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公开(公告)号：CA273167A
公开(公告)日：1927-08-16
申请号：CA273167D
Applicant: TOMLINSON JAMES E
Inventor： TOMLINSON JAMES E
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公开(公告)号：WO2002070707A3
公开(公告)日：2002-09-12
申请号：PCT/US2001/049168
申请日：2001-12-18
Applicant: CURAGEN CORPORATION , COR THERAPEUTICS, INC. , PADIGARU, Muralidhara , GERLACH, Valerie, L. , SMITHSON, Glennda , STONE, David , BIN-YANG, Ruey , CONLEY, Pamela , HART, Matthew , TOMLINSON, James, E. , TOPPER, James, N. , KEKUDA, Ramesh , CASMAN, Stacie, J. , EDINGER, Schlomit , MACDOUGALL, John, R.
Inventor： PADIGARU, Muralidhara , GERLACH, Valerie, L. , SMITHSON, Glennda , STONE, David , BIN-YANG, Ruey , CONLEY, Pamela , HART, Matthew , TOMLINSON, James, E. , TOPPER, James, N. , KEKUDA, Ramesh , CASMAN, Stacie, J. , EDINGER, Schlomit , MACDOUGALL, John, R.
IPC: C12N15/12
Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：WO2002070660A3
公开(公告)日：2002-09-12
申请号：PCT/US2002/006485
申请日：2002-03-04
Applicant: CURAGEN CORPORATION , COR THERAPEUTICS , KEKUDA, Ramesh , CONLEY, Pamela, B. , BIN-YANG, Ruey , HART, Matthew , TOMLINSON, James, E. , TOPPER, James, Newman , SHIMKETS, Richard, A. , LEACH, Martin, D. , ZERHUSEN, Bryan, D. , KOMUVES, Laszlo , PADIGARU, Muralidhara
Inventor： KEKUDA, Ramesh , CONLEY, Pamela, B. , BIN-YANG, Ruey , HART, Matthew , TOMLINSON, James, E. , TOPPER, James, Newman , SHIMKETS, Richard, A. , LEACH, Martin, D. , ZERHUSEN, Bryan, D. , KOMUVES, Laszlo , PADIGARU, Muralidhara
IPC: C07K14/00
Abstract: Disclosed are polypeptides and nucleic acids encoding same. Also disclodes are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.
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公开(公告)号：WO02070660A2
公开(公告)日：2002-09-12
申请号：PCT/US0206485
申请日：2002-03-04
Applicant: CURAGEN CORP , COR THERAPEUTICS , KEKUDA RAMESH , CONLEY PAMELA B , BIN-YANG RUEY , HART MATTHEW , TOMLINSON JAMES E , TOPPER JAMES NEWMAN , SHIMKETS RICHARD A , LEACH MARTIN D , ZERHUSEN BRYAN D , KOMUVES LASZLO , PADIGARU MURALIDHARA
Inventor： KEKUDA RAMESH , CONLEY PAMELA B , BIN-YANG RUEY , HART MATTHEW , TOMLINSON JAMES E , TOPPER JAMES NEWMAN , SHIMKETS RICHARD A , LEACH MARTIN D , ZERHUSEN BRYAN D , KOMUVES LASZLO , PADIGARU MURALIDHARA
Abstract: Disclosed are polypeptides and nucleic acids encoding same. Also disclodes are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same.
