公开(公告)号：WO2009039135A1

公开(公告)日：2009-03-26

申请号：PCT/US2008/076594

申请日：2008-09-17

Applicant: ABBOTT LABORATORIES ,  DONNER, Pamela L. ,  RANDOLPH, John T. ,  KRUEGER, Allan C. ,  BETEBENNER, David A. ,  HUTCHINSON, Douglas K. ,  LIU, Dachun ,  LIU, Yaya ,  LONGENECKER, Kenton L. ,  MARING, Clarence J. ,  PRATT, John K. ,  ROCKWAY, Todd W. ,  STEWART, Kent D. ,  WAGNER, Rolf ,  BARNES, David M. ,  CHEN, Shuang ,  FRANCZYK II, Thaddeus S. ,  GAO, Yi ,  HAIGHT, Anthony R. ,  HENGEVELD, John E. ,  HENRY, Rodger F. ,  KOTECKI, Brian J. ,  LOU, Xiaochun ,  ZHANG, Geoff G. Z.

Inventor： DONNER, Pamela L. ,  RANDOLPH, John T. ,  KRUEGER, Allan C. ,  BETEBENNER, David A. ,  HUTCHINSON, Douglas K. ,  LIU, Dachun ,  LIU, Yaya ,  LONGENECKER, Kenton L. ,  MARING, Clarence J. ,  PRATT, John K. ,  ROCKWAY, Todd W. ,  STEWART, Kent D. ,  WAGNER, Rolf ,  BARNES, David M. ,  CHEN, Shuang ,  FRANCZYK II, Thaddeus S. ,  GAO, Yi ,  HAIGHT, Anthony R. ,  HENGEVELD, John E. ,  HENRY, Rodger F. ,  KOTECKI, Brian J. ,  LOU, Xiaochun ,  ZHANG, Geoff G. Z.

IPC: C07D239/22 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D239/553 ,  A61K31/513 ,  A61K31/506 ,  A61P31/14

CPC classification number: C07D239/22 ,  A61K31/513 ,  C07D239/54 ,  C07D239/553 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions. The compounds are usefull in the treatment of hepatitis C and are of the following general structure: Formula (I)

Abstract translation: 本发明涉及：（a）特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。 该化合物在丙型肝炎的治疗中是有用的，具有以下通用结构：式（I）

公开(公告)号：WO2008046919A2

公开(公告)日：2008-04-24

申请号：PCT/EP2007/061231

申请日：2007-10-19

Applicant: ABBOTT GMBH & CO. KG ,  TURNER, Sean Colm ,  BAKKER, Margaretha Henrica Maria ,  STEWART, Kent D.

Inventor： TURNER, Sean Colm ,  BAKKER, Margaretha Henrica Maria ,  STEWART, Kent D.

IPC: C07D401/12 ,  C07D413/14 ,  C07D471/04 ,  A61K31/4709 ,  A61K31/497 ,  A61P25/00

CPC classification number: C07D401/12 ,  C07D241/20 ,  C07D413/14 ,  C07D471/04

Abstract: The present invention relates to a heterocyclic compound of the general formula (I) and their use and preparation, methods of making the compounds, compositions containing at least one of said compounds, and methods of treatment using at least one compound. In particular, compounds of the general formula (I) are useful for inhibiting glycogen synthase kinase 3 (GSK-3),

Abstract translation: 本发明涉及通式（I）的杂环化合物及其用途和制备方法，制备该化合物的方法，含有至少一种所述化合物的组合物和使用至少一种化合物的治疗方法。 特别地，通式（I）的化合物可用于抑制糖原合成酶激酶3（GSK-3），

公开(公告)号：WO2007027651A2

公开(公告)日：2007-03-08

申请号：PCT/US2006033620

申请日：2006-08-25

Applicant: ABBOTT LAB ,  PEI ZHONGHUA ,  VON GELDERN THOMAS ,  MADAR DAVID J ,  LI XIAOFENG ,  BASHA FATIMA ,  YONG HONG ,  LONGENECKER KENTON L ,  BACKES BRADLEY J ,  JUDD ANDREW S ,  MULHERN MATHEW M ,  STEWART KENT D

