栓剂的第二药剂组合施用。

公开(公告)号：WO2002070707A3

公开(公告)日：2002-09-12

申请号：PCT/US2001/049168

申请日：2001-12-18

Applicant: CURAGEN CORPORATION ,  COR THERAPEUTICS, INC. ,  PADIGARU, Muralidhara ,  GERLACH, Valerie, L. ,  SMITHSON, Glennda ,  STONE, David ,  BIN-YANG, Ruey ,  CONLEY, Pamela ,  HART, Matthew ,  TOMLINSON, James, E. ,  TOPPER, James, N. ,  KEKUDA, Ramesh ,  CASMAN, Stacie, J. ,  EDINGER, Schlomit ,  MACDOUGALL, John, R.

Inventor： PADIGARU, Muralidhara ,  GERLACH, Valerie, L. ,  SMITHSON, Glennda ,  STONE, David ,  BIN-YANG, Ruey ,  CONLEY, Pamela ,  HART, Matthew ,  TOMLINSON, James, E. ,  TOPPER, James, N. ,  KEKUDA, Ramesh ,  CASMAN, Stacie, J. ,  EDINGER, Schlomit ,  MACDOUGALL, John, R.

IPC: C12N15/12

Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

公开(公告)号：WO2002070660A3

公开(公告)日：2002-09-12

申请号：PCT/US2002/006485

申请日：2002-03-04

Applicant: CURAGEN CORPORATION ,  COR THERAPEUTICS ,  KEKUDA, Ramesh ,  CONLEY, Pamela, B. ,  BIN-YANG, Ruey ,  HART, Matthew ,  TOMLINSON, James, E. ,  TOPPER, James, Newman ,  SHIMKETS, Richard, A. ,  LEACH, Martin, D. ,  ZERHUSEN, Bryan, D. ,  KOMUVES, Laszlo ,  PADIGARU, Muralidhara

Inventor： KEKUDA, Ramesh ,  CONLEY, Pamela, B. ,  BIN-YANG, Ruey ,  HART, Matthew ,  TOMLINSON, James, E. ,  TOPPER, James, Newman ,  SHIMKETS, Richard, A. ,  LEACH, Martin, D. ,  ZERHUSEN, Bryan, D. ,  KOMUVES, Laszlo ,  PADIGARU, Muralidhara

IPC: C07K14/00

Abstract: Disclosed are polypeptides and nucleic acids encoding same. Also disclodes are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.

公开(公告)号：WO02070660A2

公开(公告)日：2002-09-12

申请号：PCT/US0206485

申请日：2002-03-04

Applicant: CURAGEN CORP ,  COR THERAPEUTICS ,  KEKUDA RAMESH ,  CONLEY PAMELA B ,  BIN-YANG RUEY ,  HART MATTHEW ,  TOMLINSON JAMES E ,  TOPPER JAMES NEWMAN ,  SHIMKETS RICHARD A ,  LEACH MARTIN D ,  ZERHUSEN BRYAN D ,  KOMUVES LASZLO ,  PADIGARU MURALIDHARA

Inventor： KEKUDA RAMESH ,  CONLEY PAMELA B ,  BIN-YANG RUEY ,  HART MATTHEW ,  TOMLINSON JAMES E ,  TOPPER JAMES NEWMAN ,  SHIMKETS RICHARD A ,  LEACH MARTIN D ,  ZERHUSEN BRYAN D ,  KOMUVES LASZLO ,  PADIGARU MURALIDHARA

IPC: A61K38/00 ,  C07K14/47 ,  C12N5/02 ,  C12N

CPC classification number: C07K14/47 ,  A61K38/00

Abstract: Disclosed are polypeptides and nucleic acids encoding same. Also disclodes are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.

