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公开(公告)号：KR1020110132746A
公开(公告)日：2011-12-09
申请号：KR1020100052254
申请日：2010-06-03
Applicant: 경상대학교산학협력단
IPC: A61K31/726 , A61K35/618 , A23L1/30
CPC classification number: A61K31/726 , A23L33/10 , A61K35/618
Abstract: PURPOSE: A pharmaceutical composition containing glycosaminoglycan isolated from Aplysia kurodai is provided to induce apoptosis of cancer cells with safety. CONSTITUTION: An anti-cancer composition contains glycosaminoglycan as an active ingredient, isolated from Aplysia kurodai. The glycosaminoglycan contains disaccharides of chemical formula 1 or 2. A food composition for preventing or treating cancer contains the anti-cancer composition as an active ingredient.
Abstract translation: 目的：提供一种含有从白芍中分离的糖胺聚糖的药物组合物，以安全地诱导癌细胞凋亡。 构成：抗癌组合物含有作为活性成分的糖胺聚糖，分离自黑腹果蝇（Aplysia kurodai）。 糖胺聚糖含有化学式1或2的二糖。用于预防或治疗癌症的食品组合物含有作为活性成分的抗癌组合物。
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公开(公告)号：KR1020110096231A
公开(公告)日：2011-08-30
申请号：KR1020100015563
申请日：2010-02-22
Applicant: 경상대학교산학협력단 , 박시향
Inventor： 최병대 , 박시향 , 팔모스그레이스누네스
Abstract: PURPOSE: A composition containing melibe essential oil is provided to ensure high antioxidation and anti-inflammation and to be used as an ingredient for a functional cosmeic and pharmaceutical products. CONSTITUTION: A method for preparing melibe essential oil comprises: a step of adding melibe to a homogenizer; a step of adding 1-5 times of mixture solvent(1:1, v/v) containing n-pentane and diethyl ether; and a step of crushing at 5,000-15,000 rpm for 3-5 minutes. The extraction solvent is hexane, ethanol, methanol, or chloroform. A cosmetic composition contains 0.000001%-90% of the melibe essential oil extract. The cosmetic composition is manufactured in the form of emulsion, lotion, cream, essential, or emulsion foundation.
Abstract translation: 目的：提供含有melibe精油的组合物，以确保高抗氧化和抗炎，并用作功能性美容和药品的成分。 构成：一种制备蜜烯精油的方法，包括：向均化器中加入蜜蜂的步骤; 加入1-5倍含有正戊烷和乙醚的混合溶剂（1：1，v / v）的步骤; 并以5000-15,000rpm的速度破碎3-5分钟的步骤。 萃取溶剂为己烷，乙醇，甲醇或氯仿。 化妆品组合物含有0.000001％-90％的蜜蜜精油提取物。 化妆品组合物以乳液，洗剂，奶油，必需或乳液粉底的形式制造。
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公开(公告)号：KR101839186B1
公开(公告)日：2018-03-15
申请号：KR1020150125013
申请日：2015-09-03
Applicant: 경상대학교산학협력단
Abstract: 본발명은망막질환예방및 치료효과가있는군소유래추출물에관한것이다. 본발명에따른군소유래추출물은망막색소상피세포의증식을효과적으로유도하여망막질환을효과적으로치료및 개선할수 있고, 식품인군소유래인것으로세포독성이없어인체에안정성이보장되고부작용이없다. 따라서, 본발명의군소유래추출물은기존의화학적으로제조된망막질환에대한치료또는개선용인공물질을대체할수 있다는점에서관련산업에폭넓게이용될수 있다.
