公开(公告)号：KR1020090007655A

公开(公告)日：2009-01-20

申请号：KR1020070070926

申请日：2007-07-15

Applicant: 강원대학교산학협력단

Inventor： 조재열 ,  이지연 ,  변세은 ,  이용규 ,  김주영 ,  천승훈 ,  박준석

IPC: A61K31/47 ,  A61K31/4184 ,  A61P37/02

CPC classification number: Y02A50/409 ,  Y02A50/423 ,  A61K31/4745 ,  Y10S424/13 ,  Y10S514/814 ,  Y10S514/824 ,  Y10S514/825 ,  Y10S514/866 ,  Y10S514/886 ,  Y10S514/893 ,  Y10S514/925

Abstract: A composition comprising 5-[4'-(piperidinomethyl)phenyl]-2,3-dihydroimidazo [2,1-a] isoquinoline is provided to inhibit inflammation and regulate immune responses in macrophages, thereby preventing and treating the inflammatory or immune diseases. The composition for prevention and treatment of inflammatory or immune diseases comprises 5-[4'-(piperidinomethyl)phenyl]-2,3-dihydroimidazo [2,1-a] isoquinoline or its pharmaceutically acceptable salt, and inhibits the expression of any one proinflammatory cytokine selected from the group consisting of IL-1(interleukin) beta, IL-6 and TNF-alpha(tumor necrosis factor-alpha).

Abstract translation: 提供包含5- [4' - （哌啶子基甲基）苯基] -2,3-二氢咪唑并[2,1-a]异喹啉的组合物，以抑制炎症和调节巨噬细胞中的免疫应答，从而预防和治疗炎症或免疫疾病。 用于预防和治疗炎症或免疫疾病的组合物包括5- [4' - （哌啶基甲基）苯基] -2,3-二氢咪唑并[2,1-a]异喹啉或其药学上可接受的盐，并且抑制任何一种 选自IL-1（白介素）β，IL-6和TNF-α（肿瘤坏死因子-α）的促炎细胞因子。