公开(公告)号：WO2009152133A1

公开(公告)日：2009-12-17

申请号：PCT/US2009/046714

申请日：2009-06-09

Applicant: ABBOTT LABORATORIES ,  WISHART, Neil ,  ARGIRIADI, Maria, A. ,  CALDERWOOD, David, J. ,  ERICSSON, Anna, M. ,  FIAMENGO, Bryan, A. ,  FRANK, Kristine, E. ,  FRIEDMAN, Michael ,  GEORGE, Dawn, M. ,  GOEDKEN, Eric, R. ,  JOSEPHSOHN, Nathan, S. ,  LI, Biqin, C. ,  MORYTKO, Michael, J. ,  STEWART, Kent, D. ,  VOSS, Jeffrey, W. ,  WALLACE, Grier, A. ,  WANG, Lu ,  WOLLER, Kevin, R.

Inventor： WISHART, Neil ,  ARGIRIADI, Maria, A. ,  CALDERWOOD, David, J. ,  ERICSSON, Anna, M. ,  FIAMENGO, Bryan, A. ,  FRANK, Kristine, E. ,  FRIEDMAN, Michael ,  GEORGE, Dawn, M. ,  GOEDKEN, Eric, R. ,  JOSEPHSOHN, Nathan, S. ,  LI, Biqin, C. ,  MORYTKO, Michael, J. ,  STEWART, Kent, D. ,  VOSS, Jeffrey, W. ,  WALLACE, Grier, A. ,  WANG, Lu ,  WOLLER, Kevin, R.

IPC: A01N43/42

CPC classification number: C07D487/14 ,  C07D498/14 ,  C07D513/14

Abstract: The invention provides a compound of Formula (I), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract translation: 本发明提供式（I）的化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。

公开(公告)号：WO2009039134A1

公开(公告)日：2009-03-26

申请号：PCT/US2008/076592

申请日：2008-09-17

Applicant: ABBOTT LABORATORIES ,  FLENTGE, Charles, A. ,  HUTCHINSON, Douglas, K. ,  BETEBENNER, David, A. ,  DEGOEY, David, A. ,  DONNER, Pamela, L. ,  KATI, Warren, M. ,  KRUEGER, Allan, C. ,  LIU, Dachun ,  LIU, Yaya ,  LONGENECKER, Kenton, L. ,  MARING, Clarence, J. ,  MOTTER, Christopher, E. ,  PRATT, John, K. ,  RANDOLPH, John, T. ,  ROCKWAY, Todd, W. ,  STEWART, Kent, D. ,  WAGNER, Rolf ,  BARNES, David, M. ,  CHEN, Shuang ,  FRANCZYK, Thaddeus, S., II ,  GAO, Yi ,  HAIGHT, Anthony, R. ,  HENGEVELD, John, E. ,  KOTECKI, Brian, J. ,  LOU, Xiaochun ,  ZHANG, Geoff, G., Z.

Inventor： FLENTGE, Charles, A. ,  HUTCHINSON, Douglas, K. ,  BETEBENNER, David, A. ,  DEGOEY, David, A. ,  DONNER, Pamela, L. ,  KATI, Warren, M. ,  KRUEGER, Allan, C. ,  LIU, Dachun ,  LIU, Yaya ,  LONGENECKER, Kenton, L. ,  MARING, Clarence, J. ,  MOTTER, Christopher, E. ,  PRATT, John, K. ,  RANDOLPH, John, T. ,  ROCKWAY, Todd, W. ,  STEWART, Kent, D. ,  WAGNER, Rolf ,  BARNES, David, M. ,  CHEN, Shuang ,  FRANCZYK, Thaddeus, S., II ,  GAO, Yi ,  HAIGHT, Anthony, R. ,  HENGEVELD, John, E. ,  KOTECKI, Brian, J. ,  LOU, Xiaochun ,  ZHANG, Geoff, G., Z.

