公开(公告)号：EP1690511B1

公开(公告)日：2010-07-14

申请号：EP06100735.7

申请日：1991-10-17

Applicant: ST. LOUIS UNIVERSITY

Inventor： Bucholz, Richard D.

IPC: A61B19/00 ,  A61B5/103 ,  A61B6/08

CPC classification number: A61B5/0073 ,  A61B5/0064 ,  A61B5/055 ,  A61B5/06 ,  A61B5/1077 ,  A61B6/12 ,  A61B6/501 ,  A61B6/5247 ,  A61B8/00 ,  A61B8/0808 ,  A61B8/5238 ,  A61B34/20 ,  A61B90/10 ,  A61B90/14 ,  A61B90/36 ,  A61B90/39 ,  A61B2017/00738 ,  A61B2034/105 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2034/2072 ,  A61B2090/363 ,  A61B2090/364 ,  A61B2090/378 ,  A61B2090/3788 ,  A61B2090/3945 ,  A61B2090/3954 ,  A61B2090/3983 ,  B82Y15/00

公开(公告)号：EP1946397A2

公开(公告)日：2008-07-23

申请号：EP06846213.4

申请日：2006-11-02

Applicant: ST. LOUIS UNIVERSITY

Inventor： MINTEER, Shelley, D. ,  KLOTZBACH, Tamara, L. ,  DUMA, Rodica

IPC: H01M8/00

CPC classification number: H01M8/16 ,  C12N9/0004 ,  H01M4/9008 ,  H01M2004/8684 ,  Y02E60/527

Abstract: Bioanodes, biocathodes, biofuel cells, immobilized enzymes and immobilization materials comprising a micellar hydrophobically modified polysaccharide are disclosed. In particular, the micellar hydrophobically modified polysaccharide can be a hydrophobically modified chitosan or a hydrophobically modified alginate.

公开(公告)号：EP0815236B1

公开(公告)日：2004-12-22

申请号：EP96909856.5

申请日：1996-03-22

Applicant: WASHINGTON UNIVERSITY ,  ST. LOUIS UNIVERSITY

Inventor： ST. GEME, Joseph, W., III ,  BARENKAMP, Stephen, J.

IPC: C12N15/31 ,  C07K14/285 ,  A61K39/102 ,  C07K16/12

CPC classification number: C07K14/285 ,  A61K38/00 ,  A61K39/00

Abstract: The invention relates to novel Haemophilus adhesion proteins, nucleic acids, and antibodies.

公开(公告)号：EP0632814B1

公开(公告)日：2002-08-28

申请号：EP93908295.4

申请日：1993-03-16

Applicant: ST. LOUIS UNIVERSITY ,  WASHINGTON UNIVERSITY

Inventor： Barenkamp, Stephen J.

IPC: C12N15/31 ,  C07K14/285 ,  A61K39/02 ,  A61K39/102

CPC classification number: C07K14/285 ,  A61K39/00 ,  Y10S435/851

Abstract: High molecular weight surface proteins of non-typeable Haemophilus influenzae which exhibit immunogenic properties and genes encoding the same are described. Specifically, genes coding for two immunodominant high molecular weight proteins, HMW1 and HMW2, have been cloned, expressed and sequenced, while genes coding for high molecular proteins HMW3 and HMW4 have been cloned, expressed and partially sequenced.

公开(公告)号：EP1121957A2

公开(公告)日：2001-08-08

申请号：EP01300783.6

申请日：2001-01-30

Applicant: ST. LOUIS UNIVERSITY

Inventor： Buchholz, Richard D. ,  Miller, D. Douglas

IPC: A61N5/10

CPC classification number: A61N5/1049 ,  A61B5/0555 ,  A61N5/1037 ,  A61N5/1064 ,  A61N5/1067 ,  A61N5/107 ,  A61N2005/1055 ,  A61N2005/1087

Abstract: A system which coordinates proton beam irradiation with an open magnetic resonance imaging (MRI) unit to achieve near-simultaneous, noninvasive localization and radiotherapy of various cell lines in various anatomic locations. A reference image of the target aids in determining a treatment plan and repositioning the patient within the MRI unit for later treatments. The patient is located within the MRI unit so that the target and the proton beam are coincident. MRI monitors the location of the target.
Target irradiation occurs when the target and the proton beam are coincident as indicated by the MRI monitoring. The patient rotates relative to the radiation source. The target again undergoes monitoring and selective irradiation. The rotation and selective irradiation during MRI monitoring repeats according to the treatment plan.

