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    NEOADJUVANT THERAPY FOR BLADDER CANCER
    11.
    发明申请
    NEOADJUVANT THERAPY FOR BLADDER CANCER 审中-公开

    公开(公告)号：US20200155683A1

    公开(公告)日：2020-05-21

    申请号：US16748332

    申请日：2020-01-21

    Applicant: PHOTOCURE ASA

    Inventor： Kjetil Hestdal

    IPC: A61K41/00 ,  A61K47/02 ,  A61N5/06 ,  A61K39/395 ,  A61K9/08 ,  A61K9/00

    Abstract: This invention relates to a neoadjuvant therapy for bladder cancer in bladder cancer patients who are scheduled for a cystectomy and methods of carrying out such a neoadjuvant therapy. In particular, the invention relates to a composition comprising hexyl 5-ALA ester (HAL) or a pharmaceutically acceptable salt thereof for use in a neoadjuvant therapy for bladder cancer in a bladder cancer patient who is scheduled for a cystectomy, the therapy comprises instilling said composition into the bladder of said patient and exposing the inside of said bladder to light.

    SEMI-SOLID COMPOSITIONS AND PHARMACEUTICAL PRODUCTS
    13.
    发明申请
    SEMI-SOLID COMPOSITIONS AND PHARMACEUTICAL PRODUCTS 有权
    半固体组合物和药物产品

    公开(公告)号：US20150238457A1

    公开(公告)日：2015-08-27

    申请号：US14707639

    申请日：2015-05-08

    Applicant: PHOTOCURE ASA

    Inventor： Gry Stensrud

    IPC: A61K31/221

    CPC classification number: A61K31/221 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/06 ,  A61K31/195 ,  A61K41/0061 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/24 ,  A61K47/26

    Abstract: This invention relates to semi-solid compositions and semi-solid pharmaceutical products for use in the photodynamic treatment (PDT) of cancer, pre-cancerous conditions and non-cancerous conditions in the female reproductive system, the anus and the penis, preferably for use in PDT of endometrial, cervical, vulvar, vaginal, anal and penile dysplasia and HPV infections of the uterus, cervix, the vulva, the vagina, the anus and the penis. The semi-solid compositions and pharmaceutical products comprise an active ingredient which is 5-aminolevulinic acid (5-ALA) or a precursor or derivative of 5-ALA or pharmaceutically acceptable salts thereof. The invention relates further to methods of PDT of cancer, pre-cancerous conditions and non-cancerous conditions in the female reproductive system, the anus and the penis, wherein said semi-solid compositions and pharmaceutical products are used.

    Abstract translation: 本发明涉及用于癌症的光动力学治疗（PDT），女性生殖系统，肛门和阴茎中的癌前病症和非癌症状态的半固体组合物和半固体药物产品，优选用于 在子宫内膜，子宫颈，外阴，阴道，肛门和阴茎发育异常和子宫，子宫颈，外阴，阴道，肛门和阴茎的HPV感染的PDT中。 半固体组合物和药物产品包含5-氨基乙酰丙酸（5-ALA）或5-ALA的前体或衍生物的活性成分或其药学上可接受的盐。 本发明还涉及在雌性生殖系统，肛门和阴茎中的癌症的PDT，癌前病症和非癌症病症的方法，其中使用所述半固体组合物和药物产品。

    USE OF AMINOLEVULINIC ACID AND DERIVATIVES THEREOF
    14.
    发明申请
    USE OF AMINOLEVULINIC ACID AND DERIVATIVES THEREOF 审中-公开
    氨基酸及其衍生物的使用

    公开(公告)号：US20130090592A1

    公开(公告)日：2013-04-11

    申请号：US13648946

    申请日：2012-10-10

    Applicant: Photocure ASA

    Inventor： Hans Christian WULF ,  Aslak Godal ,  Jo Klaveness

    IPC: A61K41/00 ,  A61N5/06

    CPC classification number: A61K41/0061 ,  A61K31/221 ,  A61N5/062

    Abstract: The invention provides the use of a photosensitiser which is 5-aminolevulinic acid (5-ALA) or a derivative (e.g. an ester) of 5-ALA, or a pharmaceutically acceptable salt thereof, in the manufacture of a composition for use in methods of photodynamic therapy (PDT) on an animal, wherein said PDT comprises: (a) administering to said animal a composition comprising said photosensitiser; and (b) photoactivating said photosensitiser, and wherein side-effects (e.g. pain and/or erythema) of said PDT are prevented or reduced by use of one or more of (i)-(iv): (i) said composition comprises said photosensitiser in a concentration of less than 10% wt (e.g. 0.5 to 8% wt), (ii) said composition is administered for less than 2 hours (e.g. 30 minutes to 90 minutes) prior to said photoactivation, (iii) said photoactivation is carried out with a light source having a fluence rate of less than 50 mW/cm2 (e.g. 5 to 40 mW/cm2), (iv) said photoactivation is carried out with sunlight. Preferably, side-effects of PDT are prevented or reduced by using (iii) or (iv) in combination with (i) and/or (ii).