IPC: C07D239/22 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  A61K31/513 ,  A61P31/12

CPC classification number: C07D239/54 ,  A61K31/513 ,  A61K45/06 ,  C07D239/22 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  A61K2300/00

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Abstract translation: 本发明涉及：（a）特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。

公开(公告)号：WO2005019191A2

公开(公告)日：2005-03-03

申请号：PCT/US2004/027000

申请日：2004-08-19

Applicant: ABBOTT LABORATORIES ,  HUTCHINSON, Douglas, K. ,  BELLETTINI, John, R. ,  BETEBENNER, David, A. ,  BISHOP, Richard, D. ,  BORCHARDT, Thomas, B. ,  BOSSE, Todd, D. ,  CINK, Russell, D. ,  FLENTGE, Charles, A. ,  GATES, Bradley, D. ,  GREEN, Brian, E. ,  HINMAN, Mira, M. ,  HUANG, Peggy, P. ,  KLEIN, Larry, L. ,  KRUEGER, Allan, C. ,  LARSON, Daniel, P. ,  LEANNA, M., Robert ,  LIU, Dachun ,  MADIGAN, Darold, L. ,  MCDANIEL, Keith, F. ,  RANDOLPH, John, T. ,  ROCKWAY, Todd, W. ,  ROSENBERG, Teresa, A. ,  STEWART, Kent, D. ,  STOLL, Vincent, S. ,  WAGNER, Rolf ,  YEUNG, Ming, C.

Inventor： HUTCHINSON, Douglas, K. ,  BELLETTINI, John, R. ,  BETEBENNER, David, A. ,  BISHOP, Richard, D. ,  BORCHARDT, Thomas, B. ,  BOSSE, Todd, D. ,  CINK, Russell, D. ,  FLENTGE, Charles, A. ,  GATES, Bradley, D. ,  GREEN, Brian, E. ,  HINMAN, Mira, M. ,  HUANG, Peggy, P. ,  KLEIN, Larry, L. ,  KRUEGER, Allan, C. ,  LARSON, Daniel, P. ,  LEANNA, M., Robert ,  LIU, Dachun ,  MADIGAN, Darold, L. ,  MCDANIEL, Keith, F. ,  RANDOLPH, John, T. ,  ROCKWAY, Todd, W. ,  ROSENBERG, Teresa, A. ,  STEWART, Kent, D. ,  STOLL, Vincent, S. ,  WAGNER, Rolf ,  YEUNG, Ming, C.

IPC: C07D285/00

CPC classification number: C07D417/12 ,  C07D285/24 ,  C07D285/30 ,  C07D513/04

Abstract: Compounds having the formula (I) are hepatitis C (HCV) polymerase inhibitors. Also disclosed are a composition and method for inhibiting hepatitis C (HCV) polymerase, processes for making the compounds, and synthetic intermediates employed in the processes.

Abstract translation: 具有式（I）的化合物是丙型肝炎（HCV）聚合酶抑制剂。 还公开了用于抑制丙型肝炎（HCV）聚合酶的组合物和方法，用于制备化合物的方法和在该方法中使用的合成中间体。

公开(公告)号：WO2011068899A1

公开(公告)日：2011-06-09

申请号：PCT/US2010/058598

申请日：2010-12-01

Applicant: ABBOTT LABORATORIES ,  WISHART, Neil ,  ARGIRIADI, Maria A. ,  BREINLINGER, Eric C. ,  CALDERWOOD, David J. ,  ERICSSON, Anna M. ,  FIAMENGO, Bryan A. ,  FRANK, Kristine E. ,  FRIEDMAN, Michael ,  GEORGE, Dawn M. ,  GOEDKEN, Eric R. ,  JOSEPHSOHN, Nathan S. ,  LI, Biqin C. ,  MORYTKO, Michael J. ,  MULLEN, Kelly D. ,  SOMAL, Gagandeep ,  STEWART, Kent D. ,  VOSS, Jeffrey W. ,  WALLACE, Grier A. ,  WANG, Lu ,  WOLLER, Kevin R.