Abstract translation: 其与开放式磁共振成像（MRI）单元坐标质子束照射的系统，以实现在不同的解剖部位的各种细胞系中的几乎同时，非侵入性的定位和放疗。 在确定性挖掘目标助剂的参考图像的治疗计划和重新定位所述MRI单元内的患者供以后处理。 患者位于MRI单元内所以做了靶和质子束重合。 MRI监视目标的位置。 发生目标照射的当目标和质子束重合由MRI监控所指示的。 病人旋转相对于所述辐射源。 目标下再次去监测和选择性照射。 MRI监测期间旋转的和选择性的照射重复gemäß治疗计划。

公开(公告)号：EP0553246B1

公开(公告)日：2000-09-13

申请号：EP91919611.3

申请日：1991-10-17

Applicant: ST. LOUIS UNIVERSITY

Inventor： BUCHOLZ, Richard, D.

IPC: A61B19/00 ,  A61B5/103 ,  A61B6/08

CPC classification number: A61B5/0073 ,  A61B5/0064 ,  A61B5/055 ,  A61B5/06 ,  A61B5/1077 ,  A61B6/12 ,  A61B6/501 ,  A61B6/5247 ,  A61B8/00 ,  A61B8/0808 ,  A61B8/5238 ,  A61B34/20 ,  A61B90/10 ,  A61B90/14 ,  A61B90/36 ,  A61B90/39 ,  A61B2017/00738 ,  A61B2034/105 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2034/2072 ,  A61B2090/363 ,  A61B2090/364 ,  A61B2090/378 ,  A61B2090/3788 ,  A61B2090/3945 ,  A61B2090/3954 ,  A61B2090/3983 ,  B82Y15/00

Abstract: A system for determining a position of a probe (302) relative to an object such as a head (390) of a body of a patient. The head includes a surface such as a forehead (394) having a contour. The head is placed in a cradle (392) equipped with an arc (393). The cross-sectional images of the head are determined relative to the arc. A hand-held unit (380) optically scans the forehead and the arc. During scanning to generate the cross-sectional images, the optical scanner (380) is used to determine the position of the forehead (394) relative to the cradle (392). During surgery, the optical scanner (380) also determines the position of the forehead (394) relative to a base ring (306). An array (300) for receiving radiation emitted from the probe (302) and from the base ring (306) generates signals indicating the position of the tip of the probe (302) relative to the base ring (306). A stereotactic imaging system selects and displays the image of the head closest to the measured position of the tip of the probe (302).

公开(公告)号：EP0869745A2

公开(公告)日：1998-10-14

申请号：EP95937379.0

申请日：1995-10-05

Applicant: ST. LOUIS UNIVERSITY ,  SURGICAL NAVIGATION TECHNOLOGIES

Inventor： BUCHOLZ, Richard, D. ,  FOLEY, Kevin, T. ,  SMITH, Kurt, R. ,  BASS, Daniel ,  WIEDENMAIER, Thomas ,  POPE, Todd ,  WIEDENMAIER, Udo

IPC: A61B5 ,  A61B6 ,  A61B8 ,  A61B17 ,  A61B19

CPC classification number: A61B5/0073 ,  A61B5/0064 ,  A61B5/055 ,  A61B5/06 ,  A61B5/1077 ,  A61B6/12 ,  A61B6/501 ,  A61B6/5235 ,  A61B8/00 ,  A61B8/0833 ,  A61B8/4227 ,  A61B8/5238 ,  A61B17/1703 ,  A61B17/1739 ,  A61B17/3403 ,  A61B34/10 ,  A61B34/20 ,  A61B90/10 ,  A61B90/11 ,  A61B90/36 ,  A61B2017/00022 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2034/207 ,  A61B2034/2072 ,  A61B2090/363 ,  A61B2090/364 ,  A61B2090/376 ,  A61B2090/378 ,  A61B2090/3929 ,  A61B2090/3945 ,  A61B2090/3983

Abstract: This invention is a system for use during a medical or surgical procedure on a body. The system generates an image representing the position of one or more body elements (10, 20, 30) using scans generated by a scanner prior or during the procedure. The image data set has reference points (10A)-(30C) for each of the body elements, the reference points of a body element having a fixed spatial relation to the body element. The system includes an apparatus (108) for identifying the relative position of each of the reference points of each of the body elements to be displayed. The system also includes a processor (104) for modifying the image data set according to the identified relative position of each of the reference points during the procedure. Also disclosed are devices for use with a surgical navigation system having a sensor array (110, 112) in communication with the device to identify its position.

公开(公告)号：EP0815236A1

公开(公告)日：1998-01-07

申请号：EP96909856.0

申请日：1996-03-22

Applicant: WASHINGTON UNIVERSITY ,  ST. LOUIS UNIVERSITY

Inventor： ST. GEME, Joseph, W., III ,  BARENKAMP, Stephen, J.

IPC: C12N15 ,  A61K39 ,  A61P31 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12P21 ,  A61K38 ,  C12R1

CPC classification number: C07K14/285 ,  A61K38/00 ,  A61K39/00

Abstract: The invention relates to novel Haemophilus adhesion proteins, nucleic acids, and antibodies.