Abstract translation: 公开了编码相同的多肽和核酸。 还揭示了用于产生多肽和多核苷酸的载体，宿主细胞，抗体和重组方法，以及使用它们的方法。
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5.发明申请METHODS AND COMPOSITIONS FOR TREATING CARDIOVASCULAR DISEASE USING 1722, 10280, 59917, 85553, 10653, 9235, 21668, 17794, 2210, 6169, 10102, 21061,17662,1468,12282, 6350, 9035,1820, 23652, 7301, 8925, 8701, 3533, 9462, 9123,12788,17729, 65552,1261, 21476, 33770, 9380, 2569654, 33556, 53656, 44143, 32612, 10671, 261, 44570, 4 审中-公开用于治疗心血管疾病的方法和组合物，使用1722,10280,59917,85553,1063,5225,26668,17794,2210,6149,10102,21061,17662,1468,12282,63050,17535,1820,236522,7301,8925， 8701,3533,9462,9123,12788,17729,65552,1261,21476,33770,9380,2569654,33556,5366,44143,32612,10671,261,4457,4
公开(公告)号：WO2004063340A2
公开(公告)日：2004-07-29
申请号：PCT/US2004/000393
申请日：2004-01-13
Applicant: MILLENNIUM PHARMACEUTICALS, INC. , STAGLIANO, Nancy, E. , HEALY, Aileen , ACTON, Susan, L. , GALVIN, Katherine, M. , DONOGHUE, Mary, A. , ROGRIGUE-WAY, Amelie , TOMLINSON, James, E.
Inventor： STAGLIANO, Nancy, E. , HEALY, Aileen , ACTON, Susan, L. , GALVIN, Katherine, M. , DONOGHUE, Mary, A. , ROGRIGUE-WAY, Amelie , TOMLINSON, James, E.
IPC: C12N
CPC classification number: C07K14/47
Abstract: The present invention relates to methods for the diagnosis and treatment of cardiovascular disease, including, but not limited to, atherosclerosis, reperfusion injury, hypertension, restenosis, arterial inflammation, thrombosis and endothelial cell disorders. Specifically, the present invention identifies the differential expression of 1722, 10280, 59917, 85553, 10653, 9235, 21668, 17794, 2210, 6169, 10102, 21061, 17662, 1468, 12282, 6350, 9035, 1820, 23652, 7301, 8925, 8701, 3533, 9462, 9123, 12788, 17729, 65552, 1261, 21476, 33770, 9380, 2569654, 33556, 53656, 44143, 32612, 10671, 261, 44570, 41922, 2552, 2417, 19319, 43969, 8921, 8993, 955, 32345, 966, 1920, 17318, 1510, 14180, 26005, 554, 16408, 42028, 112091, 13886, 13942, 1673, 54946 and 2419 genes in cardiovascular disease states, relative to their expression in normal, or noncardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. The present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating cardiovascular disease. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
Abstract translation: 本发明涉及用于诊断和治疗心血管疾病的方法，包括但不限于动脉粥样硬化，再灌注损伤，高血压，再狭窄，动脉炎症，血栓形成和内皮细胞疾病。 具体地说，本发明鉴定了1722,1028,8059917,85553,1063,53235,26668,17794,2210,6169,1010,21061,17662,1468,12282,65050,9035,1820,236522,7301,6005的标准差， 8925,8701,33533,9462,9123,12788,17729,65552,1261,21476,33770,9380,2569654,33556,5366,44143,32612,10677,261,44570,41922,2552,2417,19319,4399， 8921,8993,905,232345,996,1920,17318,1510,14180,26205,554,16408,42028,112091,13886,13942,1673,5496和2419中的基因，相对于它们在正常的表达，心血管疾病状态， 或非心血管疾病状态，和/或响应与心血管疾病相关的操作。 本发明描述了各种心血管疾病的诊断评估和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。 本发明还提供了鉴定能调节心血管疾病的化合物的方法。 本发明还提供了用于鉴定和治疗化合物作为心血管疾病治疗的方法。