Inventor： WISHART, Neil ,  ARGIRIADI, Maria A. ,  BREINLINGER, Eric C. ,  CALDERWOOD, David J. ,  ERICSSON, Anna M. ,  FIAMENGO, Bryan A. ,  FRANK, Kristine E. ,  FRIEDMAN, Michael ,  GEORGE, Dawn M. ,  GOEDKEN, Eric R. ,  JOSEPHSOHN, Nathan S. ,  LI, Biqin C. ,  MORYTKO, Michael J. ,  MULLEN, Kelly D. ,  SOMAL, Gagandeep ,  STEWART, Kent D. ,  VOSS, Jeffrey W. ,  WALLACE, Grier A. ,  WANG, Lu ,  WOLLER, Kevin R.

IPC: A01N43/42 ,  A61K31/44

CPC classification number: C07F9/06 ,  C07D471/14 ,  C07D487/14 ,  C07D498/14 ,  C07D513/14

Abstract: The invention provides a compound of Formula (Ia), (Ib), (Ic), (Id), (Ie), (If), (Ig), (Ih), (Ii), (Ij), (Ik), or (Il) as defined herein, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract translation: 本发明提供了式（Ia），（Ib），（Ic），（Id），（Ie），（If），（Ig），（Ih），（Ii），（Ij），（Ik） ，或（II），其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。

公开(公告)号：WO2010111437A1

公开(公告)日：2010-09-30

申请号：PCT/US2010/028561

申请日：2010-03-25

Applicant: ABBOTT LABORATORIES ,  ROCKWAY, Todd W. ,  BETEBENNER, David A. ,  DEGOEY, David A. ,  FLENTGE, Charles A. ,  HUTCHINSON, Douglas K. ,  KATI, Warren M. ,  KRUEGER, Allan C. ,  LIU, Dachun ,  LONGENECKER, Kenton L. ,  PRATT, John K. ,  STEWART, Kent D. ,  WAGNER, Rolf

Inventor： ROCKWAY, Todd W. ,  BETEBENNER, David A. ,  DEGOEY, David A. ,  FLENTGE, Charles A. ,  HUTCHINSON, Douglas K. ,  KATI, Warren M. ,  KRUEGER, Allan C. ,  LIU, Dachun ,  LONGENECKER, Kenton L. ,  PRATT, John K. ,  STEWART, Kent D. ,  WAGNER, Rolf

IPC: C07D401/04 ,  C07D403/04 ,  C07D407/04 ,  C07D409/14 ,  A61K31/513 ,  A61P31/12

CPC classification number: C07D401/04 ,  C07D403/04 ,  C07D407/04 ,  C07D409/14

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Abstract translation: 本发明涉及：（a）特别是抑制HCV的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备此类中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。

公开(公告)号：WO2009039127A1

公开(公告)日：2009-03-26

申请号：PCT/US2008/076576

申请日：2008-09-17

Applicant: ABBOTT LABORATORIES ,  WAGNER, Rolf ,  TUFANO, Michael D. ,  STEWART, Kent D. ,  ROCKWAY, Todd W. ,  RANDOLPH, John T. ,  PRATT, John K. ,  MOTTER, Christopher E. ,  MARING, Clarence J. ,  LONGENECKER, Kenton L. ,  LIU, Yaya ,  LIU, Dachun ,  KRUEGER, Allan C. ,  KATI, Warren M. ,  HUTCHINSON, Douglas K. ,  HUANG, Peggy P. ,  FLENTGE, Charles A. ,  DONNER, Pamela L. ,  DEGOEY, David A. ,  BETEBENNER, David A. ,  BARNES, David M. ,  CHEN, Shuang ,  FRANCZYK II, Thaddeus S. ,  GAO, Yi ,  HAIGHT, Anthony R. ,  HENGEVELD, John E. ,  HENRY, Rodger F. ,  KOTECKI, Brian J. ,  LOU, Xiaochun ,  SARRIS, Kathy ,  ZHANG, Geoff G. Z.

