公开(公告)号：WO2017141245A1

公开(公告)日：2017-08-24

申请号：PCT/IL2017/050199

申请日：2017-02-15

Applicant: CONVERGENT R.N.R LTD.

Inventor： BAR-DAVID, Aharon ,  BURSHTEIN, Zeev ,  KELLER, Avigail ,  HAREL, Zeev

IPC: H01J47/00 ,  A61N5/10

CPC classification number: A61N5/1075

Abstract: A method of evaluating a maximal dose deposited by an X-ray beam within a medium comprises the steps of: (a) irradiating said medium by said X-rays beam penetrating into a depth of said medium along an axis of said X-ray beam; (b) measuring a dose distribution along said axis. The step of measuring said dose distribution further comprises measuring cross-sectional distributions with a predetermined incremental shift thereof along said beam axis, and calculating a 1-dimesional function of said maximal dose in dependence on said depth taken from maximum dose at each cross-sectional distribution at each depth.

Abstract translation: 在介质内评估由X射线束沉积的最大剂量的方法包括以下步骤：（a）通过穿过所述介质深度的所述X射线束照射所述介质， 所述X射线束的轴线; （b）沿着所述轴线测量剂量分布。 测量所述剂量分布的步骤进一步包括测量具有沿着所述射束轴线的预定增量移位的横截面分布，并且根据从每个横截面处的最大剂量取得的所述深度计算所述最大剂量的一维函数 分布在每个深度。

公开(公告)号：WO2016108235A1

公开(公告)日：2016-07-07

申请号：PCT/IL2015/051265

申请日：2015-12-29

Applicant: CONVERGENT R.N.R LTD

Inventor： BAR-DAVID, Aharon ,  MARKOVICH, Miri ,  KELLER, Avigail ,  BURSHTEIN, Zeev ,  HAREL, Zeev

IPC: G21K1/06

CPC classification number: G21K1/067 ,  G21K1/06 ,  G21K2201/062

Abstract: New techniques for converging X-rays are described. These techniques can be used for the design of an X-ray lens for the converging of X-rays into a focal point or a focal volume using a point source or an extended source. The aim of this design is to add important new features over those of the previous suggested patented device. The additional features are to provide control of the size and shape of the focal volume, the beam shape, uniformity and quality, and ease of manufacturing.

Abstract translation: 描述了用于会聚X射线的新技术。 这些技术可用于设计用于使用点源或扩展源将X射线会聚到焦点或焦点体积的X射线透镜。 这种设计的目的是增加与以前提出的专利设备相比的重要新功能。 附加的特征是提供焦距体积的大小和形状的控制，光束形状，均匀性和质量以及易于制造。

公开(公告)号：WO2013121418A1

公开(公告)日：2013-08-22

申请号：PCT/IL2013/050121

申请日：2013-02-10

Applicant: CONVERGENT R.N.R LTD

Inventor： BURSHTEIN, Zeev ,  HAREL, Zeev ,  BAR-DAVID, Aharon ,  KORN, Donald M.

IPC: A61N5/10 ,  A61N5/00 ,  G21K1/06

CPC classification number: A61N5/1049 ,  A61B6/06 ,  A61B6/4021 ,  A61B6/4035 ,  A61B6/483 ,  A61N5/1065 ,  A61N5/1077 ,  A61N5/1084 ,  A61N2005/1054 ,  A61N2005/1061 ,  A61N2005/1091 ,  A61N2005/1095 ,  G21K1/04 ,  G21K1/065 ,  G21K1/067 ,  G21K2201/064 ,  H05G1/70

Abstract: Methods and devices are provided to enable treatment and imaging of a target in an X-ray system. In some configurations, radiation from a single X-ray source is used to provide both imaging and treatment radiations. A shutter is placed in a path between the X-ray source and the target to selectively control the imaging radiation that irradiates the target. Another shutter can be placed in a path between the X-ray source and the target to selectively control the treatment radiation. The operations of the shutters are controlled to allow simultaneous or time-multiplexed irradiation of the target with the imaging and treatment radiations. A detector captures the imaging radiation after it has interacted with the target and enables accurate determination of target characteristics, including the size and shape of the target.

