公开(公告)号：WO2015087319A1

公开(公告)日：2015-06-18

申请号：PCT/IL2014/051065

申请日：2014-12-07

Applicant: CONVERGENT R.N.R LTD

Inventor： BAR-DAVID, Aharon ,  MARKOVICH, Miri ,  BURSHTEIN, Zeev ,  HAREL, Zeev

IPC: A61N5/10

CPC classification number: A61N5/1077 ,  A61N5/1031 ,  A61N5/1048 ,  A61N5/1084

Abstract: A standard of care protocol for increasing efficiency of a radiotherapy or radiosurgery treatment and reducing the treatment's side effects by radiating with a converging x-ray beam source emitting a converging x-ray beam (102) towards at least one volume of treatment (VOT) (103) within a patient's body; the beam is passing through at least one organ preceding said VOT (PO) (105) and at least one organ distal to said VOT (DO) (106); the VOT is receiving, on average, at least 80% of maximum dose whilst thr PO and DO are receiving, on average, no more than 40% of the maximum dose.

Abstract translation: 一种用于提高放射治疗或放射外科治疗效率的护理方案的标准，并且通过用朝向至少一个治疗体积（VOT）发射会聚的X射线束（102））的会聚x射线束源辐射来减少治疗的副作用， （103）在患者体内; 光束穿过所述VOT（PO）（105）之前的至少一个器官和远离所述VOT（DO）（106）的至少一个器官; VOT平均接受最大剂量的至少80％，而PO和DO接受平均不超过最大剂量的40％。

公开(公告)号：WO2020170245A1

公开(公告)日：2020-08-27

申请号：PCT/IL2020/050181

申请日：2020-02-18

Applicant: CONVERGENT R.N.R LTD.

Inventor： HAREL, Zeev ,  BAR-DAVID, Aharon ,  BURSHTEIN, Zeev

IPC: A61B6/00 ,  A61B10/00 ,  A61B90/17 ,  A61N5/10

Abstract: An arrangement for securing a female breast during a medical procedure comprises a receptacle conformed to a shape of the female breast. The receptacle is configured to be vacuumed such that the female breast is releasably securable within the receptacle. The arrangement comprises a first and second concave shell-like articles; the first article is sieve and forms the receptacle. The first article is nested into the second article such that an internal cavity is formed therebetween. The female breast when placed into the receptacle is securable therewithin by exhausting air from the internal cavity and pneumatically attaching tissues of the female breast to the first sieve article.

公开(公告)号：WO2014045273A1

公开(公告)日：2014-03-27

申请号：PCT/IL2013/050739

申请日：2013-09-01

Applicant: CONVERGENT R.N.R LTD

Inventor： BAR-DAVID, Aharon ,  BURSHTEIN, Zeev ,  HAREL, Zeev

IPC: G02B17/00 ,  G06K1/06

CPC classification number: G21K1/062 ,  A61N5/1042 ,  A61N5/1084 ,  A61N2005/1091 ,  A61N2005/1095 ,  G21K5/04 ,  G21K2201/064

Abstract: An X-ray lens arrangement for forming a radiation pattern as a focal track is disclosed. The pattern comprises at least one 3-dimensional focal track of radiation. The aforesaid lens arrangement has a main axis passing through intensity weighted centroids of the X- ray source and the pattern. The lens arrangement includes at least one reflecting surface of continuously varying Rowland arcs. Each point belonging to the focal track is linked to each elemental point composing an emitting surface of said source by a corresponding Rowland arc.

Abstract translation: 公开了一种用于形成辐射图案作为焦点轨迹的X射线透镜装置。 该图案包括至少一个辐射的三维焦点轨迹。 上述透镜装置具有通过X射线源的强度加权质心和图案的主轴。 透镜装置包括连续变化的罗兰弧的至少一个反射表面。 属于焦点轨迹的每个点通过相应的罗兰弧连接到构成所述源的发射表面的每个元素点。

公开(公告)号：WO2016024279A1

公开(公告)日：2016-02-18

申请号：PCT/IL2015/050824

申请日：2015-08-12

Applicant: CONVERGENT R.N.R LTD

Inventor： HAREL, Zeev ,  BURSHTEIN ZEEV, Zeev ,  BAR-DAVID, Aharon ,  MARKOVICH, Miri

IPC: A61N5/10 ,  A61K41/00

CPC classification number: A61M37/00 ,  A61K9/0009 ,  A61K41/00 ,  A61K41/0052 ,  A61M2037/0007 ,  A61N5/10 ,  A61N2005/1091 ,  A61N2005/1098

Abstract: The present invention provides a method for activating a pro-drug in vivo comprising the steps of: (a) administering a pro-drag to a subject; (b) locating a target site which has been at least partially dosed with the pro-drug at a predetermined concentration; and (d) exposing the target site to X-ray radiation. The step of exposing the target site to X-ray radiation is characterized by providing a converging X-ray of a controllable waist, substantially uniform at the target site, sufficient to convert the pro-drug to an active drug, whilst the X-ray photon dosage at the target site is higher than the X-ray photon dosage at an adjacent non target site.