Inventor： PEI ZHONGHUA ,  VON GELDERN THOMAS ,  MADAR DAVID J ,  LI XIAOFENG ,  BASHA FATIMA ,  YONG HONG ,  LONGENECKER KENTON L ,  BACKES BRADLEY J ,  JUDD ANDREW S ,  MULHERN MATHEW M ,  STEWART KENT D

IPC: C07C217/54 ,  C07C211/40 ,  C07D213/38 ,  C07D213/68 ,  C07D317/64

CPC classification number: C07C211/48 ,  C07C211/40 ,  C07C217/52 ,  C07C217/54 ,  C07C217/74 ,  C07C217/84 ,  C07C217/86 ,  C07C225/22 ,  C07C229/42 ,  C07C229/48 ,  C07C229/60 ,  C07C233/43 ,  C07C233/78 ,  C07C235/46 ,  C07C237/24 ,  C07C237/30 ,  C07C237/42 ,  C07C255/54 ,  C07C255/58 ,  C07C311/22 ,  C07C311/36 ,  C07C317/22 ,  C07C317/36 ,  C07C2601/14 ,  C07C2601/16 ,  C07D207/16 ,  C07D209/08 ,  C07D209/48 ,  C07D211/46 ,  C07D211/60 ,  C07D211/62 ,  C07D213/30 ,  C07D213/38 ,  C07D213/64 ,  C07D213/68 ,  C07D213/74 ,  C07D213/82 ,  C07D217/04 ,  C07D263/56 ,  C07D263/60 ,  C07D277/04 ,  C07D277/64 ,  C07D295/135 ,  C07D295/185 ,  C07D295/205 ,  C07D317/66 ,  C07D319/18 ,  C07D333/34 ,  C07D333/38 ,  C07D409/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

Abstract: The present invention relates to compounds, which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, metabolic syndrome , hyperinsulinemia, obesity, atherosclerosis, various immunomodulatory diseases, and other diseases.

Abstract translation: 本发明涉及抑制二肽基肽酶IV（DPP-IV）的化合物，其可用于预防或治疗糖尿病，特别是II型糖尿病，以及高血糖症，代谢综合征，高胰岛素血症，肥胖症，动脉粥样硬化，各种免疫调节疾病 ，等疾病。

公开(公告)号：WO2006124813A3

公开(公告)日：2006-11-23

申请号：PCT/US2006/018796

申请日：2006-05-16

Applicant: ABBOTT LABORATORIES ,  GRACIAS, Vijaya, J. ,  ABAD-ZAPATERO, Celerino ,  DJURIC, Stevan, W. ,  JI, Zhiqin ,  MICHAELIDES, Michael, R. ,  STEWART, Kent, D. ,  ZANZE, Irini

Inventor： GRACIAS, Vijaya, J. ,  ABAD-ZAPATERO, Celerino ,  DJURIC, Stevan, W. ,  JI, Zhiqin ,  MICHAELIDES, Michael, R. ,  STEWART, Kent, D. ,  ZANZE, Irini

IPC: C07D487/04 ,  A61K31/551 ,  A61P35/00

Abstract: Compounds having the Formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

公开(公告)号：WO2011079105A1

公开(公告)日：2011-06-30

申请号：PCT/US2010/061475

申请日：2010-12-21

Applicant: ABBOTT LABORATORIES ,  ERICSSON, Anna M. ,  EDMUNDS, Jeremy J. ,  HOBSON, Adrian D. ,  STEWART, Kent D. ,  WISHART, Neil ,  WANG, Lei ,  IHLE, David C. ,  FERENZ, Catherine R. ,  DUNSTAN, Theresa A. ,  WANG, Lu

Inventor： ERICSSON, Anna M. ,  EDMUNDS, Jeremy J. ,  HOBSON, Adrian D. ,  STEWART, Kent D. ,  WISHART, Neil ,  WANG, Lei ,  IHLE, David C. ,  FERENZ, Catherine R. ,  DUNSTAN, Theresa A. ,  WANG, Lu

IPC: C07D265/00

CPC classification number: C07D487/04 ,  C07D487/08 ,  C07D495/04 ,  C07D498/04

Abstract: The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract translation: 本发明提供式（I）化合物的药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。