Abstract translation: 本发明涉及具有预防和治疗视网膜疾病作用的局部衍生的提取物。 海兔中提取在根据本发明推导可以是有效的治疗和改善视网膜疾病有效地诱导视网膜色素上皮细胞的增殖，不具有细胞毒性，但也不能保证稳定性，对人体和副作用是次要茎产品。 因此，本发明的局部衍生的提取物可以广泛用于相关行业，因为它可以替代用于治疗的人造物质或改进现有的化学制造的视网膜疾病。
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公开(公告)号：KR101826396B1
公开(公告)日：2018-02-08
申请号：KR1020150125009
申请日：2015-09-03
Applicant: 경상대학교산학협력단
Abstract: 본발명은간질환예방및 치료효과가있는굴 유래펩타이드에관한것이다. 본발명에따른굴 가수분해물유래펩타이드는아세트아미노펜에의해서유도된간 손상을효과적으로치료및 개선할수 있고, 알코올에의해유도된독성또한완화하므로이로인하여간질환의치료, 예방또는개선에유용할뿐만아니라, 식품인굴 유래인것으로안정성이보장되고부작용이없다. 또한, 3면이바다인우리나라에서풍부하게수확되는굴로부터효소처리에의하여수득할수 있는것이므로, 상기펩타이드의제조는기존화학적으로인공합성하는것에비하여, 경제성도우수하다는장점이있다. 따라서, 본발명의펩타이드는기존의화학적으로제조된간 질환에대한치료또는개선용인공물질을대체할수 있다는점에서관련산업에폭넓게이용될수 있다.
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公开(公告)号：KR1020130122188A
公开(公告)日：2013-11-07
申请号：KR1020120045314
申请日：2012-04-30
Applicant: 경상대학교산학협력단
CPC classification number: A61K8/987 , A61K8/735 , A61K2800/84 , A61Q19/08
Abstract: The present invention relates to a cosmetic composition containing an ascidian shell extract as an active ingredient for improving anti-wrinkling. The composition according to the present invention suppresses the activity of collagenase related to anti-wrinkling without skin irritation and promotes collagenesis and cytothesis, thereby being used for anti-wrinkling. [Reference numerals] (AA) Cytotoxic (%);(BB) Control group
Abstract translation: 本发明涉及一种含有海滨壳提取物作为改善抗皱作用的活性成分的化妆品组合物。 根据本发明的组合物抑制与抗皱纹相关的胶原酶的活性而不引起皮肤刺激，并且促进胶原和细胞化，从而用于抗皱。 （AA）细胞毒性（％）;（BB）对照组
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Patent Agency Ranking
公开(公告)号：KR1020110132719A
公开(公告)日：2011-12-09
申请号：KR1020100052201
申请日：2010-06-03
Applicant: 경상대학교산학협력단
IPC: A61K35/618 , A23L1/30
CPC classification number: A61K35/618 , A23L33/10
Abstract: PURPOSE: A pharmaceutical composition containing Aplysia kurodai extract is provided to induce apoptosis of cancer cells without side effect and to prevent or treat cancer without cytotoxicity. CONSTITUTION: A composition for anti-cancer contains Aplysia kurodai extract as an active ingredient. The Aplysia kurodai extract is Aplysia kurodai-derived polysaccharides. A composition or food composition for treating or preventing cancer contains the composition for anti-cancer as an active ingredient. A method for preparing the composition for anti-cancer comprises: a step of freeze-drying and pulverizing Aplysia kurodai; a step of adding flavozyme to the pulverized Aplysia kurodai and reacting at 57°C-63°C for 14-16 hours; a step of adding trichloroacetic acid to remove protein; and a step of adding ethanol to isolate polysaccharides.
Abstract translation: 目的：提供含有黑腹果蝇提取物的药物组合物，以诱导癌细胞凋亡，无副作用，预防或治疗癌细胞，无细胞毒性。 构成：抗癌组合物含有黑腹果糖提取物作为活性成分。 Aplysia kurodai提取物是Aplysia kurodai衍生的多糖。 用于治疗或预防癌症的组合物或食物组合物含有抗癌组合物作为活性成分。 制备抗癌组合物的方法包括：冷冻干燥并粉碎黑腹果蝇的步骤; 向粉碎的阿普利氏菌中加入黄酶的步骤，在57℃-63℃下反应14-16小时; 加入三氯乙酸去除蛋白质的步骤; 和加入乙醇分离多糖的步骤。
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公开(公告)号：KR101917504B1
公开(公告)日：2018-11-12
申请号：KR1020170051494
申请日：2017-04-21
Applicant: 경상대학교산학협력단
IPC: A61K35/618 , A23L33/10
Abstract: 본발명은군소추출물을포함하는천식의예방또는치료용조성물에관한것으로, 구체적으로군소추출물을포함하는천식의예방또는치료용약학적조성물, 식품조성물및 천식의치료방법에관한것이다. 본발명에따른군소추출물은 Th2 사이토카인(IL-4, IL-5, IL-13), 염증성사이토카인(TNF-α및 IL-1ß), 류코트리엔(LTD4 및 LTE4) 및히스타민의분비를감소시키고, 기관지내에존재하는염증세포또는배상세포수를감소시키며, 평활근세포의수축을감소시키는효과를나타내므로, 천식의예방또는치료에유용하게사용될수 있다.