Abstract translation: 本发明提供了一种在体内活化前药的方法，包括以下步骤：（a）向受试者施用阻遏物; （b）将至少部分给予前药的目标部位定位在预定浓度下; 和（d）将目标部位暴露于X射线辐射。 将目标部位暴露于X射线辐射的步骤的特征在于提供可控腰部的会聚X射线，其在目标部位基本均匀，足以将前药转化为活性药物，同时X射线 目标位点的光子剂量高于相邻非靶位点处的X射线光子剂量。

公开(公告)号：WO2015140796A1

公开(公告)日：2015-09-24

申请号：PCT/IL2015/050281

申请日：2015-03-16

Applicant: CONVERGENT R.N.R LTD

Inventor： BAR-DAVID, Aharon ,  BURSHTEIN, Zeev ,  KELLER, Avigail ,  HAREL, Zeev

IPC: G21K1/06 ,  G21K5/04 ,  G01N23/02

CPC classification number: G01N23/046 ,  G01N2223/316 ,  G21K1/067

Abstract: An X-ray system is arranged for Imaging using converging X-rays that is produced by a converging device, for example an X-ray lens, that converges the X-rays towards a focusing point. The purpose of the system is to image a small volume at the target location with improved quality and the ability to magnify the image and obtaining additional information.

Abstract translation: X射线系统被布置成用于使用由会聚装置（例如X射线透镜）产生的会聚X射线的成像，其将X射线会聚到聚焦点。 该系统的目的是在目标位置对较小的体积进行成像，并提高质量，并具有放大图像和获得附加信息的能力。

公开(公告)号：WO2021059271A1

公开(公告)日：2021-04-01

申请号：PCT/IL2020/051039

申请日：2020-09-23

Applicant: CONVERGENT R.N.R LTD

Inventor： BORUKHIN, Shirly ,  KLECKNER, Michael ,  BAR-DAVID, Aharon ,  HAREL, Zeev

IPC: G21K1/06 ,  B23B7/00

Abstract: A method of manufacturing burr-edged reflecting tile elements for a mosaic X-ray lens configured for forming an X-ray beam comprises steps of: (a) providing a single crystal having first and second faces thereof being parallel therebetween; single crystal having crystallographic planes thereof being parallel to first and second faces of the single crystal; the first face dedicated for reflecting an X-ray beam to be incident thereto; (b) cutting the single crystal by means of a wire electrical discharging machine normally to the main faces. The step of cutting the single crystal comprises moving a wire within a cut in direction from the second face to the first face; such that burrs configured for reflecting the X-ray beam to be incident thereto are formed on edges of the cut.

公开(公告)号：WO2019003229A1

公开(公告)日：2019-01-03

申请号：PCT/IL2018/050708

申请日：2018-06-28

Applicant: CONVERGENT R.N.R LTD.

Inventor： BAR-DAVID, Aharon ,  MARKOVICH, Miri ,  KELLER, Avigail ,  BURSHTEIN, Zeev ,  HAREL, Zeev

IPC: G21K1/06 ,  A61N5/00 ,  G01N23/083

Abstract: An X-ray system for providing a converging X-rays comprising: (a) an X-ray source having an optical axis thereof; (b) an X-ray lens arrangement comprising at least one first ring having a first Bragg reflecting surface formed by a plurality of tiles made from single crystal. At least one ring is provided with at least one second ring mounted adjacently thereto along said optical axis in a coaxial manner; said second ring has a second Bragg reflecting surface reflecting surface thereof.

公开(公告)号：WO2017141245A1

公开(公告)日：2017-08-24

申请号：PCT/IL2017/050199

申请日：2017-02-15

Applicant: CONVERGENT R.N.R LTD.