Inventor： WAGNER, Rolf ,  TUFANO, Michael D. ,  STEWART, Kent D. ,  ROCKWAY, Todd W. ,  RANDOLPH, John T. ,  PRATT, John K. ,  MOTTER, Christopher E. ,  MARING, Clarence J. ,  LONGENECKER, Kenton L. ,  LIU, Yaya ,  LIU, Dachun ,  KRUEGER, Allan C. ,  KATI, Warren M. ,  HUTCHINSON, Douglas K. ,  HUANG, Peggy P. ,  FLENTGE, Charles A. ,  DONNER, Pamela L. ,  DEGOEY, David A. ,  BETEBENNER, David A. ,  BARNES, David M. ,  CHEN, Shuang ,  FRANCZYK II, Thaddeus S. ,  GAO, Yi ,  HAIGHT, Anthony R. ,  HENGEVELD, John E. ,  HENRY, Rodger F. ,  KOTECKI, Brian J. ,  LOU, Xiaochun ,  SARRIS, Kathy ,  ZHANG, Geoff G. Z.

IPC: C07D239/22 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  A61P31/12 ,  A61K31/513

CPC classification number: A61K31/513 ,  A61K31/5377 ,  C07D239/22 ,  C07D239/54 ,  C07D401/10 ,  C07D403/10 ,  C07D405/10 ,  C07D409/10 ,  C07D413/10 ,  C07D417/10 ,  C07D417/14

Abstract: Present application relates to the compounds of formula I useful to treat hepatitis C (HCV) infections. In the structure of the disclosed compounds is the uracil or thymine derivative linked via a phenylene into either fused 2-ring cyclic system (R6) or alternatively via additional two-atom linker (L) to a 5-6 membered monocycle (R6). Application further discloses polymorphs and pseudopolymorphs of two specific compounds: N-(6(3-t-butyl-5-(2>4-dioxo-3,4-dihydropyrimidin-1 (2H)- y!)2-methoxy-phenyl)naphthalen-2-yl)methanesulfonamide and (E)-N-(4(3-t- butyl-5-(2,4-dioxo-3)4-dihydropyrimidin-1 (2H)-yl)2-methoxy-styryl- phenyl)methanesulfonamide.

Abstract translation: 本申请涉及可用于治疗丙型肝炎（HCV）感染的式I化合物。 所公开的化合物的结构是通过亚苯基连接成稠合的2-环环系（R6）或者另外通过另外的两个原子连接基（L）与5-6元单环（R6）连接的尿嘧啶或胸腺嘧啶衍生物。 应用进一步公开了两种特定化合物的多晶型物和假多晶型物：N-（6（3-叔丁基-5-（2,4-二氧代-3,4-二氢嘧啶-1（2H） - 基）-2-甲氧基 - 苯基 ）萘-2-基）甲磺酰胺和（E）-N-（4（3-叔丁基-5-（2,4-二氧代-3）4-二氢嘧啶-1（2H） - 基）2-甲氧基 - 苯乙烯基 - 苯基）甲磺酰胺。

公开(公告)号：WO2008046919A3

公开(公告)日：2008-09-25

申请号：PCT/EP2007061231

申请日：2007-10-19

Applicant: ABBOTT GMBH & CO KG ,  TURNER SEAN COLM ,  BAKKER MARGARETHA HENRICA MARI ,  STEWART KENT D

Inventor： TURNER SEAN COLM ,  BAKKER MARGARETHA HENRICA MARI ,  STEWART KENT D

IPC: C07D401/12 ,  A61K31/4709 ,  A61K31/497 ,  A61P25/00 ,  C07D413/14 ,  C07D471/04

CPC classification number: C07D401/12 ,  C07D241/20 ,  C07D413/14 ,  C07D471/04

Abstract: The present invention relates to a heterocyclic compound of the general formula (I) and their use and preparation, methods of making the compounds, compositions containing at least one of said compounds, and methods of treatment using at least one compound. In particular, compounds of the general formula (I) are useful for inhibiting glycogen synthase kinase 3 (GSK-3),

Abstract translation: 本发明涉及通式（I）的杂环化合物及其用途和制备方法，制备该化合物的方法，含有至少一种所述化合物的组合物，以及使用至少一种化合物的治疗方法。 特别地，通式（I）的化合物可用于抑制糖原合酶激酶3（GSK-3），

公开(公告)号：WO2007027651A3

公开(公告)日：2007-03-08

申请号：PCT/US2006/033620

申请日：2006-08-25

Applicant: ABBOTT LABORATORIES ,  PEI, Zhonghua ,  VON GELDERN, Thomas ,  MADAR, David, J. ,  LI, Xiaofeng ,  BASHA, Fatima ,  YONG, Hong ,  LONGENECKER, Kenton, L. ,  BACKES, Bradley, J. ,  JUDD, Andrew, S. ,  MULHERN, Mathew, M. ,  STEWART, Kent, D.

