公开(公告)号：JPS53127844A

公开(公告)日：1978-11-08

申请号：JP3909378

申请日：1978-04-03

Applicant: INDIANA UNIVERSITY FOUNDATION

Inventor： JIYOSEFU SHII MUURAA ,  KAARU JIEI KUREBAA ,  REI JII KERII

IPC: A23G3/34 ,  A23G3/00 ,  A23G3/36 ,  A23L29/00 ,  A61K8/00 ,  A61K8/20 ,  A61K8/23 ,  A61K8/26 ,  A61K8/34 ,  A61K8/36 ,  A61K8/362 ,  A61K8/60 ,  A61K8/73 ,  A61Q11/00

公开(公告)号：JPS57208954A

公开(公告)日：1982-12-22

申请号：JP3453182

申请日：1982-03-04

Applicant: INDIANA UNIVERSITY FOUNDATION

Inventor： JIYOSEFU SHII MUURAA ,  KAARU JIEI KUREBAA ,  RONARUDO ERU RIIMU ,  DEEBITSUDO EMU MUUA

IPC: A23G4/00

公开(公告)号：JPS5296775A

公开(公告)日：1977-08-13

申请号：JP915377

申请日：1977-01-29

Applicant: INDIANA UNIVERSITY FOUNDATION

Inventor： JIYOSEFU SHII MUURAA ,  KAARU JIEI KUREBAA ,  REI JII KERII

IPC: A23G3/34 ,  A21D2/18 ,  A23G3/00 ,  A23G3/42 ,  A23L27/00 ,  A23L27/30

公开(公告)号：CA2219460C

公开(公告)日：2009-04-14

申请号：CA2219460

申请日：1996-06-07

Applicant: INDIANA UNIVERSITY FOUNDATION

Inventor： ROESKE ROGER W

IPC: A61K38/00 ,  C07K7/23 ,  A61K38/08 ,  A61K38/09 ,  A61P5/00 ,  A61P5/04 ,  A61P35/00 ,  C07K7/08

Abstract: Novel LHRH antagonist peptides, pharmaceutical compositions thereof, and methods of use thereof, are disclosed. The LHRH antagonist comprise a peptide compound, wherein a residue of the peptide compound corresponding to the amino acid at position 6 of natural mammalian LHRH comprises a hydrophilic N-acyl moiety, a dipolar moiety, a sulfonium moiety, a receptor-modifying moiety or a small polar moiety.

公开(公告)号：DE69233724T2

公开(公告)日：2009-04-02

申请号：DE69233724

申请日：1992-05-01

Applicant: UNIV YALE ,  INDIANA UNIVERSITY FOUNDATION

Inventor： ARTAVANIS-TSAKONAS SPYRIDON ,  FEHON RICHARD GRANT ,  REBAY ILARIA

IPC: C12N15/09 ,  C12N15/12 ,  A61K38/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/485 ,  C07K14/52 ,  C07K14/705 ,  C07K16/00 ,  C07K16/18 ,  C07K19/00 ,  C12N5/10 ,  C12N15/62 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91

Abstract: The present invention provides methods for the manipulation of cell differentiation comprising contacting a cell with an amount of a toporythmic protein, or with a fragment or derivative of a first toporythmic protein which fragment or derivative being able to bind to a second toporythmic protein, or with an amount of an antibody or fragment thereof containing the idiotype thereof which binds to a toporythmic protein, said toporythmic protein being effective to manipulate the differentiation of the contacted cell.

公开(公告)号：AT397661T

公开(公告)日：2008-06-15

申请号：AT99101563

申请日：1992-05-01

Applicant: UNIV YALE ,  INDIANA UNIVERSITY FOUNDATION

Inventor： ARTAVANIS-TSAKONAS SPYRIDON ,  MUSKAVITCH MARC ALAN TELANDER ,  FEHON RICHARD GRANT ,  SHEPARD SCOTT

IPC: C12N15/09 ,  C12N15/12 ,  A61K38/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/485 ,  C07K14/52 ,  C07K14/705 ,  C07K16/00 ,  C07K16/18 ,  C07K19/00 ,  C12N5/10 ,  C12N15/62 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91

Abstract: The present invention provides methods for the manipulation of cell differentiation comprising contacting a cell with an amount of a toporythmic protein, or with a fragment or derivative of a first toporythmic protein which fragment or derivative being able to bind to a second toporythmic protein, or with an amount of an antibody or fragment thereof containing the idiotype thereof which binds to a toporythmic protein, said toporythmic protein being effective to manipulate the differentiation of the contacted cell.