Inventor： BAR-DAVID, Aharon ,  BURSHTEIN, Zeev ,  KELLER, Avigail ,  HAREL, Zeev

IPC: H01J47/00 ,  A61N5/10

CPC classification number: A61N5/1075

Abstract: A method of evaluating a maximal dose deposited by an X-ray beam within a medium comprises the steps of: (a) irradiating said medium by said X-rays beam penetrating into a depth of said medium along an axis of said X-ray beam; (b) measuring a dose distribution along said axis. The step of measuring said dose distribution further comprises measuring cross-sectional distributions with a predetermined incremental shift thereof along said beam axis, and calculating a 1-dimesional function of said maximal dose in dependence on said depth taken from maximum dose at each cross-sectional distribution at each depth.

Abstract translation: 在介质内评估由X射线束沉积的最大剂量的方法包括以下步骤：（a）通过穿过所述介质深度的所述X射线束照射所述介质， 所述X射线束的轴线; （b）沿着所述轴线测量剂量分布。 测量所述剂量分布的步骤进一步包括测量具有沿着所述射束轴线的预定增量移位的横截面分布，并且根据从每个横截面处的最大剂量取得的所述深度计算所述最大剂量的一维函数 分布在每个深度。

公开(公告)号：WO2016108235A1

公开(公告)日：2016-07-07

申请号：PCT/IL2015/051265

申请日：2015-12-29

Applicant: CONVERGENT R.N.R LTD

Inventor： BAR-DAVID, Aharon ,  MARKOVICH, Miri ,  KELLER, Avigail ,  BURSHTEIN, Zeev ,  HAREL, Zeev

IPC: G21K1/06

CPC classification number: G21K1/067 ,  G21K1/06 ,  G21K2201/062

Abstract: New techniques for converging X-rays are described. These techniques can be used for the design of an X-ray lens for the converging of X-rays into a focal point or a focal volume using a point source or an extended source. The aim of this design is to add important new features over those of the previous suggested patented device. The additional features are to provide control of the size and shape of the focal volume, the beam shape, uniformity and quality, and ease of manufacturing.

Abstract translation: 描述了用于会聚X射线的新技术。 这些技术可用于设计用于使用点源或扩展源将X射线会聚到焦点或焦点体积的X射线透镜。 这种设计的目的是增加与以前提出的专利设备相比的重要新功能。 附加的特征是提供焦距体积的大小和形状的控制，光束形状，均匀性和质量以及易于制造。

公开(公告)号：WO2013121418A1

公开(公告)日：2013-08-22

申请号：PCT/IL2013/050121

申请日：2013-02-10

Applicant: CONVERGENT R.N.R LTD

Inventor： BURSHTEIN, Zeev ,  HAREL, Zeev ,  BAR-DAVID, Aharon ,  KORN, Donald M.

IPC: A61N5/10 ,  A61N5/00 ,  G21K1/06

CPC classification number: A61N5/1049 ,  A61B6/06 ,  A61B6/4021 ,  A61B6/4035 ,  A61B6/483 ,  A61N5/1065 ,  A61N5/1077 ,  A61N5/1084 ,  A61N2005/1054 ,  A61N2005/1061 ,  A61N2005/1091 ,  A61N2005/1095 ,  G21K1/04 ,  G21K1/065 ,  G21K1/067 ,  G21K2201/064 ,  H05G1/70

Abstract: Methods and devices are provided to enable treatment and imaging of a target in an X-ray system. In some configurations, radiation from a single X-ray source is used to provide both imaging and treatment radiations. A shutter is placed in a path between the X-ray source and the target to selectively control the imaging radiation that irradiates the target. Another shutter can be placed in a path between the X-ray source and the target to selectively control the treatment radiation. The operations of the shutters are controlled to allow simultaneous or time-multiplexed irradiation of the target with the imaging and treatment radiations. A detector captures the imaging radiation after it has interacted with the target and enables accurate determination of target characteristics, including the size and shape of the target.

Abstract translation: 提供了方法和装置以使得能够在X射线系统中对靶进行治疗和成像。 在一些配置中，来自单个X射线源的辐射用于提供成像和处理辐射。 快门被放置在X射线源和靶之间的路径中，以选择性地控制照射目标的成像辐射。 另一个快门可以放置在X射线源和靶之间的路径中，以选择性地控制治疗辐射。 控制百叶窗的操作以允许用成像和处理辐射同时或时间多次地照射目标物。 检测器在与目标物体相互作用后捕获成像辐射，能够精确确定目标特征，包括目标的大小和形状。