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Patent Agency Ranking
公开(公告)号：WO02070707A2
公开(公告)日：2002-09-12
申请号：PCT/US0149168
申请日：2001-12-18
Applicant: CURAGEN CORP , COR THERAPEUTICS INC , PADIGARU MURALIDHARA , GERLACH VALERIE L , SMITHSON GLENNDA , STONE DAVID , BIN-YANG RUEY , CONLEY PAMELA , HART MATTHEW , TOMLINSON JAMES E , TOPPER JAMES N , KEKUDA RAMESH , CASMAN STACIE J , EDINGER SCHLOMIT , MACDOUGALL JOHN R
Inventor： PADIGARU MURALIDHARA , GERLACH VALERIE L , SMITHSON GLENNDA , STONE DAVID , BIN-YANG RUEY , CONLEY PAMELA , HART MATTHEW , TOMLINSON JAMES E , TOPPER JAMES N , KEKUDA RAMESH , CASMAN STACIE J , EDINGER SCHLOMIT , MACDOUGALL JOHN R
IPC: A61K38/00 , C07K14/705 , C12N15/12 , A61K31/7088 , A61K38/17 , A61K39/395 , C07K16/28 , C12N15/63 , C12Q1/68 , G01N33/50 , G01N33/53
CPC classification number: C07K14/705 , A61K38/00 , A61K2039/505
Abstract: Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Abstract translation: 本文公开了编码G偶联蛋白 - 受体相关多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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公开(公告)号：WO0216599A2
公开(公告)日：2002-02-28
申请号：PCT/US0126510
申请日：2001-08-27
Applicant: CURAGEN CORP , COR THERAPEUTICS INC , BURGESS CATHERINE E , CONLEY PAMELA B , GROSSE WILLIAM M , HART MATTHEW , KEKUDA RAMESH , SHIMKETS RICHARD A , SPYTEK KIMBERLY A , SZEKERES EDWARD S JR , TOMLINSON JAMES E , TOPPER JAMES N , YANG RUEY BIN
Inventor： BURGESS CATHERINE E , CONLEY PAMELA B , GROSSE WILLIAM M , HART MATTHEW , KEKUDA RAMESH , SHIMKETS RICHARD A , SPYTEK KIMBERLY A , SZEKERES EDWARD S JR , TOMLINSON JAMES E , TOPPER JAMES N , YANG RUEY-BIN
Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses tehrapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
Abstract translation: 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及前述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任何一种相关的病症的治疗，诊断和研究方法。
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8.发明申请METHODS FOR PRODUCTION OF PURIFIED SOLUBLE TYPE B AND TYPE A HUMAN PLATELET-DERIVED GROWTH FACTOR RECEPTOR FRAGMENTS 审中-公开纯化溶剂型B和A型人类平板衍生生长因子受体片段的生产方法
公开(公告)号：WO1993011223A1
公开(公告)日：1993-06-10
申请号：PCT/US1992010430
申请日：1992-12-01
Applicant: COR THERAPEUTICS, INC. , WOLF, David , TOMLINSON, James, E.
Inventor： COR THERAPEUTICS, INC.
IPC: C12N01/21
Abstract: Cell lines and methods for high efficiency production of soluble peptides having platelet-derived growth factor (PDGF) ligand binding activity. Cell lines are provided which secrete soluble fragments from extracellular regions of PDGF receptor (PDGF-R) polypeptides. Methods using these cell lines for production of the fragments are also provided.