Abstract translation: 提供了方法和装置以使得能够在X射线系统中对靶进行治疗和成像。 在一些配置中，来自单个X射线源的辐射用于提供成像和处理辐射。 快门被放置在X射线源和靶之间的路径中，以选择性地控制照射目标的成像辐射。 另一个快门可以放置在X射线源和靶之间的路径中，以选择性地控制治疗辐射。 控制百叶窗的操作以允许用成像和处理辐射同时或时间多次地照射目标物。 检测器在与目标物体相互作用后捕获成像辐射，能够精确确定目标特征，包括目标的大小和形状。

公开(公告)号：US12109439B2

公开(公告)日：2024-10-08

申请号：US17166064

申请日：2021-02-03

Applicant: Convergent R.N.R Ltd.

Inventor： Aharon Bar-David ,  Michael Kleckner ,  Shirly Borukhin ,  Zeev Harel

IPC: A61N5/10

CPC classification number: A61N5/1075 ,  A61N5/1065 ,  A61N2005/1076 ,  A61N2005/1085

Abstract: A method of a radiotherapy or radiosurgery treatment comprises steps of: (a) providing a converging x-ray beam source configured for emitting a converging X-ray beam propagating along an axis thereof; (b) emitting the converging x-ray beam towards a volume of treatment (VOT) having a length along the axis of the converging X-ray beam ranging between 2 mm and 5 cm within a patient's body such that a waist portion is within the VOT; (c) propagating the beam through tissues previously located relative to the VOT (PO); the VOT per se and tissues distally located to the VOT (DO). The converging X-ray beam characterized by a convergent angle ranging between 2 and 30 degrees providing 80% to 100% of a maximum dose is received by the VOT and less than 60% of the maximum dose is received by the PO and the DO.

公开(公告)号：US20210113855A1

公开(公告)日：2021-04-22

申请号：US17071098

申请日：2020-10-15

Applicant: CONVERGENT R.N.R LTD.

Inventor： Aharon BAR-DAVID ,  Michael KLECKNER ,  Shirly BORUKHIN ,  Zeev BURSHTEIN ,  Avigail KELLER ,  Zeev HAREL

IPC: A61N5/10

Abstract: A method of evaluating a maximal dose deposited by a non-uniform X-ray beam within a medium comprising the steps of: (a) irradiating said medium by said non-uniform X-ray beam penetrating into a depth of said medium along an axis of said X-ray beam; (b) incrementally measuring a number of transversal dose distributions at successive depths along said axis; (c) determining a maximum dose within each of said number of transversal dose distributions; and (d) calculating a 1-Dimesional depth dependance of said maximal doses obtained from said number of transversal dose distributions.

公开(公告)号：US10265510B2

公开(公告)日：2019-04-23

申请号：US15503006

申请日：2015-08-12

Applicant: CONVERGENT R.N.R LTD

Inventor： Zeev Harel ,  Zeev Burshtein ,  Aharon Bar-David ,  Miri Markovich

IPC: A61M37/00 ,  A61N5/10 ,  A61K41/00 ,  A61K9/00

Abstract: The present invention provides a method for activating a pro-drug in vivo comprising the steps of: (a) administering a pro-drag to a subject; (b) locating a target site which has been at least partially dosed with the pro-drug at a predetermined concentration; and (d) exposing the target site to X-ray radiation. The step of exposing the target site to X-ray radiation is characterized by providing a converging X-ray of a controllable waist, substantially uniform at the target site, sufficient to convert the pro-drug to an active drug, while the X-ray photon dosage at the target site is higher than the X-ray photon dosage at an adjacent non target site.

公开(公告)号：US20210193345A1

公开(公告)日：2021-06-24

申请号：US17196340

申请日：2021-03-09

Applicant: CONVERGENT R.N.R LTD.

