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    Weighting detector configurations in SPECT imaging
    11.
    发明授权
    Weighting detector configurations in SPECT imaging 有权

    公开(公告)号：US11579315B2

    公开(公告)日：2023-02-14

    申请号：US17586847

    申请日：2022-01-28

    Applicant: MOLECULAR DYNAMICS LIMITED

    Inventor： Tal Kenig ,  Zvi Devir

    IPC: G01T1/166

    Abstract: Method and apparatus for scanning a region of interest (ROI) by a gamma detector. An exemplary method includes determining, for each of multiple detector configurations, a respective weight based on an absorption profile, associating each of a plurality of portions of the ROI with a respective gamma attenuation value; and detecting gamma radiation from multiple detector configurations for time periods allocated among the detector configurations based on the weights determined.

    Weighting detector configurations in SPECT imaging
    12.
    发明授权
    Weighting detector configurations in SPECT imaging 有权

    公开(公告)号：US11249198B2

    公开(公告)日：2022-02-15

    申请号：US16484191

    申请日：2018-02-06

    Applicant: MOLECULAR DYNAMICS LIMITED

    Inventor： Tal Kenig ,  Zvi Devir

    IPC: G01T1/166

    Abstract: Method and apparatus for scanning a region of interest (ROI) by a gamma detector. An exemplary method includes determining, for each of multiple detector configurations, a respective weight based on an absorption profile, associating each of a plurality of portions of the ROI with a respective gamma attenuation value; and detecting gamma radiation from multiple detector configurations for time periods allocated among the detector configurations based on the weights determined.

    ROLLING CIRCLE AMPLIFICATION ASSAY FOR NUCLEIC ACID ANALYSIS
    14.
    发明申请
    ROLLING CIRCLE AMPLIFICATION ASSAY FOR NUCLEIC ACID ANALYSIS 审中-公开
    用于核酸分析的滚动圆放大测定

    公开(公告)号：WO0157256A3

    公开(公告)日：2002-07-25

    申请号：PCT/US0103439

    申请日：2001-02-02

    Applicant: MOLECULAR DYNAMICS INC ,  MAHTANI MELANIE M

    Inventor： MAHTANI MELANIE M

    IPC: C12Q1/68

    CPC classification number: C12Q1/6827 ,  C12Q1/6816 ,  C12Q1/6844 ,  C12Q2525/307 ,  C12Q2521/501 ,  C12Q2531/125 ,  C12Q2521/307 ,  C12Q2561/125 ,  C12Q2525/301 ,  C12Q2521/301

    Abstract: Method and reagents for analysis of nucleic acid sequences is disclosed. In this method a plurality of padlock probes is provided. Each padlock probe may hybridize to a locus on a target nucleic acid under hybridization conditions. If a targeted variant is present at the locus, the padlock probe may be ligated to form an amplification target circle. The amplification target circle acts as a template for production of tandem-sequence DNA. The tandem-sequence DNA may then be digested into non-tandem detection fragments which are subsequently separated and detected. The plurality of padlock probes are designed such that ligation of the probes, amplification of the target circle, and digestion of the tandem-sequence DNA subsequently produced, and detection may all be effected with the same set of reagents. Each probe targets a unique locus variant on the target nucleic acid sequence and produces a detection fragment that may be distinguished from detection fragments produced from other padlock probe in the plurality of padlock probes by using a fragment analysis detector.

    Abstract translation: 公开了分析核酸序列的方法和试剂。 在该方法中，提供了多个挂锁探针。 每个挂锁探针可以在杂交条件下与目标核酸上的位点杂交。 如果在该位置处存在目标变体，则可以将挂锁探针连接以形成扩增目标圆。 扩增目标圈作为串联序列DNA生产的模板。 然后将串联序列DNA消化成非串联检测片段，随后分离和检测。 多个挂锁探针被设计成使得探针的连接，目标循环的扩增和随后产生的串联序列DNA的消化以及检测都可以用同一组试剂进行。 每个探针靶向靶核酸序列上的唯一基因座变体，并产生检测片段，其可以与通过使用片段分析检测器在多个挂锁探针中由其他挂锁探针产生的检测片段区分开。

    FLUORESCENCE IMAGING SYSTEM EMPLOYING A MACRO SCANNING OBJECTIVE
    17.
    发明申请
    FLUORESCENCE IMAGING SYSTEM EMPLOYING A MACRO SCANNING OBJECTIVE 审中-公开
    使用宏观扫描目标的荧光成像系统

    公开(公告)号：WO1996018205A1

    公开(公告)日：1996-06-13

    申请号：PCT/US1995013531

    申请日：1995-10-20

    Applicant: MOLECULAR DYNAMICS, INC.