Abstract translation: 公开了编码相同的多肽和核酸。 还揭示了用于产生多肽和多核苷酸的载体，宿主细胞，抗体和重组方法，以及使用它们的方法。

公开(公告)号：WO2011006169A1

公开(公告)日：2011-01-13

申请号：PCT/US2010/041749

申请日：2010-07-12

Applicant: PORTOLA PHARMACEUTICALS, INC. ,  GURBEL, Paul A. ,  CONLEY, Pamela B. ,  ANDRE, Patrick ,  GRETLER, Daniel D. ,  JUREK, Marzena

Inventor： GURBEL, Paul A. ,  CONLEY, Pamela B. ,  ANDRE, Patrick ,  GRETLER, Daniel D. ,  JUREK, Marzena

IPC: A61K31/216 ,  A61K31/517 ,  C12Q1/68

CPC classification number: A61K31/4365 ,  A61K31/216 ,  A61K31/517 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158

Abstract: Genetic polymorphisms in the 2C19*2 gene are useful as biomarkers for diagnosing an increased risk for high platelet reactivity or increased bleeding in a subject suffering from a cardiovascular disorder. In particular, the invention relates to methods of treating and preventing coronary artery disease using P2Y-12 receptor inhibitors. In addition, the present invention relates to kits for use in identifying patients with coronary heart disease with an increased risk for high platelet reactivity or increased bleeding.

Abstract translation: 2C19 * 2基因中的遗传多态性可用作用于诊断患有心血管疾病的受试者中高血小板反应性增加的风险增加或出血增加的生物标志物。 特别地，本发明涉及使用P2Y-12受体抑制剂治疗和预防冠状动脉疾病的方法。 此外，本发明涉及用于鉴定具有高血小板反应性或出血增加的风险增加的冠心病患者的试剂盒。

公开(公告)号：WO2007112367A3

公开(公告)日：2008-01-24

申请号：PCT/US2007064956

申请日：2007-03-26

Applicant: PORTOLA PHARM INC ,  ZWAAL ROBERT F A ,  CONLEY PAMELA B

Inventor： ZWAAL ROBERT F A ,  CONLEY PAMELA B

IPC: A61K31/41 ,  A61K38/00

CPC classification number: A61K31/4745

Abstract: Methods of modulating platelet procoagulant response are taught herein. Inhibition of platelet procoagulant response with agents that inhibit the Ca 2 +-sensitive K + channels, or Gardos channels, preferably while maintaining platelet bleeding arrest function, may be used to treat a variety of disorders.

Abstract translation: 本文教导了调节血小板促凝血反应的方法。 可以使用抑制抑制Ca 2+ 2敏感性高通道或Gardos通道的药物对血小板促凝血反应的抑制，优选在维持血小板渗血阻滞功能的同时治疗 各种疾病。

公开(公告)号：WO2008137787A2

公开(公告)日：2008-11-13

申请号：PCT/US2008/062561

申请日：2008-05-02

Applicant: PORTOLA PHARMACEUTICALS, INC. ,  CONLEY, Pamela B. ,  ANDRE, Patrick ,  SINHA, Uma

Inventor： CONLEY, Pamela B. ,  ANDRE, Patrick ,  SINHA, Uma

IPC: A61K31/235 ,  A61K31/422 ,  A61K31/435 ,  A61K31/517 ,  A61K38/10 ,  A61K45/06 ,  A61P7/02 ,  A61P7/00 ,  A61P9/00

CPC classification number: A61K31/422 ,  A61K31/235 ,  A61K31/435 ,  A61K31/4545 ,  A61K31/517 ,  A61K38/4846 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention is directed to pharmaceutical compositions and methods of using combination therapies containing [4 (6-fluoro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea, or a pharmaceutically acceptable salt thereof, for the treatment of thrombosis diseases.

Abstract translation: 本发明涉及使用梳子的药物组合物和方法

公开(公告)号：WO2002016599A3

公开(公告)日：2002-02-28

申请号：PCT/US2001/026510

申请日：2001-08-27

Applicant: CURAGEN CORPORATION ,  COR THERAPEUTICS, INC. ,  BURGESS, Catherine, E. ,  CONLEY, Pamela, B. ,  GROSSE, William, M. ,  HART, Matthew ,  KEKUDA, Ramesh ,  SHIMKETS, Richard, A. ,  SPYTEK, Kimberly, A. ,  SZEKERES, Edward, S., Jr. ,  TOMLINSON, James, E. ,  TOPPER, James, N. ,  YANG, Ruey-Bin

Inventor： BURGESS, Catherine, E. ,  CONLEY, Pamela, B. ,  GROSSE, William, M. ,  HART, Matthew ,  KEKUDA, Ramesh ,  SHIMKETS, Richard, A. ,  SPYTEK, Kimberly, A. ,  SZEKERES, Edward, S., Jr. ,  TOMLINSON, James, E. ,  TOPPER, James, N. ,  YANG, Ruey-Bin

IPC: C12N15/00

Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses tehrapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.