中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

60 records (took 0.027 seconds)

    QUINIDINE CONJUGATES AND THEIR USE IN IMMUNOASSAYS
    11.
    发明申请
    QUINIDINE CONJUGATES AND THEIR USE IN IMMUNOASSAYS 审中-公开
    喹诺酮联合用药及其在免疫中的应用

    公开(公告)号：WO1997006166A1

    公开(公告)日：1997-02-20

    申请号：PCT/US1996012649

    申请日：1996-08-02

    Applicant: DADE CHEMISTRY SYSTEMS INC.

    Inventor： DADE CHEMISTRY SYSTEMS INC. ,  SIMONS, Donald, Max

    IPC: C07D453/04

    CPC classification number: C07C271/16 ,  C07C217/08 ,  C07C269/04 ,  C07D453/04 ,  G01N33/9453

    Abstract: This invention relates to quinidine derivatives and immunogenic conjugates and reporter conjugates prepared therefrom. The immunogenic conjugates and reporter conjugates are useful for eliciting antibodies and for performing immunoassays for quinidine. A particle agglutination immunoassay for quinidine is also provided.

    Abstract translation: 本发明涉及由其制备的奎尼丁衍生物和免疫原性缀合物及其报道偶联物。 免疫原性缀合物和报告物缀合物可用于引发抗体和用于进行奎尼丁的免疫测定。 还提供了用于奎尼丁的颗粒凝集免疫测定。

    14.
    发明专利
    未知

    公开(公告)号：DE69319693D1

    公开(公告)日：1998-08-20

    申请号：DE69319693

    申请日：1993-09-09

    Applicant: DADE CHEMISTRY SYSTEMS INC

    Inventor： LOYD JOSEPH ,  SEARCH BARBARA A

    IPC: C12N9/12 ,  C12N9/96 ,  C12Q1/50 ,  G01N33/573

    Abstract: A formulation for stabilizing enzymatic activity and immunoreactivity of creatine kinase and creatine kinase isoenzymes comprising animal serum, creatine kinase and/or creatine kinase isoenzymes, an effective amount of a buffer having a pKa in the range of 6.2-7.6 to maintain pH of the formulation at 6.7+/-0.1, an effective amount of a non-thiol antioxidant to prevent oxidation of creatine kinase or creatine kinase isoenzyme thiol groups, an effective amount of a non-reducing polyol to stabilize immunoreactivity of creatine kinase or creatine kinase isoenzymes, and an effective amount of an antimicrobial to prevent microbial growth is provided.

    15.
    发明专利
    未知

    公开(公告)号：DE69316281D1

    公开(公告)日：1998-02-19

    申请号：DE69316281

    申请日：1993-07-02

    Applicant: DADE CHEMISTRY SYSTEMS INC

    Inventor： PACE SALVATORE J ,  HAMERSLAG JAMES DAVID

    IPC: G01N27/28 ,  G01N27/27 ,  G01N27/403 ,  G01N27/416

    Abstract: A readily disposable ion selective electrode assembly, free of onboard reagents, for use in analyzers has a reference element and plural sensor elements linearly positioned in parallel on a substrate. An elastomeric flow channel member containing two parallel grooves creates flow channels on the substrate above the elements. The substrate holds the elastomer in compression and is retained by snaps injection molded into a housing. Electrical contacts and leakfree fluidic connections are provided by spring loaded connectors through the housing. Reference and sample fluids are drawn through the respective flow channels and come together to form a liquid junction downstream from the sensor elements. Bubbles, that might otherwise cause erroneous results, are detected.

    19.
    发明专利
    未知

    公开(公告)号：DE69214942T2

    公开(公告)日：1997-03-27

    申请号：DE69214942

    申请日：1992-03-12

    Applicant: DADE CHEMISTRY SYSTEMS INC

    Inventor： OBZANSKY DAVID ,  SIMONS DONALD ,  TSENG SUSAN

    IPC: G01N33/53 ,  G01N33/543

    Abstract: Immunoassays and DNA probe assays utilizing a non-immune, reversible binding displacement system are provided. In the assay, a releasable ligand, a binding partner for the releasable ligand, an analyte of interest, an analytically detectable (reporter) group, and at least one binding partner for the analyte, are first attached to an insoluble phase so as to form reporter-labeled complex bound to an insoluble phase, followed by the addition of a displacer ligand which displaces the releasable ligand along with some portion of the reporter-labeled complex, so that the released reporter is analytically detectable in a free liquid medium and can be related to the concentration of analyte in the sample.

Patent Agency Ranking