    Abstract translation: 本发明提供了5-氨基乙酰丙酸（5-ALA）或5-ALA衍生物（例如酯）或其药学上可接受的盐的光敏剂在制备用于 光动力疗法（PDT），其中所述PDT包括：（a）向所述动物施用包含所述光敏剂的组合物; 和（b）光活化所述光敏剂，并且其中通过使用（i） - （iv）中的一种或多种来防止或减少所述PDT的副作用（例如疼痛和/或红斑）：（i）所述组合物包含 浓度小于10％wt（例如0.5至8％wt）的光敏剂，（ii）所述组合物在所述光活化前施用少于2小时（例如30分钟至90分钟），（iii）所述光活化是 用光通量小于50mW / cm2（例如5〜40mW / cm2）的光源进行，（iv）所述的光活化是在太阳光下进行的。 优选地，通过使用（iii）或（iv）与（i）和/或（ii）组合来防止或减少PDT的副作用。

    Neoadjuvant therapy for bladder cancer
    16.
    发明授权
    Neoadjuvant therapy for bladder cancer 有权

    公开(公告)号：US11311620B2

    公开(公告)日：2022-04-26

    申请号：US16748332

    申请日：2020-01-21

    Applicant: PHOTOCURE ASA

    Inventor： Kjetil Hestdal

    IPC: A61K41/00 ,  A61K9/00 ,  A61K9/08 ,  A61K39/395 ,  A61K47/02 ,  A61N5/06

    Abstract: This invention relates to a neoadjuvant therapy for bladder cancer in bladder cancer patients who are scheduled for a cystectomy and methods of carrying out such a neoadjuvant therapy. In particular, the invention relates to a composition comprising hexyl 5-ALA ester (HAL) or a pharmaceutically acceptable salt thereof for use in a neoadjuvant therapy for bladder cancer in a bladder cancer patient who is scheduled for a cystectomy, the therapy comprises instilling said composition into the bladder of said patient and exposing the inside of said bladder to light.

    METHOD OF PHOTODYNAMIC THERAPY (PDT) FOR BLADDER CANCER
    18.
    发明申请
    METHOD OF PHOTODYNAMIC THERAPY (PDT) FOR BLADDER CANCER 审中-公开

    公开(公告)号：US20190022404A1

    公开(公告)日：2019-01-24

    申请号：US16063142

    申请日：2016-12-19

    Applicant: PHOTOCURE ASA

    Inventor： Kjetil Hestdal ,  Aslak Godal

    IPC: A61N5/06 ,  A61K41/00

    Abstract: This invention relates to a method of photodynamic therapy (PDT) for bladder cancer and its use as an adjuvant or neoadjuvant therapy in the treatment of bladder cancer. The invention provides a composition comprising hexyl 5-ALA ester (HAL) or a pharmaceutically acceptable salt thereof for use in a method of photodynamic therapy for bladder cancer, wherein said composition is instilled into the bladder of a patient in need of such treatment and the inside of said bladder is exposed to blue light having a fluence rate of 1.5 to 12.5 mW/cm2

    IRRADIATION DEVICE
    20.
    发明申请
    IRRADIATION DEVICE 审中-公开
    辐射装置

    公开(公告)号：US20170072217A1

    公开(公告)日：2017-03-16

    申请号：US15362112

    申请日：2016-11-28

    Applicant: Photocure ASA

    Inventor： Bjorn Klem ,  Morten Groseth

    IPC: A61N5/06 ,  A61K31/221 ,  A61K9/00 ,  A61B5/00

    CPC classification number: A61N5/062 ,  A61B5/0084 ,  A61K9/0036 ,  A61K31/221 ,  A61K41/0061 ,  A61N5/0603 ,  A61N2005/0608 ,  A61N2005/0611 ,  A61N2005/0626 ,  A61N2005/0645 ,  A61N2005/0652 ,  A61N2005/0658

    Abstract: An irradiation device for insertion into an orifice of the body for providing photodynamic therapy or diagnosis comprises: a housing 1, 21, 31, 51, 61, 71 adapted to be fully inserted and secured in the orifice, the housing 1, 21, 31, 51, 61, 71 enclosing an LED lamp system 5, 25, 35, 45, 54, 62, 72 and a power source 41, 68, 78, for powering the LED lamp system 5, 25, 35, 45, 54, 62, 72, wherein the device is independently operational while located within the orifice.

    Abstract translation: 用于插入身体的用于提供光动力学治疗或诊断的孔的照射装置包括：适于完全插入并固定在孔中的壳体1，21，31，51，61，71，壳体1，21，31 ，51,61,71，其包围LED灯系统5,25,35,45,54,62,72以及用于为LED灯系统5,25,35,45,54,55供电的电源41,68,78， 62,72，其中所述装置在位于所述孔内时独立地工作。

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