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公开(公告)号：KR1020170037546A
公开(公告)日：2017-04-04
申请号：KR1020160122025
申请日：2016-09-23
Applicant: 경상대학교산학협력단
Abstract: 본발명은굴 가수분해물제조방법및 이로부터분리된펩타이드를제공하는것으로서, 상기제조방법에의해제조된굴 가수분해물은프로콜라겐타입-1의생성을증가시키고, MMP-1의생합성을저해시키는효과가있어주름개선용건강기능식품또는화장료조성물로유용하게사용될수 있다.
Abstract translation: 本发明提供生产牡蛎水解产物和从其中分离的肽的方法，其中通过上述方法产生的牡蛎水解产物增加了原胶原-1型的产生并抑制了MMP-1的产生 并且可以有效地用作改善皱纹的保健功能食品或化妆品组合物。
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公开(公告)号：KR1020170037545A
公开(公告)日：2017-04-04
申请号：KR1020160122024
申请日：2016-09-23
Applicant: 경상대학교산학협력단
Abstract: 본발명은굴 가수분해물제조방법및 이로부터분리된펩타이드를제공하는것으로서, 상기제조방법에의해제조된굴 가수분해물은멜라닌세포의세포수를감소시키고멜라닌세포주변또는피부의표피층에존재하는멜라닌과립의분포를감소시키는효과가있어피부미백용건강기능식품또는화장료조성물로유용하게사용될수 있다.
Abstract translation: 本发明牡蛎酶解生产过程中，并以提供肽从其分离的黑色素颗粒的通过所述方法牡蛎水解产物制备降低了黑素的细胞的数量被存在于皮肤中的黑素细胞周或表面层 因此它可以有效地用作皮肤美白或化妆品组合物的保健功能性食品。
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公开(公告)号：KR1020130130573A
公开(公告)日：2013-12-02
申请号：KR1020120054488
申请日：2012-05-22
Applicant: 경상대학교산학협력단
CPC classification number: A61K36/03 , A61K8/97 , A61K8/987 , A61K9/0014 , A61K31/726 , A61K31/737 , A61K35/655 , A61K47/46 , A61K2236/37 , A61K2800/75 , A61Q19/00 , A61K2300/00
Abstract: The present invention relates to a composition for alleviating atopic dermatitis, containing an extract of a mixture of Undaria pinnatifida Sporophyll and an ascidian tunic purified substance. The composition of the present invention exhibits an excellent effect of alleviating atopic dermatitis through synergistic action of an anti-inflammatory effect of the Undaria pinnatifida Sporophyll and a cell regeneration effect of the ascidian tunic purified substance. The composition of the present invention is not involved in suppressing cytokine generation, but is expected to suppress inflammation and regenerate skin, resulting in exhibiting efficacy. [Reference numerals] (1) Undaria pinnatifida sporophyll + deionized water;(3) Cooling (cool water);(4) 1/2 weight division;(5) Rotate in a centrifuge;(6) Extract an Undaria pinnatifida sporophyll crude liquid (35 ml);(7) Undaria pinnatifida sporophyll + ascidian tunic powder 70 mg;(8) Obtain a mixture extract;(AA) Inject organic foreign materials;(BB) Waste concrete powder;(CC) Water
Abstract translation: 本发明涉及一种用于缓解特应性皮炎的组合物，其含有菠萝丝虫和海鞘长尾纯化物质的混合物的提取物。 本发明的组合物通过Undaria pinnatifida Sporophyll的抗炎作用的协同作用和海滨长袍纯化物质的细胞再生作用表现出优异的缓解特应性皮炎的作用。 本发明的组合物不涉及抑制细胞因子的产生，而是预期抑制炎症并再生皮肤，从而显示出效力。 [参考数字]（1）无花粉虱+去离子水;（3）冷却（冷水）;（4）1/2重分割;（5）在离心机中旋转;（6）提取无孢子虫 （35毫升）;（7）无花果粉刺+海滨长袍粉70毫克;（8）获得混合物提取物;（AA）注射有机异物;（BB）废混凝土粉;（CC）水
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