Abstract:
The present invention relates to a drug delivery complex enabling direct monitoring of delivery and cellular uptake of drug and a method for preparing the same. More specifically, the present invention relates to a drug delivery complex comprising a fluorescent marker containing a disulfide bond residue, a cancer cell targeting molecule, and an effective drug ingredient, and a method for preparing the drug delivery complex. The present invention can provide both the imaging and treatment effects on various target cells, and effectively miniaturize the monitoring and treatment effects on the target cells, thereby opening a new chapter of the development of new medicines for theragnosis, capable of functioning at cellular levels.
Abstract:
본 발명은 티올 선택성을 갖는 화학정량 형광 표지자, 그 제조방법 및 이를 이용한 생체내 티올 영상화 방법에 관한 것으로서, 더욱 구체적으로는, 화학식 1의 티올 선택성을 갖는 화학정량 형광 표지자, 그 제조방법 및 이를 이용한 생체내 티올 영상화 방법에 관한 것이다:
본 발명에 따른 티올 선택성을 갖는 화학정량 형광 표지자는 티올에 대해서 높은 선택성을 나타내며, 우수한 발광 특성을 보이고, 생체 내에서, 특히 간 티올을 직접적이면서도 실시간으로 영상화하는 것을 가능케 한다.
Abstract:
PURPOSE: Chemical dosimeter of coumarin-Cu(II) association is provided to selectively detect cyanide ion from the aqueous media as it clearly strengthen fluorescence compared to other anion class in an aqueous condition and be very useful even for the detection of small amount of cyanide ion by having a non-emitting fluorescence mechanism. CONSTITUTION: Chemical dosimeter of coumarin-Cu(II) association is indicated as chemical formula 1 and detects the cyanide ion. The compound of chemical formula 1 is produced as the compound of the chemical formula 2 and Cu(II) ion forms a complex. The compound of chemical formula 1 changes into the compound of chemical formula 3 as the cyanide ion unites with Cu(II) ion of the compound to form a complex of cyanide ion-copper ion in the existence of cyanide ion. The compound of chemical formula 3 tells the presence of cyanide ion among the detection object sample by emitting strong fluorescence.
Abstract:
PURPOSE: A stoichiometric fluorescent marker having thiol selectivity, a manufacturing method thereof, and an in-vivo thiol imaging method using the same are provided to show excellent light emittance, and to directly visualize thiol in the living body in real time. CONSTITUTION: A stoichiometric fluorescent marker has the thiol selectivity represented by chemical formula 1. A manufacturing method of the stoichiometric fluorescent marker having the thiol selectivity comprises a step of manufacturing a compound represented by the chemical formula 1 by performing deacetylation reaction on a compound represented by chemical formula 2. The compound represented by the chemical formula 2 is manufactured by reacting a compound represented by chemical formula 3 with the triphosgene and 2,2'-dithioethanol. The compound represented by the chemical formula 3 is manufactured by reacting a compound represented by chemical formula 4 with the galactose tetraacetate derivative having a -NH2 end group.
Abstract:
오라클 데이터베이스에서 데이터를 복원하는 방법 및 장치에 관한 것으로서, 데이터 복원 장치가 데이터베이스로부터 시스템 파일을 입력받고, 시스템 파일에 포함된 시스템 테이블을 조회하여 시스템 파일 내의 하나 이상의 테이블들에 대한 스키마 정보를 도출하고, 스키마 정보에 기초하여 하나 이상의 테이블들 중 삭제된 테이블을 선별하고, 선별된 테이블의 오브젝트 ID를 통해 삭제된 레코드를 포함하는 데이터 블록을 검색하여 도출하며, 도출된 데이터 블록에서 삭제된 레코드를 식별하여 추출함으로써, 삭제된 레코드를 복구한다.
Abstract:
The present invention relates to a probe complex visualizing mitochondrial thioredoxin activity and a method for preparing the same, more specifically to a probe complex containing a fluorescent marker with a bisulfide bond residue and a mitochondrial targeting molecule, and a method for preparing the same. According to the present invention, a user can effectively observe mitochondrial thioredoxin activity and obtain useful information for the research about cell functions regarding cancer which is connected to the development of new drugs.
Abstract:
PURPOSE: A compound based on rhodamine as a chemical sensor is provided to detect Fe^3+ and to ensure fluorescence change characteristic. CONSTITUTION: A rhodamine derivative is denoted by chemical formula 1. The rhodamine derivative is used for selectively detecting trivalent iron ion in a sample. The sample is an aqueous solution. A chemical sensor for detecting the trivalent iron ion has the rhodamine derivative. The rhodamine derivative detects Fe^3+ in hepatocytes. The rhodamine derivative has high selectivity to metal cation such as Fe^3+, Fe^2+, K^+, Na^+, and Ca^2+.