    Inventor： MOLECULAR DYNAMICS, INC. ,  KAIN, Robert, C.

    IPC: H01J03/14

    CPC classification number: G02B21/002 ,  G02B21/16

    Abstract: Fluorescence imaging system includes objective (21) which is achromatic and has an external entrance pupil (29), serves as a condenser for the system, and positioned above sample (23) in close proximity to one another. Laser (18) directs collimated light (19) to scan device (20) located at entrance pupil (29). Scan device (20) reflects, refracts, or diffracts light through objective (21) to illuminate a spot (22) on the sample's surface, and illuminates a line or an area on the sample surface by varying the angle of laser light into objective (21). Sample (23) emits fluorescent light (24) in response to the illumination. The fluorescent light (24) is collected by objective (21) and passes through the system along the path of the illumination light. Wavelength-discriminating dichroic filter (25), placed along the optical axis between laser (18) and objective (21), directs fluorescent light (24) onto photodetector (26) to produce a signal representing the sample surface emitting the fluorescent light. Display (37) displays the digitized data in a raster format.

    Abstract translation: 荧光成像系统包括不消色的物镜（21），并具有外部入射光瞳（29），用作系统的冷凝器，并且位于彼此靠近的样品（23）上方。 激光器（18）将准直光（19）引导到位于入射光瞳（29）处的扫描装置（20）。 扫描装置（20）通过物镜（21）反射，折射或衍射光以照射样品表面上的斑点（22），并且通过将激光的角度改变为目标来照射样品表面上的线或区域 21）。 样品（23）响应于照明而发射荧光（24）。 荧光灯（24）由物镜（21）收集并沿着照明光的路径通过系统。 沿着激光（18）和物镜（21）之间的光轴放置的波长鉴别二向色滤光器（25）将荧光（24）引导到光电检测器（26）上，以产生表示发射荧光的样品表面的信号。 显示（37）以光栅格式显示数字化数据。

    HIGH-SPEED FLUORESCENCE SCANNER
    18.
    发明申请
    HIGH-SPEED FLUORESCENCE SCANNER 审中-公开
    高速荧光扫描仪

    公开(公告)号：WO1996002824A1

    公开(公告)日：1996-02-01

    申请号：PCT/US1995007834

    申请日：1995-06-20

    Applicant: MOLECULAR DYNAMICS

    Inventor： MOLECULAR DYNAMICS ,  HUETON, Iain ,  VAN GELDER, Ezra

    IPC: G01N21/61

    CPC classification number: G01N21/6452 ,  G01N27/44721 ,  G01N2021/6417 ,  G01N2201/101

    Abstract: A high-speed fluorescence scanner for scanning a sample at equal angles has most of its optical components, including a light beam source (11), a detector (19), filters (18), lenses (17), and reflectors (15-16), in a fixed position (24), removed from the scan head (22). The lightweight scan head contains a single reflector (13) and lens (12) combination which is reciprocated rapidly along one axis to lengthen and shorten a region of the path of a collimated excitation beam (30) and to form a scan line (25-26) on a sample. The fluorescence emission is gathered by the lens (12) of the scan head and directed back, generally along the optical path of the excitation beam, to a detector. Another embodiment places the light source (43), in miniature form, directly on the scan head. The sample may be translated in an axis orthogonal to the scan line to stimulate fluorescent emission from two-dimensional portion of the sample.

    Abstract translation: 用于以相等的角度扫描样品的高速荧光扫描器具有其大部分光学部件，包括光束源（11），检测器（19），滤光器（18），透镜（17）和反射器（15- 在固定位置（24）中，从扫描头（22）移除。 轻型扫描头包含单个反射器（13）和透镜（12）组合，其沿着一个轴线快速往复运动，以延长和缩短准直激励光束（30）的路径的区域并形成扫描线（25- 26）。 荧光发射由扫描头的透镜（12）聚集，并且通常沿着激发光束的光路向后指向检测器。 另一实施例将光源（43）以微型形式放置在扫描头上。 样品可以在与扫描线正交的轴上平移以刺激来自样品的二维部分的荧光发射。

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