公开(公告)号：EP0699050A1

公开(公告)日：1996-03-06

申请号：EP94916567.0

申请日：1994-04-25

Applicant: ST. LOUIS UNIVERSITY

Inventor： BUCHOLZ, Richard, D.

IPC: A61B5 ,  A61B6 ,  A61B8 ,  A61B17 ,  A61B19

CPC classification number: A61B5/0073 ,  A61B5/0064 ,  A61B5/055 ,  A61B5/061 ,  A61B5/1077 ,  A61B6/12 ,  A61B6/501 ,  A61B6/5247 ,  A61B8/00 ,  A61B8/0808 ,  A61B8/5238 ,  A61B34/20 ,  A61B90/10 ,  A61B90/14 ,  A61B90/36 ,  A61B90/39 ,  A61B2034/105 ,  A61B2034/2055 ,  A61B2034/2063 ,  A61B2034/2065 ,  A61B2034/2068 ,  A61B2034/2072 ,  A61B2090/061 ,  A61B2090/363 ,  A61B2090/364 ,  A61B2090/373 ,  A61B2090/378 ,  A61B2090/3925 ,  A61B2090/3929 ,  A61B2090/3945 ,  A61B2090/3954 ,  A61B2090/3979 ,  A61B2090/3983 ,  A61B2090/3995

Abstract: This is a system for determining a position of a probe (302) relative to an object such as a head of a body of a patient. The head includes a surface such as a forehead having a contour. Cross-sectional images of the head are scanned and stored as a function of the forehead contour. If the forehead contour does not appear in the scan images, then the position of the forehead contour relative to the scan images is determined with an optical scanner (380) and ring (590). During surgery, the optical scanner (380) also determines the position of the tip of the forehead relative to the ring (590). An array (300) for receiving radiation emitted from the probe and from the ring generates signals indicating the position of the tip (301) of the probe (302) relative to the ring (590). A stereo-tactic imaging system (324) generates and displays an image of the head corresponding to the measured position of the tip (301) of the probe (302).

Abstract translation: 这是用于确定探针（302）相对于物体（例如患者的身体的头部）的位置的系统。 头部包括诸如具有轮廓的前额的表面。 作为前额轮廓的函数扫描和存储头部的横截面图像。 如果前额轮廓没有出现在扫描图像中，则用光学扫描器（380）和环（590）确定前额轮廓相对于扫描图像的位置。 在手术期间，光学扫描器（380）还确定前额相对于环（590）的尖端的位置。 用于接收从探针和环产生的辐射的阵列（300）产生指示探针（302）相对于环（590）的尖端（301）的位置的信号。 立体战术成像系统（324）产生并显示与探头（302）的尖端（301）的测量位置相对应的头部的图像。

公开(公告)号：EP0553246A1

公开(公告)日：1993-08-04

申请号：EP91919611.0

申请日：1991-10-17

Applicant: ST. LOUIS UNIVERSITY

Inventor： BUCHOLZ, Richard, D.

IPC: A61B5 ,  A61B6 ,  A61B8 ,  A61B17 ,  A61B19

CPC classification number: A61B5/0073 ,  A61B5/0064 ,  A61B5/055 ,  A61B5/06 ,  A61B5/1077 ,  A61B6/12 ,  A61B6/501 ,  A61B6/5247 ,  A61B8/00 ,  A61B8/0808 ,  A61B8/5238 ,  A61B34/20 ,  A61B90/10 ,  A61B90/14 ,  A61B90/36 ,  A61B90/39 ,  A61B2017/00738 ,  A61B2034/105 ,  A61B2034/2055 ,  A61B2034/2068 ,  A61B2034/2072 ,  A61B2090/363 ,  A61B2090/364 ,  A61B2090/378 ,  A61B2090/3788 ,  A61B2090/3945 ,  A61B2090/3954 ,  A61B2090/3983 ,  B82Y15/00

Abstract: Un système de détermination d'une position d'une sonde (302) par rapport à un objet tel que la tête (390) du corps d'un patient est décrit. La tête comprend une surface telle que le front (394) présentant un contour. La tête est placée dans un berceau (392) équipé d'un arc (393). Les images en coupe transversale de la tête sont déterminées par rapport à l'arc. Une unité portable (380) explore optiquement le front et l'arc. Pendant l'exploration en vue de produire les images en coupe transversale, le scanner optique (380) est utilisé pour déterminer la position du front (394) par rapport au berceau (392). Pendant l'opération chirurgicale, le scanner optique (380) détermine également la position du front (394) par rapport à l'anneau de base (306). Un réseau (300) recevant la radiation émise par la sonde (302) et par l'anneau de base (306) génère des signaux indiquant la position de la pointe de la sonde (302) par rapport à l'anneau de base (306). Un système d'imagerie stéréotactique sélectionne et affiche l'image de la tête la plus proche de la position mesurée de la pointe de la sonde (302).