Inventor： Aharon BAR-DAVID ,  Zeev HAREL ,  Zeev BURSHTEIN

IPC: G21K5/04 ,  A61B6/00 ,  G21K1/06 ,  A61N5/10

Abstract: An X-ray lens arrangement for forming a radiation pattern as a focal track is disclosed. The pattern comprises at least one 3-dimensional focal track of radiation. The aforesaid lens arrangement has a main axis passing through intensity weighted centroids of the Xray source and the pattern. The lens arrangement includes at least one reflecting surface of continuously varying Rowland arcs. Each point belonging to the focal track is linked to each elemental point composing an emitting surface of said source by a corresponding Rowland arc.

公开(公告)号：US20190175953A1

公开(公告)日：2019-06-13

申请号：US16258612

申请日：2019-01-27

Applicant: CONVERGENT R.N.R LTD

Inventor： Aharon BAR-DAVID ,  Miri MARKOVICH ,  Zeev BURSHTEIN ,  Zeev HAREL

IPC: A61N5/10

Abstract: A method of a radiotherapy or radiosurgery treatment comprises steps of: (a) providing a converging x-ray beam source configured for emitting a converging X-ray beam propagating along an axis thereof; (b) emitting the converging x-ray beam towards a volume of treatment (VOT) having a length along the axis of the converging X-ray beam ranging between 2 mm and 5 cm within a patient's body such that a waist portion is within the VOT; (c) propagating the beam through tissues previously located relative to the VOT (PO); the VOT per se and tissues distally located to the VOT (DO). The converging X-ray beam characterized by a convergent angle ranging between 2 and 30 degrees providing 80% to 100% of a maximum dose is received by the VOT and less than 60% of the maximum dose is received by the PO and the DO.

公开(公告)号：US20170232245A1

公开(公告)日：2017-08-17

申请号：US15503006

申请日：2015-08-12

Applicant: CONVERGENT R.N.R LTD

Inventor： Zeev HAREL ,  Zeev BURSHTEIN ,  Aharon BAR-DAVID ,  Miri MARKOVICH

IPC: A61M37/00 ,  A61K41/00 ,  A61N5/10

CPC classification number: A61M37/00 ,  A61K9/0009 ,  A61K41/00 ,  A61K41/0052 ,  A61M2037/0007 ,  A61N5/10 ,  A61N2005/1091 ,  A61N2005/1098

Abstract: The present invention provides a method for activating a pro-drug in vivo comprising the steps of: (a) administering a pro-drag to a subject; (b) locating a target site which has been at least partially dosed with the pro-drug at a predetermined concentration; and (d) exposing the target site to X-ray radiation. The step of exposing the target site to X-ray radiation is characterized by providing a converging X-ray of a controllable waist, substantially uniform at the target site, sufficient to convert the pro-drug to an active drug, whilst the X-ray photon dosage at the target site is higher than the X-ray photon dosage at an adjacent non target site.

公开(公告)号：US20150248942A1

公开(公告)日：2015-09-03

申请号：US14430683

申请日：2013-09-01

Applicant: CONVERGENT R.N.R. LTD

Inventor： Aharon Bar-David ,  Zeev Burshtein ,  Zeev Harel

IPC: G21K1/06

CPC classification number: G21K1/062 ,  A61N5/1042 ,  A61N5/1084 ,  A61N2005/1091 ,  A61N2005/1095 ,  G21K5/04 ,  G21K2201/064

Abstract: An X-ray lens arrangement for forming a radiation pattern as a focal track is disclosed. The pattern comprises at least one 3-dimensional focal track of radiation. The aforesaid lens arrangement has a main axis passing through intensity weighted centroids of the X-ray source and the pattern. The lens arrangement includes at least one reflecting surface of continuously varying Rowland arcs. Each point belonging to the focal track is linked to each elemental point composing an emitting surface of said source by a corresponding Rowland arc.

Abstract translation: 公开了一种用于形成辐射图案作为焦点轨迹的X射线透镜装置。 该图案包括至少一个辐射的三维焦点轨迹。 上述透镜装置具有通过X射线源的强度加权质心和图案的主轴。 透镜装置包括连续变化的罗兰弧的至少一个反射表面。 属于焦点轨迹的每个点通过相应的罗兰弧连接到构成所述源的发射表面的每个元素点。