Inventor： PEI, Zhonghua ,  VON GELDERN, Thomas ,  MADAR, David, J. ,  LI, Xiaofeng ,  BASHA, Fatima ,  YONG, Hong ,  LONGENECKER, Kenton, L. ,  BACKES, Bradley, J. ,  JUDD, Andrew, S. ,  MULHERN, Mathew, M. ,  STEWART, Kent, D.

IPC: C07C211/40 ,  C07C211/54 ,  C07C211/62 ,  C07D213/38 ,  C07D213/68 ,  C07D317/64 ,  C07D487/04 ,  A61K31/137

Abstract: The present invention relates to compounds, which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, metabolic syndrome , hyperinsulinemia, obesity, atherosclerosis, various immunomodulatory diseases, and other diseases.

公开(公告)号：WO2006124813A2

公开(公告)日：2006-11-23

申请号：PCT/US2006018796

申请日：2006-05-16

Applicant: ABBOTT LAB ,  GRACIAS VIJAYA J ,  ABAD-ZAPATERO CELERINO ,  DJURIC STEVAN W ,  JI ZHIQIN ,  MICHAELIDES MICHAEL R ,  STEWART KENT D ,  ZANZE IRINI

Inventor： GRACIAS VIJAYA J ,  ABAD-ZAPATERO CELERINO ,  DJURIC STEVAN W ,  JI ZHIQIN ,  MICHAELIDES MICHAEL R ,  STEWART KENT D ,  ZANZE IRINI

CPC classification number: C07D487/04

Abstract: Compounds having the Formula (I) are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract translation: 具有式（I）的化合物可用于抑制蛋白酪氨酸激酶。 本发明还公开了制备化合物的方法，含有该化合物的组合物和使用该化合物的处理方法。

公开(公告)号：WO2011068881A1

公开(公告)日：2011-06-09

申请号：PCT/US2010/058572

申请日：2010-12-01

Applicant: ABBOTT LABORATORIES ,  WISHART, Neil ,  ARGIRIADI, Maria, A. ,  CALDERWOOD, David, J. ,  ERICSSON, Anna, M. ,  FIAMENGO, Bryan, A. ,  FRANK, Kristine, E. ,  FRIEDMAN, Michael ,  GEORGE, Dawn, M. ,  GOEDKEN, Eric, R. ,  JOSEPHSOHN, Nathan, S. ,  LI, Biqin, C. ,  MORYTKO, Michael, J. ,  STEWART, Kent, D. ,  VOSS, Jeffrey, W. ,  WALLACE, Grier, A. ,  WANG, Lu ,  WOLLER, Kevin, R.

Inventor： WISHART, Neil ,  ARGIRIADI, Maria, A. ,  CALDERWOOD, David, J. ,  ERICSSON, Anna, M. ,  FIAMENGO, Bryan, A. ,  FRANK, Kristine, E. ,  FRIEDMAN, Michael ,  GEORGE, Dawn, M. ,  GOEDKEN, Eric, R. ,  JOSEPHSOHN, Nathan, S. ,  LI, Biqin, C. ,  MORYTKO, Michael, J. ,  STEWART, Kent, D. ,  VOSS, Jeffrey, W. ,  WALLACE, Grier, A. ,  WANG, Lu ,  WOLLER, Kevin, R.

IPC: A01N43/58

CPC classification number: C07D487/14 ,  A61K31/437 ,  A61K31/4985 ,  A61K45/06 ,  C07D471/14 ,  C07D498/14 ,  C07D513/14

Abstract: The invention provides compounds of Formula (I) and Formula (II), pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treating immunological and oncological conditions.

Abstract translation: 本发明提供式（I）和式（II）的化合物，其药学上可接受的盐，前药，生物活性代谢物，立体异构体和异构体，其中变量在本文中定义。 本发明的化合物可用于治疗免疫学和肿瘤学病症。