Abstract translation: 用于高效生产具有血小板衍生生长因子（PDGF）配体结合活性的可溶性肽的细胞系和方法。 提供从PDGF受体（PDGF-R）多肽细胞外区分泌可溶性片段的细胞系。 还提供了使用这些细胞系生产片段的方法。
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9.发明申请METHODS AND COMPOSITIONS FOR TREATING CARDIOVASCULAR DISEASE USING 1722, 10280, 59917, 85553, 10653, 9235, 21668, 17794, 2210, 6169, 10102, 21061,17662,1468,12282, 6350, 9035,1820, 23652, 7301, 8925, 8701, 3533, 9462, 9123,12788,17729, 65552,1261, 21476, 33770, 9380, 2569654, 33556, 53656, 44143, 32612, 10671, 261, 44570, 4 审中-公开用于治疗心血管疾病的方法和组合物，使用1722,10280,59917,85553,1063,5225,26668,17794,2210,6149,10102,21061,17662,1468,12282,63050,17535,1820,236522,7301,8925， 8701,3533,9462,9123,12788,17729,65552,1261,21476,33770,9380,2569654,33556,5366,44143,32612,10671,261,4457,4
公开(公告)号：WO2004063340A3
公开(公告)日：2005-07-14
申请号：PCT/US2004000393
申请日：2004-01-13
Applicant: MILLENNIUM PHARM INC , STAGLIANO NANCY E , HEALY AILEEN , ACTON SUSAN L , GALVIN KATHERINE M , DONOGHUE MARY A , ROGRIGUE-WAY AMELIE , TOMLINSON JAMES E
Inventor： STAGLIANO NANCY E , HEALY AILEEN , ACTON SUSAN L , GALVIN KATHERINE M , DONOGHUE MARY A , ROGRIGUE-WAY AMELIE , TOMLINSON JAMES E
CPC classification number: C07K14/47
Abstract: The present invention relates to methods for the diagnosis and treatment of cardiovascular disease, including, but not limited to, atherosclerosis, reperfusion injury, hypertension, restenosis, arterial inflammation, thrombosis and endothelial cell disorders. Specifically, the present invention identifies the differential expression of 1722, 10280, 59917, 85553, 10653, 9235, 21668, 17794, 2210, 6169, 10102, 21061, 17662, 1468, 12282, 6350, 9035, 1820, 23652, 7301, 8925, 8701, 3533, 9462, 9123, 12788, 17729, 65552, 1261, 21476, 33770, 9380, 2569654, 33556, 53656, 44143, 32612, 10671, 261, 44570, 41922, 2552, 2417, 19319, 43969, 8921, 8993, 955, 32345, 966, 1920, 17318, 1510, 14180, 26005, 554, 16408, 42028, 112091, 13886, 13942, 1673, 54946 and 2419 genes in cardiovascular disease states, relative to their expression in normal, or noncardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. The present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating cardiovascular disease. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
Abstract translation: 本发明涉及用于诊断和治疗心血管疾病的方法，包括但不限于动脉粥样硬化，再灌注损伤，高血压，再狭窄，动脉炎症，血栓形成和内皮细胞疾病。 具体地说，本发明鉴定了1722,1028,8059917,85553,1063,53235,26668,17794,2210,6169,1010,21061,17662,1468,12282,65050,9035,1820,236522,7301,6005的标准差， 8925,8701,33533,9462,9123,12788,17729,65552,1261,21476,33770,9380,2569654,33556,5366,44143,32612,10677,261,44570,41922,2552,2417,19319,4399， 8921,8993,905,232345,996,1920,17318,1510,14180,26205,554,16408,42028,112091,13886,13942,1673,5496和2419中的基因，相对于它们在正常的表达，心血管疾病状态， 或非心血管疾病状态，和/或响应与心血管疾病相关的操作。 本发明描述了各种心血管疾病的诊断评估和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。 本发明还提供了鉴定能调节心血管疾病的化合物的方法。 本发明还提供了用于鉴定和治疗化合物作为心血管疾病治疗的方法。
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公开(公告)号：WO2002016599A3
公开(公告)日：2002-02-28
申请号：PCT/US2001/026510
申请日：2001-08-27
Applicant: CURAGEN CORPORATION , COR THERAPEUTICS, INC. , BURGESS, Catherine, E. , CONLEY, Pamela, B. , GROSSE, William, M. , HART, Matthew , KEKUDA, Ramesh , SHIMKETS, Richard, A. , SPYTEK, Kimberly, A. , SZEKERES, Edward, S., Jr. , TOMLINSON, James, E. , TOPPER, James, N. , YANG, Ruey-Bin
Inventor： BURGESS, Catherine, E. , CONLEY, Pamela, B. , GROSSE, William, M. , HART, Matthew , KEKUDA, Ramesh , SHIMKETS, Richard, A. , SPYTEK, Kimberly, A. , SZEKERES, Edward, S., Jr. , TOMLINSON, James, E. , TOPPER, James, N. , YANG, Ruey-Bin
IPC: C12N15/00
Abstract: Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses tehrapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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