公开(公告)号：DK0930365T3

公开(公告)日：2008-06-02

申请号：DK99101562

申请日：1992-05-01

Applicant: UNIV YALE ,  INDIANA UNIVERSITY FOUNDATION

Inventor： ARTAVANIS-TSAKONAS SPYRIDON ,  FEHON RICHARD ,  REBAY ILARIA

IPC: C12N15/09 ,  C12N15/12 ,  A61K38/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/485 ,  C07K14/52 ,  C07K14/705 ,  C07K16/00 ,  C07K16/18 ,  C07K19/00 ,  C12N5/10 ,  C12N15/62 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91

Abstract: The present invention provides methods for the manipulation of cell differentiation comprising contacting a cell with an amount of a toporythmic protein, or with a fragment or derivative of a first toporythmic protein which fragment or derivative being able to bind to a second toporythmic protein, or with an amount of an antibody or fragment thereof containing the idiotype thereof which binds to a toporythmic protein, said toporythmic protein being effective to manipulate the differentiation of the contacted cell.

公开(公告)号：AT386116T

公开(公告)日：2008-03-15

申请号：AT99101562

申请日：1992-05-01

Applicant: UNIV YALE ,  INDIANA UNIVERSITY FOUNDATION

Inventor： ARTAVANIS-TSAKONAS SPYRIDON ,  FEHON RICHARD ,  REBAY ILARIA

IPC: C12N15/09 ,  C12N15/12 ,  A61K38/00 ,  C07K14/435 ,  C07K14/47 ,  C07K14/485 ,  C07K14/52 ,  C07K14/705 ,  C07K16/00 ,  C07K16/18 ,  C07K19/00 ,  C12N5/10 ,  C12N15/62 ,  C12P21/02 ,  C12P21/08 ,  C12R1/91

Abstract: The present invention provides methods for the manipulation of cell differentiation comprising contacting a cell with an amount of a toporythmic protein, or with a fragment or derivative of a first toporythmic protein which fragment or derivative being able to bind to a second toporythmic protein, or with an amount of an antibody or fragment thereof containing the idiotype thereof which binds to a toporythmic protein, said toporythmic protein being effective to manipulate the differentiation of the contacted cell.

公开(公告)号：BG63148B1

公开(公告)日：2001-05-31

申请号：BG10206497

申请日：1997-11-21

Applicant: MERCK & CO INC ,  INDIANA UNIVERSITY FOUNDATION

Inventor： SPONSEL WILLIAM E ,  HARRIS ALON

IPC: A61K45/00 ,  A61K31/00 ,  A61K31/382 ,  A61K31/425 ,  A61K31/433 ,  A61P27/02 ,  A61P27/06 ,  A61K31/38

Abstract: The invention relates to a composition comprising an effective amount of an inhibitor of carbonate dehydrogenase and a pharmaceutical tolerable carrier for local administration in the eye, and to its utilization for increasing the speed of the flow of the retinal blood circulation. The inhibitor is selected amongst dorsolamide, acetazolamide, metazolamide, in particular dorsolamide, and is in quantities ranging from 0.01 to 5% and 0.5 - 2% solution in an ophthalmologically acceptable carrier. 11 claims

公开(公告)号：PT644722E

公开(公告)日：2001-03-30

申请号：PT93915371

申请日：1993-06-15

Applicant: INDIANA UNIVERSITY FOUNDATION

Inventor： STOOKEY GEORGE K

IPC: A23K1/00 ,  A23K1/16 ,  A23K1/175 ,  A23K1/18 ,  A61K8/00 ,  A61K8/24 ,  A61Q11/00 ,  A23K1/10 ,  A23K1/22

Abstract: The novel agents for preventing dental calculus in domestic animals of the present invention are sequestering agents that are applied as coatings to commercially-prepared diets for domestic animals and that are significantly superior in terms of their anticalculus efficacy to the soluble pyrophosphate crystal growth inhibitors of the prior art. The sequestering agents of the present invention form soluble calcium complexes in saliva and dental plaque fluids thereby preventing the calcification of dental plaque. Sodium hexametaphosphate has been utilized as the preferred sequestering agents of the invention to date.